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| 1 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 2 | Impacts of algal blooms removal by chitosan-modified soils on zooplankton community in Taihu Lake,China显示文摘It is important to assess the eflect on zooplankton when perform the environmental protection or restoration technology,especially removing algal blooms,because algae were the major primary producer in algal lakes.The influence on zooplankton community after half a year of algal blooms removed by chitosan-modified soils in Taihu Lake was assessed and the rationality of carrying out the process semiannually was evaluated in the present study.Morphological composition and genetic diversity of zooplankton community were investigated by microscope checkup and polymerase chain reaction-denatured gradient gel electrophoresis(PCR-DGGE) .A total of 44 zooplankton taxa(23 protozoa,17 rotifers,3 copepoda and 1 cladocera) were detected by microscope checkup,and a total of 91 bands(28 bands amplified by primers F1427-GC and R1616,63 bands amplified by primers Fung-GC and NS1) were detected by PCR-DGGE.The results of cluster analysis or detrended correspondence analysis indicated that there was no considerable diflerence in morphological composition of zooplankton and DGGE profiles between experimental and control sites,and DGGE profiles could represent the biologic diversity.The study showed that zooplankton community could recover original condition after half year of algal blooms removed by chitosan-modified soils and it was acceptable to apply this process semiannually.In addition,the results revealed that PCR-DGGE could be applied to investigate the impacts of the environmental protection or restoration engineering on zooplankton community diversity. | Jiajia Ni Yuhe Yu Weisong Feng Qingyun Yan Gang Pan Bo Yang Xiang Zhang Xuemei Li | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 3 | Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata显示文摘From an aqueous extract of“tian ma”(the steamed and dried rhizomes of Gastrodia elata),ten new compounds gastrodiben-zins A−D(1−4)and gastrotribenzins A−F(5−10),along with known analogues(11−20),having structure features coupling between two and three p-hydroxybenzyl-derived units via carbon-and/or ether-bonds,were isolated and characterized by spectroscopic data analysis.Meanwhile,the new compounds 5a,6a,8a,22,and 23,as well as the known derivatives 13a,14a,15,17−21,24,25,and p-hydroxybenzyl aldehyde were isolated and identified from a refluxed aqueous solution of p-hydroxybenzyl alcohol.Methylation of 5a and 6a in methanol and ethylation of 6a,8a,13a,and 14a in ethanol produced 5 and 6 and 7,8,13,and 14,respectively.using ultra-performance liquid chromatography high-resolution electrospray ioniza-tion mass spectrometry(UPLC-HRESIMS)analysis of the refluxed solutions of p-hydroxybenzyl alcohol and the refluxed extracts of the fresh G.elata rhizome and“tian ma”extracts indicated consistent production and variation of the dimeric and trimeric derivatives of p-hydroxybenzyl alcohol upon extracting solvents and refluxing time.In various assays,the dimeric and trimeric derivatives showed more potent activities than p-hydroxybenzyl alcohol itself and gastrodin,which are the main known active constituents of“tian ma”.These results revealed for the first time that the more effective dimers and trimers can be produced through condensation of the co-occurring p-hydroxybenzyl alcohol during processing and decocting of the G.elata rhizomes,demonstrating insights into medicinal chemistry behind application protocols of traditional Chinese medicines. | Yanan Wang Min Zhang Xue Zhou Chengbo Xu Chenggen Zhu Yuhe Yuan Naihong Chen Yongchun Yang Qinglan Guo Jiangong Shi | 2021 | Natural Products and Bioprospecting2021，11，1： | 6 |
