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| 1 | Effect of tacrolimus in idiopathic membranous nephropathy: a meta-analysis显示文摘 | Santosh, Thapa Liu Hong Liu Bicheng | 2014 | Chinese Medical Journal2014，，14： | 17 |
| 2 | Numerical study of the effects of local atmospheric circulations on a pollution event over Beijing–Tianjin–Hebei, China显示文摘Currently, the Chinese central government is considering plans to build a trilateral economic sphere in the Bohai Bay area, including Beijing, Tianjin and Hebei(BTH), where haze pollution frequently occurs. To achieve sustainable development, it is necessary to understand the physical mechanism of the haze pollution there. Therefore, the pollutant transport mechanisms of a haze event over the BTH region from 23 to 24 September 2011 were studied using the Weather Research and Forecasting model and the FLEXible-PARTicle dispersion model to understand the effects of the local atmospheric circulations and atmospheric boundary layer structure. Results suggested that the penetration by sea-breeze could strengthen the vertical dispersion by lifting up the planetary boundary layer height(PBLH) and carry the local pollutants to the downstream areas; in the early night, two elevated pollution layers(EPLs) may be generated over the mountain areas: the pollutants in the upper EPL at the altitude of 2–2.5 km were favored to disperse by long-range transport, while the lower EPL at the altitude of 1 km may serve as a reservoir, and the pollutants there could be transported downward and contribute to the surface air pollution.The intensity of the sea–land and mountain–valley breeze circulations played an important role in the vertical transport and distribution of pollutants. It was also found that the diurnal evolution of the PBLH is important for the vertical dispersion of the pollutants,which is strongly affected by the local atmospheric circulations and the distribution of urban areas. | Yucong Miao Shuhua Liu Yijia Zheng Shu Wang Bicheng Chen Hui Zheng Jingchuan Zhao | 2015 | Journal of Environmental Sciences2015，27，4： | 14 |
| 3 | Multiple Time Scale Analysis of River Runoff Using Wavelet Transform for Dagujia River Basin, Yantai, China显示文摘Based on monthly river runoff and meteorological data, a method of Morlet wavelet transform was used to analyze the multiple time scale characteristics of river runoff in the Dagujia River Basin, Yantai City, Shandong Prov- ince. The results showed that the total annual river runoff in the Dagujia River Basin decreased significantly from 1966 to 2004, and the rate of decrease was 48×106m3/10yr, which was higher than the mean value of most rivers in China. Multiple time scale characteristics existed, which accounted for different aspects of the changes in annual river runoff, and the major periods of the runoff time series were identified as about 28 years, 14 years and 4 years with decreasing levels of fluctuation. The river runoff evolution process was controlled by changes in precipitation to a certain extent, but it was also greatly influenced by human activities. Also, for different time periods and scales, the impacts of cli- mate changes and human activities on annual river runoff evolution occurred at the same time. Changes in the annual river runoff were mainly associated with climate change before the 1980s and with human activities after 1981. | LIU Delin LILT Xianzhao LI Bicheng ZHAO Shiwei LI Xiguo | 2009 | Chinese Geographical Science2009，19，2： | 10 |
| 4 | GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth显示文摘 | Bicheng Zhan Jun Huang Hong-Liang Li Ting Liu Yan-Yi Wang Paul Waterman Ai-Ping Mao Liang-Guo Xu Zhonghe Zhai Depei Liu Philippa Marrack Hong-Bing Shu | 2008 | Cell Research2008，18，9： | 4 |
| 5 | A Multi-Scale Urban Atmospheric Dispersion Model for Emergency Management显示文摘To assist emergency management planning and prevention in case of hazardous chemical release into the atmosphere, especially in densely built-up regions with large populations, a multi-scale urban atmospheric dispersion model was established.Three numerical dispersion experiments, at horizontal resolutions of 10 m, 50 m and 3000 m, were performed to estimate the adverse effects of toxic chemical release in densely built-up areas. The multi-scale atmospheric dispersion model is composed of the Weather Forecasting and Research(WRF) model, the Open Source Field Operation and Manipulation software package, and a Lagrangian dispersion