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| 1 | Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy显示文摘AIM:To investigate the efficacy of premedication with pronase,a proteolytic enzyme,in improving imagequality during magnifying endoscopy.METHODS:The study was of a blinded,randomized,prospective design.Patients were assigned to groups administered oral premedication of either pronase and simethicone(Group A)or simethicone alone(Group B).First,the gastric mucosal visibility grade(1-4)was determined during conventional endoscopy,and then a magnifying endoscopic examination was conducted.The quality of images obtained by magnifying endoscopy at the stomach and the esophagus was scored from1 to 3,with a lower score indicating better visibility.The endoscopist used water flushes as needed to obtain satisfactory magnifying endoscopic views.The main study outcomes were the visibility scores during magnifying endoscopy and the number of water flushes.RESULTS:A total of 144 patients were enrolled,and data from 143 patients(M:F=90:53,mean age 57.5 years)were analyzed.The visibility score was significantly higher in the stomach following premedication with pronase(73%with a score of 1 in Group A vs 49%in Group B,P<0.05),but there was no difference in the esophagus visibility scores(67%with a score of 1in Group A vs 58%in Group B).Fewer water flushes[mean 0.7±0.9 times(range:0-3 times)in Group A vs 1.9±1.5 times(range:0-6 times)in Group B,P<0.05]in the pronase premedication group did not affect the endoscopic procedure times[mean 766 s(range:647-866 s)for Group A vs 760 s(range:678-854 s)for Group B,P=0.88].The total gastric mucosal visibility score was also lower in Group A(4.9±1.5 vs 8.3±1.8in Group B,P<0.01).CONCLUSION:The addition of pronase to simethicone premedication resulted in clearer images during magnifying endoscopy and reduced the need for water flushes. | Gwang Ha Kim Yu Kyung Cho Jae Myung Cha Sun-Young Lee Il-Kwun Chung | 2015 | World Journal of Gastroenterology2015，21，8： | 21 |
| 2 | Oxidative stress and antioxidants in hepatic pathogenesis显示文摘Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases,including hepatocellular carcinoma (HCC). The HBV encod-ed proteins,hepatitis B virus X protein and preS,appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress,which can damage cellular molecules like lipids,proteins,and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants,such as curcumin,silymarin,green tea,and vitamins C and E,can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis,focusing upon HBV and alcohol,and suggests antioxidant therapeutic approaches. | Hye-Lin Ha Hye-Jun Shin Mark A Feitelson Dae-Yeul Yu | 2010 | World Journal of Gastroenterology2010，16，48： | 18 |
| 3 | Altered serum level of cartilage oligomeric matrix protein and its association with coronary calcification in patients with coronary heart disease显示文摘BackgroundCartilage oligomeric 矩阵蛋白质(COMP ) 主要在骨胳的系统和脉管的光滑的肌肉房间被发现。最近的研究证明它在血容器上有保护的功能并且能也禁止脉管的石灰化。我们在冠的心疾病( CHD )调查了浆液 COMP 病人,并且在浆液 COMP 和首先经历了多片跟随的冠的 angiography 的 233 个连续的胸疼痛病人全部的冠的 artery.MethodsA 的石灰化之间的关系在六个月以内计算了断层摄影术( MSCT )被招募并且根据缩小百分比的冠的 angiography 钠直径划分了成二个组:CHD 组(缩小 50% 的直径, n = 194 ) 并且控制组(直径变窄 <50% , n = 39 ) 。Gensini 分数,句法分数和冠的动脉钙分数(CAC ) 是计算的。浆液 COMP 水平用 COMP 的 ELISA.ResultsThe 层次被决定比在控制组在 CHD 组是显著地更高的 155.7 (124.5-194.5 ) ng/mL 对 128.4 (113.0-159.9 ) ng/mL, P = 0.019。在 COMP, Gensini 分数,句法分数,冠的狭窄的严厉和有狭窄的冠的动脉的数字之间没有关联 >50% 。浆液 COMP 与年龄被相关(r = 0.294, P < 0.001 ) , fasting 葡萄糖(r = 0.163, P = 0.015 ) , HbA1c (r = 0.194, P = 0.015 ) 并且 CAC (r = 0.137, P = 0.037 ) 。逐步的线性回归分析显示出那 COMP 水平,年龄是在 CHD 病人的 CAC 的独立预言者(= 0.402, t = 2.612, P = 0.015;= 0.472, t = 3.077, P = 0.005 ) 。为预言 CHD 的 COMP 的性能在曲线(AUC ) 下面作为区域被显示出:0.632, 95% CI:0.549-0.715 和上面的 tertile CAC 是 AUC:0.602, 95% CI:在操作冠的动脉的特征(巨鸟) 曲线 analysis.ConclusionCalcification 的接收装置的 0.526-0.678 是浆液 COMP 的一个独立预言者。 | Fang-Fang WANG Lahati HA Hai-Yi YU Lin MI Jiang-Li HAN Wei GAO | 2017 | Journal of Geriatric Cardiology2017，14，2： | 15 |
