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| 1 | Endostatin enhances antitumor effect of tumor antigen-pulsed dendritic cell therapy in mouse xenograft model of lung carcinoma显示文摘Objective: To investigate the antitumor effect of endostatin combined with tumor antigen-pulsed dendritic cell(DC)-T cell therapy on lung cancer.Methods: Transplanted Lewis lung cancer(LLC) models of C57BL/6 mice were established by subcutaneous injection of LLC cells in left extremity axillary. Tumor antigen-pulsed DC-T cells from spleen cells and bone of mice were cultured in vitro. Tumor-bearing mice were randomly divided into three groups, including DCT+endostatin group, DC-T group, and phosphate-buffered saline(PBS) control group. Microvessel density(MVD) of tumor tissue in tumor-bearing mice was determined by immunohistochemistry(IHC). The expressions of vascular endothelial growth factor(VEGF) and hypoxia-inducible factor-1α(HIF-1α) were determined by Western blotting and IHC staining. The proportions of CD8+ T cells, mature dendritic cells(m DC), tumor-associated macrophages [TAM(M1/M2)], and myeloid-derived suppressor cells(MDSC) in suspended cells of tumor tissue were determined by flow cytometry. The expressions of interleukin(IL)-6, IL-10, IL-17, transforming growth factor-β(TGF-β) and interferon-γ(IFN-γ) in suspended cells of tumor tissue were detected by enzyme-linked immune sorbent assay(ELISA).Results: DC-T cells combined with endostatin remarkably suppressed tumor growth. MVD of mice in DCT+endostatin group was significantly lower than that of the control group and DC-T monotherapy group. The expressions of VEGF, IL-6 and IL-17 in tumors were markedly decreased, but IFN-γ and HIF-1α increased after treating with DC-T cells combined with endostatin, compared to control group and DC-T group. In the DCT+endostatin group, the proportions of MDSC and TAM(M2 type) were significantly decreased, m DC and TAM(M1 type) were up-regulated, and CD8+ T cells were recruited to infiltrate tumors, in contrast to PBS control and DC-T monotherapy. DC-T cells combined with endostatin potently reduced the expressions of IL-6, IL-10, TGF-β and IL-17 in tumor tissue, and enhanced the expression of IFN-γ.Conclusions: The study indicated the synergic antitumor effects between endostatin and tumor antigen-pulsed DC-T cells, which may be a prospective therapy strategy to achieve potent antitumor effects on lung cancer. | ring Liang Xiaolin Liu Qi Xie Guoling Chen Xingyu Li Yanrui Jia Beibei Yin Xun Qu Yan Li | 2016 | Chinese Journal of Cancer Research2016，28，4： | 8 |
| 2 | Size control of monodisperse nonporous silica particles by seed particle growth显示文摘Monodisperse nonporous silica particles were prepared by sol-precipitation via seed particle growth method,and the particle size,which varied from 1.0 to 4.7 m,was strictly controlled in our experiment. The formation of secondary particles,which resulted in a multimodal distribution of particle size,was suppressed by changing tetraethoxysilane(TEOS) concentration and reaction temperature. Furthermore,the effect of adding small amounts of electrolyte to the hydrolysis mixture was examined. | Beibei Zhao Caihua Tian Yan Zhang Tao Tang Fengyun Wang | 2011 | Particuology2011，9，3： | 7 |
| 3 | Preparation of high-purity monodisperse silica microspheres by the sol-gel method coupled with polymerization-induced colloid aggregation显示文摘Ultra-pure mesoporous silica microspheres with good monodispersity were synthesized in two steps:nanometer-sized silica sol was produced by the sol-gel process,then micrometer-sized silica microspheres were synthesized by polymerization-induced colloid aggregation of the silica sol.The total metal content of the microspheres was extremely low,which eliminated the tailing of chromatographic peaks by chelating reagents.The pore structure of the silica microspheres could be controlled by altering the sol-gel conditions.The silica microsphere particle size could be adjusted by using different polymerizationinduced colloid aggregation conditions. | Beibei Zhao Yan Zhang Tao Tang Fengyun Wang Tong Li Qiyu Lu | 2015 | Particuology2015，13，5： | 7 |
