|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reconstruction of Soil Particle Composition During Freeze-Thaw Cycling: A Review显示文摘在几十年进行的研究证明了结冰融化周期在土壤是精力输入和输出的进程,它帮助驾驶土壤结构的形成,通过由结晶化和由热坡度的水和盐的运动的水扩大。然而,大多数这些研究用俄语或汉语被出版并且对国际研究人员不太可存取。这评论在在土壤结构上结冰并且融化的效果上召集了大量研究。下列调查结果被总结:我) 在结冰融化周期以后的土壤结构更加变化,变化由于粗糙的矿物质粒子和土壤的聚集罚款的土壤的机械破碎粒子;ii ) 土壤的粒子尺寸变得同类,当结冰融化周期的数字增加,在土壤结构的变化变弱;iii ) 在土壤的结冰过程,在土壤粒子结合的变化的一个重要原则表现为:冷凝作用 →
聚集 →
结晶化;iv ) 结冰融化骑车的过程由在土壤以内改变矿物质粒子和结构的 granulometric 作文在土壤结构上有强壮的效果。骑车的过程加强粒子结合的结冰融化,在土壤的总数稳定性引起全面增加,从破坏显示出一个过程到重建。 | ZHANG Ze MA Wei FENG Wenjie XIAO Donghui HOU Xin | 2016 | Pedosphere2016，26，2： | 37 |
| 2 | Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana显示文摘瞄准:为了调查 ursolic (UA ) 和它的衍生物的反肿瘤活动,在肝细胞癌上从美┦木孤立 decaisneana 在试管内和在活体内。方法:在活体内细胞毒性被 3- 首先屏蔽[4,5-dimethylthiazol-2-yl ]-2, 5-diphenyltetrazolium 溴化物(MTT ) 试金。词法观察, DNA 梯子,流动血细胞计数分析,西方的污点和实时 PCR 被采用阐明 UA 的细胞毒素的机制。植入的老鼠肝细胞瘤 H22 被用来评估生长 UA 的禁止的效果在活体内。结果:UA 能显著地禁止 HepG2 和它的药抵抗的增长紧张, R-HepG2 房间,而是首先有教养的正常老鼠 hepatocytes 上的有的不禁止的效果而 UA 的所有六衍生物不能禁止所有的生长,测试房间排队。机制上的进一步的学习证明那 apoptosis 和 G0/G1 拘捕涉及多(自动数据处理核糖) 的细胞毒性和劈开聚合酶(PARP ) 。cyclooxygenase-2 (COX-2 ) 的 Downregulation 蛋白质并且在热吃惊蛋白质(HSP ) 的规定上面, 105 mRNA 相关到与 UA 对待的 HepG2 房间的 apoptosis。另外, UA 能也禁止 H22 肝细胞瘤在活体内的生长。结论:UA 是一个有希望的反肿瘤代理人,但是推进工作需要被做改进它的溶解度。 | Ze Tian Geng Lin Rui-Xia Zheng Feng Huang Meng-Su Yang Pei-Gen Xiao | 2006 | World Journal of Gastroenterology2006，12，6： | 31 |
| 3 | Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association | Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 30 |
| 4 | Carbon carry capacity and carbon sequestration potential in China based on an integrated analysis of mature forest biomass显示文摘Forests play an important role in acting as a carbon sink of terrestrial ecosystem.Although global forests have huge carbon carrying capacity(CCC)and carbon sequestration potential(CSP),there were few quantification reports on Chinese forests.We collected and compiled a forest biomass dataset of China,a total of 5841 sites,based on forest inventory and literature search results.From the dataset we extracted 338 sites with forests aged over 80 years,a threshold for defining mature forest,to establish the mature forest biomass dataset.After analyzing the spatial pattern of the carbon density of Chinese mature forests and its controlling factors,we used carbon density of mature forests as the reference level,and conservatively estimated the CCC of the forests in China by interpolation methods of Regression Kriging,Inverse Distance Weighted and Partial Thin Plate Smoothing Spline.Combining with the sixth National Forest Resources Inventory,we also estimated the forest CSP.The results revealed positive relationships between carbon density of mature forests and temperature,precipitation and stand age,and the horizontal and elevational patterns of carbon density of mature forests can be well predicted by temperature and precipitation.The total CCC and CSP of the existing forests are 19.87 and 13.86 Pg C,respectively.Subtropical forests would have more CCC and CSP than other biomes.Consequently,relying on forests to uptake carbon by decreasing disturbance on forests would be an alternative approach for mitigating greenhouse gas concentration effects besides afforestation and reforestation. | LIU Ying Chun YU Gui Rui WANG Qiu Feng ZHANG Yang Jian XU Ze Hong | 2014 | Science China(Life Sciences)2014，57，12： | 15 |
| 5 | The influence of freeze-thaw cycles on the granulometric composition of Moscow morainic clay显示文摘The freeze-thaw cycling process considerably changes the composition,structure,and properties of soils.Since the grain size is the most important factor in determining soil characteristics,our current research primarily aims to investigate dynamic changes of the soil fraction when exposed to freeze-thaw conditions.We observed two series of Moscow morainic clayey specimens(g QmII):(I) the original series,and(II) the remolded series.We subjected each series of soil specimens to different frequencies of freeze-thaw cycles(3,6,20,and 40 cycles),and we used granulometric tests to analyze both series