| 4 | Efforts to increase image quality during endoscopy:The role of pronase显示文摘Clear visualization of the gastrointestinal mucosal surface is essential for thorough endoscopy. An unobstructed assessment can reduce the need for additional timeconsuming manipulations such as frequent washing and suction,which tend to prolong total procedure time. However,mucus,foam,and bubbles often hinder clear visibility during endoscopy. Premedication with pronase,a compound of mixed proteolytic enzymes,has been studied in order to improve mucosal visibility during endoscopy. Although its effects differ according to the location in the stomach,premedication with pronase 10 to 20 min before endoscopy significantly improves mucosal visibility without affecting the accuracy of Helicobacter pylori identification. The effects of pronase as premedication also extend to chromoendoscopy,narrow-band imaging,magnifying endoscopy,and endoscopic ultrasonography. In addition,endoscopic flushing with pronase during endoscopy may improve the quantity and the quality of a biopsy to some degree. Although improved mucosal visibility does not necessarily improve clinical outcomes,premedication with pronase may be helpful for increasing the detection rate of early cancers. | Gwang Ha Kim Yu Kyung Cho Jae Myung Cha Sun-Young Lee Il-Kwun Chung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，5： | 13 |
| 5 | Association between serum cartilage oligomeric matrix protein and coronary artery calcification in maintenance hemodialysis patients显示文摘Background Coronary artery calcification(CAC)is common in end-stage renal disease(ESRD)patients,and the extent of CAC is closely related to cardiovascular outcomes in ESRD patients.Cartilage oligomeric matrix protein(COMP),as a component of the vascular matrix,has been found to be an inhibitor of arterial calcification in basic studies.However,there is no clinical research on the correlation between COMP and CAC in maintenance hemodialysis(MHD)patients.The aim of this study was to explore the relationship between serum COMP levels and CAC and cardiovascular events in MHD patients.Methods Serum COMP levels were compared between 54 MHD patients and 66 healthy people.MHD patients were then divided into three groups according to the tertiles of the concentration of COMP level and were followed up for major adverse cardiac events(MACEs),which were defined as a combined end point of new onset angina pectoris,nonfatal myocardial infarction,heart failure,coronary artery revascularization,hospitalization due to angina pectoris and all-cause deaths.The CAC score was calculated based on computed tomography scans.Results The serum COMP level in MHD patients was significantly higher than that in the general population[984.23(248.43-1902.61)ng/mL vs.219.01(97.26-821.92)ng/mL,P<0.01].Serum COMP levels were positively correlated with CAC(r=0.313,P=0.021)and serum parathyroid hormone in MHD patients(r=0.359,P<0.01).Linear regression suggested that after adjusting for age,fasting blood glucose(Glu)and glycosylated hemoglobin(HbAlc),CAC score was an independent predictor in the final model for COMP level(β=0.424,t=3.130,P<0.01).The receiver operating characteristic(ROC)curve showed that COMP≥994 mg/mL had 68.0%sensitivity and 72.4%specificity for the prediction of severe CAC[area under the curve(AUC):0.674,P=0.030,95%CI:0.526-0.882].After a median follow-up of 16 months(8-24 months),there was no difference in the incidence rate of MACEs between the upper,middle and lower serum COMP groups.Conclusions Our study found that MHD patients have higher levels of circulating COMP than controls.The serum COMP level is positively correlated with CAC score and could be used as a biomarker of severe CAC in MHD patients.However,there is no obvious correlation between serum COMP levels and the incidence of cardiovascular events. | Lahati HA Jun-Bao SHI Hai-Yi YU Kun YANG Hai-Ning WANG Fang-Fang WANG Jiang-Li HAN | 2020 | Journal of Geriatric Cardiology2020，17，2： | 11 |
