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| 1 | Multilocular Cystic Renal Cell Carcinoma:A Series of 8 Cases and Review of the Literature显示文摘OBJECTIVE To study the clinical,pathologic and imaging features of multilocular cystic renal cell carcinoma(MCRCC)and to review the diagnosis and treatment of this subtype of renal cell carcinoma(RCC). METHODS The data from 8 cases(mean age,49.4;5 men and 3 women) who had been treated from 2004 to 2006,were reviewed retrospectively. Radiologic and pathologic documents were evaluated.For treatments,radi- cal nephrectomy was conducted in 4 patients,partial nephrectomy in 2 and laparoscopic nephrectomy in 2. RESULTS Postoperative pathological findings confirmed the diagnosis of MCRCC.The stage of al 8 cases was pT1.For pathologic grade,7 cases were G1 and 1 case was G2.Seven patients available for follow-up had sur- vived tumor-free during the mean time of 8 months. CONCLUSION MCRCC is an uncommon subtype of RCC,it has a lower malignant potential and a better prognosis compared with other types of RCC.Nephron-sparing surgery may be an appropriate treatment options for MCRCC. | Shuo Liu Guang Sun Zhanjun Guo Xiaodong Li | 2007 | Chinese Journal of Clinical Oncology2007，4，2： | 9 |
| 2 | Senegenin promotes in vitro proliferation of human neural progenitor cells显示文摘Senegenin,an effective component of Polygala tenuifolia root extract,promotes proliferation and differentiation of neural progenitor cells in the hippocampus.However,the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood.Cells from a ventral mesencephalon neural progenitor cell line(ReNcell VM) were utilized as models for pharmaceutical screening.The effects of various senegenin concentrations on cell proliferation were analyzed,demonstrating that high senegenin concentrations(5,10,50,and 100 μmo/L),particularly 50 μmol/L,significantly promoted proliferation of ReNcell VM cells.In the mitogen-activated protein kinase signal transduction pathway,senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases.Moreover,cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors.Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase. | Shi, Fang Liang, Zhigang Guo, Zixuan Li, Ran Yu, Fen Zhang, Zhanjun Wang, Xuan Wang, Xiaomin | 2011 | Neural Regeneration Research2011，6，3： | 5 |
| 3 | Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells显示文摘Near infrared(NIR) light-driven nitric oxide(NO) release nano-platform based on upconversion nanoparticles(UCNPs) and light sensitive NO precursor Roussin's black salt(RBS) was fabricated to generate NO upon 808 nm irradiation. The application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. The combination of UCNPs and RBS could realize the on-demand release of NO at desired time and location by simply controlling the output of NIR laser.Cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells(CSCs)rather than non-CSCs. Therefore, a synergistic cancer therapy strategy to eradicate both CSCs and nonCSCs simultaneously was developed. Traditional chemo-drug could inhibit non-CSCs but has low killing efficiency in CSCs. However, we found that the combination of NO and chemotherapy could efficiently inhibit CSCs in bulk cells, including inhibiting mammosphere formation ability, decreasing CD44^+/CD24^- subpopulation and reducing tumorigenic ability. The mechanism studies confirmed that NO could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in CSCs. This UCNPsbased platform may provide a new combinatorial strategy of NO and chemotherapy to improve cancer treatment. | Xiao Zhang Zhao Guo Jing Liu Gan Tian Kui Chen Shicang Yu Zhanjun Gu | 2017 | Science Bulletin2017，62，14： | 3 |
| 4 | X protein mutations in hepatitis B virus DNA predict postoperative survival in hepatocellular carcinoma显示文摘 | Ying Xie Shufeng Liu Yue Zhao Zhanjun Guo Jinsheng Xu | 2014 | Tumor Biology2014，，10： | 3 |
