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| 1 | Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression显示文摘Despite being a common therapy for hepatocellular carcinoma(HCC),insufficient thermal ablation can leave behind tumor residues that can cause recurrence.This is believed to augment M2 inflammatory macrophages that usually play a pro-tumorigenic role.To address this problem,we designed D-mannose-chelated iron oxide nanoparticles(man-IONPs) to polarize M2-like macrophages into the antitumor Ml phenotype.In vitro and in vivo experiments demonstrated that man-IONPs specifically targeted M2-like macrophages and accumulated in peri-ablation zones after macrophage infiltration was augmented under insufficient microwave ablation(MWA).The nanoparticles simultaneously induced polarization of pro-tumorigenic M2 macrophages into antitumor M1 phenotypes,enabling the transformation of the immunosuppressive microenvironment into an immunoactivating one.Post-MWA macrophage polarization exerted robust inhibitory effects on HCC progression in a well-established orthotopic liver cancer mouse model.Thus,combining thermal ablation with man-IONPs can salvage residual tumors after insufficient MWA.These results have strong potential for clinical translation. | Rui Cui Luo Wang Dongyun Zhang Kun Zhang Jianping Dou Linan Dong Yixuan Zhang Jiapeng Wu Longfei Tan Jie Yu Ping Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 2 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 3 | Resilience Enhancement of Urban Energy Systems via Coordinated Vehicle-to-grid Control Strategies显示文摘Coordinated vehicle-to-grid(V2G)control strategies can sustain essential loads of an energy system during islanding,thereby increasing resilience.In this context,this paper investigates the resilience enhancement benefits of smart V2G control,the value of electric vehicle(EV)owner cooperation on system resilience,as well as the complementary effects of PV and EV interaction in an urban multi-energy microgrid(MEMG).By using a rolling horizon approach to optimize day-ahead operation of the MEMG and subsequently dispatching EVs,uncertainties in outage start time,EV arrival/departure times,and initial state of charge(SOC)are mitigated.Results show that smart V2G control can provide a substantial essential load curtailment reduction compared to a non-EV scenario,meanwhile,non-coordinated grid-to-vehicle(G2V)operation was shown to slightly burden the system with a slight increase in non-essential load curtailment.Investigations into the influence of EV cooperation on resilience showed that a high percentage of system-prioritized(SP)EVs could help greatly further reduce essential load curtailment compared to individual-prioritized(IP)EVs.Finally,the complementary benefits of smart V2G control and PV were demonstrated,showing a reduction in both PV and essential load curtailments with increasing numbers of EVs.Overall,the application of smart V2G control,especially with cooperation of EV owners,can drive significant resilience enhancement during islanding,while further benefits can be obtained through having a sufficient number of EVs to utilize high PV penetration. | Lascelle Mauricette Zihang Dong Linan Zhang Xi Zhang Ning Zhang Goran Strbac | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 1 |
| 4 | Suppressing byproduct formation for high selective CO_(2) reduction over optimized Ni/TiO_(2) based catalysts显示文摘One of the challenges for catalytic CO_(2)reduction is to control product selectivity,and new findings that can modify selectivity would be transformative.Herein,two kinds of TiO_(2)(homemade and commercial)with the same crystal phase but different surface properties are chosen as supports to prepare Ni-based catalysts for CO_(2)reduction,which show distinctly different product selectivity for CO_(2)reduction to CH_(4) or CO,as well as the CO_(2)conversion.The catalysts based on the homemade TiO_(2)support are highly selective for CH_(4) formation,while the latter ones are about 100%selective for CO formation under the same reaction conditions.In addition,the former ones are much active(more than 3 times)than the latter ones.We found that the collaborative contribution of Ti^(3+)and Ni^(2+)species and the electronic metal-support interactions effect maybe the main driving force behind for determining the product selectivity.Methane is almost exclusively produced over the catalysts with abundant Ti^(3+)and Ni^(2+)species and greater electronic metal-support interaction,otherwise,it will give priority to CO generation.The addition of CeO_(2)can reduce the Ni particle size and improve the dispersion of Ni nanoparticles,as well as create more Ti^(3+)species,contributing to the enhancement of CO_(2)conversion,but shows a negligible effect on product selectivity.Furthermore,the in situ DRIFT experiments and kinetic experiments indicate that the CO route is probably involved in the CO_(2)reduction process over the homemade Ni-CeO_(2)/TiO_(2)-CO catalyst with abundant Ti^(3+)and Ni^(2+)species and a strong electronic transform effect. | Danyang Li Ruidong Xu Roong Jien Wong Xing Zhu Dong Tian Lei Jiang Qingjie Guo Hongcun Bai Linan Huang Wen Liu Hua Wang Kongzhai Li | 2022 | Journal of Energy Chemistry2022，31，9： | 0 |
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