| 4 | Aluminum-Enhanced Proton Release Associated with Plasma Membrane H^+-Adenosine Triphosphatase Activity and Excess Cation Uptake in Tea (Camellia sinensis) Plant Roots显示文摘Cultivated tea(Camellia sinensis) plants acidify the rhizosphere, and Aluminum(Al) toxicity is recognized as a major limiting factor for plant growth in acidic soils. However, the mechanisms responsible for rhizosphere acidification associated with Al have not been fully elucidated. The present study examined the effect of Al on root-induced rhizosphere acidification, plasma membrane H^+-adenosine triphosphatase(H^+-ATPase) activity, and cation-anion balance in tea plant roots. The exudation of H^+from tea plant roots with or without Al treatment was visualized using an agar sheet with bromocresol purple. The H^+-ATPase activity of plasma membranes isolated from the roots was measured after hydrolysis using the two-phase partition system. The Al treatment strongly enhanced the exudation of H^+, and the acidification of tea plant roots by Al was closely associated with plasma membrane H^+-ATPase activity. The root plasma membrane H^+-ATPase activity increased with Al concentration. The Al content, amount of protons released, and H^+-ATPase activity were significantly higher in roots treated with Al than in those untreated. The results of the cation-anion balance in roots showed an excess of cations relative to anions, with the amount of excess cation uptake increasing with increasing Al concentrations. These suggest that Al-enhanced proton release is associated with plasma membrane H^+-ATPase activity and excess cation uptake. Findings of this study would provide insights into the contributing factors of soil acidification in tea plantations. | WAN Qing MI Yuhe YANG Yiyang Xu Renkou LI Xinghui | 2018 | Pedosphere2018，28，5： | 5 |
| 5 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 6 | Recent progress on three-dimensional nanoarchitecture anode materials for lithium/sodium storage显示文摘High-performance batteries with high density and low cost are needed for the development of largescale energy storage fields such as electric vehicles and renewable energy systems.The anode with threedimensional(3D)nanoarchitecture is one of the most attractive candidates for high-performance lithiumion batteries(LIBs)and sodium-ion batteries(SIBs)due to its efficient electron/ion transport and high active material mass loading.Although some important breakthroughs have been made in 3D nanoarchitecture anode materials,more improvements are still needed for high cycling stability and high energy density.Herein,the latest research progress of 3D nanoarchitecture anode materials for LIBs and SIBs is reviewed,including nanoporous metal,nanoporous graphene,and their derived foams.Specifically,the storage properties of Li/Na ions,the kinetics of ion/electron transport,and specific chemical interactions are discussed based on the structure design.In addition,the research strategies and structural characteristics of 3D nanoarchitecture anode materials are summarized,providing a reference for the further development of LIBs and SIBs.Meanwhile,the future research directions of LIBs and SIBs have also prospected. | Zhijia Zhang Yuefang Chen Shihao Sun Kai Sun Heyi Sun Hongwei Li Yuhe Yang Mengmeng Zhang Weijie Li Shulei Chou Huakun Liu Yong Jiang | 2022 | Journal of Materials Science & Technology2022，，24： | 2 |
| 7 | LASER GLAZING OF Ni-Nb AND Ni-Nb-Cr ALLOYS AND CORROSION RESISTANCE OF AMORPHOUS LAYERS显示文摘Partially amorphous Ni-Nb alloy was made by 1.91 kW cw CO2 laser melt-quenching,and fully amorphous by 4.5 kW and 4.9 kW.The corrosion resistance of the amor-phous layer was improved by adding Cr.Potentiodynamic polarization curves showthat the amorphous Ni50Nb40Cr10 is in more corrosion-resistant than the amorphousNi60Nb40and 18-8 stainless steel. | YAN Yuhe YANG Yongqiang ZHAO Changming Tianjin Institute of Textile Science and Technology,Tianjin,ChinaWU Weitao WANG Maocai Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,ChinaLU Mengfu Tianjin Institute of Science and Technology,Tianjin,China Lecturer,Laser Processing Lab.,Tianjin Institute of Textile Science and Technology,Tianjin 300160,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，7： | 1 |
| 8 | Plankton Community Succession in Artificial Systems Subjected to Cyanobacterial Blooms Removal using Chitosan-Modified Soils显示文摘 | Qingyun Yan Yuhe Yu Weisong Feng Gang Pan Hao Chen Juan Chen Bo Yang Xuemei Li Xiang Zhang | 2009 | Microbial Ecology2009，，1： | 1 |
| 9 | Selective catal- ytic reduction of nitric oxide with ammonia over ZSM-5 based catalysts for diesel engine applications 显示文摘 | Qi Gongshin Wang Yuhe Yang Ralph T | 2008 | Catalysis Letters2008，121，12： | 1 |
