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| 1 | A precise velocity field of tectonic deformation in China as inferred from intensive GPS observations显示文摘Active tectonics, e.g., faulting, folding, and rifting are clearly manifested over the vast territory of China. The in-tensive crustal deformation with long-lived structures has given rise to numerous highly-elevated mountains in the western China with the Yangtze and Yellow rivers downstreaming to the east, | LI Qiang YOU XinZhao YANG ShaoMin DU RuiLin QIAO XueJun ZOU Rong WANG Qi | 2012 | Science China Earth Sciences2012，55，5： | 23 |
| 2 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 3 | Multiplicity of solutions to geophysical inversion reflected by rupture slip distribution of the 2015 Nepal earthquake显示文摘The equivalence of geophysical fields,the finiteness of measurements and the measurement errors make the result of geophysical inversion non-unique.For example,the measurements and inversion method used,the priori rupture model determined and the slip distribution smoothing factor selected will have significant influences on the earthquake rupture slip distribution.Using different data and methods,different authors have given different rupture slip distribution models of the 2015 Mw7.9 Nepal earthquake,with the maximum slip ranging from 3.0 m to 6.8 m.In this paper,geometry parameters of the single rectangular fault model in elastic half-space were inferred constraining with the Global Positioning System(GPS) and Interferometric Synthetic Aperture Radar(InSAR) coseismic deformations and bounding the slip with approximate average value;and then,the single rectangular fault was divided into multiple sub-faults,and the final slip smoothing factor,the final slip distribution and the maximum slip were determined with the misfit-roughness tradeoff curve,the cross-validation sum of squares(CVSS) and the third-party observation data or indexes being comprehensively taken into account.The results show that,the rupture of the Nepal earthquake extended by over 100 km east by south.The maximum slip of the earthquake was about 6.5-6.7 m,and most of the slip is confined at depths of 8-20 km,consistent with the depth distribution of aftershocks.The method for reducing the multiplicity of solutions to rupture slip distribution in this paper was ever used in inversion of rupture slip distribution for the 2008 Wenchuan and 2013 Lushan earthquakes,and the third-party measurement-surface dislocation has very large effect on reducing the multiplicity of solutions to inversion of the Wenchuan earthquake.Other priori information or indicators,such as fault strike,dip,earthquake magnitude,seismic activity,Coulomb stress,and seismic period,can be used for beneficial validation of and comparison with inversion results. | Kai Tan Caihong Zhang Bin Zhao Qi Wang Ruilin Du Rui Zhang Xuejun Qiao Yong Huang | 2017 | Geodesy and Geodynamics2017，8，1： | 2 |
| 4 | Possible ferromagnetism in Li, Na and K-doped AlN: A first-principle study显示文摘 | Ruilin Han Wei Yuan Hui Yang Xiaobo Du Yu Yan Hanmin Jin | 2013 | Journal of Magnetism and Magnetic Materials2013，，： | 1 |
| 5 | Fluorescence Signal Amplification Strategies Based on DNA Nanotechnology for miRNA Detection显示文摘In this review,the most recent progresses in the field of fluorescence signal amplification strategies based on DNA nanotechnology for miRNA are summarized.The types of signal amplification are given and the principles of amplification strategies are explained,including rolling circle amplification(RCA),catalytic hairpin assembly(CHA),hybridization chain reaction(HCR)and DNA walker.Subsequently,the application of these signal amplification methods in biosensing and bioimaging are covered and described.Finally,the challenges and the outlook of fluorescence signal amplification methods for miRNA detection are briefly commented. | LI Tao DUAN Ruilin DU AN Zhijuan HUANG Fujian XIA Fan | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 6 | Time headway distribution analysis of naturalistic road users based on aerial datasets显示文摘Purpose–Time headway(THW)is an essential parameter in traffic safety and is used as a typical control variable by many vehicle control algorithms,especially in safety-critical ADAS and automated driving systems.However,due to the randomness of human drivers,THW cannot be accurately