| 4 | Hypertensive stretch regulates endothelial exocytosis of WeibeI-Palade bodies through VEGF receptor 2 signaling pathways显示文摘Weibel-Palade 身体(WPB ) 的调整 endothelial exocytosis,在白血球 trafficking 的第一个阶段,在发炎和损害起一个枢轴的作用。尖锐的机械段仔细与脉管的发炎被联系了,尽管精确机制是未知的。这里,我们证明那高血压的段通过 VEGF 受体 2 调整 endothelial 房间(EC ) 的 WPB 的 exocytosis (VEGFR2 ) 表明小径。段触发一个快速的版本(在分钟以内) 从在有教养的人的 EC 的 WPB 的 von Willebrand 因素和 interleukin-8,通过 P-selectin 的 translocation 把在白血球和 EC 之间的相互作用提升到房间膜。我们进一步证明那高血压的段显著地导致未经触动的 EC 的 P-selectin translocation 并且两个都提高白血球粘附前 vivo 并且在 vivo。导致段的 endothelial exocytosis 经由 VEGFR2/PLCγ 被调停; 1/calcium 小径。有趣地,段也经由一条 VEGFR2/Akt/nitric 氧化物小径导致否定反馈。如此的双效果在颈动脉动脉片断,以及在尖锐高血压的老鼠模型用药理学和基因途径被证实。这些研究为 endothelial exocytosis 作为有势力收缩筋揭示机械段,它被 VEGFR2 发信号调制。因此, VEGFR2 发信号小径可以在限制高血压的段相关的发炎代表新奇治疗学的目标。 | Yan Xiong Zhenqian Hu Xiaofan Han Beibei Jiang Rongli Zhan Xiaoyu Zhang Yao Lu Chenyang Geng Wei Li Yulong He Yingqing Huo Masabuml Shlbuya Jincai Luo | 2013 | Cell Research2013，23，6： | 7 |
| 5 | Metalens-integrated compact imaging devices for wide-field microscopy显示文摘Metasurfaces have demonstrated unprecedented capabilities in manipulating light with ultrathin and flat architectures.Although great progress has been made in the metasurface designs and function demonstrations,most metalenses still only work as a substitution of conventional lenses in optical settings,whose integration advantage is rarely manifested.We propose a highly integrated imaging device with silicon metalenses directly mounted on a complementary metal oxide semiconductor image sensor,whose working distance is in hundreds of micrometers.The imaging performances including resolution,signal-to-noise ratio,and field of view(FOV)are investigated.Moreover,we develop a metalens array with polarization-multiplexed dual-phase design for a wide-field microscopic imaging.This approach remarkably expands the FOV without reducing the resolution,which promises a non-limited space-bandwidth product imaging for wide-field microscopy.As a result,we demonstrate a centimeter-scale prototype for microscopic imaging,showing uniqueness of meta-design for compact integration. | Beibei Xu Hanmeng Li Shenglun Gao Xia Hu Cheng Yang Chen Chen Feng Yan Shining Zhu Tao Li | 2020 | Advanced Photonics2020，2，6： | 6 |
| 6 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 7 | Cluster-formula-embedded machine learning for design of multicomponent β-Ti alloys with low Young’s modulus显示文摘The present work formulated a materials design approach,a cluster-formula-embedded machine learning(ML)model,to search for body-centered-cubic(BCC)β-Ti alloys with low Young’s modulus(E)in the Ti–Mo–Nb–Zr–Sn–Ta system.The characteristic parameters,including the Mo equivalence and the cluster-formula approach,are implemented into the ML to ensure the accuracy of prediction,in which the former parameter represents the BCC-βstructural stability,and the latter reflects the interactions among elements expressed with a composition formula.Both auxiliary gradient-boosting regression tree and genetic algorithm methods were adopted to deal with the optimization problem in the ML model. | Fei Yang Zhen Li Qing Wang Beibei Jiang Biaojie Yan Pengcheng Zhang Wei Xu Chuang Dong Peter K.Liaw | 2020 | npj Computational Materials2020，，1： | 5 |
| 8 | Tribocorrosion behavior of nickel-aluminium bronze sliding against alumina under the lubrication by seawater with different halide concentrations显示文摘The tribocorrosion failure mechanism of nickel-aluminium bronze(NAB) in different halide concentrations of seawater was studied using a pin-on-disc tribometer that was modified to conduct in-situ electrochemical detection during the sliding process. It has been reported that high-halide-concentration seawater provided a good lubricating effect, and thus reduced the coefficient of friction and wear rate of NAB during the tribocorrosion process. However, the existence of halide ions corroded the passive film and hindered the repassivation of the damaged areas in the wear track, resulting in an increased corrosion rate. In addition, the morphology of the wear scar revealed the occurrence of abrasive, delamination, and adhesive wear of NAB in seawater. For the whole range of halide concentration values, a positive synergy between wear and corrosion was proven, and the quantification of this synergy was discussed in detail. The results show that the corrosionwear synergism was decreased with increasing halide concentration in seawater, and the corrosion-induced wear was dominant in the two synergistic components. | Beibei ZHANG Jianzhang WANG Junya YUAN Fengyuan YAN | 2019 | Friction2019，7，5： | 5 |
