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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 3 | Spatiotemporal dynamic simulation of grassland carbon storage in China显示文摘Based on the Terrestrial Ecosystem Model(TEM 5.0), together with the data of climate(temperature, precipitation and solar radiation) and environment(grassland vegetation types, soil texture, altitude, longitude and latitude, and atmospheric CO2 concentration data), the spatiotemporal variations of carbon storage and density, and their controlling factors were discussed in this paper. The results indicated that:(1) the total carbon storage of China's grasslands with a total area of 394.93×104 km2 was 59.47 Pg C. Among them, there were 3.15 Pg C in vegetation and 56.32 Pg C in soil carbon. China's grasslands covering 7.0–11.3% of the total world's grassland area had 1.3–11.3% of the vegetation carbon and 9.7–22.5% of the soil carbon in the world grasslands. The total carbon storage increased from 59.13 to 60.16 Pg C during 1961–2013 with an increasing rate of 19.4 Tg C yr^(-1).(2) The grasslands in the Qinghai-Tibetan Plateau contributed most to the total carbon storage during 1961–2013, accounting for 63.2% of the total grassland carbon storage, followed by Xinjiang grasslands(15.8%) and Inner Mongolia grasslands(11.1%).(3) The vegetation carbon storage showed an increasing trend, with the average annual growth rate of 9.62 Tg C yr^(-1) during 1961–2013, and temperature was the main determinant factor, explaining approximately 85% of its variation. The vegetation carbon storage showed an increasing trend in most grassland regions, however, a decreasing trend in the central grassland in the southern China, the western and central parts of the Inner Mongolian grasslands as well as some parts on the Qinghai-Tibetan Plateau. The soil carbon storage showed a significantly increasing trend with a rate of 7.96 Tg C yr^(-1), which resulted from the interaction of more precipitation and low temperature in the 1980 s and 1990 s. Among them, precipitation was the main determinant factor of increasing soil carbon increases of China's grasslands. | ZHANG Li ZHOU GuangSheng JI YuHe BAI YongFei | 2016 | Science China Earth Sciences2016，59，10： | 8 |
| 4 | Impacts of algal blooms removal by chitosan-modified soils on zooplankton community in Taihu Lake,China显示文摘It is important to assess the eflect on zooplankton when perform the environmental protection or restoration technology,especially removing algal blooms,because algae were the major primary producer in algal lakes.The influence on zooplankton community after half a year of algal blooms removed by chitosan-modified soils in Taihu Lake was assessed and the rationality of carrying out the process semiannually was evaluated in the present study.Morphological composition and genetic diversity of zooplankton community were investigated by microscope checkup and polymerase chain reaction-denatured gradient gel electrophoresis(PCR-DGGE) .A total of 44 zooplankton taxa(23 protozoa,17 rotifers,3 copepoda and 1 cladocera) were detected by microscope checkup,and a total of 91 bands(28 bands amplified by primers F1427-GC and R1616,63 bands amplified by primers Fung-GC and NS1) were detected by PCR-DGGE.The results of cluster analysis or detrended correspondence analysis indicated that there was no considerable diflerence in morphological composition of zooplankton and DGGE profiles between experimental and control sites,and DGGE profiles could represent the biologic diversity.The study showed that zooplankton community could recover original condition after half year of algal blooms removed by chitosan-modified soils and it was acceptable to apply this process semiannually.In addition,the results revealed that PCR-DGGE could be applied to investigate the impacts of the environmental protection or restoration engineering on zooplankton community diversity. | Jiajia Ni Yuhe Yu Weisong Feng Qingyun Yan Gang Pan Bo Yang Xiang Zhang Xuemei Li | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 5 | Development and Application of Lightning Protection Technologies in Power Grids of China显示文摘In recent years,along with the rapid expansion of power grids,the increasing complication of grid structures,and the development of smart grids and energy technologies,the lightning protection of power grids becomes increasingly prominent.Power grids of China have acquired significant achievements on lightning protection technologies,which are reviewed in this paper.A technical