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| 1 | Morphometric measurement of the patella on 3D model reconstructed from CT scan images for the southern Chinese population显示文摘 | Shang Peng Zhang Linan Hou Zengtao Bai Xueling Ye Xin Xu Zhaobin Huang Xu | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 2 | Persimmon leaf flavonoid promotes brain ischemic tolerance显示文摘Persimmon leaf flavonoid has been shown to enhance brain ischemic tolerance in mice,but its mechanism of action remains unclear.The bilateral common carotid arteries were occluded using a micro clip to block blood flow for 10 minutes.After 10 minutes of ischemic preconditioning,200,100,and 50 mg/kg persimmon leaf flavonoid or 20 mg/kg ginaton was intragastrically administered per day for 5 days.At 1 hour after the final administration,ischemia/reperfusion models were established by blocking the middle cerebral artery for 2 hours.At 24 hours after model establishment,compared with cerebral ischemic rats without ischemic preconditioning or drug intervention,plasma endothelin,thrombomodulin and von Willebrand factor levels significantly decreased and intercellular adhesion molecule-1 expression markedly reduced in brain tissue from rats with ischemic preconditioning.Simultaneously,brain tissue injury reduced.Ischemic preconditioning combined with drug exposure noticeably improved the effects of the above-mentioned indices,and the effects of 200mg/kg persimmon leaf flavonoid were similar to 20 mg/kg ginaton treatment.These results indicate that ischemic preconditioning produces tolerance to recurrent severe cerebral ischemia.However,persimmon leaf flavonoid can elevate ischemic tolerance by reducing inflammatory reactions and vascular endothelial injury.High-dose persimmon leaf flavonoid showed an identical effect to ginaton. | Mingsan Miao Xuexia Zhang Ming Bai Linan Wang | 2013 | Neural Regeneration Research2013，8，28： | 6 |
| 3 | Persimmon leaf flavonoid induces brain ischemic tolerance in mice显示文摘The persimmon leaf has been shown to improve cerebral ischemic outcomes; however, its mechanism of action remains unclear. In this study, mice were subjected to 10 minutes of ischemic preconditioning, and persimmon leaf flavonoid was orally administered for 5 days. Results showed that the persimmon leaf flavonoid significantly improved the content of tissue type plasminogen activator and 6-keto prostaglandin-F1 α in the cerebral cortex, decreased the content of thromboxane B2, and reduced the content of plasminogen activator inhibitor-1 in mice. Following optical microscopy, persimmon leaf flavonoid was also shown to reduce cell swelling and nuclear hyperchromatism in the cerebral cortex and hippocampus of mice. These results suggested that persimmon leaf flavonoid can effectively inhibit brain thrombosis, improve blood supply to the brain, and relieve ischemia-induced pathological damage, resulting in brain ischemic tolerance. | Mingsan Miao Xuexia Zhang Linan Wang | 2013 | Neural Regeneration Research2013，8，15： | 3 |
| 4 | Doxorubicin-loaded zein in situ gel for interstitial chemotherapy of colorectal cancer显示文摘The aim of this research was to evaluate doxorubicin(DOX)-loaded zein in situ gels,a new drug delivery system in which a liquid state drug can be transformed into semi-solid after intratumoral injection.In vitro release of DOX-loaded zein was investigated and the pharmacokinetics,biodistribution and therapeutic efficacy of these DOX-loaded zein formulations were investigated using BAI B/c nude tumor-bearing mice.In vitro release of DOX from the gels extended up to 7 days.Efficient accumulation of DOX in the tumor with lower drug concentration in blood and normal organs was obtained resulting in effective inhibition of tumor growth and fewer off-target side effects.In conclusion,a DOX-loaded in situ gel was developed with sustained release,enhanced anti-cancer efficacy for colorectal cancer in vivo,and especially with reduced off-target side effects. | Ning Shen Jie Hu Linan Zhang Li Zhang Yongjun Sun Yinghua Xie Shaomei Wu Lei Liu Zibin Gao | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 3 |