| 5 | Baicalin and jasminoidin effects on gene expression and compatibility in the hippocampus following focal cerebral ischemia显示文摘The compound traditional Chinese medicine Qingkailing,which is an ingredient used to treat cerebral ischemia,has been limited to studies concerning single genes or single pathways.Interactions and pharmacological mechanisms of the compound ingredients(baicalin and jasminoidin) remain poorly understood.In the present study,baicalin and jasminoidin,as well as the combination,were used to separately treat mouse models of cerebral ischemia.cDNA microarray analyses of 374 cerebral ischemia-related genes were utilized to determine changes in gene-expression profiles.Arraytrack 3.40 and Ingenuity Pathway Analysis(IPA) databases were utilized to analyze changes in gene molecular functions and network path functions.Baicalin or jasminoidin alone effectively reduced infarct area,and the combination resulted in significantly better outcomes.IPA showed inhibited cell apoptosis in the baicalin group and Ca2+ channel regulation in the jasminoidin group.The combination of baicalin and jasminoidin activated HTR3A and F5 expression,regulated Ca2+ channels,activated kappa light polypeptide gene enhancer inhibitor IKBKG in B cells to control IkB kinase/nuclear factor-kB cascade,suppressed activation of inflammatory cytokine interleukin-6 receptors and activated transduction of guanine-nucleotide-binding protein(G protein) signal.Results suggested that the combination of baicalin and jasminoidin resulted in similar molecular mechanisms to baicalin and jasminoidin alone.However,novel pharmacological actions of compatibility were detected,demonstrating significant protection against cerebral ischemia. | Guo, Lin Meng, Fanyun Zhang, Guodong Zhao, Jing Zhang, Zhanjun Zhou, Caixiu Wang, Zhong | 2011 | Neural Regeneration Research2011，6，3： | 2 |
| 6 | Graphite blocks with high thermal conductivity derived from natural graphite flake显示文摘 | Zhanjun Liu Quangui Guo Jingli Shi | 2008 | Carbon2008，46，3： | 1 |
| 7 | Graphite blockswith high thermal conductivity derived from natural graphiteflake显示文摘 | Zhanjun Liu Quangui Guo Jingli Shi | 2008 | Carbon2008，46，： | 1 |
| 8 | Carbon seal materials with superior mechanical properties and fine-grained structure fabricated by a new process显示文摘 | Zhanjun Liu Quangui Guo Yan Song Jingli Shi Jinren Song Lang Liu | 2006 | Materials Letters2006，，8： | 1 |
| 9 | Antifertility Effects of Orally Administration of Low Dose Gossypol Acetic Acid Combined with Methyltestosterone Plus Ethinyl Estradiol on Male Rat显示文摘Objective To investigate the feasibility and optimal regimen of orally administration of low dose gossypol acetic acid(GA) combined with methyltestosterone(MT) plus ethinyl estradiol(EE) for contraception in males. Methods Wistar male rats were randomly assigned into four groups,20 in each group. Animals in group A or B were administered daily with 1% methyl cellulose or GA(12 mg/kg) suspended in 1% methyl cellulose,respectively. Rats in group C or D took firstly GA 12 mg/kg+MT 20 mg/kg+EE 0.1 mg/kg or MT 20 mg/kg+EE 0.1 mg/kg,in a suspension with 1% methyl cellulose,via gastric intubation. After the infertilities were initiated(6 weeks for group C,8 weeks for group D) ,GA was served alone while MT+EE were withdrawn in rats of groups C and D. The treatment was ceased after 18 weeks and some males from group C were permitted to recover. Fertility testing,10 males per group,was served for determining infertility or restoration of fertility in treated rats. Examinations of histology and biochemistry in treated rats were used to examine the morphologic influences on sperm,testis,epididymides and viscera,and biochemical changes in blood. The growth and development of F1 generation of the rats would also be tested in a series of behavioral tests. Results Ten rats from group C were infertile at week 6 after treatment,and the fulfilled infertility was maintained with low-dose GA(12 mg/kg) only daily. Six weeks after cessation of treatment,all of treated males recovered their fertility. However,8 of 10 rats from group D were in sterility at 6th week of treatment and all at 8th week oftreatment,but the infertility could not be kept with the similar dose GA alone later on. Moreover,no adverse effects were found in our present experiments. Conclusion Administration of oral low dose GA combined with MT and EE as loading dose could successfully induce infertility in short term,whereafter the efficacy could completely be maintained by similar low dose of GA alone for long term. The combined regimen should be safe,effective,reversible and long term,and then optimal and promised contraception for male. | Zhanjun YANG Wei-san YE Lan WANG Yan GUO She-pu XUE | 2008 | Journal of Reproduction and Contraception2008，19，4： | 1 |
