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| 1 | Grey-matter volume as a potential feature for the classification of Alzheimer's disease and mild cognitive impairment: an exploratory study显示文摘Specific patterns of brain atrophy may be helpful in the diagnosis of Alzheimer's disease(AD). In the present study, we set out to evaluate the utility of grey-matter volume in the classification of AD and amnestic mild cognitive impairment(aMCI) compared to normal control(NC) individuals. Voxel-based morphometric analyses were performed on structural MRIs from 35 AD patients, 27 aMCI patients, and 27 NC participants. A two-sample two-tailed t-test was computed between the NC and AD groups to create a map of abnormal grey matter in AD. The brain areas with significant differences were extracted as regions of interest(ROIs), and the grey-matter volumes in the ROIs of the aMCI patients were included to evaluate the patterns of change across different disease severities. Next, correlation analyses between the grey-matter volumes in the ROIs and all clinical variables were performed in aMCI and AD patients to determine whether they varied with disease progression. The results revealed significantly decreased grey matter in the bilateral hippocampus/parahippocampus, the bilateral superior/middle temporal gyri, and the right precuneus in AD patients.The grey-matter volumes were positively correlated with clinical variables. Finally, we performed exploratory linear discriminative analyses to assess the classifying capacity of grey-matter volumes in the bilateral hippocampus and parahippocampus among AD, aMCI, and NC. Leave-one-out crossvalidation analyses demonstrated that grey-matter volumes in hippocampus and parahippocampus accurately distinguished AD from NC. These findings indicate that grey-matter volumes are useful in the classification of AD. | Yane Guo Zengqiang Zhang Bo Zhou Pan Wang Hongxiang Yao Minshao Yuan Ningyu An Haitao Dai Luning Wang Xi Zhang Yong Liu | 2014 | Neuroscience Bulletin2014，30，3： | 7 |
| 2 | The density matrix picture of laser coherent control current显示文摘The physical substance of the coherent control current and the optical rectification have been analyzed based on density matrix perturbation theory. The analytical results demonstrate that they arise from the real and virtual manifestations of the same nonlinear process associated with diagonal and non-diagonal density matrix. And in terms of polarization, they respectively arise from the intraband and interband polarizations. Both the evolution of the coherent control current exited by ultrafast laser pulse and its dependence on frequency have been studied in time and frequency domains. In order to get an explicit knowledge of intraband polarization and the origination of the coherent control current, we have investigated the initial photo-carriers momentum distribution. The ultrafast decay of the polar momentum population in order of tens of femtosends is given to illustrate its instantaneous optical response. | SHOU Qian ZHANG Haichao LIU Luning LIN Weizhu | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，2： | 3 |
| 3 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 4 | Optimized design and experiment of the three-arm transplanting mechanism for rice potted seedlings显示文摘The transplanting arm of two-arm transplanting mechanism is easy to cause seedlings injury and missing due to its faster speed relative to the seedlings.In order to solve the existed problems,a three-arm transplanting mechanism for rice potted seedlings was developed in this study.The developed three-arm transplanting mechanism for rice potted seedling can make the transplanting arm realize special trajectory and attitude through the unequal planetary gear transmission.The kinematic model of three-arm transplanting mechanism for rice potted seedling was established,and the optimal design software was developed.Based on the heuristic optimization algorithm named“parameter guide”,a set of satisfied mechanism parameters required by the rice potted seedling transplanting were obtained.The trajectory and attitude of three-arm transplanting mechanism