| 5 | Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression显示文摘Despite being a common therapy for hepatocellular carcinoma(HCC),insufficient thermal ablation can leave behind tumor residues that can cause recurrence.This is believed to augment M2 inflammatory macrophages that usually play a pro-tumorigenic role.To address this problem,we designed D-mannose-chelated iron oxide nanoparticles(man-IONPs) to polarize M2-like macrophages into the antitumor Ml phenotype.In vitro and in vivo experiments demonstrated that man-IONPs specifically targeted M2-like macrophages and accumulated in peri-ablation zones after macrophage infiltration was augmented under insufficient microwave ablation(MWA).The nanoparticles simultaneously induced polarization of pro-tumorigenic M2 macrophages into antitumor M1 phenotypes,enabling the transformation of the immunosuppressive microenvironment into an immunoactivating one.Post-MWA macrophage polarization exerted robust inhibitory effects on HCC progression in a well-established orthotopic liver cancer mouse model.Thus,combining thermal ablation with man-IONPs can salvage residual tumors after insufficient MWA.These results have strong potential for clinical translation. | Rui Cui Luo Wang Dongyun Zhang Kun Zhang Jianping Dou Linan Dong Yixuan Zhang Jiapeng Wu Longfei Tan Jie Yu Ping Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 6 | Iron isotopic analyses of geological reference materials on MC-ICP-MS with instrumental mass bias corrected by three independent methods显示文摘Here we report iron(Fe) isotopic data of three pure Fe solution standards(IRMM-014, GSB Fe, and NIST3126a) and five widely used geological reference materials(RMs) from the United States Geological Survey and Geological Survey of Japan obtained on a Neptune Plus multi-collector–inductively coupled plasma–mass spectrometer(MC-ICP-MS) in our laboratory over the past 3 years. The instrumental mass bias was corrected by three independent methods: sample-standard bracketing(SSB),Ni doping + SSB, and ^(57)Fe–^(58)Fe double spike + SSB.Measurements reveal that both the Ni doping and double spike methods helped calibrate short-term fluctuations in mass bias. Collectively, almost all measurements of RMs yielded δ^(56)Fe within ± 0.05 of recommended values,provided that each sample was measured four times on MC-ICP-MS. For the first time, new recommended values for NIST SRM3126a are reported(δ^(56)Fe = 0.363 ± 0.006,2SE, 95% CI; and δ^(57)Fe = 0.534 ± 0.010, 2SE). | Chuanwei Zhu Wenning Lu Yongsheng He Shan Ke Hongjie Wu Linan Zhang | 2018 | Acta Geochimica2018，37，5： | 2 |
| 7 | Characterization of Genome-Wide Microsatellites of Saccharina japonica Based on a Preliminary Assembly of Illumina Sequencing Reads显示文摘Microsatellites or simple sequence repeats(SSR) function widely and locate dependently in genome. However, their characteristics are often ignored due to the lack of genomic sequences of most species. Kelp(Saccharina japonica), a brown macroalga, is extensively cultured in China. In this study, the genome of S. japonica was surveyed using an Illumina sequencing platform, and its microsatellites were characterized. The preliminarily assembled genome was 469.4 Mb in size, with a scaffold N_(50) of 20529 bp. Among the 128370 identified microsatellites, 90671, 25726 and 11973 were found in intergenic regions, introns and exons, averaging 339.3, 178.8 and 205.4 microsatellites per Mb, respectively. These microsatellites distributed unevenly in S. japonica genome. Mononucleotide motifs were the most abundant in the genome, while trinucleotide ones were the most prevalent in exons. The microsatellite abundance decreased significantly with the increase of motif repeat numbers, and the microsatellites with a small number of repeats accounted for a higher proportion of the exons than those of the intergenic regions and introns. C/G-rich motifs were more common in exons than in intergenic regions and introns. These characteristics of microsatellites in S. japonica genome may associate with their functions, and ultimately their adaptation and evolution. Among the 120140 pairs of designed microsatellite primers, approximately 75% were predicted to be able to amplify S. japonica DNA. These microsatellite markers will be extremely useful for the genetic breeding and population evolution studies of kelp. | ZHANG Linan PENG Jie LI Xiaojie CUI Cuiju SUN Juan YANG Guanpin | 2016 | Journal of Ocean University of China2016，15，3： | 2 |