route of lightning protection is introduced in detail; it allows us to find problems through detection and measurement of lightning,to analyze problems through evaluation and simulation of lightning,to solve problems through lightning protection measures,and to prevent problems through hazard risk warning of lightning.Following the route,the technical breakthroughs of these four aspects in China are presented,including the chinese lightning detection network(CLDN),natural lightning observations,lightning faults detection at transmission lines,lightning current measurements,progresses in lightning distribution maps,lightning fault replays,lightning hazard risk evaluations,and lightning simulated experiments,as well as novel lightning protection measures.The practical devices and systems corresponding to the technologies mentioned above are also introduced and discussed.Due to the progress of lightning protection technologies in recent years,despite the rapidly growing length of transmission lines in China,the lightning accident rate is controlled at a certain level. | GU Shanqiang CHEN Jiahong FENG Wanxing ZHAO Chun FANG Yuhe LI Tao | 2013 | 高电压技术2013，39，10： | 8 |
| 6 | Variation of net primary productivity and its drivers in China’s forests during 2000-2018显示文摘Background:Net primary productivity(NPP)in forests plays an important role in the global carbon cycle.However,it is not well known about the increase rate of China’s forest NPP,and there are different opinions about the key factors controlling the variability of forest NPP.Methods:This paper established a statistics-based multiple regression model to estimate forest NPP,using the observed NPP,meteorological and remote sensing data in five major forest ecosystems.The fluctuation values of NPP and environment variables were extracted to identify the key variables influencing the variation of forest NPP by correlation analysis.Results:The long-term trends and annual fluctuations of forest NPP between 2000 and 2018 were examined.The results showed a significant increase in forest NPP for all five forest ecosystems,with an average rise of 5.2 gC·m-2·year-1 over China.Over 90%of the forest area had an increasing NPP range of 0-161 gC·m-2·year-1.Forest NPP had an interannual fluctuation of 50-269 gC.m-2·year-1 for the five major forest ecosystems.The evergreen broadleaf forest had the largest fluctuation.The variability in forest NPP was caused mainly by variations in precipitation,then by temperature fluctuations.Conclusions:All five forest ecosystems in China exhibited a significant increasing NPP along with annual fluctuations evidently during 2000-2018.The variations in China’s forest NPP were controlled mainly by changes in precipitation. | Yuhe Ji Guangsheng Zhou Tianxiang Luo Yakir Dan Li Zhou Xiaomin Lv | 2020 | Forest Ecosystems2020，7，2： | 8 |
| 7 | Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies显示文摘 | Liu Yuhe Xue Junfang Zhao Danhua Chen Li Yuan Yun Wang Zhaoxia | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 8 | Aluminum-Enhanced Proton Release Associated with Plasma Membrane H^+-Adenosine Triphosphatase Activity and Excess Cation Uptake in Tea (Camellia sinensis) Plant Roots显示文摘Cultivated tea(Camellia sinensis) plants acidify the rhizosphere, and Aluminum(Al) toxicity is recognized as a major limiting factor for plant growth in acidic soils. However, the mechanisms responsible for rhizosphere acidification associated with Al have not been fully elucidated. The present study examined the effect of Al on root-induced rhizosphere acidification, plasma membrane H^+-adenosine triphosphatase(H^+-ATPase) activity, and cation-anion balance in tea plant roots. The exudation of H^+from tea plant roots with or without Al treatment was visualized using an agar sheet with bromocresol purple. The H^+-ATPase activity of plasma membranes isolated from the roots was measured after hydrolysis using the two-phase partition system. The Al treatment strongly enhanced the exudation of H^+, and the acidification of tea plant roots by Al was closely associated with plasma membrane H^+-ATPase activity. The root plasma membrane H^+-ATPase activity increased with Al concentration. The Al content, amount of protons released, and H^+-ATPase activity were significantly higher in roots treated with Al than in those untreated. The results of the cation-anion balance in roots showed an excess of cations relative to anions, with the amount of excess cation uptake increasing with increasing Al concentrations. These suggest that Al-enhanced proton release is associated with plasma membrane H^+-ATPase activity and excess cation uptake. Findings of this study would provide insights into the contributing factors of soil acidification in tea plantations. | WAN Qing MI Yuhe YANG Yiyang Xu Renkou LI Xinghui | 2018 | Pedosphere2018，28，5： | 5 |