| 6 | Gender Affects the Median Effective Dose and 95% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naive Adult Patients显示文摘 | Xian-Hui Kang Fang-Ping Bao Hong-Gang Zhang Dan-Jun Yu Ke Ha Qing Xie Sheng-Mei Zhu | 2018 | Chinese Medical Journal2018，，16： | 10 |
| 7 | HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway显示文摘AIM:To investigate the role of hepatitis B virus X-protein(HBx)-induced reactive oxygen species(ROS)on liver carcinogenesis in HBx transgenic mice and HepG2-HBx cells.METHODS:Cell growth rate was analyzed,and through western blotting,mitogenic signaling was observed.Endogenous ROS from wild and HBx transgenic mice and HepG2-Mock and HBx cells were assayed by FACS-calibur.Identification of oxidized and reduced phosphatase and tensin homolog(PTEN)was analyzed through N-ethylmaleimide alkylation,nonreducing electrophoresis.RESULTS:We observed that the cell-proliferation-related phosphoinositide 3-kinase/Akt pathway is activated by HBx in vivo and in vitro.Increased ROS were detected by HBx.Tumor suppressor PTEN,via dephosphorylation of Akt,was oxidized and inactivated by increased ROS.Increased oxidized PTEN activated the mitogenic pathway through over-activated Akt.However,treatment with ROS scavenger N-acetyl cysteine can reverse PTEN to a reduced form.Endogenously produced ROS also stimulated HBx expression.CONCLUSION:HBx induced ROS promoted Akt pathways via oxidized inactive PTEN.HBx and ROS maintained a positive regulatory loop,which aggravated carcinogenesis. | Hye-Lin Ha Dae-Yeul Yu | 2010 | World Journal of Gastroenterology2010，16，39： | 8 |
| 8 | Effect of a seasonal diffuse pollution migration on natural organic matter behavior in a stratified dam reservoir显示文摘This article aims to describe the influence of diffuse pollution on the temporal and spatial characteristics of natural organic matter (NOM) in a stratified dam reservoir,the Daecheong Dam,on the basis of intensive observation results and the dynamic water quality simulation using CE-QUAL-W2.Turbidity is regarded as a comprehensive representation of allochothonous organic matter from diffuse sources in storm season because the turbidity concentration showed reasonable significance in a statistical correlation with the UV absorbance at 254 nm and total phosphorus.CE-QUAL-W2 simulation results showed good consistency with the observed data in terms of dissolved organic matter (DOM) including refractory dissolved organic carbon (RDOC) and labile DOC and also well explained the internal movement of constituents and stratification phenomenon in the reservoir.Instead turbidity and NOM were related well in the upper region of the reservoir according to flow distance,gradually as changing to dissolved form of organic matter,RDOM affected organic matter concentration of reservoir water quality compared to turbidity.To control the increase of soluble organic matters in the dam reservoir,appropriate dam water discharge gate operation provided effective measurement.Because of the gate operation let avoid the accumulation of organic matter within a dam reservoir by shorten of turbid regime retention time. | Soon Ju Yu Jae Yil Lee Sung Ryong Ha | 2010 | Journal of Environmental Sciences2010，22，6： | 5 |
| 9 | Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway显示文摘Consumption of kava(Piper methysticum Forst) has been linked to reduced cancer risk in the South Pacific Islands.Kavalactones are major bioactive components in kava root extracts, which have recently demonstrated anti-cancer activities. However, molecular mechanisms of kavalactones' anti-cancer action remain largely unknown. We have identified two kavalactones, yangonin and 5' 6'-dehydrokawain, as potent inducers of autophagic cell death in bladder cancer cells. The effect of yangonin inducing autophagy is associated with increased expression of beclin and ATG5.In addition, yangonin increases the expression of LKB1 and decreases the phosphorylation of Akt, PRAS40, rpS6,p70S6 K and 4E-BP1, leading to increased binding of 4E-BP1 to m7 GTP. The growth inhibitory effects of yangonin were attenuated in TSC1 or LKB1 knockout mouse