model. Quantification of the adverse health effects of these chemical release events are given by referring to the U.S. Environmental Protection Agency's Acute Exposure Guideline Levels. The wind fields of the urban-scale case, with 3 km horizontal resolution, were simulated by the Beijing Rapid Update Cycle system, which were utilized by the WRF model. The sub-domain-scale cases took advantage of the computational fluid dynamics method to explicitly consider the effects of buildings. It was found that the multi-scale atmospheric dispersion model is capable of simulating the flow pattern and concentration distribution on different scales, ranging from several meters to kilometers, and can therefore be used to improve the planning of prevention and response programs. | MIAO Yucong LIU Shuhua ZHENG Hui ZHENG Yijia CHEN Bicheng WANG Shu | 2014 | Advances in Atmospheric Sciences2014，31，6： | 4 |
| 6 | On a Half-Discrete Reverse Mulholland-Type Inequality and an Extension显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2014 | Journal of Inequalities and Applications2014，，1： | 1 |
| 7 | On a Multidimensional Hilbert-Type Integral Inequality with Logarithe Function 显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2015 | Mathematical Inequalities ~ Applications2015，18，4： | 1 |
| 8 | On a Half-Discrete Reverse Mulholland-Type Inequality and an Extension显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2014 | Journal of Inequalities and Applications2014，，1： | 1 |
| 9 | Efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection for the treatment of renal anemia in Chinese hemodialysis patients:A randomized,open-label,parallel-group,noninferiority phase III trial显示文摘Background:This study was to explore the clinical efficacy and safety of darbepoetin alfa injection replacing epoetin alfa injection(recombinant human erythropoietin injection,rHuEPO)for the treatment of anemia associated with chronic kidney failure in Chinese patients undergoing hemodialysis.Method:This study was a multicenter,randomized,open-label,intergroup parallel control phase III noninferiority trial from April 19,2013 to September 9,2014 at 25 sites.In this study,the members of the darbepoetin alfa group underwent intravenous administration once per week or once every two weeks.The members of the control drug epoetin alfa group underwent intravenous administration two or three times per week.All subjects underwent epoetin alfa administration during the 8-week baseline period.After that,subjects were randomly assigned to the darbepoetin alfa group or epoetin alfa group.The noninferiority in the changes of the average Hb concentrations from the baseline to the end of the evaluation period(noninferiority threshold:-1.0 g/dl)was tested between the two treatments.The time-dependent hemoglobin(Hb)concentration and the maintenance rate of the target Hb concentration(the proportion of subjects with Hb concentrations between 10.0 and 12.0 g/dl)were also evaluated.Iron metabolism,including changes in the serum iron,total iron-binding capacity,ferritin,transferrin saturation,and comparisons of the dose adjustments between the two groups during the treatment period were analyzed further.Adverse events(AEs)were also observed and compared,and the safety was analyzed between the two treatment groups.The conversion rate switching from epoetin alfa to darbepoetin alfa was also discussed.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:Four hundred and sixty-six patients were enrolled in this study,and ultimately 384 cases were analyzed for safety,including 267 cases in the darbepoetin alfa group and 117 cases in the epoetin alfa group.There were 211 cases in the per-protocol set,including 152 cases in the darbepoetin alfa group and 59 cases in the epoetin alfa group.The changes in the average Hb concentrations from the baseline to the end of the evaluation period were-0.07 and-0.15 g/dl in the darbepoetin alfa group and epoetin alfa group respectively.The difference between the two groups was 0.08 g/dl(95%confidence interval[CI]:-0.22 to 0.39),and the lower limit of the 95%CI was-0.22>-1.0 g/dl.The average Hb concentrations of the two groups were 10.88-11.43 g/dl(darbepoetin alfa)and 10.91-11.38 g/dl(epoetin alfa)during the study period of Weeks 0-28,with the maintenance rates of the target Hb concentration ranging within 71%-87%and 78%-95%in the darbepoetin alfa group and epoetin alfa group respectively.During the period of comparison between the two