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222篇 您的检索式:作者名="Yu Tai"
    题名 作者 年代 出处 被引量
1Transcriptional Repression by Histone Deacetylases in Plants显示文摘在 histone 尾巴的 N 终点的可逆 histone acetylation 和 deacetylation 在 eukaryoticgene 活动的规定起关键作用。核心 histones 的 Acetylation 通常导致开的染色质结构并且与基因激活被联系,而 histone 的 deacetylation 经常与关上的染色质和基因压抑被相关。由 histone deacetylases (HDAC ) 的 Histone deacetylation iscatalyzed。越来越多的研究在植物表明了 histone deacetylation/acetylationon 染色体稳定性, transcriptional 规定,和开发的重要性。而且, HDAC 被显示交往在多重 developmentalprocesses 涉及 transcriptional 压抑的 withvarious 染色质 remolding 因素和抄写因素。在这评论,我们在 transcriptional 压抑上总结了最近的调查结果在 plants.Key 词由 HDAC 调停了:Xuncheng Liua Songguang Yang Minglei Zhaoa Ming Luo Chun-Wei Yu Chia-Yang Chen Ready Tai Keqiang Wu 2014Molecular Plant2014,7,5:16
2Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation.Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu 2019Cancer Biology & Medicine2019,16,1:14
3Characterization of disinfection byproduct formation potential in 13 source waters in China显示文摘The formation potential of four trihalomethanes (THMFP) and seven haloacetic acids (HAA 7 FP) in 13 source waters taken from four major water basin areas in China was evaluated using the simulated distribution system (SDS) chlorination method.The specific ultraviolet absorbance (SUVA 254:the ratio of UV 254 to dissolved organic carbon (DOC)),which ranged between 0.9 and 5.0 L/(mg·m),showed that the organic compounds in different source waters exhibited different reactivities with chlorine.The HAA 7 FP of source waters ranged from 20 to 448 μg/L and the THMFP ranged from 29 to 259 μg/L.The HAA 7 FP concentrations were higher than the THMFP concentrations in all but one of the samples.Therefore,the risks of haloacetic acids (HAAs) should be of concern in some source waters.TCM (chloroform) and BDCM (bromodichloromethane) were the major THM constituents,while TCAA (trichloroacetic acid) and DCAA (dichloroacetic acid) were the major HAA species.Br-THM (brominated THM species) were much higher than BrHAA (brominated HAA species),and the formation of Br-DBP (Br-THM and Br-HAA) should be of concern when the bromide concentration is over 100 μg/L.Junzhi Zhang Jianwei Yu Wei An Juan Liu Yongjing Wang Youjun Chen Jia Tai Min Yang 2011Journal of Environmental Sciences2011,23,2:13
4Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury显示文摘瞄准:高血压蛋白原酶血管收缩素系统(地岬) 在血压控制和身体液体和电解质动态平衡起一个关键作用。在过去几年里,血管收缩素(Ang )(1-7 ) 被报导了抵抗 Ang II 的效果并且甚至在地岬被看作一个新 therapeutical 目标。现在的学习试图在本地地岬上在一个糖尿病的动物模型和调整上调查 Ang (1-7 ) 管理的效果。方法:Streptozotocin (STZ ) 导致注射的糖尿病的老鼠在实验被使用。动物被划分成 3 个组:(1 ) 控制;(2 )导致 STZ 的糖尿病;并且(3 ) 有长期的 Ang (1-7 ) 处理的导致 STZ 的糖尿病[D+Ang (1-7 )] 。在 D+Ang (l-7 ) 组, 25 μ g · k g~ 的剂量(Ang (1-7 ) 的 -1) · h^(-1) 被嵌入微型渗透的泵 6 个星期不断地通过颈部的静脉注射。血浆葡萄糖,到体重的肾的比率,和 24 h 尿蛋白质和浆液肌酸酐被常规测量监视。血浆和肾的 Ang II 层次被放射性免疫测定测量。Ang-con-verting 酶(王牌) , ACE2, Ang II 打 1 (AT1 ) 受体, Ang II 打 2 (AT2 ) 受体, Ang (1-7 ) 妈受体,和 TGF-β 1 niRNA 层次被实时 PCR 测量;王牌, ACE2,和 TGF-β 1 蛋白质层次被西方的弄污分析。结果:当时,糖尿病的老鼠的肾的函数显著地被倒退与控制老鼠的相比。在由为 6 个星期的经常的 Ang (1-7 ) 静脉注射的处理以后,肾的功能被发现平比糖尿病的老鼠,和两 TGF-β 1 更坏 mRNA 和蛋白质层次与糖尿病的老鼠相比在 D+Ang (l-7 ) 组被提高。即时 PCR 结果也在 D+Ang (1-7 ) 组在 ACE2 mRNA 水平在王牌 mRNA 表示和减少看了增加是否与糖尿病的老鼠相比。受体在 Ang (1-7 ) 增加了的 ATI 的数字注射了组,当 AT2 和妈受体的数字减少了时。结论:外长的 Ang (1-7 ) 注射没改善导致 STZ 的糖尿病的老鼠肾损伤;相反,它加速了进步糖尿病的 nephropathies。Ying SHAO Ming HE Li ZHOU Tai YAO Yu HUANG Li-min LU 2008Acta Pharmacologica Sinica2008,29,7:12