embryonic fibroblasts, suggesting that TSC1 and LKB1 expression may contribute to optimal growth inhibition by yangonin. Furthermore, yangonin reduces the viability of bladder cancer cell lines derived from different stages of human bladder cancer, and acts synergistically with apoptosis-inducing agents such as docetaxel and flavokawain A. Our results support a novel anti-bladder cancer mechanism by yangonin and further studies are needed to assess the potential use of yangonin for bladder cancer prevention and | Zhongbo Liu U-Syn Ha Ke Yu Chunli Wu Noriko Yokoyama Xiaolin Zi | 2017 | The Journal of Biomedical Research2017，31，5： | 4 |
| 10 | Characterization of CD8+CD57+ T cells in patients wit acute myocardial infarction显示文摘 | Hee Tae Yu Jong-Chan Youn Jino Lee Seunghyun Park Ho-Seok Chi Jungsul Lee Chulhee Choi Sungha Park Donghoon Choi Jong-Won Ha Eui-Cheol Shin | 2015 | Cellular & Molecular Immunology2015，12，4： | 3 |
| 11 | Ecological niches and blood sources of sand fly in an endemic focus of visceral leishmaniasis in Jiuzhaigou,Sichuan,China显示文摘Background:Sand fly Phlebotomus chinensis is a principle vector for the visceral leishmaniasis(VL)in China with a wide geographic distribution.Jiuzhaigou,Sichuan is a mountain type endemic area of VL in China.Long term effective control efforts in the region have successfully reduced VL transmission.To assess the current status of the sand flies and their ecological aspects in the region,a survey was conducted in the summer of 2014 and 2015.Methods:Sand fly specimens were collected by light traps in a village and blood sources were identified by PCR and sequencing of the mitochondrial cytochrome b gene.Results:In a rock cave,65.2%–79.8%of collected sand flies were male.On a rabbit farm,92.9%–98.8%of specimens were female.In pig pens,61.1%of specimens were female.Some females had visible blood residues.The feeding rate was 49.4%from the pig pens,12.3%from the cave,and only 1.7%from the rabbit farm.Pig,rabbit,chicken,dog,and human blood were detected in the fed specimens.Swine blood,present in all tested samples,was a preferred blood source,while chicken and dog blood were present in a third of the samples.Conclusions:In Jiuzhaigou County,Sichuan Province of China,the considerable sandfly density and the peridomestic feeding behavior all increases the risk of VL transmission,and insecticide spraying in animal sheds could be exploited to reduce sand fly populations in human surroundings. | Huiying Chen Kaili Li Hua Shi Yong Zhang Yu Ha Yan Wang Jinjin Jiang Yubin Wang Zhenzhou Yang Jiannong Xu Yajun Ma | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 12 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial显示文摘 | Sung Hoon Noh Sook Ryun Park Han-Kwang Yang Hyun Cheol Chung Ik-Joo Chung Sang-Woon Kim Hyung-Ho Kim Jin-Hyuk Choi Hoon-Kyo Kim Wansik Yu Jong Inn Lee Dong Bok Shin Jiafu Ji Jen-Shi Chen Yunni Lim Stella Ha Yung-Jue Bang | 2014 | Lancet Oncology2014，，12： | 3 |
| 13 | Development of seeder for mixed planting of corn and soybeans显示文摘Corn and soybeans should be sown between 5 cm and 10 cm apart in mixed cultivation to increase protein content and improve productivity of the forage.However,existing sowers cannot plant at intervals of less than 20 cm.Consequently,mixed cultivation of corn and soybeans is currently performed by first sowing corn seeds with a tractor and then manually planting soybean seeds.This method results in irregular intervals between the seeds,it is laborious and time consuming.This study aimed at developing a seeder that can simultaneously,precisely and efficiently plant corn and soybean.The geometrical and rheological properties of corn and soybeans were initially measured.The seed conveying equipment were designed using the EDEM software.The sowing interval between seeds,depth of soil over planted seed,and sowing performance were analyzed.The EDEM simulation results indicated that a 6-mm-wide and 3-mm-deep grooved seed-delivering roller had the highest particle mobility of the designs considered,with