used for the rice potted seedling were analyzed.Besides,the virtual simulation results were basically consistent with the optimization software results,and the correctness of theoretical analysis and virtual simulation were also verified by each other.When the developed transplanting mechanism picked up the seedling,the velocity of transplanting arm relative to the seedling was reduced by about 30%.The results showed that the injury rate of rice potted seedling transplanting mechanism was 0.04%,the missing rate of seedling was 1.4%,the integrity rate of seedling pot matrix was 96%,and the success rate of picking seedling was 99.92%. | Jianjun Yin Zeliang Wang Maile Zhou Luning Wu Yan Zhang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，5： | 3 |
| 5 | REM sleep behavior disorder in a patient with pontine stroke显示文摘 | Zhang Xi Wang Luning | 2007 | Sleep Medicine2007，，1： | 2 |
| 6 | Angular distribution of terahertz emission from laser interactions with solid targets显示文摘Intense femtosecond laser-plasma interactions can produce high power terahertz radiations.In our experiment,the polished copper target was irradiated by a p-polarized laser with intensity of more than 1018 W/cm2 at an incident angle of 67.5 from the target normal.The THz energy from three dierent detection angles is measured.The maximum emission is found in the direction at an angle of 45 to the laser backward direction,which is more than one order of magnitude higher than in the other two directions.A simple theoretical model has been established to explain the measurements. | DU Fei LI Chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi GE XuLei LI YuTong MA JingLong LIU XiaoLong ZHANG Lu SHENG ZhengMing CHEN LiMing LU Xin DONG QuanLi WANG ZhaoHua WEI ZhiYi ZHANG Jie | 2012 | Science China(Information Sciences)2012，55，1： | 2 |
| 7 | Filaments in high-speed counter-streaming plasma interactions driven by high-power laser pulses显示文摘Interactions of two counter-streaming plasmas driven by high power laser pulses are studied on Shenguang II laser facility.Filamentary structures were observed in the interaction region after the electrostatic shockwave decay.Theoretical analysis and observations indicate that the filaments are because of collisionless mechanisms,which are caused by the electromagnetic instability,such as the beam-Weibel instability.Collision experiments were also carried out for comparison and no filaments were generated. | YUAN DaWei LI YuTong SU LuNing LIAO GuoQian YIN ChuanLei ZHU BaoJun ZHANG Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 2 |
| 8 | Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis显示文摘The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available. | Jiuyang Xu Chaolin Huang Guohui Fan Zhibo Liu Lianhan Shang Fei Zhou Yeming Wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang Lixue Huang Xiaoying Gu Hui Li Yi Zhang Yimin Wang Frederick G.Hayden Peter W.Horby Bin Cao Chen Wang | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 9 | On the Tectonic Problems of the Southern East China Sea and Adjacent Regions:Evidence from Gravity and Magnetic Data显示文摘In this paper,two sets of gravity and magnetic data were used to study the tectonics of the southern East China Sea and Ryukyu trench-arc system:one data set was from the ‘Geological-geophysical map series of China Seas and adjacent areas' database and the other was newly collected by R/V Kexue III in 2011.Magnetic and gravity data were reorganized and processed using the software MMDP,MGDP and RGIS.In addition to the description of the anomaly patterns in different areas,deep and shallow structure studies were performed by using several kinds of calculation,including a spectrum analysis,upward-continuation of the Bouguer anomaly and horizontal derivatives of the total-field magnetic anomaly.The depth of the Moho and magnetic basement were calculated.Based on the above work,several controversial tectonic problems were discussed.Compared to the shelf area and Ryukyu Arc,the Okinawa Trough has an obviously thinned crust,with the thinnest area having thickness less than 14 km in the southern part.The Taiwan-Sinzi belt,which