| 8 | Effect of reactor pressure on the growth rate and structural properties of GaN films显示文摘The effect of reactor pressure on the growth rate, surface morphology and crystalline quality of GaN films grown on sapphire by metalorganic chemical vapor deposition is studied. The results show that as the reactor pressure increases from 2500 to 20000 Pa, the GaN surface becomes rough and the growth rate of GaN films decreases. The rough surface morphology is associated with the initial high temperature GaN islands, which are large with low density due to low adatom surface diffusion under high reactor pressure. These islands prolong the occurrence of 2D growth mode and decrease the growth rate of GaN film. Meanwhile, the large GaN islands with low density lead to the reduction of threading dislocation density during subsequent island growth and coalescence, and consequently decrease the full width at half maximum of X-ray rocking curve of the GaN film. | NI JinYu HAO Yue ZHANG JinCheng YANG LinAn | 2009 | Chinese Science Bulletin2009，54，15： | 2 |
| 9 | Stochastic dynamics of conduction failure of action potential along nerve fiber with Hopf bifurcation显示文摘Action potentials can be induced by external electronic impulsive stimulations applied at one end of the unmyelinated fibers(C-fibers), while some action potentials fail to conduct to the other end of the fiber when the stimulation frequency becomes high. Such a phenomenon is called as conduction failure, which was observed in the biological experiments and related to the painful diabetic neuropathy, inflammation, and trauma in the previous studies. On-off firing pattern was recorded from the fiber when conduction failure happened. In the present study, the diffusion Hodgkin-Huxley(HH) model with resting state near a Hopf bifurcation is adopted to simulate the experimental observations. When the periodic electrical pulses with high frequency are applied to one end of the fiber described by the deterministic HH model, conduction failure and the corresponding firing patterns different from the on-off firing pattern are simulated. When noise is introduced to form the stochastic HH model, the firing pattern corresponding to conduction failure becomes the on-off firing pattern, which is characterised by transition behaviors between on-phase(continuous action potentials) and off-phase(a long quiescent state) and large variations in the durations of both phases. Furthermore, the increase of potassium conductance can enhance the conduction failure degree, which closely matches those observed in the experiment and is suggested to be related to the reduction of pain signals. The results show that noise is an important factor to evoke the on-off firing pattern, reveal the functional capability in the pain signals propagation along C-fiber,and present a possible measure for the treatment of chronic pain. | ZHANG XinJing GU HuaGuang GUAN LiNan | 2019 | Science China(Technological Sciences)2019，62，9： | 2 |
| 10 | Effects of land-use and climate change on sediment and nutrient retention in Guizhou,China显示文摘Introduction:Sediment and nutrient retention have significant impacts on agricultural productivity and water quality.Obvious changes of climate and land-use have deeply affected freshwater ecosystem services in the last several decades.Nevertheless,it is unclear what the differences are in the impact of climate and land-use changes on freshwater ecosystem services.Outcomes:The impacts of climate and land-use change on sediment and nutrient retention(two essential freshwater ecosystem services)were evaluated with the help of the Integrated Valuation of Environmental Services and Tradeoffs(InVEST)model.The results from the study area suggest a decreasing trend in sediment and nutrient retention from 1995 to 2015 when climate and land-use were changed simultaneously.A