represented,affecting scholars’more profound research.Design/methodology/approach–In this work,two data sets are used as the experimental data to calculate the goodness-of-fit of 18 commonly used distribution models of THW to select the best distribution model.Subsequently,the characteristic parameters of traffic flow are extracted from the data set,and three variables with higher importance are extracted using the random forest model.Combining the best distribution model parameters of the data set,this study obtained a distribution model with adaptive parameters,and its performance and applicability are verified.Findings–In this work,two data sets are used as the experimental data to calculate the goodness-of-fit of 18 commonly used distribution models of THW to select the best distribution model.Subsequently,the characteristic parameters of traffic flow are extracted from the data set,and three variables with higher importance are extracted using the random forest model.Combining the best distribution model parameters of the data set,this study obtained a distribution model with adaptive parameters,and its performance and applicability are verified.Originality/value–The results show that the proposed model has a 62.7%performance improvement over the distribution model with fixed parameters.Moreover,the parameter function of the distribution model can be regarded as a quantitative analysis of the degree of influence of the traffic flow state on THW. | Ruilin Yu Yuxin Zhang Luyao Wang Xinyi Du | 2022 | Journal of Intelligent and Connected Vehicles2022，5，3： | 0 |
| 7 | L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways显示文摘At present,Hepatocarcinoma is one of the main causes of tumor related death all over the world.However,there are still many clinical restrictions on the treatment of liver cancer.Recently,L-Selenocystine has been shown to be a novel treatment for tumors,especially human glioma cells.But,the mechanism of L-Selenocystine against hepatocellular carcinoma remains unclear.Therefore,the main objective of this study was to investigate the effects of L-Selenocystine on HepG2 cell proliferation and activation of reactive oxygen species(ROS)mediated signaling pathway.L-Selenocystine can significantly inhibit HepG2 cell proliferation by activating caspase-3 and cleaving PARP to induce apoptosis.Moreover,the excessive production of ROS and the influence of Bax signaling pathway which can promote cell apoptosis are key factors for L-Selenocystine to induce HepG2 cell apoptosis.Therefore,the date of this study suggest that ROS mediated signal transduction mechanism may provide certain reference significance for L-Selenocystine induced HepG2 cell apoptosis. | HAIYANG CHEN JINGYAO SU DANYANG CHEN YUYE DU RUILIN ZHENG QINGLIN DENG QIANQIAN DU BING ZHU YINGHUA LI | 2022 | BIOCELL2022，46，10： | 0 |
| 8 | Achieving macroscale superlubricity with ultra-short running-in period by using polyethylene glycol-tannic acid complex green lubricant显示文摘Superlubricating materials can greatly reduce the energy consumed and economic losses by unnecessary friction.However,a long pre-running-in period is indispensable for achieving superlubricity;this leads to severe wear on the surface of friction pairs and has become one of the important factors in the wear of superlubricating materials.In this study,a polyethylene glycol-tannic acid complex green liquid lubricant(PEG10000-TA)was designed to achieve macroscale superlubricity with an ultrashort running-in period of 9 s under a contact pressure of up to 410 MPa,and the wear rate was only 1.19×10^(–8)mm^(3)·N^(−1)·m^(−1).This is the shortest running-in time required to achieve superlubricity in Si_(3)N_(4)/glass(SiO_(2)).The results show that the strong hydrogen bonds between PEG and TA molecules can significantly reduce the time required for the tribochemical reaction,allowing the lubricating material to reach the state of superlubrication rapidly.Furthermore,the strong hydrogen bond can share a large load while fixing free water molecules in the contact zone to reduce shear interaction.These findings will help advance the use of liquid superlubricity technology in industrial and biomedical. | Changhe DU Tongtong YU Zishuai WU Liqiang ZHANG Ruilin SHEN Xiaojuan LI Min FENG Yange FENG Daoai WANG | 2023 | Friction2023，11，5： | 0 |
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