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| 1 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 2 | Mitochondrial DNA A1555G mutation screening using a testing kit method and its significance in preventing aminoglycoside-related hearing loss显示文摘To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics. | LIU Xin,1 DAI Pu,1* HUANG Deliang,1 YUAN Huijun,1 LI Weiming,1 YU Fei,1 ZHANG Xin,1 KANG Dongyang,1 CAO Juyang,1 YANG Weiyan,1 HAN Dongyi,1 JIN Zhengce2, GUAN Minxin3 1. Department of Otolaryngology, Chinese PLA General Hospital, Beijing, China2. Weihai Aomaier Gene Technological CO.,LTD.,Weihai,Shandong 264200, China.3. Division and Program in Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA | 2006 | Journal of Otology2006，1，1： | 7 |
| 3 | Selectivity enhancement of quaternized poly(arylene ether ketone)membranes by ion segregation for vanadium redox flow batteries显示文摘Quaternary ammonium densely functionalized octa-benzylmethyl-containing poly(arylene ether ketone)s(QA-OMPAEKs) with ion exchange capacities(IECs) ranging from 1.23 to 2.21 mmol g^(-1) were synthesized from:(1) Ullmann coupling extension of tetra-benzylmethyl-containing bisphenol A;(2) condensation polymerization with activated dihalide in the presence of K_2CO_3;(3) selective bromination using N-bromosuccinimide; and(4) quantitative quaternization using trimethylamine. Both smallangle X-ray scattering(SAXS) and transmission electron microscope(TEM) characterizations revealed distinct nano-phase separation in QA-OMPAEKs as a result of the dense quaternization. The QA-OMPAEK-20 with an IEC of 1.98 mmol g^(-1) exhibited a high SO_4^(2-) conductivity of 11.4 mS cm^(-1) and a low VO^(2+) permeability of 0.06×10^(-12) m^2 s^(-1) at room temperature,leading to a dramatically higher ion selectivity than Nafion N212. Consequently, the vanadium redox flow battery(VRFB)assembled with QA-OMPAEK-20 achieved a Coulombic efficiency of 96.9% and an energy efficiency of 84.8% at a current density of 50 mA cm^(-2), which were much higher than those of the batteries assembled with Nafion N212 and a home-made control membrane without distinct nano-phase separation. Therefore, ion segregation is demonstrated to be a strategical route for the design of high performance anion exchange membranes(AEMs) for VRFBs. | Yu Chen Zhongcheng Liu Meijin Lin Qilang Lin Bihai Tong Dongyang Chen | 2019 | Science China Chemistry2019，62，4： | 6 |
| 4 | Optimal dispatching method for integrated energy system based on robust economic model predictive control considering source-load power interval prediction显示文摘Effective source-load prediction and reasonable dispatching are crucial to realize the economic and reliable operations of integrated energy systems(IESs).They can overcome the challenges introduced by the uncertainties of new energies and various types of loads in the IES.Accordingly,a robust optimal dispatching method for the IES based on a robust economic model predictive control(REMPC)strategy considering source-load power interval prediction is proposed.First,an operation model of the IES is established,and an interval prediction model based on the bidirectional long short-term memory network optimized by beetle antenna search and bootstrap is formulated and applied to predict the photovoltaic power and the cooling,heating,and electrical loads.Then,an optimal dispatching scheme based on REMPC is devised for the IES.The source-load interval prediction results are used to improve the robustness of the REPMC and reduce the influence of source-load uncertainties on dispatching.An actual IES case is selected to conduct simulations;the results show that compared with other prediction techniques,the proposed method has higher prediction interval coverage probability and prediction interval normalized averaged width.Moreover,the operational cost of the IES is decreased by the REMPC strategy.With the devised dispatching scheme,the ability of the IES to handle the dispatching risk caused by prediction errors is enhanced.Improved dispatching robustness and operational economy are also achieved. | Yang Yu Jiali Li Dongyang Chen | 2022 | Global Energy Interconnection2022，5，5： | 3 |