| 9 | Mapping a leaf senescence gene els1 by BSR-Seq in common wheat显示文摘Leaf senescence is normally the last stage of plant development. Early senescence of functional leaves significantly reduces the photosynthetic time and efficiency, seriously affecting grain yield and quality in wheat. Discovering genes responsible for early leaf senescence(els) are necessary for developing novel germplasms and cultivars with delayed leaf-senescence through molecular manipulation and marker assisted selection. In this study, we identified an early leaf senescence line M114 in a derivative of a wheat breeding population. Genetic analysis indicated that early leaf senescence in M114 is controlled by a single recessive gene, provisionally designated els1. By applying bulked segregant analysis and RNA-Seq(BSR-Seq), seven polymorphic markers linked to els1 were developed and the gene was located on chromosome arm 2 BS in a 1.5 c M genetic interval between markers WGGB303 and WGGB305. A co-segregating marker, WGGB302, provide a starting point for fine mapping and map-based cloning of els1. | Miaomiao Li Beibei Li Guanghao Guo Yongxing Chen Jingzhong Xie Ping Lu Qiuhong Wu Deyun Zhang Huaizhi Zhang Jian Yang Panpan Zhang Yan Zhang Zhiyong Liu | 2018 | The Crop Journal2018，6，3： | 3 |
| 10 | High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase显示文摘The enantiomers separation of ei ght pharmaceutical racemates collected in Chinese Pharmacopoeia 2010(Ch.P2010),including nitrendipine,felodipine,omeprazole,praziquantel,sulpiride,clenbuterol hydrochloride,verapamil hydrochloride and chlorphenamine maleate,was performed on chiral stationary phase of amylose ramification by high performance liquid chromatography(HPLC)on Chiralpak AD-H column and Chiralpak AS-H column with the mobile phase consisted of isopropanol and n-hexane.The detection wavelength and the flow rate were set at 254 nm and 0.7 mL/min,respectively.The effects of proportion of organic additives,alcohol displacer and temperature on the separation were investigated.The results indicated that eight chiral drugs were separated on chiral stationary phase of amylase ramification in normal phase chroma tographic system.The chromatographic retention and resolution of enantiomers were adjusted by factors,including the changes of the concentration of alcohol displacer in mobile phase,organic alkaline modifier and column temperature.It was shown that the resolution was improved with reducing concentration of alcohol displacer.When the concentration of organic alkaline modifier was 0.2%,the resolution and the peak shape were fairly good.Most racemates mentioned above had the best resolution at column temperature of 25℃.The best temperature should be kept unchanged in the process of separation so as to obtain stable separation results. | Yan Wang Ying Zhou Chao Ma Beibei Yang Ru Feng Yiying Zhang Jie Fu Wenjing Chen Yupeng Sun Jingyi Ma Qiming Zhang Yulin Deng Yukui Zhang Wenyi He | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 3 |
| 11 | Bcl-2 gene and its family genes Bax,Bcl-Xl as well as Fas/Apo-1 and their clinical significance in acute leukemia显示文摘Bcl2geneislocatedonhumanchromosome18q21andconsistsof270Kb.Itisanimportantgenewhichcansupprescelularapoptosis.ApartfromBcl2... | Chen Yan , Zhou Jianfeng , Yue Beibei , Xiang Zhifu , Song Xiaohua Li Chongyu and Wang Bianming | 1998 | Chinese Medical Journal1998，，8： | 2 |