before and after exposure to freeze-thaw conditions.As a result of our experiments,the granulometric compositions tended to be distributed evenly after 40 freeze-thaw processes(i.e.,content of fraction for 0.1–0.05 mm was increased after 40 freeze-thaw cycles) because the division of coarse grains and the aggregation of fine grains were synchronized during the freeze-thaw process.The soil grains in both series changed bi-directionally.In the original series,changes of the sand grains were conjugated with the clay grains,and in the remolded series,changes of the sand grains were conjugated with the silt grains,because potential energy difference caused the division and aggregation processes to relate to the counteraction process.The even distribution of soil grain size indicated the state of equilibrium or balance.The granulometric compositions were altered the most during the sixth freeze-thaw cycle,because the coefficient of the intensity variation of the grain fineness(Kvar) had its maximum value at that time. | Ze Zhang Vadim V.Pendin WenJie Feng ZhongQiong Zhang | 2015 | Research in Cold and Arid Regions2015，7，3： | 7 |
| 6 | Expert Consensus on Wenxin Granule for Treatment of Cardiac Arrhythmias显示文摘 | Guo, Ji-Hong Yan, Gan-Xin Wu, Lin Zhao, Bu-Chang Wang, Yi-Min Gu, Fu-Sheng Zhou, Yu-Ping Antzelevitch, Charles Guo, Jing-Xuan Yang, Jie-Fu Yang, Xin-Chun Ding, Yan-Sheng Zhang, Ping Zhang, Hai-Cheng Liu, Hong-Xu Lu, Wei-Xing Xing, Yan-Wei Fan, Jian-Feng Ze, Feng Li, Guang-ping Li, Yi-Gang Liao, De-Ning Xue, Xiao-Lin | 2017 | Chinese Medical Journal2017，，2： | 6 |
| 7 | High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways显示文摘The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary habits.Since sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases,including SLE.Given the importance of dendritic cells(DCs)in the pathogenesis of SLE,we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE model.We used an induced lupus model in which bone marrow-derived dendritic cells(BMDCs)were incubated with activated lymphocyte-derived DNA(ALD-DNA)and transferred into C57BL/6 recipient mice.We observed that a high-salt diet(HSD)markedly exacerbated lupus progression,which was accompanied by increased DC activation.NaCl treatment also stimulated the maturation,activation and antigenpresenting ability of DCs in vitro.Pretreatment of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced lupus.These mice had increased production of autoantibodies and proinflammatory cytokines,more pronounced splenomegaly and lymphadenopathy,and enhanced pathological renal lesions.The p38 MAPK–STAT1 pathway played an important role in NaClinduced DC immune activities.Taken together,our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of SLE.Thus,changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases. | Ze Xiu Xiao Xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 8 | A pure blue light emitting binaphthyl derivative:Synthesis and properties显示文摘有 3 和 3 个′位置上的分核的联萘衍生物被综合并且经由铃木描绘了偶合反应。在答案最大的排放被作为参考拿 9,10-diphenyl 蒽与 68% 的量子效率在 390 nm 定位,当它与从聚集状态导致固态膜的 104 nm 的 FWHM 被转移到 450 nm 时。玻璃化转变温度(Tg ) 和分解温度被测量分别地,由 DSC 和 TGA 是 184 和 447 ° C。不同于它的光致发光光谱,电镀物品发光光谱在大约 460 nm 和表演达到顶点相应于纯蓝排出物的 69 nm 的 FWHM。刺激电压,发光性和效率最大值是有并列的 CIE 颜色的 5 V, 2953 cd/m2 和 1.37 cd/A (0.16, 0.15 ) ,在 ITO/NPB (40 nm ) 的设备结构 /PY-BN-PY (15 nm )/BPhen (40 nm )/Mg :47 号元素银的化学符号。 | Qing Guo He Zeng Ze Chu Gang Tie Lei An Jun Qin Hong Zhen Lin Feng Lian Bai Jian Gong Cheng Yong Qiu | 2008 | Chinese Chemical Letters2008，19，4： | 4 |