| 5 | Analysis of the regional spectral properties in northwestern South China Sea based on an empirical orthogonal function显示文摘This study presents an analysis of the spectral characteristics of remote sensing reflectance(Rrs)in northwestern South China Sea based on the in situ optical and water quality data for August 2018.Rrswas initially divided into four classes,classes A to D,using the max-classification algorithm,and the spectral properties of whole Rrs were characterized using the empirical orthogonal function(EOF)analysis.Subsequently,the dominant factors in each EOF mode were determined.The results indicated that more than 95%of the variances of Rrs are partly driven by the back-scattering characteristics of the suspended matter.The initial two EOF modes were well correlated with the total suspended matter and back-scattering coefficient.Furthermore,the first EOF modes of the four classes of Rrs(A-D Rrs-EOF1)significantly contributed to the total variances of each Rrs class.In addition,the correlation coefficients between the amplitude factors of class A-D Rrs-EOF1 and the variances of the relevant water quality and optical parameters were better than those of the unclassified ones.The spectral shape of class ARrs-EOF1 was governed by the absorption characteristic of chlorophyll a and colored dissolved organic matter(CDOM).The spectral shape of class B Rrs-EOF1 was governed by the absorption characteristic of CDOM since it exhibited a high correlation with the absorption coefficient of CDOM(ag(λ)),whereas the spectral shape of class C Rrs-EOF1 was governed by the back-scattering characteristics but not affected by the suspended matter.The spectral shape of class D Rrs-EOF1 exhibited a relatively good correlation with all the water quality parameters,which played a significant role in deciding its spectral shape. | Dongyang Fu Yuye Huang Dazhao Liu Shan Liao Guo Yu Xiaolong Zhang | 2020 | Acta Oceanologica Sinica2020，39，7： | 3 |
| 6 | Salivary microbiota may predict the presence of esophageal squamous cell carcinoma显示文摘The aim is to explore the predictive value of salivary bacteria for the presence of esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, and allocated to screening and verification cohorts, respectively. In the screening phase, after saliva DNA was extracted, 16S rRNA V4 regions of salivary bacteria were amplified by polymerase chain reaction (PCR) with high-throughput sequencing. Highly expressed target bacteria were screened by Operational Taxonomic Units clustering, species annotation and microbial diversity assessment. In the verification phase, the expression levels of target bacteria identified in the screening phase were verified by absolute quantitative PCR (Q-PCR). Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of target salivary bacteria. LEfSe analysis revealed higher proportions of Fusobacterium, Streptococcus and Porphyromonas, and Q-PCR assay showed significantly higher numbers of Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in patients with ESCC, when compared with healthy controls (all P < 0.05). The areas under the ROC curves for Streptococcus salivarius, Fusobacterium nucleatum, Porphyromonas gingivalis and the combination of the three bacteria for predicting patients with ESCC were 69%, 56.5%, 61.8% and 76.4%, respectively. The sensitivities corresponding to cutoff value were 69.3%, 22.7%, 35.2% and 86.4%, respectively, and the matched specificity were 78.4%, 96.1%, 90.2% and 58.8%, respectively. These highly expressed Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in the saliva, alone or in combination, indicate their predictive value for ESCC. | Junmin Wei Ruifeng Li Yanxian Lu Fan Meng Bohong Xian Xiaorong Lai Xiayi Lin Yu Deng Dongyang Yang Huabin Zhang Liangfang Li Xiaosong Ben Guibin Qiao Wanwei Liu Zijun Li | 2022 | Genes & Diseases2022，9，4： | 2 |
| 7 | Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA mutation in 16 Chinese families: Implication for early detection and prevention of deafness显示文摘 | Pu Dai Xin Liu Dongyi Han Yaping Qian Deliang Huang Huijun Yuan Weiming Li Fei Yu Ruining Zhang Hongyan Lin Yong He Youjun Yu Quanzhu Sun Huaiyi Qin Ronghua Li Xin Zhang Dongyang Kang Juyang Cao Wie-Yen Young Min-Xin Guan | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 2 |