terminates to the south by the NW-SE trending Miyako fault belt,contains the relic volcanic arc formed by the splitting of the paleo Ryukyu volcanic arc as a result of the opening of the Okinawa Trough.As an important tectonic boundary,the strike-slip type Miyako fault belt extends northwestward into the shelf area and consists of several discontinuous segments.A forearc terrace composed of an exotic terrane collided with the Ryukyu Arc following the subduction of the Philippine Sea Plate.Mesozoic strata of varying thicknesses exist beneath the Cenozoic strata in the shelf basin and significantly influence the magnetic pattern of this area.The gravity and magnetic data support the existence of a Great East China Sea,which suggests that the entire southern East China Sea shelf area was a basin in the Mesozoic without alternatively arranged uplifts and depressions,and might have extended southwestward and connected with the northern South China Sea shelf basin. | SHANG Luning ZHANG Xunhua HAN Bo DU Runlin | 2016 | Journal of Ocean University of China2016，15，1： | 2 |
| 10 | Impaired Functional Connectivity of the Thalamus in Alzheimer’ s Disease and Mild Cognitive Impairment: A Resting-State fMRI Study显示文摘 | Bo Zhou Yong Liu Zengqiang Zhang Ningyu An Hongxiang Yao Pan Wang Luning Wang Xi Zhang Tianzi Jiang | 2013 | Current Alzheimer Research2013，，7： | 1 |
| 11 | Synthesis, characterization and upconversion emission properties of the nanocrystals of Yb^3+/Er^3+ -codoped YF3 -YOF-Y2O3 system 显示文摘 | Li Zhihua Zheng Longzhen Zhang Luning Xiong Leyan | 2007 | Luminescence2007，126，2： | 1 |
| 12 | The influence of target material and thickness on proton energy and angular distribution显示文摘The paper has studied the influence of target material and thickness on energy and angular distributions of the protons generated by using an 800 nm,60 fs,0.24 J laser pulse to irradiate solid target foils.The results show that the initial density and thickness of the targets will affect the formation of the acceleration sheath fields in the target normal direction.For the same target thickness,using lower density target materials can obtain a higher proton maximum energy.However,lower density targets tend to be deformed due to the shock waves launched by the laser pulses,making the proton spatial distribution more divergent. | SU LuNing LIU BiCheng LIN XiaoXuan LIU Feng DU Fei LIU XiaoLong ZHENG Yi GE XuLei LI YuTong SHENG ZhengMing CHEN LiMing WANG WeiMin MA JingLong LU Xin WEI ZhiYi CHEN JiaEr ZHANG Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 1 |
| 13 | One-step chromatography method for efficient separation and purification of R-phycoerythrin from Polysiphonia urceolata 显示文摘 | Liu Luning Chen XiuLan Zhang X Y | 2005 | Journal of Biotechnology2005，116，1： | 1 |
| 14 | Synthesis,characterization and upconversion emission properties of the nanocrystals of Yb3+/Er3+-codoped YF3-YOF-Y2O3 system显示文摘 | Li Zhihua Zheng Longzhen Zhang Luning | 2007 | J Lumin2007，126，2： | 1 |
| 15 | Histopathological studies of sclerotia of Rhizoctonia solani parasitized by the EGFP transformant of Trichoderma virens显示文摘 | Liu Luning Zhang Jingze Xu Tong | 2009 | Lett Appl Microbiol2009，49，6： | 1 |
| 16 | A new weapon for gene therapy-RNA interference technology application' s summary 显示文摘 | Song Xiaoyu Sun Luning Zhang Haipeng | 2004 | Journal of International Pathology and Clinical Medicine2004，24，4： | 1 |
| 17 | Experimental study on static/circulatory flash evaporation显示文摘 | Yan Junjie Zhang Dan Chong Daotong Wang Guifang Li Luning | 2010 | International Journal of Heat and Mass Transfer2010，，23： | 1 |