| 10 | Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA and age-at-onset of patients with chronic kidney disease显示文摘 | Bai Yaling Guo Zhanjun Xu Jinsheng Zhang Junxia Cui Liwen Zhang Huiran Zhang Shenglei Ai Xiaolu | 2014 | Chinese Medical Journal2014，，17： | 1 |
| 11 | Graphite blocks with high thermal conductivity derived from natural graphite flake显示文摘 | Liu Zhanjun Guo Quangui Shi Jingli | 2008 | Carbon2008，，46： | 1 |
| 12 | Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer显示文摘 | Cuiju Wang Yingnan Wang Huiying Wang Ruixing Zhang Zhanjun Guo | 2014 | Tumor Biology2014，，12： | 1 |
| 13 | A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer显示文摘 | Cuiju Wang Zhanjun Guo Chensi Wu Yan Li Shan Kang | 2012 | Cancer Genetics (-)2012，，7： | 1 |
| 14 | A polymorphism at the miR-502 binding site in the 3’ untranslated regionof the SET8 gene is associated with the outcome of small-cell lung cancer显示文摘 | Cuimin Ding Ruijuan Li Jingcui Peng Shengmian Li Zhanjun Guo | 2012 | Experimental and Therapeutic Medicine2012，，4： | 1 |
| 15 | A functional hydrogenase mimic that catalyzes robust H_(2) evolution spontaneously in aqueous environment显示文摘Although great progress has been made in improving hydrogen production,highly efficient catalysts,which are able to produce hydrogen in a fast and steady way at ambient temperature and pressure,are still in large demand.Here,we report a[NiCo]-based hydrogenase mimic,NiCo_(2)O_(4) nanozyme,that can catalyze robust hydrogen evolution spontaneously in water without external energy input at room temperature.This hydrogenase nanozyme facilitates water splitting reaction by forming a three-center Ni-OH-Co bond analogous to the[NiFe]-hydrogenase reaction by using aluminum as electron donor,and realizes hydrogen evolution with a high production rate of 915 L·h^(-1) per gram of nanozymes,which is hundreds of times higher than most of the natural hydrogenase or hydrogenase mimics.Furthermore,the NiCo_(2)O_(4) nanozyme can robustly disrupt the adhesive oxidized layer of aluminum and enable the full consumption of electrons from aluminum.In contrast to the often-expensive synthetic catalysts that rely on rare elements and consume high energy,we envision that this NiCo_(2)O_(4) nanozyme can potentially provide an upgrade for current hydrogen evolution,accelerate the development of scale-up hydrogen production,and generate a clean energy future. | Ningning Song Zhanjun Guo Shuo Wang Yongli Li Yunpeng Liu Meishuai Zou Minmin Liang | 2024 | Nano Research2024，17，5： | 0 |
| 16 | Recent research progress of laser plasma interactions in Shenguang laser facilities显示文摘Wereport experimental research on laser plasma interaction(LPI)conducted in Shenguang laser facilities during the past ten years.The research generally consists of three phases:(1)developing platforms for LPI research in mm-scale plasma with limited drive energy,where both gasbag and gas-filled hohlraum targets are tested;(2)studying the effects of beam-smoothing techniques,such as continuous phase plate and polarization smoothing,on the suppression of LPI;and(3)exploring the factors affecting LPI in integrated implosion experiments,which include the laser intensity,gas-fill pressure,size of the laser-entrance hole,and interplay between different beam cones.Results obtained in each phase will be presented and discussed in detail. | Tao Gong Liang Hao Zhichao Li Dong Yang Sanwei Li Xin Li Liang Guo Shiyang Zou Yaoyuan Liu Xiaohua Jiang Xiaoshi Peng Tao Xu Xiangming Liu Yulong Li Chunyang Zheng Hongbo Cai Zhanjun Liu Jian Zheng Zhebin Wang Qi Li Ping Li Rui Zhang Ying Zhang Fang Wang Deen Wang Feng Wang Shenye Liu Jiamin Yang Shaoen Jiang Baohan Zhang Yongkun Ding | 2019 | Matter and Radiation at Extremes2019，4，5： | 0 |