| 8 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 9 | Dynamic carrier transports and low thermal conductivity in n-type layered InSe thermoelectrics显示文摘Semiconductor InSe with wide bandgap and layered crystal structure is expected to be a promising thermoelectric material,and its excellent plasticity brings great potential applications in flexible and wearable thermoelectric devices.To advance its thermoelectric performance,this work systematically investigates the carrier and phonon transport properties in n-type InSe.It is found that InSe compound presents an exceptional dynamic carrier transport property due to the amphoteric indium(In+and In^(3+)),which contributes to favorable temperature-dependent increasing carrier concentration.More importantly,with S alloying in InSe,the carrier concentration can be further enhanced from∼3.2×10^(13) cm–3 in InSe to∼4.8×10^(15) cm^(-3) in InSe_(0.97)S_(0.03) at 300 K,because S(χP∼2.58)with larger Pauling electronegativity than Se(χP∼2.55)can induce more In3+state to increase carrier concentration in matrix.This boosted dynamic carrier transport property benefits an obviously enhanced power factor.Additionally,InSe compound presents intrinsically low thermal conductivity∼1.6 W m^(-1) K^(-1) at 300 K due to low-symmetry crystal structure and strong anharmonicity.This work indicates that the special dynamic carrier transport property and intrinsically low thermal conductivity in InSe make it as a worthexpecting thermoelectric material. | Haonan Shi Dongyang Wang Yu Xiao Li-Dong Zhao | 2021 | Aggregate2021，2，4： | 1 |
| 10 | Topological superradiant state in Fermi gases with cavity induced spin-orbit coupling显示文摘 | Dongyang Yu Jian-Song Pan Xiong-Jun Liu Wei Zhang Wei Yi | 2018 | Frontiers of physics2018，13，1： | 1 |
| 11 | Fabrication of necklace-like structures via electrospinning 显示文摘 | Jin Yu Yang Dayong Kang Dongyang | 2010 | Lang- muir2010，26，2： | 1 |
| 12 | Different analysis techniques for fluorescence exeitation-emission matrix spectroscopy to assess compost maturity 显示文摘 | TANG Zhu YU Guanghui LIU Dongyang | 2011 | Chemosphere2011，82，8： | 1 |
| 13 | Study on modeling of muhispectral emissivity and optimization algorithm显示文摘 | YU Yong ZHAO Dongyang | 2006 | IEEE Trans on Neural Networks2006，17，1： | 1 |
| 14 | Building ultra-stable K–Te battery by molecular regulation显示文摘Tellurium (Te) is an ideal electrode for potassium ion batteries (PIBs) owing to its excellent electronic conductivity and high volumetric capacity.However,the Te electrode is prone to capacity fading as the shuttle effect.To address this challenge,we propose molecular regulated Se–Te solid solutions on N-doped porous carbon as the PIBs electrode.After optimizing the Se content in Se–Te solid solutions,the resultant SeTe_(6.8) on N-doped porous carbon (SeTe_(6.8)@C) delivered a capacity of over 400 mAh g^(-1) with a flat plateau of 1.0 V at 500 m A g^(-1).It also achieved a superiorly long cycle life,running for more than 1600 cycles (over 7 months with 0.015%degeneration per cycle) at 100 mA g^(-1) and excellent rate performance (179.9 mAh g^(-1) at 10000 mA g^(-1)).This remarkable electrochemical energy storage of the Te electorde likely arises from suppression of the shuttle effect after doping the Te with strongly electronegative Se atoms (forming K_(s)Te_(3) which is not easily soluble in electrolyte).This study presents a fresh approach for designing and developing ultra-stable Te-based electrodes for PIBs and beyond. | Jiawan Zhou Dongyang Shen Xinzhi Yu Bingan Lu | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 15 | Changes in biochemical and microbiological parameters during the period of rapid composting of dairy manure with rice chaff显示文摘 | Dongyang Liu Ruifu Zhang Hongsheng Wu Dabing Xu Zhu Tang Guanghui Yu Zhihui Xu Qirong Shen | 2011 | Bioresource Technology2011，，19： | 1 |
| 16 | Different analysis techniques for fluorescence excitation-emission matrix spectroscopy to assess compost maturity显示文摘 | TANG Zhu YU Guanghui LIU Dongyang | 2011 | Chemosphere2011，82，8： | 1 |
| 17 | Dynamic grouping control of electric vehicles based on improved k-means algorithm for wind power fluctuations suppression显示文摘To address the significant lifecycle degradation and inadequate state of charge(SOC)balance of electric vehicles(EVs)when mitigating wind power fluctuations,a dynamic grouping control strategy is proposed for EVs based on an improved k-means algorithm.First,a swing door trending(SDT)algorithm based on compression result feedback was designed to extract the feature data points of wind power.The gating coefficient of the SDT was adjusted based on the compression ratio and deviation,enabling the acquisition of grid-connected wind power signals through linear interpolation.Second,a novel algorithm called IDOA-KM is proposed,which utilizes the Improved Dingo Optimization Algorithm(IDOA)to optimize the clustering centers of the k-means algorithm,aiming to address