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| 1 | Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis显示文摘A 72-year-old woman with a sigmoid colon cancer and a synchronous colorectal liver metastasis(CRLM),which involved the right hepatic vein(RHV)and the inferior vena cava(IVC),was referred to our hospital.The metastatic lesion was diagnosed as initially unresectable because of its invasion into the confluence of the RHV and IVC.After she had undergone laparoscopic sigmoidectomy for the original tumor,she consequently had 3 courses of modified 5-fluorouracil,leucovorin,and oxaliplatin(m FOLFOX6)plus cetuximab.Computed tomography revealed a partial response,and the confluence of the RHV and IVC got free from cancer invasion.After 3 additional courses of m FOLFOX6 plus cetuximab,preoperative percutaneous transhepatic portal vein embolization(PTPE)was performed to secure the future remnant liver volume.Finally,a right hemihepatectomy was performed.The postoperative course was uneventful.The patient was discharged from the hospital on postoperative day 13.She had neither local recurrence nor distant metastasis 18 mo after the last surgical intervention.This multidisciplinary strategy,consisting of conversion chemotherapy using FOLFOX plus cetuximab and PTPE,could contribute in facilitating curative hepatic resection for initially unresectable CRLM. | Kenta Baba Akihiko Oshita Mohei Kohyama Satoshi Inoue Yuta Kuroo Takuro Yamaguchi Hiroyuki Nakamura Yoichi Sugiyama Tatsuya Tazaki Masaru Sasaki Yuji Imamura Yutaka Daimaru Hideki Ohdan Atsushi Nakamitsu | 2015 | World Journal of Gastroenterology2015，21，6： | 10 |
| 2 | CD44v6 expression is related to mesenchymal phenotype and poor prognosisin patients with colorectal cancer显示文摘 | Seiya Saito Hirohisa Okabe Masayuki Watanabe Takatsugu Ishimoto Masaaki Iwatsuki Yoshifumi Baba Youhei Tanaka Junji Kurashige Yuji Miyamoto Hideo Baba | 2013 | Oncology Reports2013，，4： | 2 |
| 3 | The MicroRNA-21/PTEN Pathway Regulates the Sensitivity of HER2-Positive Gastric Cancer Cells to Trastuzumab显示文摘 | Kojiro Eto Masaaki Iwatsuki Masayuki Watanabe Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2014 | Annals of Surgical Oncology2014，，1： | 2 |
| 4 | Enzymatic synthesis of steryl esters of polyunsaturated fatty acids显示文摘 | Yuji Shimada Yoshinori Hirota Takashi Baba | 1999 | JAOCS1999，76，： | 1 |
| 5 | Adsorption and mobility of aromatic arsenicals in Japanese agricultural soils显示文摘 | Yuji Maejima Hirotatsu Murano Takashi Iwafune Tomohito Arao Koji Baba | 2011 | Soil Science and Plant Nutrition2011，，3： | 1 |
| 6 | Chemotherapy and Targeted Therapy for Patients with Initially Unresectable Colorectal Liver Metastases, Focusing on Conversion Hepatectomy and Long-Term Survival显示文摘 | Toru Beppu Yuji Miyamoto Yasuo Sakamoto Katsunori Imai Hidetoshi Nitta Hiromitsu Hayashi Akira Chikamoto Masayuki Watanabe Takatoshi Ishiko Hideo Baba | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 7 | Primary Malignant Melanoma of the Esophagus With Extensive Intraepithelial Extension显示文摘 | Kyoko Inadomi Takatsugu Ishimoto Masayuki Watanabe Masaaki Iwatsuki Kota Arima Satoshi Ida Yohei Nagai Shiro Iwagami Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Yumi Honda Ken-ichi Iyama Hideo Baba | 2012 | The Annals of Thoracic Surgery2012，，6： | 1 |
| 8 | Conformal radiation therapy for portal vein tumor thrombosis of hepatocellular carcinoma显示文摘 | Ryo Toya Ryuji Murakami Yuji Baba Ryuichi Nishimura Shoji Morishita Osamu Ikeda Koichi Kawanaka Toru Beppu Shinichi Sugiyama Takashi Sakamoto Yasuyuki Yamashita Natsuo Oya | 2007 | Radiotherapy and Oncology2007，，3： | 1 |
| 9 | p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma显示文摘 | Asuka Murata Yoshifumi Baba Masayuki Watanabe Hironobu Shigaki Keisuke Miyake Ryuichi Karashima Yu Imamura Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2013 | Medical Oncology2013，，4： | 1 |
| 10 | Usefulness of Transcription–Reverse Transcription Concerted Reaction Method for Detecting Circulating Tumor Cells in Patients With Colorectal Cancer显示文摘 | Nobutaka Sato Naoko Hayashi Yu Imamura Yohei Tanaka Koichi Kinoshita Jyunji Kurashige Seiya Saito Ryuichi Karashima Kotaro Hirashima Yohei Nagai Yuji Miyamoto Masaaki Iwatsuki Yoshifumi Baba Masayuki Watanabe Hideo Baba | 2012 | Annals of Surgical Oncology2012，，6： | 1 |