| 17 | Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification显示文摘During criminal case investigations,blood evidence tracing is critical for criminal investigation.However,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult tracking.Therefore,a highly sensitive and specific method for the rapid detection of human blood stains remains urgent.To solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and specificity.To construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme strip.The developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood samples.Finally,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to do.The results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry. | Juanji Hong Zhanjun Guo Dihan Duan Yi Zhang Xin Chen Yongjiu Li Zheng Tu Lei Feng Lei Chen Xiyun Yan Lizeng Gao Minmin Liang Demin Duan | 2024 | Nano Research2024，17，3： | 0 |
| 18 | Multiscale structural design of MnO_(2)@GO superoxide dismutase nanozyme for protection against antioxidant damage显示文摘Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase(SOD)nanozymes.Here,we reported a novel SOD nanozyme design,with employing graphene oxide(GO)as the framework,andδ-MnO_(2)as the active sites,to mimic the natural Mn-SOD.This MnO_(2)@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology,providing highly specific surface area for·O_(2)−adsorption and confined spaces for subsequent catalytic reactions.Thus,the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%,which is 222.6%and 1605.4%amplification over GO and MnO_(2)nanoparticles,respectively.Additionally,such unique hierarchical structural design endows MnO_(2)@GO with catalytic specificity,which was not present in the individual component(GO or MnO_(2)).This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes. | Yue Yu Yinuo Zhang Yu Wang Wenxing Chen Zhanjun Guo Ningning Song Minmin Liang | 2023 | Nano Research2023，16，8： | 0 |
| 19 | Recent progress in single-atom nanozymes research显示文摘Single-atom nanozyme(SAzyme)is the hot topic of the current nanozyme research.Its intrinsic properties,such as high activity,stability,and low cost,present great substitutes to natural enzymes.Moreover,its fundamental characteristics,i.e.,maximized atom utilizations and well-defined geometric and electronic structures,lead to higher catalytic activities and specificity than traditional nanozymes.SAzymes have been applied in many biomedical areas,such as anti-tumor therapy,biosensing,antibiosis,and anti-oxidation therapy.Here,we will discuss a series of representative examples of SAzymes categorized by their biomedical applications in this review.In the end,we will address the future opportunities and challenges SAzymes facing in their designs and applications. | Bing Jiang Zhanjun Guo Minmin Liang | 2023 | Nano Research2023，16，2： | 0 |
| 20 | The effects of incident light wavelength difference on the collective stimulated Brillouin scattering in plasmas显示文摘The first laser–plasma interaction experiment using lasers of eight beams grouped into one octad has been conducted on the Shenguang Octopus facility.Although each beam intensity is below its individual threshold for stimulated Brillouin backscattering(SBS),collective behaviors are excited to enhance the octad SBS.In particular,when two-color/cone lasers with wavelength separation 0.3 nm are used,the backward SBS reflectivities show novel behavior in which beams of longer wavelength achieve higher SBS gain.This property of SBS can be attributed to the rotation of the wave vectors of common ion acoustic waves due to the competition of detunings between geometrical angle and wavelength separation.This mechanism is confirmed using massively parallel supercomputer simulations with the three-dimensional laser–plasma interaction code LAP3D. | Qiang Wang Zhichao Li Zhanjun Liu Tao Gong Wenshuai Zhang Tao Xu Bin Li Ping Li Xin Li Chunyang Zheng Lihua Cao Xincheng Liu Kaiqiang Pan Hang Zhao Yonggang Liu Bo Deng Lifei Hou Yingjie Li Xiangming Liu Yulong Li Xiaoshi Peng Zanyang Guan Qiangqiang Wang Xingsen Che Sanwei Li Qiang Yin Wei Zhang Liqiong Xia Peng Wang Xiaohua Jiang Liang Guo Qi Li Minqing He Liang Hao Hongbo Cai Wudi Zheng Shiyang Zou Dong Yang Feng Wang Jiamin Yang Baohan Zhang Yongkun Ding Xiantu He | 2023 | Matter and Radiation at Extremes2023，8，5： | 0 |
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