5BAFF, involved in B cell activation through the NF-κB pathway, is related to disease activity and bone destruction in rheumatoid arthritis显示文摘B cell activating factor of TNF family(BAFF)is a member of TNF ligand superfamily and plays a key role in B cell homeostasis,proliferation,maturation,and survival.In this study,we detected BAFF level,the expressions of BAFF receptors and important molecules in NF-κB pathway in rheumatoid arthritis(RA)patients and analyzed the correlation between BAFF level and clinical variables,laboratory parameters or X-ray scores in order to elucidate the roles of BAFF in RA.A total of 50 RA patients and 50 healthy controls(HCs)were enrolled.We showed that the serum BAFF level in RA patients was significantly higher than that of HCs,and the percentages of B cell subsets(CD19^(+)B cells,CD19^(+)CD27^(+)B cells,CD19^(+)CD20^(+)CD27^(+)B cells,and CD19^(+)CD20−CD27^(+)B cells)in the serum of RA patients were significantly increased compared with those of HCs.The percentages of CD19^(+)BAFFR^(+)B cells,CD19^(+)BCMA^(+)B cells,and CD19^(+)TACI^(+)B cells in RA patients were significantly increased compared with those in HCs.The expression of important molecules in the NF-κB pathway(MKK3,MKK6,p-P38,p-P65,TRAF2,and p52)was significantly higher in RA patients than in HCs,but p100 level in RA patients was lower than that in HCs.The serum BAFF level was positively correlated with C-reactive protein,rheumatoid factor,disease activity score(in 28 joints),swollen joint counts,tender joint counts,and X-ray scores.When normal B cells were treated with BAFF in vitro,the percentages of the B cell subset and the expression of BAFF receptors were significantly upregulated.BAFF also promoted the expression of MKK3,MKK6,p-P38,p-P65,TRAF2,and p52.In conclusion,this study demonstrates that BAFF level is correlated with the disease activity and bone destruction of RA.BAFF is involved in the differentiation,proliferation,and activation of B cells in RA through NF-κB signaling pathway,suggesting that BAFF might be an ideal therapeutic target for RA.Ling-ling Zhang Hui Xiao Feng Zhang Yu-jing Wu Jin-ling Shu Ying Li Yu Tai Sheng-qian Xu Jian-hua Xu Wei Wei 2021Acta Pharmacologica Sinica2021,42,10:9
6Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells显示文摘Hong XUE Ping YUAN Li ZHOU Tai YAO Yu HUANG Li-min LU 2009Acta Pharmacologica Sinica2009,30,8:7
7Preparation,Characterization and Comparative NH_3-sensing Characteristic Studies of PANI/inorganic Oxides Nanocomposite Thin Films显示文摘Polyaniline (PANI), polyaniline/titanium dioxide (PANI/TiO2), polyaniline/tin oxide (PANI/SnO2) and polyani- line/indium oxide ℃(PANI/In2O3) thin films were developed by using an in-situ self-assembly method at ~10℃. Chemical structure, optical property and morphology of all the thin films were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, UV-Vis absorption spectroscopy, scanning electron mi- croscopy (SEM) and transmission electron microscopy (TEM). NH3 gas-sensing properties of PANI and PANI nanocomposite thin films were examined at ambient temperature. The results showed that all the sensors composed of PANI nanocomposite thin films had faster response/recovery rate with better reproducibility, selectivity and long-term stability to NH3 than PANI thin film sensor, and PANI/TiO2 nanocomposite thin film sensor showed optimum NH3 gas-sensing characteristics. The effect of humidity on the responses of all the sensors was also investigated.Hulling Tai Yadong Jiang Cuangzhong Xie Junsheng Yu 2010Journal of Materials Science & Technology2010,26,7:7