a 2.5%misplanting rate.A performance test showed that no misplanting occurred in the sections sowed with soybean seeds at a seeding interval that averaged 32 mm(321 seeds sown in 10 m)and that misplanting occurred in one section sowed with corn at a seeding interval that averaged 247 mm(40 seeds sown over 10 m).The sowing efficiency for both corn and soybeans was found to be 0.42 h/hm2.The average depth of soil over seed was 32.7 mm for soybean and 39.7 mm for corn.These average depths are within the stipulated range for the depth of soil over seed,which is 5 to 10 times the seed size.This study developed an efficient seeding machine that can simultaneously plant soybean and corn precisely,consequently improving forage yield and saving man-hours. | Seung Min Woo Daniel Dooyum Uyeh Moon Sang Sagong Yu Shin Ha | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 3 |
| 14 | Easy calibration method of vision system for in-situ measurement of strain of thin films显示文摘An easy calibration method was presented for in-situ measurement of displacement in the order of nanometer during micro-tensile test for thin films by using CCD camera as a sensing device. The calibration of the sensing camera in the system is a central element part to measure displacement in the order of nanometer using images taken with the camera. This was accomplished by modeling the optical projection through the camera lens and relative locations between the object and camera in 3D space. A set of known 3D points on a plane where the film is located on is projected to an image plane as input data. These points, known as a calibration points, are then used to estimate the projection parameters of the camera. In the measurement system of the micro-scale by CCD camera, the calibration data acquisition and one-to-one matching steps between the image and 3D planes need precise data extraction procedures and repetitive user's operation to calibrate the measuring devices. The lack of the robust image feature extraction and easy matching prevent the practical use of these methods. A data selection method was proposed to overcome these limitations and offer an easy and convenient calibration of a vision system that has the CCD camera and the 3D reference plane with calibration marks of circular type on the surface of the plane. The method minimizes the user's intervention such as the fine tuning of illumination system and provides an efficient calibration method of the vision system for in-situ axial displacement measurement of the micro-tensile materials. | Jun-Hyub PARK Dong-Joong KANG Myung-Soo SHIN Sung-Jo LIM Son-Cheol YU Kwang-Soo LEE Jong-Eun HA Sung-Hoon CHOA | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 3 |
| 15 | Comparison of Endoscopic Papillary Balloon Dilation and Sphincterotomy in Young Patients with CBD Stones and Gallstones显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Ji Su Ha Tae Hoon Lee Sang-Woo Cha Young Deok Cho Sang-Heum Park Sun-Joo Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 2 |
| 16 | Autologous Adipose Tissue‐Derived Stem Cells Treatment Demonstrated Favorable and Sustainable Therapeutic Effect for Crohn’s Fistula显示文摘 | Woo Yong Lee Kyu Joo Park Yong Beom Cho Sang Nam Yoon Kee Ho Song Do Sun Kim Sang Hun Jung Mihyung Kim Hee‐Won Yoo Inok Kim Hunjoo Ha Chang Sik Yu | 2013 | Stem Cells2013，，11： | 2 |
| 17 | CT features of systemic lupus erythematosus in patients with acute abdomen pain:emphasis on ischemic bowel disease显示文摘 | Byun JY Ha HK Yu SY | | 0，，： | 1 |
| 18 | Xanthogranulomatous cholecysitis : CT features with emphasis on differentiation from gallbladder carcinoma显示文摘 | Chun KA Ha HK Yu ES | 1997 | Radiology1997，203，1： | 1 |
| 19 | Reactive oxygen species-regulated signaling pathway in diabetic nephropathy显示文摘 | Lee HB Yu MR Yang YQ Jiang ZP Ha H | 2003 | J Am Soc Nephrol2003，14，： | 1 |
| 20 | Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells显示文摘 | Ha H Yu M R Choi Y J | 2002 | J Am Soc Nephrol2002，13，： | 1 |
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