| 1 | Organocatalytic Stereoselective[8+2]Cycloaddition of Tropones with Azlactones显示文摘Herein,we report an organocatalytic asymmetric[8+2]higher-order cycloaddition of tropones with azlactones employing bifunctional guanidines as hydrogen-bond-mediated catalysts via a 1,8-addition/annulation process.The reaction has a broad scope with respect to both cycloaddition partners and hence offers rapid access to an array of[5.3.0]bicyclic compounds with excellent outcomes[up to 95%yield,>19:1 diastereomeric ratio(dr),and 96%enantiomeric excess(ee)].Besides,the synthetic utility of the protocol provides rapid transformation into enantioenrichedα-amino acid derivatives.Moreover,the isolated[1,5]-H shift isomer,X-ray crystal structure of chiral guanidinium salt,and density functional theory(DFT)calculations provide convincing evidence for the interpretation of diastereo-and enantioselection. | Jinzhao Li Yuhao Mo Liqiao Yan Xiaoming Feng Zhishan Su Xiaohua Liu | 2022 | CCS Chemistry2022，4，2： | 0 |
| 2 | The link between genetic variation and variability in vaccine responses:a narrative review显示文摘Vaccines are one of the biggest successes in modern history and are particularly important in light of the multiple ongoing epidemics.Recently,vaccines have protected peoples’health and lives around the world during the coronavirus disease 2019 pandemic.Different types of vaccines have their own characteristics and advantages and are used in the context of different epidemics.Responses to vaccination are also different,and can include adverse reactions and absent responses.These individual differences are thought to be influenced by host genes.In this review,we first discuss vaccine types and characteristics.Second,we discuss different responses to vaccination,primarily focusing on the association between genetic variation and inter-individual differences. | Yingtian Zhang Mingzhe Zhao Wei Zhou Luan Chen Mo Li Bixuan Jiang Xianglong Zhao Hao Wu Lu Shen Na Zhang Hengwei Qin Yuhao Tang Chenhan Jiad Lin He Shengying Qin | 2022 | Journal of Bio-X Research2022，5，2： | 0 |
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