| 9 | Effect of Nanocomposites Coatings on Exterior Performance of Bamboo during Aging显示文摘Bamboo deterioration caused by light becomes a significant problem as application of bamboo extends from indoor to outdoor.The color and roughness of bamboo are two important exterior performances.This study focused on UV resistant nano composites coatings for exterior use and what aimed to find a formulation which could enhance the durability of bamboo.Four kinds of film-forming materials and four kinds of nano particles were used to improve bamboo exterior performance.The color and roughness of nano composites coatings were measured during accelerated weathering.Artificial aging time was 174 h at the temperature of 50 ℃.The experiment showed nanocomposites coatings had significant improvement in UV-shielding and nearly all the samples presented a darkening tendency in ΔL* and increasing tendency in Δa*,ΔE* and ΔRa.The orthogonal experiment obtained the least change in color and Ra which could be achieved with nano composites coating made by melamine resin and TiO2 when a* was considered as an important index.Film-forming material was the only factor which had significant influence on color and roughness when a* was not considered as important index,then melamine resin was the best choice. | LI Neng CHEN Yuhe BAO Yongjie ZOU Yijia CAI Hanjiang | 2012 | Chinese Forestry Science and Technology2012，11，Z1： | 4 |
| 10 | Comparative study on the gut microbiotas of four economically important Asian carp species显示文摘Gut microbiota of four economically important Asian carp species(silver carp, Hypophthalmichthys molitrix; bighead carp,Hypophthalmichthys nobilis; grass carp, Ctenopharyngodon idella; common carp, Cyprinus carpio) were compared using 16 S rRNA gene pyrosequencing. Analysis of more than 590,000 quality-filtered sequences obtained from the foregut, midgut and hindgut of these four carp species revealed high microbial diversity among the samples. The foregut samples of grass carp exhibited more than 1,600 operational taxonomy units(OTUs) and the highest alpha-diversity index, followed by the silver carp foregut and midgut. Proteobacteria, Firmicutes, Bacteroidetes and Fusobacteria were the predominant phyla regardless of fish species or gut type. Pairwise(weighted) UniFrac distance-based permutational multivariate analysis of variance with fish species as a factor produced significant association(P<0.01). The gut microbiotas of all four carp species harbored saccharolytic or proteolytic microbes, likely in response to the differences in their feeding habits. In addition, extensive variations were also observed even within the same fish species. Our results indicate that the gut microbiotas of Asian carp depend on the exact species, even when the different species were cohabiting in the same environment. This study provides some new insights into developing commercial fish feeds and improving existing aquaculture strategies. | Xinghao Li Yuhe Yu Chang Li Qingyun Yan | 2018 | Science China(Life Sciences)2018，61，6： | 4 |
| 11 | Spatio-temporal patterns of zooplankton in a main-stem dam affected tributary: a case study in the Xiangxi River of the Three Gorges Reservoir, China显示文摘As the ecologically important recipient channels for riverine ecosystems, tributaries provide unique microhabitats for microorganisms, among which zooplankton constitutes the most important heterotrophic organisms. In particular, the reduced water velocity caused by dams is more favorable for zooplankton development;therefore, dammed rivers are expected to support extremely diverse and abundant zooplankton communities and notably different spatiotemporal distribution patterns. So far,however, only very few molecular studies support these assumptions. Using high-throughput sequencing, a high number of 350 operational taxonomic units(OTUs;97% cutoff) were retrieved from 30 samples collected in the Xiangxi River, the nearest large tributary upstream of the Three Gorges Dam. Zooplankton did not show significant spatial distribution in the channel. Instead,the community structures varied significantly over sampling dates, corroborating the seasonal patterns found in lakes and ponds in the subtropical zone. As expected, the community compositions were deterministically governed by environmental filtering processes(phylogenetic clustering), in which water velocity appeared to be much less important than other investigated environmental factors. Moreover, most of the detected phylotypes(OTUs) had a relatively high(>90%) sequence similarity to previously deposited sequences, suggesting a mediocre degree of genetic novelty within the zooplankton communities in the Xiangxi River. | Xinghao Li Jie Huang Sabine Filker Thorsten Stoeck Yonghong Bi Yuhe Yu Weibo Song | 2019 | Science China(Life Sciences)2019，62，8： | 4 |