| 9 | Variability of Soil Salinity at Multiple Spatio-Temporal Scales and the Related Driving Factors in the Oasis Areas of Xinjiang,China显示文摘Located in the inland arid area of central Asia, salt-affected farmlands take up one third of the total irrigated land area in Xinjiang of Northwest China. Spatio-temporal variability of soil salinity and the underlying mechanism are fundamental problems challenging the sustainability of oasis agriculture in China. In this study, the data of total dissolved solids(TDS) measured for soil samples collected from 27 representative study areas in the oasis areas of Xinjiang were analyzed and the coefficient of variation(CV) and stratification ratio(SR) of TDS were used to describe the lateral and vertical soil salinity variations, respectively. Weekly, monthly,and annual changes in soil salinity were also summarized. Results showed that the top(0–20 cm) soil salinity was highly variable(CV> 75%) for most studied areas. Lateral variation of soil salinity was significantly correlated with the sampling interval; as a result, a maximum sampling interval of 0.9 m was found for reducing evaluation uncertainty. The top 0–20 cm soil salt accounted for about25.2% of the total salt in the 0–100 cm soil profile. The stratification ratio values(the ratio of TDS at the 20–40 cm depth to that at the 0–20 cm depth) were mostly smaller than 1 and on average 0.92, illustrating that the top 0–20 cm soil contained slightly more salt and a considerable amount of salt still existed in subsurface and deep horizons. Irrigation reduced top soil salinity by 0.52 g kg-1, or14.6%, within the first week. On average, the relative range of soil salinity, calculated to indicate monthly changes in soil salinity, was58.2% from May to September. A 27-year experiment indicated that cultivation increased soil salinity by 44.4% at a rate of 0.14 g kg-1year-1. At small spatio-temporal scales, soil salinity variation was mainly affected by anthropogenic factors, such as irrigation and land use. However, natural factors, including groundwater, topography, and climate conditions, mainly influenced soil salinity variation at large spatio-temporal scales. This study displayed the highly variable nature of soil salinity in space and time. Those driving factors identified in this study could provide guidelines for developing sustainable agriculture in the oasis areas and combating salinization in arid regions of China. | ZHANG Wen-Tai WU Hong-Qi GU Hai-Bin FENG Guang-Long WANG Ze SHENG Jian-Dong | 2014 | Pedosphere2014，24，6： | 4 |
| 10 | Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes显示文摘编码 adiponectin 受体 1 的基因( ADIPOR1 )和小象ubiquitin一样修饰词( SUMO4 ) 4 被连接了到 anti-atherogenic 效果,但是很少对是否被知道在二基因的多型性,独立行动或交往,没有 diabetes.MethodsWe genotyped ,影响冠的动脉疾病( CAD )的风险没有糖尿病的 200 个 CAD 病人和没有 CAD 的 200 控制,它被选择基于前一个没有 diabetes.ResultsRisk 等位基因,协会也是的潜力在 ADIPOR1 (rs7539542-G, rs7514221-C 和 rs3737884-G ) 在三 SNP 在这些 SNP 和 CAD 的临床的特征之间探索了,没有糖尿病,在在 SUMO4 的 SNP rs237025 的 G 等位基因显著地增加了 CAD 的风险,与从 1.79 ~ 4.44 的 ORs。任何这四风险等位基因的搬运人出现了类似不利 ? 临床的特征。与有 CC 或 GC 遗传型的个人相比,有在 rs3737884 的 GG 遗传型的那些在影响了左前面的下降冠的动脉的 CAD 的显著地更高的风险(或:6.77, P = 0.009 ) ,恰好冠的动脉(或:4.81, P = 0.028 ) 或容器的一个相对大的数字(P = 0.04 ) 。没有糖尿病,在 SUMO4 在 SNP 象风险等位基因一样在 ADIPOR1 在三 SNP 中的至少一个带风险等位基因的个人比不带任何风险等位基因的个人在 CAD 的显著地更高的风险(或:5.82, 95% CI:1.2327.7, P = 0.013 ) 没有糖尿病,在 ADIPOR1 和 SUMO4 的 .ConclusionsSNPs 与 CAD 的提高的风险被联系,并且在二基因的 SNP 可以交往联合影响疾病风险。 | Hong LI Ze YANG Lian-Mei PU Xiang LI Yang RUAN Fan YANG Shuai MENG Duo YANG Wei YAO Hao FU Feng ZHANG Ze-Ning JIN | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 11 | Back-n white neutron source at CSNS and its applications显示文摘Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March 2018.The Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices.In addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the world.Equipped with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional measurements.This article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn. | Jing-Yu Tang Qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Yi-Wei Yang Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 | 2021 | Nuclear Science and Techniques2021，32，1： | 4 |