groups,the incidence of AEs in the darbepoetin alfa group was 61.42%,while in the epoetin alfa group it was 56.41%.All of the adverse events and reactions in the study were those commonly associated with hemodialysis.Conclusion:The overall efficacy and safety of darbepoetin alfa for the treatment of Chinese renal anemia patients undergoing hemodialysis are consistent with those of epoetin alfa. | Bicheng Liu Nan Chen Jinghong Zhao Aiping Yin Xiongfei Wu Changying Xing Gengru Jiang Junzhou Fu Mei Wang Rong Wang Jianying Niu Ping Fu Zhaohui Ni Fanfan Hou Jiuyang Zhao Jing Chen Yuqing Chen Wei Shi Jianghua Chen Wenge Li Gang Xu Ling Zhong Wenhu Liu Guohua Ding Yuichiro Kondo Changhe Yue Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 1 |
| 10 | The influence of target material and thickness on proton energy and angular distribution显示文摘The paper has studied the influence of target material and thickness on energy and angular distributions of the protons generated by using an 800 nm,60 fs,0.24 J laser pulse to irradiate solid target foils.The results show that the initial density and thickness of the targets will affect the formation of the acceleration sheath fields in the target normal direction.For the same target thickness,using lower density target materials can obtain a higher proton maximum energy.However,lower density targets tend to be deformed due to the shock waves launched by the laser pulses,making the proton spatial distribution more divergent. | SU LuNing LIU BiCheng LIN XiaoXuan LIU Feng DU Fei LIU XiaoLong ZHENG Yi GE XuLei LI YuTong SHENG ZhengMing CHEN LiMing WANG WeiMin MA JingLong LU Xin WEI ZhiYi CHEN JiaEr ZHANG Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 1 |
| 11 | Multi-time scale analysis of precipitation variation in Guyuan, China:1957-2005显示文摘Morlet wavelet transformation is used in this paper to analyze the multi time scale characteristics of pre cipitation data series from 1957 to 2005 in Guyuan region.The results showed that(1) the annual precipitation evo lution process had obvious multi time scale variation characteristics of 15 25 years,7 12 years and 3 6 years,and different time scales had different oscillation energy densities;(2) the periods at smaller time scales changed more frequently,which often nested in a biggish quasi periodic oscillations,so the concrete time domain should be ana lyzed if necessary;(3) the precipitation had three main periods(22 year,9 year and 4 year) and the 22 year period was especially outstanding,and the analysis of this main period reveals that the precipitation would be in a relative high water period until about 2012. | Liu Delin Li Bicheng | 2008 | Ecological Economy2008，4，4： | 1 |
| 12 | Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis patients with chronic kidney failure:A randomized,open-label,parallel-group,non-inferiority Phase III trail显示文摘Background:Erythropoietin is a glycoprotein that mainly regulates erythropoiesis.In patients with chronic renal failure with anemia,darbepoetin alfa can stimulate erythropoiesis,correct anemia,and maintain hemoglobin levels.This study was designed to demonstrate the efficacy and safety of darbepoetin alfa injections as being not inferior to epoetin alfa injections(Recombinant Human Erythropoietin injection,rHuEPO)when maintaining hemoglobin(Hb)levels within the target range(10.0-12.0 g/dL)for the treatment of renal anemia.Methods:Ninety-five patients were enrolled in this study from April 15,2013 to April 10,2014 at 25 sites.In this study,patients(n=95)aged 18-70 years were randomized into a once per week intravenous darbepoetin alfa group(n=56)and a twice or three times per week intravenous epoetin alfa group(n=39)for 28 weeks,who had anemia with hemoglobin levels between 6 g/dL and 10 g/dL due to chronic kidney disease(CKD)and were undergoing hemodialysis or hemofiltration with ESA-naive(erythropoiesis stimulating agent-naive).The primary efficacy profile was the mean Hb level(the non-inferiority margin was-1.0 g/dL,week 21-28);the secondary efficacy profiles were the Hb increase rate(week 0-4),the target Hb achievement cumulative rate and time,the change trends of the Hb levels,and the target Hb maintenance ratio.Adverse events(AEs)were observed and compared,and the efficacy and safety were analyzed between the two treatment groups.Additionally,the frequencies of dose adjustments between the darbepoetin alfa and epoetin alfa groups were compared during the treatment period.SAS?software