8Safety Assesment Model for Fully-Mechanized CoalfaceWANG Lian\|guo 1,\ SUN Qiu\|zhi 2,\ WANG Yu\|zhen 3 1. Systems Engineering Institute, Shandong Univercity of Science and Technology Tai′an, 271000 2. Computing Centre, Shandong College of Hydraulic Engineering Tai′an, 271000 3. Institute of S 2000Systems Science and Systems Engineering2000,10,3:6
9Paeoniflorin-6′-0-benzene sulfonate alleviates collageninduced arthritis in mice by downregulating BAFF-TRAF2-NF-kB signaling: comparison with biological agents显示文摘Paeoniflorin-6′-0-benzene sulfonate (CP-25) is a new ester derivative of paeoniflorin with improved lipid solubility and oral bioavailability, as well as better anti-inflammatory activity than its parent compound. In this study we explored whether CP-25 exerted therapeutic effects in collagen-induced arthritis (CIA) mice through regulating B-cell activating factor (BAFF)-BAFF receptors-mediated signaling pathways. CIA mice were given CP-25 or injected with biological agents rituximab or etanercept for 40 days. In CIA mice, we found that T cells and B cells exhibited abnormal proliferation;the percentages of CD19^+ total B cells, CD19^+CD27^+-activated B cells, CD19^+BAFFR^+ and CD19^+TACI^+cells were significantly increased in PBMCs and spleen lymphocytes. CP-25 suppressed the indicators of arthritis, alleviated histopathology, accompanied by reduced BAFF and BAFF receptors expressions, inhibited serum immunoglobulin levels, decreased the Bell subsets percentages, and prevented the expressions of key molecules in NF-kB signaling. Furthermore, we showed that treatment with CP-25 reduced CD19+TRAF2^+ cell expressions stimulated by BAFF and decreased TRAF2 overexpression in HEK293 cells in vitro. Thus, CP-25 restored the abnormal T cells proliferation and B-cell percentages to the normal levels, and normalized the elevated levels of IgA, lgG2a and key proteins in NF-kB signaling. In comparison, rituximab and etanercept displayed stronger antiinflammatory activities than CP-25;they suppressed the elevated inflammatory indexes to below the normal levels in CIA mice. In summary, our results provide evidence that CP-25 alleviates CIA and regulates the functions of B cells through BAFF-TRAF2-NF-kB signaling. CP-25 would be a soft immunomodulatory drug with anti-inflammatory effect.Jin-ling Shu Xian-zheng Zhang Le Han Feng Zhang Yu-jing Wu Xiao-yu Tang Chen Wang Yu Tai Qing-tong Wang Jing-yu Chen Yan Chang Hua-xun Wu Ling-ling Zhang Wei Wei 2019Acta Pharmacologica Sinica2019,40,6:6
10Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells显示文摘Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells(A10 cells). BAM15 relaxed phenylephrine(PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium. Pretreatment with BAM15 inhibited PEinduced constriction of rat mesenteric arteries with intact and denuded endothelium. BAM15, CCCP,and niclosamide had the comparable IC50 value of vasorelaxation in PE-induced constriction of rat mesenteric arteries. BAM15 was less cytotoxic in A10 cells compared with CCCP and niclosamide.BAM15 depolarized mitochondrial membrane potential, induced mitochondrial fission, increased mitochondrial ROS production, and increased mitochondrial oxygen consumption rate in A10 cells.BAM15 potently activated AMPK in A10 cells and the efficacy of BAM15 was stronger than that of CCCP, niclosamide, and AMPK positive activators metformin and AICAR. In conclusion, BAM15 activates AMPK in vascular smooth muscle cells with higher potency than that of CCCP, niclosamide and the known AMPK activators metformin and AICAR. The present work indicates that BAM15 is a potent AMPK activator.Yu Tai Lanjun Li Xuan Peng Junxue Zhu Xihai Mao Nan Qin Minghui Ma Rong Huo Yunlong Bai Deli Dong 2018Acta Pharmaceutica Sinica B2018,8,6:5
11Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells:comparison of vasorelaxant effects of verapamil and phentolamine显示文摘Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of mitochondrial fission in smooth muscle cells was associated with arterial relaxation. Here, we used the typical vasorelaxants, verapamil and phentolamine, to further confirm the coupling between arterial constriction and mitochondrial fission in rat aorta. Results showed that phentolamine but not verapamil induced vasorelaxation in phenylephrine(PE)-induced rat thoracic aorta constriction. Verapamil, but not phentolamine, induced vasorelaxation in high K^+(KPSS)-induced rat thoracic aorta constriction. Pre-treatment with phentolamine prevented PEbut not KPSS-induced aorta constriction and pre-treatment with verapamil prevented both PE-and KPSSinduced aorta constriction. Transmission electron microscopy(TEM) results showed that verapamil but not phentolamine inhibited KPSS-induced excessive mitochondrial fission in aortic smooth muscle cells,and verapamil prevented both PE-and KPSS-induced excessive mitochondrial fission in aortic smoothmuscle cells. Verapamil inhibited KPSS-induced excessive mitochondrial fission in cultured vascular smooth muscle cells(A10). These results further demonstrate that arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells.Jing Jin Xin Shen Yu Tai Shanliang Li Mingyu Liu Changlin Zhen Xiuchen Xuan Xiyue Zhang Nan Hu Xinzi Zhang Deli Dong 2017Acta Pharmaceutica Sinica B2017,7,3:5
12Outgassing analysis of molecular glass photoresists under EUV irradiation显示文摘A device was designed and assembled to analyze the outgassing of molecular glass(MG)photoresists under extreme ultraviolet(EUV)exposure.The outgassing of the photoresists with different components and different concentrations of tert-butoxycarbonyl(t-Boc),photo-generated acid(PAG),and acid quencher was systematically investigated.Based on experiments,some solutions for reducing the outgassing of MG photoresists were proposed.CHEN Li XU Jian YUAN Hua YANG Shu Min WANG Lian Sheng WU Yan Qing ZHAO Jun CHEN Ming LIU Hai Gang LI Sha Yu TAI Ren Zhong WANG Shuang Qing YANG Guo Qiang 2014Science China Chemistry2014,57,12:4
13Correlation between TERT C228T and clinic-pathological features in pediatric papillary thyroid carcinoma显示文摘The aims of the present study were to reveal the prevalence of the TERT C228 T mutation in pediatric papillary thyroid carcinoma(PPTC) and to further investigate the role of the TERT C228 T mutation in PPTC. We also tested another TERT mutation, TERT C250 T, although this was not detected in PPTC patients. In this study, 48 patients with PPTC(41 with classic PPTC) were enrolled. DNA was extracted from PPTC tissues and TERT C228 T mutation analysis was performed. Chi-squared analysis,Fisher’s exact test, and a t-test were applied to test the significance of differences. The TERT C228 T mutation presented in 13(27.1%) of the 48 PPTC patients and 10(24.4%) of the 41 classical PPTC patients. There were significant differences between PPTC patients with the TERT C228 T mutation and those without in terms of modified radical neck dissection, multifocality,capsular invasion, extrathyroidal invasion, and American Joint Committee on Cancer(AJCC) tumor stage(P<0.05). In classical PPTC, there were additional significant differences in other clinic-pathological features, such as AJCC nodal stage(P=0.009)and American Thyroid Association(ATA) PPTC stage(P=0.021) between patients with and without the TERT C228 T mutation.These findings indicate that the TERT C228 T mutation is significantly correlated with certain aggressive clinic-pathological features of PPTC.Jiangqiao Geng Yuanhu Liu Yongli Guo Huanmin Wang Jun Tai Yaqiong Jin Jie Zhang Yongbo Yu Shengcai Wang Yingluan Song Xin Ni 2019Science China(Life Sciences)2019,62,12:3