its dependence and sensitivity on the initial centers.The EVs were categorized into priority charging,standby,and priority discharging groups using the IDOA-KM.Finally,an two-layer power distribution scheme for EVs was devised.The upper layer determines the charging/discharging sequences of the three EV groups and their corresponding power signals.The lower layer allocates power signals to each EV based on the maximum charging/discharging power or SOC equalization principles.The simulation results demonstrate the effectiveness of the proposed control strategy in accurately tracking grid power signals,smoothing wind power fluctuations,mitigating EV degradation,and enhancing the SOC balance. | Yang Yu Mai Liu Dongyang Chen Yuhang Huo Wentao Lu | 2023 | Global Energy Interconnection2023，6，5： | 0 |
| 18 | Chaotic CPG Based Locomotion Control for Modular Self-reconfigurable Robot显示文摘 | Jizhuang Fan Yu Zhang Hongzhe Jin Xiaolu Wang Dongyang Bie Jie Zhao Yanhe Zhu | 2016 | Journal of Bionic Engineering2016，13，1： | 0 |
| 19 | Spatiotemporal characteristics and remote sensing estimation of colored dissolved organic matter around the Leizhou Peninsula显示文摘Colored dissolved organic matter(CDOM)is an important optically active substance in marine environment.Its biochemical conservatism makes it an important indicator to offshore pollution process.Monitoring the content,composition,and diffusion process of CDOM is a good approach to analyze the terrestrial input,optical properties,and ecological environment of offshore areas.The spatiotemporal characteristics of CDOM around the Leizhou Peninsula were analyzed based on field observation data collected in the autumn 2020 and spring 2021,and an empirical inversion model of the ag(355)(absorption coefficient at 355 nm)and spectral slope(Sg)(g stands for gelbstoff/gilvin,which is called CDOM)based on Sentinel-3A ocean and land color instrument(OLCI)images was constructed.The results show(1)the order of average ag(355)value around the Leizhou Peninsula was east coast(0.503/m)>Qiongzhou Strait(0.502/m)>west coast(0.365/m);(2)the best band combinations of CDOM inversion in spring and autumn were(B4+B11)/B3 and(B7-B1)/B6(B stands for the band of spectral images),and the final inversion results are close to the measured results,indicating that the model has good accuracy;(3)the S_(g)value of the CDOM absorption spectrum was fitted to the hyperbolicexponential model.The fitting accuracy of the model was higher than those of the exponential model and the hyperbolic model,and the best S_(g)inversion model was constructed by selecting Sg(275-295)and Sg(250-295)in spring and autumn;(4)the spatial distributions of ag(355)and S_(g)were inverted,and CDOM in the waters around the Leizhou Peninsula originated from terrestrial organic matter carried by coastal aquaculture zones and runoff in the northeast Zhanjiang and the northern Beibu Gulf. | Dongyang FU Shiyun WEI Guo YU Yafei LUO Huabing XU Zhaoguang CHEN | 2023 | Journal of Oceanology and Limnology2023，41，4： | 0 |
| 20 | Design and experiment of a novel pneumatic soft arm based on a deployable origami exoskeleton显示文摘T Soft arms have shown great application potential because of their flexibility and compliance in unstructured environments.However,soft arms made from soft materials exhibit limited cargo-loading capacity,which restricts their ability to manipulate objects.In this research,a novel soft arm was developed by coupling a rigid origami exoskeleton with soft airbags.The joint module of the soft arm was composed of a deployable origami exoskeleton and three soft airbags.The motion and load performance of the soft arm of the eight-joint module was tested.The developed soft arm withstood at least 5 kg of load during extension,contraction,and bending motions;exhibited bistable characteristics in both fully contracted and fully extended states;and achieved a bending angle of more than 240°and a contraction ratio of more than 300%.In addition,the high extension,contraction,bending,and torsional stiffnesses of the soft arm were experimentally demonstrated.A kinematic-based trajectory planning of the soft arm was performed to evaluate its error in repetitive motion.This work will provide new design ideas and methods for flexible manipulation applications of soft arms. | Yuwang LIU Wenping SHI Peng CHEN Yi YU Dongyang ZHANG Dongqi WANG | 2023 | Frontiers of Mechanical Engineering2023，18，4： | 0 |
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