| 10 | Overexpressed alpha- synuclein regulated the nuclear factor-kappaB signal pathway 显示文摘 | Yuan Yuhe Jin Jin Yang Bo | 2008 | Cell Mol Neurobiol2008，28，1： | 1 |
| 11 | Desulfuriza- tion of high-sulfur jet fuel by mesoporous ,rr-complexation adsorbents 显示文摘 | Chen Hao Wang Yuhe Frances H Yang ct al | 2009 | Chemical Engineering Science2009，64，24： | 1 |
| 12 | Desulfuriza- tion of jet fuel JP-5 light fraction by MCM-41 and SBA-15 supported cuprous oxide for fuel cell applications 显示文摘 | Wang Yuhe Ralph T Yang John M Heinzel | 2008 | Industrial & Engineering Chemistry Research2008，48，1： | 1 |
| 13 | Diploid chromosome-level reference genome and population genomic analyses provide insights into Gypenoside biosynthesis and demographic evolution of Gynostemma pentaphyllum (Cucurbitaceae)显示文摘Gynostemma pentaphyllum(Thunb.)Makino is a perennial creeping herbaceous plant in the family Cucurbitaceae,which has great medicinal value and commercial potential,but urgent conservation efforts are needed due to the gradual decreases and fragmented distribution of its wild populations.Here,we report the high-quality diploid chromosome-level genome of G.pentaphyllum obtained using a combination of next-generation sequencing short reads,Nanopore long reads,and Hi-C sequencing technologies.The genome is anchored to 11 pseudo-chromosomes with a total size of 608.95 Mb and 26588 predicted genes.Comparative genomic analyses indicate that G.pentaphyllum is estimated to have diverged from Momordica charantia 60.7 million years ago,with no recent whole-genome duplication event.Genomic population analyses based on genotyping-by-sequencing and ecological niche analyses indicated low genetic diversity but a strong population structure within the species,which could classify 32 G.pentaphyllum populations into three geographical groups shaped jointly by geographic and climate factors.Furthermore,comparative transcriptome analyses showed that the genes encoding enzyme involved in gypenoside biosynthesis had higher expression levels in the leaves and tendrils.Overall,the findings obtained in this study provide an effective molecular basis for further studies of demographic genetics,ecological adaption,and systematic evolution in Cucurbitaceae species,as well as contributing to molecular breeding,and the biosynthesis and biotransformation of gypenoside. | Xiao Zhang Yuhe Zhao Yixuan Kou Xiaodan Chen Jia Yang Hao Zhang Zhe Zhao Yuemei Zhao Guifang Zhao Zhonghu Li | 2023 | Horticulture Research2023，10，1： | 0 |
| 14 | MoLrp1-mediated signaling induces nuclear accumulation of MoMsn2 to facilitate fatty acid oxidation for infectious growth of the rice blast fungus显示文摘Fatty acid b-oxidation is critical for fatty acid degradation and cellular development.In the rice blast fungus Magnaporthe oryzae,fatty acid b-oxidation is reported to be important mainly for turgor generation in the appressorium.However,the role of fatty acid b-oxidation during invasive hyphal growth is rarely documented.We demonstrated that blocking peroxisomal fatty acid b-oxidation impaired lipid droplet(LD)degradation and infectious growth of M.oryzae.We found that the key regulator of pathogenesis,MoMsn2,which we identified previously,is involved in fatty acid b-oxidation by targeting MoDCI1(encoding dienoyl-coenzyme A[CoA]isomerase),which is also important for LD degradation and infectious growth.Cytological observations revealed that MoMsn2 accumulated from the cytosol to the nucleus during early infection or upon treatment with oleate.We determined that the low-density lipoprotein receptor-related protein MoLrp1,which is also involved in fatty acid b-oxidation and infectious growth,plays a critical role in the accumulation of MoMsn2 from the cytosol to the nucleus by activating the cyclic AMP signaling pathway.Our results provide new insights into the importance of fatty acid oxidation during invasive hyphal growth,which is modulated by MoMsn2 and its related signaling pathways in M.oryzae. | Ting Zhang Xingyu Wang Xue Li Ya-Nan Li Yuhe Li Shuang Wu Lele Xu Ruiwen Zhou Jing Yang Guotian Li Xinyu Liu Xiaobo Zheng Zhengguang Zhang Haifeng Zhang | 2023 | Plant Communications2023，4，4： | 0 |
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