| 11 | Selective extraction of In(Ⅲ),Ga(Ⅲ) and Zn(Ⅱ) using a novel extractant with phenylphosphinic acid显示文摘A new extractant,[N,N-di(2-ethylhexyl)amino]methylphenylphosphinic acid(DEAPP),was synthesized to develop the mutual separation techniques of In(III),Ga(III) and Zn(II).The extraction selectivity for In(III),Ga(III)and Zn(II) with DEAPP was higher than that of the commercial phosphorus acid extractants such as D2 EHPA and PC-88 A.The extraction selectivity for metal ions in 1 mol·L-1aqueous ammonium nitrate solution with DEAPP was in the following order:In(III) N Ga(III) N Zn(II).These selective extraction behaviors indicate that the amino moiety of DEAPP plays an important role in the mutual separation of In(III),Ga(III) and Zn(II).The extraction equilibria of In(III),Ga(III) and Zn(II) with DEAPP(=HR) were expressed by the following reactions:In3++ 2HRT2In R3HRT + 3H+,Ga3++ 1.5HRT-2+ NO3 GaR 2eHRT N O3T + 2H+,and Zn2++ 2HRT2 Zn R2HRT2+ 2H+.The extraction equilibrium constants of In(III),Ga(III) and Zn(II) with DEAPP were determined to be Kex,M= 1.7 × 104[dm3·mol-1],4.17 [(dm3·mol-1)0.5],and 1.55 x 10-2[–],respectively. | Yuji Sasaki Naoki Matsuo Tatsuya Oshima Yoshinari Baba | 2016 | Chinese Journal of Chemical Engineering2016，24，2： | 1 |
| 12 | p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma显示文摘 | Asuka Murata Yoshifumi Baba Masayuki Watanabe Hironobu Shigaki Keisuke Miyake Ryuichi Karashima Yu Imamura Satoshi Ida Takatsugu Ishimoto Shiro Iwagami Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Hideo Baba | 2013 | Medical Oncology2013，，4： | 1 |
| 13 | Clinical significance of occult micrometastasis in lymph nodes from patients with early gastric cancer who died of recurrence显示文摘 | Yoshihiko Maehara Tatsuo Oshiro Kazuya Endo Hideo Baba Shinya Oda Yuji Ichiyoshi Shunji Kohnoe Keizo Sugimachi | 1996 | Surgery1996，，4： | 1 |
| 14 | Starch biosynthesis of amylomaine during endosperm development 显示文摘 | Tadashi Baba Takeshi Yamamoto Arai Yuji | 1981 | Phytochemistry1981，20，7： | 1 |
| 15 | Chemotherapy and Targeted Therapy for Patients with Initially Unresectable Colorectal Liver Metastases, Focusing on Conversion Hepatectomy and Long-Term Survival显示文摘 | Toru Beppu Yuji Miyamoto Yasuo Sakamoto Katsunori Imai Hidetoshi Nitta Hiromitsu Hayashi Akira Chikamoto Masayuki Watanabe Takatoshi Ishiko Hideo Baba | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 16 | The clinical signifi cance of circulating tumor cells in gastrointestinal cancer显示文摘Circulating tumor cells(CTCs)are originated from the primary tumor lesion into the blood stream.CTCs could lead to recurrence of gastrointestinal(GI)cancers,even after a curative resection and colonizing in the distant organs to facilitate tumor distant metastasis;however,it has been challenging in clinic to detect CTCs for a long time,such as detection methodology or molecular markers for identifi cation of CTCs.This review discussed the recent technical advances and biomarkers in the detection of CTCs and the molecular mechanism of CTC in cancer progression and metastasis.Moreover,novel concepts,such as cancer stem cells and epithelial-mesenchymal transition,could lead to CTCs and tumor progression and metastasis.Nevertheless,the involvement of CTCs varies greatly among cancer types in the GI and much remains to be learned.Thus,further study will provide more insightful information from a clinical and translational viewpoint to use CTCs for cancer early diagnosis or prediction of tumor recurrence and investigation of tumor progression and metastasis as well. | Masaaki Iwatsuki Junji Kurashige Takatsugu Ishimoto Keisuke Kosumi Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Masayuki Watanabe Hideo Baba | 2015 | Journal of Cancer Metastasis and Treatment2015，1，1： | 0 |
| 17 | Molecular insights into colorectal cancer stem cell regulation by environmental factors显示文摘Colorectal cancer remains a signifi cant cause of cancer-related mortality worldwide,mainly because of tumor relapse and metastases.Cancer stem cells(CSCs)are considered to be the main cause of resistance to chemotherapeutic agents,as well as being responsible for distant metastases.Although CSCs themselves possess innate abilities for self-renewal and differentiation,the environment surrounding CSCs provides oxygen,nutrients and secreted factors,and also supports angiogenesis,thus it's responsible for maintaining their CSC properties.Furthermore,extensive investigations have revealed that obesity,accompanied by excess visceral adipose tissue,induces chronic infl ammation,and is linked to the risk and progression of several gastrointestinal cancers,through modulating the capacities of the CSCs.This review presents the evidence linking colorectal CSCs and their environment and summarizes our current understanding of the molecular mechanisms underlying this relationship. | Daisuke Izumi Takatsugu Ishimoto Yasuo Sakamoto Yuji Miyamoto Hideo Baba | 2015 | Journal of Cancer Metastasis and Treatment2015，1，1： | 0 |