version 9.2 was used to perform all statistical analyses.Descriptive statistics were used for all efficacy,safety,and demographic variable analyses,including for the primary efficacy indicators.Results:The mean Hb level was 11.3 g/dL in the darbepoetin alfa group and 10.7 g/dL in the epoetin alfa group,respectively;the difference of the lower limits of the 95%confidence intervals(CI)between the two groups was 0.1 g/dL(>-1.0 g/dL),and non-inferiority was proven;the Hb levels started to increase in the first four weeks at a similar increase rate;no obvious differences were observed between the groups in the target Hb achievement cumulative rates,and the Hb levels as well as the target Hb level maintenance rate changed over time.The incidence of AEs was 62.5%in the darbepoetin alfa group and 76.9%in the epoetin alfa group.All the adverse events observed in the study were those commonly associated with hemodialysis.Conclusion:Darbepoetin alfa intravenously once per week can effectively increase Hb levels and maintain the target Hb levels well,which makes it not inferior to epoetin alfa intravenously twice or three times per week.Darbepoetin alfa shows an efficacy and safety comparable to epoetin alfa for the treatment of renal anemia. | Nan Chen Changying Xing Jianying Niu Bicheng Liu Junzhou Fu Jiuyang Zhao Zhaohui Ni Mei Wang Wenhu Liu Jinghong Zhao Ling Zhong Xiongfei Wu Wenge Li Yuqing Chen Wei Shi Jianghua Chen Aiping Yin Ping Fu Rong Wang Gengru Jiang Fanfan Hou Guohua Ding Jing Chen Gang Xu Yuichiro Kondo Yuliang Su Changlin Mei | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 1 |
| 13 | On a Half-Discrete Reverse Mulholland-Type Inequality and an Extension显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2014 | Journal of Inequalities and Applications2014，，1： | 1 |
| 14 | 1,25-Dihydroxyvitamin D3 Promotes High Glucose-Induced M1 Macrophage Switching to M2 via the VDR-PPAR γ Signaling Pathway显示文摘 | Xiaoliang Zhang Min Zhou Yinfeng Guo Zhixia Song Bicheng Liu Youhua Liu | 2015 | BioMed Research International2015，，： | 1 |
| 15 | Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage显示文摘 | Chunhua Zhu Songming Huang Yanggang Yuan Guixia Ding Ronghua Chen Bicheng Liu Tianxin Yang Aihua Zhang | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 16 | Monitoring land use change at a small watershed scale on the Loess Plateau,China:applications of landscape metrics,remote sensing and GIS显示文摘 | Liu Delin Li Bicheng Liu Xianzhao | | 0，，： | 1 |
| 17 | CdS decorated resorcinol-formaldehyde spheres as an inorganic/organic S-scheme photocatalyst for enhanced H_(2)O_(2)production显示文摘Photocatalytic H_(2)O_(2)production provides a clean and sustainable strategy for artificial photosynthesis.Herein,an inorganic/organic composite photocatalyst was fabricated by in-situ growth of CdS nanoparticles on the surface of resorcinol-formaldehyde(RF)resin spheres.RF spheres played multiple roles:(i)acting as a substrate for the growth of CdS and constructing a core-shell structure with seamless con-tact;(ⅱ)improving visible light absorption of CdS;(ⅲ)forming an S-scheme heterojunction with CdS and promoting the charge separation and transfer.Consequently,under visible light illumination,CdS/RF composite presented remarkably enhanced H_(2)O_(2)production activity.Its H_(2)O_(2)yield in 60 min was 801μmol L^(-1),which was 5.2 and 1.5 times higher than that of RF spheres and CdS hollow spheres,respectively.The charge migration between CdS and RF followed the S-scheme photocatalytic mechanism,which was verified by work function measurement,ex-situ and in-situ irradiated X-ray photoelectron spectroscopy.This work brings a novel insight into designing RF-based inorganic/organic S-scheme heterojunction pho-tocatalysts for efficient H_(2)O_(2)production. | Bicheng Zhu Jingjing Liu Jian Sun Fei Xie Haiyan Tan Bei Cheng Jianjun Zhang | 2023 | Journal of Materials Science & Technology2023，，31： | 0 |
| 18 | A rare case of easily misdiagnosed primary mucoepidermoid carcinoma of the liver显示文摘To the editor,Mucoepidermoid carcinoma(MEC)is a common malignancy of the salivary glands,which account for approximately 30%of all malignant salivary gland neoplasms that originate in both the major and minor glands.1 But it is relatively rare at other organs,extremely rare in the hepatobiliary system.To the best of our knowledge,since primary MEC of the liver was first reported in 1971,2 no more than 20 cases have been reported worldwide. | Fusheng Liu Bicheng Wang Zhonglin Zhang Yufeng Yuan Haitao Wang | 2022 | Genes & Diseases2022，9，3： | 0 |
