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| 1 | Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface显示文摘To investigate how the biofilm three-dimensional(3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy. The enamel surface and mineral content characteristics were examined successively via optical profilometry and microradiography analyses. Sucrose-mediated biofilm formation created spatial heterogeneities manifested by complex networks of bacterial clusters(microcolonies). Acidic regions(pH<5.5) were found only in the interior of microcolonies,which impedes rapid neutralization(taking more than 120 min for neutralization). Glucose exposure rapidly re-created the acidic niches, indicating formation of diffusion barriers associated with microcolonies structure. Enamel demineralization(white spots),rougher surface, deeper lesion and more mineral loss appeared to be associated with the localization of these bacterial clusters at the biofilm-enamel interface. Similar 3D architecture was observed in plaque-biofilms formed in vivo in the presence of sucrose. The formation of complex 3D architectures creates spatially heterogeneous acidic microenvironments in close proximity of enamel surface, which might correlate with the localized pattern of the onset of carious lesions(white spot like) on teeth. | Jin Xiao Anderson T Hara Dongyeop Kim Domenick T Zero Hyun Koo Geelsu Hwang | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 2 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 3 | Patient knowledge of upper respiratory infections implications for antibiotic expectations and unnecessary utilization显示文摘 | Mutinous AG Zero ob RJ Haynes DM | 1997 | J Fan Bract1997，317，： | 1 |
| 4 | Assessing patients' caries risk显示文摘 | Fontana M Zero DT | 2006 | J Am Dent Assoc2006，137，9： | 1 |
| 5 | Etiology of dental erosion-extrinsic factors显示文摘 | Zero DT | 1996 | Eur J Oral Sci1996，104，22： | 1 |
| 6 | The remineralizing effect of an essential oil fluoride mouthrinse in an intraoral caries test显示文摘 | Zero DT Zhang JZ Harper DS | 2004 | J Am Dent Assoc2004，135，2： | 1 |
| 7 | Assessing patients'caries risk显示文摘 | Fontana M Zero DT | 2006 | J Am Dent Assoc2006，137，9： | 1 |
| 8 | Dental caries and pulpal disease 显示文摘 | Zero DT Zandona AF Vail MM | 2011 | Dent Olin North Am2011，55，1： | 1 |
| 9 | Comparision of the iodide per- meability test the surface microhardness test and mineral dissolu- tion of bovine enamel following acid challenge 显示文摘 | Zero DT Rahbek I FU J | 1990 | Caries Res1990，24，3： | 1 |
| 10 | The Seeds from Plantago Ovata Lower Plasma Lipids by Altering Hepatic and Bile Acid M etabo lism in Guinea pigs显示文摘 | Romero Ana Lourdes West Kristy L Zero Toeca | 2002 | Journal of Nutrition2002，132，6： | 1 |
| 11 | Influence of fluoride availability of dentifrices on eroded enamel remineralization in situ显示文摘 | Hara AT Kelly SA Zero DT | 2009 | Caries Res2009，43，1： | 1 |
| 12 | Quality Comes to Service显示文摘 | Reichheld F F Sasser W E Zero Defection | 1990 | Harverd Business Review1990，68，5： | 1 |
| 13 | Natural and experimental constraints on formation of the continental crust based on niobium -tantalum fractionation 显示文摘 | Ding Xing Lundstrom C Huang Fang Li Jie Zhang Zeroing Sun Xiaoming Liang Jinlong Sun Weidong | 2009 | Int Geol Rev2009，51，6： | 1 |
| 14 | The morphology of silicon carbide in C/C-SiC composites显示文摘 | Schuh-Fischedick J Zero A Mayer J | 2002 | Mater Sci Eng A2002，332，： | 1 |
| 15 | Techniques for as - sessing tooth surfaces in school - based sealant programs 显示文摘 | Fontana M Zero DT Beltran - Aguilar ED | 2010 | J Am DenrAssoc2010，141，7： | 1 |
| 16 | A ssessing patients' caries risk 显示文摘 | Fontana M Zero DT | 2006 | J Am Dent Assoc2006，137，9： | 1 |
| 17 | Topical fluoride for caries prevention显示文摘 | Robert J. Weyant Sharon L. Tracy Theresa (Tracy) Anselmo Eugenio D. Beltrán-Aguilar Kevin J. Donly William A. Frese Philippe P. Hujoel Timothy Iafolla William Kohn Jayanth Kumar Steven M. Levy Norman Tinanoff J. Timothy Wright Domenick Zero Krishna Aravam | 2013 | The Journal of the American Dental Association2013，，11： | 1 |
| 18 | The role of diet in the aetiology of dental erosion显示文摘 | Lussi A Jaeggi T Zero D | 2004 | Caries Res2004，38，1： | 1 |
| 19 | Surface deformation of Long Valley Caldera and Mono Basin, California, investigated with the SBAS-InSAR approach显示文摘 | TIZZANI P BERARDINO P CASU F EUILLADES P MANZO M RICC1ARDI G P ZEro G LANARI R | 2007 | Remote Sensing of Environment2007，108，3： | 1 |
| 20 | Etiology of dental erosion - extrinsic factors 显示文摘 | Zero D T | 1996 | European Journal of Oral Sciences1996，104，： | 1 |
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