| 12 | Bat origin of a new human coronavirus:there and back again显示文摘A novel coronavirus reported to cause pneumonia in 41 people during December 2019 in Wuhan,the capital of Hubei province,China,was identified and designated as the 2019 novel coronavirus(2019-nCoV)(Zhu et al.,2020;Li et al.,2020).Infection with 2019-nCoV results in clusters of severe respiratory illness similar to that caused by severe acute respiratory syndrome coronavirus(SARS-CoV)and is associated with high mortality(Chen et al.,2020;Huang et al.,2020).This new coronavirus belongs to genus Betacoronavirus,family Coronaviridae,with a single-stranded,positive-sense RNA genome,but genetically distinct from SARS-CoV and Middle East respiratory syndrome coronavirus(MERS-CoV). | Xiang Li Yuhe Song Gary Wong Jie Cui | 2020 | Science China(Life Sciences)2020，63，3： | 3 |
| 13 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 14 | Characterization and Expression of Ammonium Transporter in Peach (Prunus persica) and Regulation Analysis in Response to External Ammonium Supply显示文摘As the preferred nitrogen(N)source,ammonium(NH_(4)^(+))contributes to plant growth and development and fruit quality.In plants,NH 4+uptake is facilitated by a family of NH_(4)^(+) transporters(AMT).However,the molecular mechanisms and functional characteristics of the AMT genes in peach have not been mentioned yet.In this present study,excess NH_(4)^(+) stress severely hindered shoot growth and root elongation,accompanied with reduced mineral accumulation,decreased leaf chlorophyll concentration,and stunned photosynthetic performance.In addition,we identified 14 putative AMT genes in peach(PpeAMT).Expression analysis showed that PpeAMT genes were differently expressed in peach leaves,stems and roots,and were distinctly regulated by external NH_(4)^(+) supplies.Putative cis-elements involved in abiotic stress adaption,Ca^(2+) response,light and circadian rhythms regulation,and seed development were observed in the promoters of the PpeAMT family genes.Phosphorylation analysis of residues within the C-terminal of PpeAMT proteins revealed many conserved phosphorylation residues in both the AMT1 and AMT2 subfamily members,which could potentially play roles in controlling the NH 4+transport activities.This study provides gene resources to study the biological function of AMT proteins in peach,and reveals molecular basis for NH_(4)^(+) uptake and N nutrition mechanisms of fruit trees. | Meiling Tang Yuhe Li Yahui Chen Lei Han Hongxia Zhang Zhizhong Song | 2020 | Phyton-International Journal of Experimental Botany2020，89，4： | 2 |
| 15 | Evaluation of CMPAS precipitation products over Sichuan,China显示文摘高质量和高分辨率的降水产品在天气预报,数值模式模拟和气象防灾减灾方面起着重要的作用.本文利用四川地区高密度的地面降水传感器观测数据,比较CMPAS四种不同时空尺度的降水实况分析产品,评估CMPAS的融合准确性与在四川地区的适用性.研究表明:四种CMPAS降水产品都在四川盆地内精度较高,攀西地区和川西高原次之.随着降水量的增加,产品的误差也随之增加.CMPAS在夏秋两季对降水量高估,在春冬两季对降水量低估.总而言之,CMPAS在四川盆地内与观测数据的融合准确性较高.由于高原地区气象观测站点数量不足且观测数据受复杂地形和气候条件影响较大,CMPAS在高原地区的适用性检验仍需进一步研究. | Shiying Li Xiaolong Huang Wei Wu Bing Du Yuhe Jiang | 2022 | Atmospheric and Oceanic Science Letters2022，15，2： | 2 |
| 16 | Recent progress on three-dimensional nanoarchitecture anode materials for lithium/sodium storage显示文摘High-performance batteries with high density and low cost are needed for the development of largescale energy storage fields such as electric vehicles and renewable energy systems.The anode with threedimensional(3D)nanoarchitecture is one of the most attractive candidates for high-performance lithiumion batteries(LIBs)and sodium-ion batteries(SIBs)due to its efficient electron/ion transport and high active material mass loading.Although some important breakthroughs have been made in 3D nanoarchitecture anode materials,more improvements are still needed for high cycling stability and high energy density.Herein,the latest research progress of 3D nanoarchitecture anode materials for LIBs and SIBs is reviewed,including