| 19 | Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8^(+)T cell responses in HLA-A transgenic mice显示文摘Since severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)-specific T cells have been found to play essential roles in host immune protection and pathology in patients with coronavirus disease 2019(COVID-19),this study focused on the functional validation of T cell epitopes and the development of vaccines that induce specific T cell responses.A total of 120 CD8^(+)T cell epitopes from the E,M,N,S,and RdRp proteins were functionally validated.Among these,110,15,6,14,and 12 epitopes were highly homologous with SARS-CoV,OC43,NL63,HKU1,and 229E,respectively;in addition,four epitopes from the S protein displayed one amino acid that was distinct from the current SARS-CoV-2 variants.Then,31 epitopes restricted by the HLA-A2 molecule were used to generate peptide cocktail vaccines in combination with Poly(I:C),R848 or poly(lactic-co-glycolic acid)nanoparticles,and these vaccines elicited robust and specific CD8^(+)T cell responses in HLA-A2/DR1 transgenic mice as well as wild-type mice.In contrast to previous research,this study established a modified DC-peptide-PBL cell coculture system using healthy donor PBMCs to validate the in silico predicted epitopes,provided an epitope library restricted by nine of the most prevalent HLA-A allotypes covering broad Asian populations,and identified the HLA-A restrictions of these validated epitopes using competitive peptide binding experiments with HMy2.CIR cell lines expressing the indicated HLA-A allotype,which initially confirmed the in vivo feasibility of 9-or 10-mer peptide cocktail vaccines against SARS-CoV-2.These data will facilitate the design and development of vaccines that induce antiviral CD8^(+)T cell responses in COVID-19 patients. | Xiaoxiao Jin Yan Ding Shihui Sun Xinyi Wang Zining Zhou Xiaotao Liu Miaomiao Li Xian Chen Anran Shen Yandan Wu Bicheng Liu Jianqiong Zhang Jian Li Yi Yang Haibo Qiu Chuanlai Shen Yuxian He Guangyu Zhao | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 20 | Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells显示文摘Background:Breast cancer stem cells(BCSCs)are considered responsible for cancer relapse and drug resistance.Understanding the identity of BCSCs may open new avenues in breast cancer therapy.Although several discoveries have been made on BCSC characterization,the factors critical to the origination of BCSCs are largely unclear.This study aimed to determine whether genomic mutations contribute to the acquisition of cancer stem-like phenotype and to investigate the genetic and transcriptional features of BCSCs.Methods:We detected potential BCSC phenotype-associated mutation hotspot regions by using whole-genome sequencing on parental cancer cells and derived serial-generation spheres in increasing order of BCSC frequency,and then performed target deep DNA sequencing at bulk-cell and single-cell levels.To identify the transcriptional program associated with BCSCs,bulk-cell and single-cell RNA sequencing was performed.Results:By using whole-genome sequencing of bulk cells,potential BCSC phenotype-associated mutation hotspot regions were detected.Validation by target deep DNA sequencing,at both bulk-cell and single-cell levels,revealed no genetic changes specifically associated with BCSC phenotype.Moreover,single-cell RNA sequencing showed profound transcriptomic variability in cancer cells at the single-cell level that predicted BCSC features.Notably,this transcriptomic variability was enriched during the transcription of 74 genes,revealed as BCSC markers.Breast cancer patients with a high risk of relapse exhibited higher expression levels of these BCSC markers than those with a low risk of relapse,thereby highlighting the clinical significance of predicting breast cancer prognosis with these BCSC markers.Conclusions:Transcriptomic variability,not genetic mutations,distinguishes BCSCs from non-BCSCs.The identified 74 BCSC markers have the potential of becoming novel targets for breast cancer therapy. | Mengying Tong Ziqian Deng Mengying Yang Chang Xu Xiaolong Zhang Qingzheng Zhang Yuwei Liao Xiaodi Deng Dekang Lv Xuehong Zhang Yu Zhang Peiying Li Luyao Song Bicheng Wang Aisha Al-Dherasi Zhiguang Li Quentin Liu | 2018 | Cancer Communications2018，38，1： | 0 |
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