| 12 | Thermodynamically Revealing the Essence of Order and Disorder Structures in Layered Cathode Materials显示文摘Layered transition metal(TM) oxides are one of the most widely used cathode materials in lithium-ion batteries. The atomic configuration in TM layer of these materials is often known to be random when multiple TM elements co-exist in the layer(e.g. Ni, Co and Mn). By contrast, the configuration tends to be ordered if the elements are Li and Mn. Here, by using special quasi-random structures(SQS) algorithm, the essential reasons of the ordering in a promising Li-rich Mn-based cathode material Li2MnO3 are investigated. The difference of internal energy and entropy between ordered and disordered materials is calculated. As a result, based on the Gibbs free energy, it is found that Li2MnO3 should have an ordered structure in TM layer. In comparison, structures with Ni-Mn ratio of 2:1 are predicted to have a disordered TM layer, because the entropy terms have larger impact on the structural ordering than internal energy terms. | ZHENG Ze WENG Mou-Yi YANG Lu-Yi HU Zong-Xiang CHEN Zhe-Feng PAN Feng | 2019 | Chinese Journal of Structural Chemistry2019，38，12： | 4 |
| 13 | Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs显示文摘AIM: To investigate the protective effect of medical ozone (O3) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl4)-induced hepatic injury in dogs. METHODS: Thirty healthy dogs were divided randomly into fi ve groups (n = 6 in each group), namely control, oleanolic acid tablet (OAT), O3, YC and O3 + YC, given either no particular pre-treatment, oral OAT, medical ozone rectal insulfflation every other day, oral YC, or oral YC plus medical ozone rectal insulfflation every other day, respectively, for 30 consecutive days. After pre-treatment, acute hepatic injury was induced in all dogs with a single-dose intraperitoneal injection of CCl4. General condition and survival time were recorded. The biochemical and hematological indexes of alanine aminotransferase (ALT), aspartate aminotransferase/ alanine aminotransferase (AST/ALT), serum total bilirubin (TBIL), prothrombin time (PT), blood ammonia (AMMO), and blood urea nitrogen (BUN) were measured after CCl4 injection. Hepatic pathological changes were also observed.RESULTS: Compared to the other four groups, the changes of group O3 + YC dogs’ general conditions (motoricity, mental state, eating, urination and defecation) could be better controlled. In group O3 + YC the survival rates were higher (P < 0.05 vs group control). AST/ALT values were kept within a normal level in group O3 + YC. Hepatic histopathology showed that hepatic injury in group O3 + YC was less serious than those in the other four groups. CONCLUSION: Medical ozone combined with TCM YC could exert a protective effect on acute liver injury induced by CCl4. | Li-Jie Li Yun-Gao Yang Zhi-Ling Zhang Sui-Feng Nie Ze Li Feng Li He-Yu Hua Yan-Jun Hu Hong-Shuan Zhang Ya-Bing Guo | 2007 | World Journal of Gastroenterology2007，13，45： | 4 |
| 14 | Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant显示文摘A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation.Over-active and continuous inflammation,however,impairs fracture healing and leads to excessive tissue damage.Adequate fracture healing could be promoted through suppression of local over-active immune cells in the fracture site.In the present study,we achieved an enriched concentration of PD-L1 from exosomes(Exos)of a genetically engineered Human Umbilical Vein Endothelial Cell(HUVECs),and demonstrated that exosomes overexpressing PD-L1 specifically bind to PD-1 on the T cell surface,suppressing the activation of T cells.Furthermore,exosomal PD-L1 induced Mesenchymal Stem Cells(MSCs)towards osteogenic differentiation when pre-cultured with T cells.Moreover,embedding of Exos into an injectable hydrogel allowed Exos delivery to the surrounding microenvironment in a time-released manner.Additionally,exosomal PD-L1,embedded in a hydrogel,markedly promoted callus formation and fracture healing in a murine model at the early over-active inflammation phase.Importantly,our results suggested that activation of T cells in the peripheral lymphatic tissues was inhibited after local administration of PD-L1-enriched Exos to the fracture sites,while T cells in distant immune organs such as the spleen were not affected.In summary,this study provides the first example of using PD-L1-enriched Exos for bone fracture repair,and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects. | Ze Lin Yuan Xiong Weilin Meng Yiqiang Hu Lili Chen Lang Chen Hang Xue Adriana CPanayi Wu Zhou Yun Sun Faqi Cao Guodong Liu Liangcong Hu Chenchen Yan Xudong Xie Chuanchuan Lin Kaiyong Cai Qian Feng Bobin Mi Guohui Liu | 2022 | Bioactive Materials2022，7，7： | 4 |