decreasing trend in sediment retention and an increasing trend in nutrient retention were presented under scenario A(climate change from 1995 to 2015 with land-use unchanged),while the sediment exported and nutrient retention exhibited a decreasing trend except sediment retained under scenario B(land-use change from 1995 to 2015 with unchanged climate).Rainfall erosivity and soil erodibility were more sensitive to the output of sediment retention,while retention efficiency produced more of an effect on nutrient retention.Discussion and Conclusion:Climate change played a dominant role in the change in sediment retention,while land-use change had a more significant effect on nutrient retention change than climate change.The results of this study provide explicitinformation for land-use managers to reduce the negative effects associated with sediment and nutrient retention. | Huiqing Han Jianqiang Yang Geng Ma Yue Liu Linan Zhang Siying Chen Shuliang Ma | 2020 | Ecosystem Health and Sustainability2020，6，1： | 1 |
| 11 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 12 | Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis显示文摘 | Wenbin Liao Victor Pham Linan Liu Milad Riazifar Egest J. Pone Shirley Xian Zhang Fengxia Ma Mengrou Lu Craig M. Walsh Weian Zhao | 2016 | Biomaterials2016，，： | 1 |
| 13 | Effects of topography and vegetation on distribution of rare earth elements in calcareous soils显示文摘This study investigated the impact of topography and vegetation on distribution of rare earth elements(REEs)in calcareous soils using methods of single extraction and mass balance calculation. The purposes of the study were to set a basis for further research on the biogeochemical REE cycle and to provide references for soil–water conservation and REE-containing fertilizer amendments. The results show a generally flat Post-Archean Average Australian Shale—normalized REE pattern for the studied calcareous soils. REE enrichment varied widely. The proportion of acidsoluble phases of heavy REEs was higher than that of light REEs. From top to bottom of the studied hills, dominant REE sources transitioned from limestone in-situ weathering to input from REE-containing phases(e.g., clay minerals,amorphous iron, REE-containing fluids). Our results indicate that the REE content of calcareous soils is mainly controlled by slope aspect, while the enrichment degree of REEs is related to geomorphological position and vegetation type.Furthermore, the proportion of acid-soluble phases of REEs is mainly controlled by geomorphological position. | Zhaoliang Song Yuntao Wu Xiaomin Yang Zijuan Xu Linan Liu Xiaodong Zhang Qian Hao Shaobo Sun Guilin Han Congqiang Liu | 2017 | Acta Geochimica2017，36，3： | 1 |
| 14 | Yellow luminescence of polar and nonpolar gan nanowires on r-plane sapphire by metal organic chemical vapor deposition 显示文摘 | XU Sheng-rui HAO Vue ZHANG Jin-cheng JIANG Teng YANG Linan LU Xiao-li LIN Zhi-yu | 2013 | Nano Letters2013，13，： | 1 |
| 15 | Resilience Enhancement of Urban Energy Systems via Coordinated Vehicle-to-grid Control Strategies显示文摘Coordinated vehicle-to-grid(V2G)control strategies can sustain essential loads of an energy system during islanding,thereby increasing resilience.In this context,this paper investigates the resilience enhancement benefits of smart V2G control,the value of electric vehicle(EV)owner cooperation on system resilience,as well as the complementary effects of PV and EV interaction in an urban multi-energy microgrid(MEMG).By using a rolling horizon approach to optimize day-ahead operation of the MEMG and subsequently dispatching EVs,uncertainties in outage start time,EV arrival/departure times,and initial state of charge(SOC)are mitigated.Results show that smart V2G control can provide a substantial essential load curtailment reduction compared to a non-EV scenario,meanwhile,non-coordinated grid-to-vehicle(G2V)operation was shown to slightly burden the system with a slight increase in non-essential load curtailment.Investigations into the influence of EV cooperation on resilience showed that a high percentage of system-prioritized(SP)EVs could help greatly further reduce