nanoporous metal,nanoporous graphene,and their derived foams.Specifically,the storage properties of Li/Na ions,the kinetics of ion/electron transport,and specific chemical interactions are discussed based on the structure design.In addition,the research strategies and structural characteristics of 3D nanoarchitecture anode materials are summarized,providing a reference for the further development of LIBs and SIBs.Meanwhile,the future research directions of LIBs and SIBs have also prospected. | Zhijia Zhang Yuefang Chen Shihao Sun Kai Sun Heyi Sun Hongwei Li Yuhe Yang Mengmeng Zhang Weijie Li Shulei Chou Huakun Liu Yong Jiang | 2022 | Journal of Materials Science & Technology2022，，24： | 2 |
| 17 | Pyrolysates distribution and kinetics of Shenmu long flame coal显示文摘 | Yuankui Lin Qingsong Li Xuefeng Li Kang Ji Haipeng Zhang Yingmin Yu Yuhe Song Yu Fu Lanyi Sun | 2014 | Energy Conversion and Management2014，，： | 1 |
| 18 | Molecular cloning and identification of full-length cDNA encoding hjgh afinity Fc receptor for bovine IgG(FcγRI)显示文摘 | Yuhe Yan Xuewu Li Aiping Wang | 2000 | Veterinary Immunology and Immunopathology2000，75，： | 1 |
| 19 | Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation显示文摘Biopolymer based hydrogels are characteristic of their biocompatibility and capability of mimicking extracellular matrix structure to support cellular behavior.However,these hydrogels suffer from low mechanical properties,uncontrolled degradation,and insufficient osteogenic activity,which limits their applications in bone regeneration.In this study,we developed hybrid gelatin(Gel)/oxidized chondroitin sulfate(OCS)hydrogels that incorporated mesoporous bioactive glass nanoparticles(MBGNs)as bioactive fillers for bone regeneration.Gel-OCS hydrogels could be self-crosslinked in situ under physiological conditions in the presence of borax.The incorporation of MBGNs enhanced the crosslinking and accelerated the gelation.The gelation time decreased with increasing the concentration of MBGNs added.Incorporation of MBGNs in the hydrogels significantly improved the mechanical properties in terms of enhanced storage modulus and compressive strength.The injectability of the hydrogels was not significantly affected by the MBGN incorporation.Also,the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro and rat cranial defect restoration in vivo were significantly promoted by the hydrogels in the presence of MBGNs.The hybrid Gel-OCS/MBGN hydrogels show promising potential as injectable biomaterials or scaffolds for bone regeneration/repair applications given their tunable degradation and gelation behavior as well as favorable mechanical behavior and osteogenic activities. | Lei Zhou Lei Fan Feng-Miao Zhang Yuhe Jiang Min Cai Cong Dai Yi-An Luo Ling-Jie Tu Zheng-Nan Zhou Xiao-Jun Li Cheng-Yun Ning Kai Zheng Aldo R.Boccaccini Guo-Xin Tan | 2021 | Bioactive Materials2021，6，3： | 1 |
| 20 | MG2C:a user-friendly online tool for drawing genetic maps显示文摘Genetic map is a linear arrangement of the relative positions of sites in the chromosome or genome based on the recombination frequency between genetic markers.It is the important basis for genetic analysis.Several kinds of software have been designed for genetic mapping,but all these tools require users to write or edit code,making it time-costing and difficult for researchers without programming skills to handle with.Here,MG2C,a new online tool was designed,based on PERL and SVG languages.Users can get a standard genetic map,only by providing the location of genes(or quantitative trait loci)and the length of the chromosome,without writing additional code.The operation interface of MG2C contains three sections:data input,data output and parameters.There are 33 attribute parameters in MG2C,which are further divided into 8 modules.Values of the parameters can be changed according to the users’requirements.The information submitted by users will be transformed into the genetic map in SVG file,which can be further modified by other image processing tools.MG2C is a user-friendly and time-saving online tool for drawing genetic maps,especially for those without programming skills.The tool has been running smoothly since 2015,and updated to version 2.1.It significantly lowers the technical barriers for the users,and provides great convenience for the researchers. | Jiangtao Chao Zhiyuan Li Yuhe Sun Oluwaseun Olayemi Aluko Xinru Wu Qian Wang Guanshan Liu | 2021 | Molecular Horticulture2021，1，1： | 1 |
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