14An APXPS endstation for gas–solid and liquid–solid interface studies at SSRF显示文摘In the past few decades, various surface analysis techniques find wide applications in studies of interfacial phenomena ranging from fundamental surface science,catalysis, environmental science and energy materials.With the help of bright synchrotron sources, many of these techniques have been further advanced into novel in-situ/operando tools at synchrotron user facilities, providing molecular level understanding of chemical/electrochemical processes in-situ at gas–solid and liquid–solid interfaces.Designing a proper endstation for a dedicated beamline is one of the challenges in utilizing these techniques efficiently for a variety of user's requests. Many factors,including pressure differential, geometry and energy of the photon source, sample and analyzer, need to be optimized for the system of interest. In this paper, we discuss the design and performance of a new endstation at beamline02 B at the Shanghai Synchrotron Radiation Facility for ambient pressure X-ray photoelectron spectroscopy studies.This system, equipped with the newly developed hightransmission HiPP-3 analyzer, is demonstrated to be capable of efficiently collecting photoelectrons up to 1500 eV from ultrahigh vacuum to ambient pressure of 20 mbar.The spectromicroscopy mode of HiPP-3 analyzer also enables detection of photoelectron spatial distribution with resolution of 2.8 ± 0.3 lm in one dimension. In addition,the designing strategies of systems that allow investigations in phenomena at gas–solid interface and liquid–solid interface will be highlighted through our discussion.Jun Cai Qiao Dong Yong Han Bao-Hua Mao Hui Zhang Patrik G.Karlsson John ?hlund Ren-Zhong Tai Yi Yu Zhi Liu 2019Nuclear Science and Techniques2019,30,5:3
15Presentation matters: Identity of gold nanocluster capping agent governs intracellular uptake and cell metabolism显示文摘Chor Yong Tay Yong Yu Magdiel Inggrid Setyawati Jianping Xie David Tai Leong 2014Nano Research2014,7,6:3
16Gold and Silver Nanoparticles Supported on Metal-organic Frameworks: a Highly Active Catalyst for Three-component Coupling Reaction显示文摘LIU Lili TAI Xishi YU Guanglin GUO Huanmei MENG Qingguo 2016Chemical Research in Chinese Universities2016,32,3:2
17The Fuzzy Control Forecast of Fully-Mechanized Coal Face Production CapacityWANG Lian\|guo\ \ WANG Yu\|zhen Res. Ins. of Systems Eng., Shandong Institute of Mining and Technology, Tai′an 271000, China 1999Systems Science and Systems Engineering1999,9,3:2
18Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression.Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang 2023Science China(Life Sciences)2023,66,2:2
19Treatment of Complicated Hepatolithiasis with Intrahepatic Biliary Stricture by Ductal Dilatation and Stenting: Long-term Results显示文摘Yu Fan Cheng Tze Yu Lee Shyr Ming Sheen-Chen Tung Liang Huang Tai Yi Chen 2000World Journal of Surgery2000,,6:2
20Production of high-content galacto-oligosaccharide by enzyme catalysis and fermentation with Kluyveromyces marxianus (vol 28, pg 793, 2006)显示文摘Cheng, C. C. Yu, M. C. Cheng, T. C. Sheu, D. C. Duan, K. J. Tai, W. L. 2007中国生物学文摘2007,21,2:2
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