essential load curtailment compared to individual-prioritized(IP)EVs.Finally,the complementary benefits of smart V2G control and PV were demonstrated,showing a reduction in both PV and essential load curtailments with increasing numbers of EVs.Overall,the application of smart V2G control,especially with cooperation of EV owners,can drive significant resilience enhancement during islanding,while further benefits can be obtained through having a sufficient number of EVs to utilize high PV penetration. | Lascelle Mauricette Zihang Dong Linan Zhang Xi Zhang Ning Zhang Goran Strbac | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 1 |
| 16 | Kyanite's status of beneficiation process and application显示文摘 | Niu Fusheng Tian Linan Zhang Jinxia | 2013 | Advanced Materials Re- search2013，，： | 1 |
| 17 | Mathematical model of spiral bevel gears manufactured by generating-line method 显示文摘 | Yang Zhaojun Wang Yankun Li Linan Zhang Xuecheng | 2001 | Advanced Materials Research2001，15，42011： | 1 |
| 18 | A bismuth modified hybrid binder carbon paste electrode for electrochemical stripping detection of trace heavy metals in soil 显示文摘 | Wang Zhiqiang Liu Gang Zhang Linan | 2012 | International Journal of Electrochemical Science2012，，12： | 1 |
| 19 | Deformation and failure behavior of heterogeneous Mg/SiC nanocomposite under compression显示文摘The heterogeneous magnesium(Mg) matrix nanocomposite with dispersed soft phase exhibits high strength and toughness. Herein, the deformation behavior and failure process were investigated to reveal the unique mechanical behavior of the heterogeneous microstructure under compression. The extensive plastic deformation is accompanied by the flattening and tilting of the soft phase, inhibiting strain localization and leading to strain hardening. Moreover, a stable crack multiplication process is activated, which endows high damage tolerance to the heterogeneous Mg matrix nanocomposites. The final failure of the composite is caused by crack coalescence in the shear plane along a tortuous path. The presence of dispersed soft phases within the hard matrix induces a noticeable change in mechanical response. Especially,the malleability of the heterogeneous Mg matrix nanocomposite is two and ten times higher than that of pure Mg and the homogeneous Mg matrix nanocomposite, respectively. The current study provides a novel strategy to break the trade-off between strength and toughness in metal matrix nanocomposites. | Xi Luo Jinling Liu Leigang Zhang Xu He Ke Zhao Linan An | 2022 | Journal of Magnesium and Alloys2022，10，12： | 1 |
| 20 | An injectable alginate/fibrin hydrogel encapsulated with cardiomyocytes and VEGF for myocardial infarction treatment显示文摘Myocardial infarction(MI)is one of the typical cardiovascular diseases,which persist as the leading cause of death globally.Due to the poor regenerative capability of endogenous cardiomyocytes(CMs),the transplantation of exogenous CMs becomes a promising option for MI treatment.However,the low retention and survival of transplanted cells still limit the clinical translation of cell therapy.Herein,an alginate/fibrin-based injectable hydrogel was prepared for the delivery of neonatal CMs and an angiogen-esis agent vascular endothelial growth factor(VEGF)locally to the infarcted area of the heart.This hydro-gel combined the specific advantages of alginate and fibrin with proper mechanical properties and cell affinity,showing good biocompatibility to support the retention and integration of the transplanted CMs to the host myocardium.Moreover,the delivered VEGF was favorable for the blood recovery to mitigate the ischemic microenvironment of the infarcted area and thus improved the survival of the transplanted CMs.Intramyocardial injection of this hydrogel to the infarcted area of the heart promoted angiogenesis,inhibited fibrosis,and improved cardiac function,exhibiting great potential for MI treatment. | Chunxia Liu Yong Wu Hong Yang Kunyan Lu Haixin Zhang Yuanyuan Wang Jingjing Wang Linan Ruan Zhenya Shen Qian Yu Yanxia Zhang | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
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