| 18 | Shen-Qi-Wan Protects the Renal Peritubular Capillary Injury from Adenine-mediated Damage by Upregulating Aquaporin 1显示文摘Background:Shen-Qi-Wan(SQW),a commonly used prescription against chronic kidney disease(CKD)in Tradi-tional Chinese Medicine(TCM),has a nephroprotective action in adenine-induced kidney injury.However,the mechanism of SQW in renal injury remains unclear.Objective:This study was undertaken to measure the effect of SQW on peritubular capillary injury both in vivo and in vitro assays.Methods:The effect of SQW on the peritubular capillary injury was evaluated according to measuring hypothalamic-pituitary-adrenal(HPA)function,inflammatory cytokines,VEGF(vascular endothelial growth fac-tor),CD34(Cluster of differentiation 34),and AQP1(Aquaporin 1)levels in the kidney,cell migration,and lumen forming capacity.Results:SQW supplementation could ameliorate dysfunction of the HPA and renal function loss induced by adenine.SQW also significantly inhibited the inflammatory cytokines including MCP-1(monocyte chemotactic protein-1)and VCAM-1(vascular cell adhesion molecule-1)level.Alternatively,SQW administration showed an ameliorating effect from the toxicity and alleviated the injury of capillaries around renal tubules instigated by adenine through increasing AQP1 mRNA and protein level.SQW medicated the serum enhanced the migration and lumen formation ability of HMEC-1 cells,and significantly increased AQP1 protein level.Moreover,AQP1 knockdown efficiently inhibited the migration and lumen formation ability in HMEC-1 cells,and weakened the effect of SQW medicated serum.Conclusion:These results suggested that SQW attenuated peritubular capillary injury in adenine-induced CKD model rats through boosting angiogenesis in endothelial cell,and AQP1 may be a potential target of SQW for treating the renal injury. | Yuting Bao Yehui Zhang Yuanxiao Yang Xueming Chen Luning Lin Yunbo Fu Liting Ji Changyu Li | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，1： | 1 |
| 19 | Vapor Phase Polymerization Deposition Conducting Polymer Nanocomposites on Porous Dielectric Surface as High Performance Electrode Materials显示文摘We report chemical vapor phase polymerization(VPP) deposition of poly(3,4-ethylenedioxythiophene)(PEDOT) and PEDOT/graphene on porous dielectric tantalum pentoxide(Ta_2O_5) surface as cathode films for solid tantalum electrolyte capacitors. The modified oxidant/oxidant-graphene films were first deposited on Ta_2O_5 by dip-coating, and VPP process was subsequently utilized to transfer oxidant/oxidant-graphene into PEDOT/PEDOT-graphene films. The SEM images showed PEDOT/PEDOT-graphene films was successfully constructed on porous Ta_2O_5 surface through VPP deposition, and a solid tantalum electrolyte capacitor with conducting polymer-graphene nano-composites as cathode films was constructed. The high conductivity nature of PEDOT-graphene leads to resistance decrease of cathode films and lower contact resistance between PEDOT/graphene and carbon paste. This nano-composite cathode films based capacitor showed ultralow equivalent series resistance(ESR) ca. 12 m? and exhibited excellent capacitance-frequency performance, which can keep 82% of initial capacitance at 500 KHz. The investigation on leakage current revealed that the device encapsulation process has no influence on capacitor leakage current, indicating the excellent mechanical strength of PEDOT/PEDOT-gaphene films. This high conductivity and mechanical strength of graphene-based polymer films shows promising future for electrode materials such as capacitors, organic solar cells and electrochemical energy storage devices. | Ya jie Yang Luning Zhang Shibin Li Zhiming Wang Jianhua Xu Wenyao Yang Yadong Jiang | 2013 | Nano-Micro Letters2013，5，1： | 1 |
| 20 | Polarization of terahertz emission out of incident plane from laser interactions with solid targets显示文摘A powerful terahertz(THz) pulse was produced by a p-polarized,70 fs,800 nm laser interacting with solid targets at an incident angle of 45°.The polarization of the THz emission was measured out of the laser incident plane.The results showed that it was linearly polarized.We established a surface current model to explain this phenomenon,assuming that the transient current moving along the plasma surface was responsible for the generation of the THz emission.The model expectation and the experimental result were in good agreement. | DU Fei LI Chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi LI YuTong MA JingLong SHENG ZhengMing CHEN LiMing LU Xin WANG ZhaoHua WEI ZhiYi ZHANG Jie | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 1 |
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