| 18 | Circulating tumor cells in gastric cancer显示文摘Circulating tumor cells(CTCs)have received a lot of attention as a novel biomarker for cancer research in past decades.CTCs infiltrate the bloodstream derived from the primary tumor,and are significantly involved in cancer metastasis and recurrence.Although clinical applications have been challenging owing to the difficulties of CTC identification,recent development of technology for specific enrichment and detection of CTCs contributes to diagnosis and treatment.Furthermore,CTC analyses will shed new light on the biological mechanisms of cancer progression and metastasis.A number of clinical studies have already been carried out on the basis of CTC technology.Nevertheless,the clinical utility of CTCs is still unknown in gastric cancer.In this review,we elaborate on the latest advances of CTC research in gastric cancer. | Kenichi Nakamura Masaaki Iwatsuki Junji Kurashige Takatsugu Ishimoto Yoshifumi Baba Yuji Miyamoto Naoya Yoshida Masayuki Watanabe Hideo Baba | 2018 | Journal of Cancer Metastasis and Treatment2018，4，1： | 0 |
| 19 | Contracted interlayer distance in graphene/sapphire heterostructure显示文摘绝缘体上的 graphene 的直接生长被期望在性能产出重要改进基于 graphene 电子并且 spintronic 设备。在这研究,我们成功地揭示原子安排和单个层的 graphene 和 -Al 2 O < 潜水艇 class= “ a-plus-plus ” > 3 (0001) 。-Al 2 O < 潜水艇 class= “ a-plus-plus ” > 3 (0001) 揭示了 apparentcontradiction。在里面飞机分析证明单个层的 graphene 不以一种单人赛水晶的取向附生的方式,但是相当在多晶的形式成长,与二强烈显著的比较喜欢的取向。这建议相对弱的界面的相互作用是起作用的。然而,我们表明那在 graphene 和 -Al 2 O <潜水艇class=“ a-plus-plus ”> 3 (0001)存在,是由在 graphene 和 -Al 2 O <潜水艇class=“ a-plus-plus ”> 3 (0001)表面。界面的相互作用被显示被涉及 graphene 系统和 -Al 2 O < 潜水艇 class= “ a-plus-plus ” > 3 (0001), 而非货车 der Waals 相互作用。做的如此的特征原因 graphene 洞并且使 graphene 能在 -Al 2 O < 潜水艇 class= “ a-plus-plus ” > 有尽管有强壮的界面的相互作用的一个仅仅小精力障碍的 3 (0001) 表面。 | Shiro Entani Liubov Yu. Antipina Pavel V. Avramov Manabu Ohtomo Yoshihiro Matsumoto Norie Hirao Iwao Shimoyama Hiroshi Naramoto Yuji Baba Pavel B. Sorokin Seiji Sakai | 2015 | Nano Research2015，8，5： | 0 |
| 20 | Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases显示文摘BACKGROUND Experimental studies suggest that self-expanding metal stents(SEMSs)enhance the aggressive behavior of obstructive colorectal cancer.The influence of SEMS placement on pathological alterations remains to be elucidated.AIM To determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma tissues.METHODS Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers,we examined the association of SEMS placement with molecular or pathological features,including tumor size,histological type,American Joint Committee on Cancer(AJCC)-pTNM stage,and mutation statuses in colorectal cancer tissues compared with the use of transanal tubes.A multivariable logistic regression model was used to adjust for potential confounders.RESULTS SEMS placement was significantly associated with venous invasion(P<0.01),but not with the other features examined,including tumor size,disease stage,mutation status,and lymphatic invasion.In both the univariable and multivariable models with adjustment for potential factors including tumor location,histological type,and AJCC-pT stage,SEMS placement was significantly associated with severe venous invasion(P<0.01).For the outcome category of severe venous invasion,the multivariable odds ratio for SEMS placement relative to transanal tube placement was 19.4(95%confidence interval:5.24–96.2).No significant differences of disease-free survival and overall survival were observed between SEMS and transanal tube groups.CONCLUSION SEMS placement might be associated with severe venous invasion in colorectal cancer tissue,providing an impetus for further investigations on the pathological alterations by SEMSs in colorectal cancer development. | Keisuke Kosumi Kosuke Mima Kosuke Kanemitsu Takuya Tajiri Toru Takematsu Yuki Sakamoto Mitsuhiro Inoue Yuji Miyamoto Takao Mizumoto Tatsuo Kubota Nobutomo Miyanari Hideo Baba | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，11： | 0 |
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