| 15 | Comparison of in vitro digestion methods for determining bioaccessibility of Hg in rice of China显示文摘Rice consumption can be a major pathway for mercury(Hg) exposure, which can cause health hazards to Chinese residents. To accurately assess the potential health risks, the bioaccessibility of Hg in rice samples collected at background and Hg-contamination sites was examined using four in vitro methods. The results showed that < 50% of the total mercury(THg) was bioaccessible in the studied rice samples. The THg bioaccessibility in the rice samples collected at the Hg-contaminated site was higher than that observed at the background area. The bioaccessibility of arsenic(As) and cadmium(Cd) was also evaluated for comparison of the four in vitro methods used in this study. The Physiologically Based Extraction Test was found to be the most accurate method based on the consistency of the results compared to those reported in previous studies. The estimated daily intakes of THg via rice consumption using the bioaccessibility data were found to meet the recommendation value set by the JECFA and the WHO in both sites. However, the potential health risk was not negligible at the Hg-contaminated sites, due to the high THg concentration and bioaccessibility in the rice samples. | Ze Wu Xinbin Feng Ping Li Che-Jen Lin Guangle Qiu Xun Wang Huifang Zhao Hui Dong | 2018 | Journal of Environmental Sciences2018，30，6： | 3 |
| 16 | The Ternary Goldbach Problem with Primes in Arithmetic Progressions | Zhen Feng ZHANG Tian Ze WANG State Key Laboratory of Information Security, Graduate School, Chinese Academy of Sciences, Beijing 100039, P. R. China Depariment of Mathematics, Henan University, Kaifeng 475001, P. R. China Department of Mathematics, Henan University, Kaifeng 475001, P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，4： | 3 |
| 17 | Characteristics of chemical components in PM2.5 at a plateau city, South-west China显示文摘 | Jianwu SHI Xiang DING Yue ZHOU Ran YOU Lu HUANG Jiming HAO Feng XIANG Jian YANG Ze SHI Xinyu HAN Ping NING | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 3 |
| 18 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 19 | Application study of the awning measure to obstruct solar radiation in permafrost regions on the Qinghai-Tibet Plateau显示文摘With globe warming,road safety will change dramatically,especially within the Qinghai-Tibet Plateau permafrost regions.Because of higher elevation and better atmospheric transparency,the Qinghai-Tibet Plateau has stronger radiation than other regions,which can change the daily variation of ground surface temperature on the Plateau.The awning measure(shading board) is one of the actively protected permafrost measures,which was adopted along the Qinghai-Tibet railway and highway and the Qing-Kang Highway in China.Field test results show that embankment surface month mean net radiation is 60-130 W/m2,but the value is below 20 W/m2 under the shading board,and the reducing level of natural net radiation is 80%-90%.The shading board reduced the heat flow entering into the embankment by 80%-90% or more,with heat entering into the soil on the common embankment,but emitting from the embankment under the shading board.At the same time,ground surface temperature under the shading board is 6-8 ℃ lower than the exposed embankment.Test results show that the shading board measure can rapidly and effectively reduce net radiation and heat flow into the embankment,decrease embankment surface and interior temperature,effectively delay increase rate of soil temperature under globe warming,ensure stability and safety of the embankment,and guarantee unblocked road projects in cold and permafrost regions. | WenJie Feng ZhiZhong Sun Zhi Wen GuoYu Li Ze Zhang WenBing Yu | 2012 | Research in Cold and Arid Regions2012，4，2： | 3 |
| 20 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员