| 12 | Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy显示文摘Cyclic dinucleotides(CDNs)as stimulator of interferon genes(STING)agonists capable of inducing strong antitumor innate immune response are highly promising for tumor immunotherapy.The efficacy of these CDNs is,however,reduced greatly by their fast clearance,poor cell uptake and inefficient cytosolic transportation.Here,we report that reduction-responsive biodegradable chimaeric polymersomes(CPs)markedly enhance tumor retention and cytosolic delivery of a synthetic CDN,ADU-S100,and bolster STING pathway activation in the tumor microenvironment and tumor draining lymph nodes,giving significantly better tumor repression and survival of B16F10 melanoma-bearing mice compared with free CDN control.The superiority of CPs-mediated CDN delivery is further verified in combination therapy with low-dose fractionated radiation,which brings about clearly stronger and longer-term immunotherapeutic effects and protection against tumor re-challenge.The development of nano-STING agonists that are able to overcome the delivery barriers of CDNs represents an effective strategy to potentiate cancer immunotherapy. | Huan Zheng Beibei Guo Xinyun Qiu Yifeng Xia Yan Qu Liang Cheng Fenghua Meng Zhiyuan Zhong | 2022 | Bioactive Materials2022，7，10： | 2 |
| 13 | The emergence of clinical resistance to tigecycline显示文摘 | Yan Sun Yun Cai Xu Liu Nan Bai Beibei Liang Rui Wang | 2012 | International Journal of Antimicrobial Agents2012，，： | 1 |
| 14 | Micro-structure of PTFE-based polymer blends and their tribologicalbehaviors under aqueous environment 显示文摘 | CHEN Beibei WANG Jianzhang YAN Fengyuan | 2012 | Tribology Lett2012，45，3： | 1 |
| 15 | The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma显示文摘 | Chengying Jiang Fangke Hu Yanhong Tai Jingli Du Beibei Mao Zengqiang Yuan Yan Wang Lixin Wei | 2012 | Journal of Cancer Research and Clinical Oncology2012，，4： | 1 |
| 16 | Enhanced sodium storage performance in flexible free- standing multichannel carbon nanofibers with enlarged interlayer spacing显示文摘一个灵活、自立的多信道的碳 nanofiber (MCNF ) 电影电极通过 electrospinning 和碳化被制作。在在真空的 MCNF 的高温度的处理以后,获得的纤维(MCNFs-V ) 有 graphene 表(0.398 nm ) 和一个极端低的特定的表面区域的扩大夹层间距(15.3 m 2/g) 。当为钠离子电池用作阳极时, MCNFs-V 证明在 0.1 V 下面的一个分泌物高原,和钠在 sodiation 过程期间被设置进叠的 graphene 表层。MCNFs-V 在 100 个周期和优秀长期的骑车稳定性以后在 0.1 A/g 的当前的密度展出了 222 mAh/g 的一个可逆、高的特定的能力,它比 MCNF 的优异。改进的钠存储表演为钠置闰与 graphene 表的扩大夹层间距被归因于 MCNFs-V 的唯一的微观结构。MCNFs-V 电极为商业钠离子电池作为阳极材料保持大诺言。 | Beibei Yuan Linchao Zeng Xizhen Sun Yan Yu Qingsong Wang | 2018 | Nano Research2018，11，4： | 1 |
| 17 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 18 | Spectrum Auction Games for Multimedia Streaming Over Cognitive Radio Networks显示文摘 | Yan Chen Yongle Wu Beibei Wang | 2010 | IEEE Transactions on Com- munications2010，，： | 1 |
| 19 | Compar- ative investigation on the tribological behaviors of CF/ PEEK composites under sea water lubrication 显示文摘 | Chen Beibei Wang Jianzhang Yan Fengyuan | 2012 | Tri- bology International2012，52，： | 1 |
| 20 | Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired aplastic anemia显示文摘Severe aplastic anemia II(SAA-II)progresses from non-severe aplastic anemia(NSAA).The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation(haplo-BMT)in patients lacking a human leukocyte antigen(HLA)-matched donor.This study aimed to investigate the efficacy of haplo-BMT for patients with SAA-II.Twenty-two patients were included and followed up,and FLU/BU/CY/ATG was used as conditioning regimen.Among these patients,21 were successfully engrafted,19 of whom survived after haplo-BMT.Four patients experienced grade II–IV aGvHD,including two with grade III–IV aGvHD.Six patients experienced chronic GvHD,among whom four were mild and two were moderate.Twelve patients experienced infections during BMT.One was diagnosed with post-transplant lymphoproliferative disorder and one with probable EBV disease,and both recovered after rituximab infusion.Haplo-BMT achieved 3-year overall survival and disease-free survival rate of 86.4%±0.73%after a median follow-up of 42 months,indicating its effectiveness as a salvage therapy.These promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with SAA-II lacking HLA-matched donors. | Hongchen Liu Xiaoli Zheng Chengtao Zhang Jiajun Xie Beibei Gao Jing Shao Yan Yang Hengxiang Wang Jinsong Yan | 2021 | Frontiers of Medicine2021，15，5： | 1 |
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