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| 1 | Artificial intelligence in medical imaging of the liver显示文摘Artificial intelligence(AI), particularly deep learning algorithms, is gaining extensive attention for its excellent performance in image-recognition tasks. They can automatically make a quantitative assessment of complex medical image characteristics and achieve an increased accuracy for diagnosis with higher efficiency. AI is widely used and getting increasingly popular in the medical imaging of the liver, including radiology, ultrasound, and nuclear medicine. AI can assist physicians to make more accurate and reproductive imaging diagnosis and also reduce the physicians' workload. This article illustrates basic technical knowledge about AI, including traditional machine learning and deep learning algorithms, especially convolutional neural networks, and their clinical application in the medical imaging of liver diseases, such as detecting and evaluating focal liver lesions, facilitating treatment, and predicting liver treatment response. We conclude that machine-assisted medical services will be a promising solution for future liver medical care. Lastly, we discuss the challenges and future directions of clinical application of deep learning techniques. | Li-Qiang Zhou Jia-Yu Wang Song-Yuan Yu Ge-Ge Wu Qi Wei You-Bin Deng Xing-Long Wu Xin-Wu Cui Christoph F Dietrich | 2019 | World Journal of Gastroenterology2019，25，6： | 21 |
| 2 | Dynamic and ultrastructural study of sphincter of Oddi in early-stage cholelithiasis in rabbits with hypercholesterolemia显示文摘AIM To study the relationship between pre-formation of gallstone and the kinetics and ultra-structure of sphincter of Oddi.METHODS Adult female rabbits were used anddivided into 3 groups,and fed with either normalor high cholesterol diet for four or eight weeks.Each group contained eight rabbits.Themanometry of sphincter of Oddi,biliarycineradiography,gallbladder volumemeasurement and ultrastructure observationunder electron microscope were performed.RESULTS In groups Ⅰ and Ⅱ,the basalpressure in low-pressure ampulla or highpressure zone of sphincter of Oddi waselevated,the amplitude of phasic contractionwas decreased and the volume of gallbladderwere increased,with a significant difference(P<0.01)from those of control.Gallstones werefound in group Ⅱ rabbits(7/8).Undercineradiography,low-pressure ampulla showeda spasmodic status without apparent peristalticcontraction.Under electron microscope,insidethe muscular cells of sphincter of Oddi,loosening of microfilament and swelling ofplasmosomes which congregated at the top wereobserved.The amount showed no obviouschange under nitric oxide synthase(NOS)stain.CONCLUSION Twisting of the microfilamentand disarrangement of kink macula densa insidethe muscular ceils suggested that the sphincterof Oddi was under spasmodic status.Theimpaired diastolic function caused andaggravated the stasis of cystic bile.Theswelling plasmosome could be one of theimportant factors in elevating the tonic pressureof sphincter of Oddi. | Wei JG Wang YC Du F Yu HJ | 2000 | World Journal of Gastroenterology2000，6，1： | 19 |
| 3 | 血小板反应蛋白1和核因子κB信号通路在婴幼儿血管瘤抗血管生成中的作用显示文摘背景:普萘洛尔是治疗婴幼儿血管瘤的一线药物,但其作用机制仍不清楚。核因子κB在肿瘤中高表达,直接或间接促进血管生成。血小板反应蛋白1是体内最重要的抗血管生成蛋白,这些蛋白质介导信号通路,可能在血管瘤治疗中发挥重要作用。本研究探讨了血小板反应蛋白1和核因子κB信号通路在普萘洛尔治疗血管瘤中的协同调节作用。 | Xu W Li S Yu F 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，5： | 7 |
| 4 | 中医与汉方医学古今溯源显示文摘中医是3 000多年前起源于中国的一种健全的医学体系,治疗方法包括草药疗法、针法、灸法、推拿手法等。近年来,中医在国际上的知名度和口碑越来越佳。日本传统医学(汉方医学)起源于1 500年前,治疗方法包括汉方(草药)、针法、按摩手法等。目前,汉方医学已经完全融入日本的现代医疗保险体系中。汉方医学源于中医,但经过长期发展,已经具有自身的特色。综述中医和汉方医学的历史渊源与各自的特点,展望传统医学的未来。 | F YU T TAKAHASHI J MORIYA | 2017 | 亚太传统医药2017，13，20： | 7 |
| 5 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 6 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 7 | Voltage-induced penetration effect in liquid metals at room temperature显示文摘Room-temperature liquid metal is discovered to be capable of penetrating through macro-and microporous materials by applying a voltage.The liquid metal penetration effects are demonstrated in various porous materials such as tissue paper;thick and fine sponges;fabrics;and meshes.The underlying mechanism is that the high surface tension of liquid metal can be significantly reduced to near-zero due to the voltage-induced oxidation of the liquid metal surface in a solution.It is the extremely low surface tension and gravity that cause the liquid metal to superwet the solid surface^leading to the penetration phenomena.These findings offer new opportunities for novel microfluidic applications and could promote further discovery of more exotic fluid states of liquid metals. | Frank F Yun Zhenwei Yu Yahua He Lei Jiang Zhao Wang Haoshuang Gu Xiaolin Wang | 2020 | National Science Review2020，7，2： | 3 |
| 8 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 9 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 3 |
| 10 | The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study显示文摘 | Charles N Bernstein James F Blanchard Patricia Rawsthorne Nancy Yu | 2001 | The American Journal of Gastroenterology2001，，4： | 3 |
| 11 | 放电脉冲重频准分子激光器在不同应用领域的发展现状(英文)显示文摘研究了脉冲宽度为25~40 ns的放电脉冲XeCl准分子激光器的工作参数。结果显示,激光器产生的脉冲能量为0.2~0.7 J,重复频率为100 Hz,表明在泵浦功率为2.8~3.3 MW/cm3时,激光器实现了2.6%的激光效率和3.8%的本征效率。 | LOSEV V F PANCHENKO Yu N DUDAREV V V IVANOV N G KONOVALOV I N PAVLINSKY A V PUCHIKIN A V | 2011 | 中国光学2011，4，1： | 3 |
| 12 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | 2013 (9882)2013，，9882： | 3 |
| 13 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 2 |
| 14 | Synthesis and Characterization of Mixed Al+AlN Nanoparticles显示文摘Mixed Al+AlN nanoparticles were synthesized by an active plasma-metal reaction method. Mean particle size of the mixed Al+AlN nanoparticles is about 30-50 nm. Defects were found in some AlN particles. Moreover, the AlN ratio and its particle size in mixed Al+AIN nanoparticles obtained in different atmospheres (N2+Ar) increase with increasing N2 particle pressure, and the specific sudece areas of the mixed Al+AlN nanoparticles increase with the AlN ratio. The surface degradation of the Al+AlN exposed to air is estimated by the infrared absorption | Sun, XC Yang, MC Ye, F Sun, XK Wei, WD Yu, YD Ping, DH | 1997 | Journal of Materials Science & Technology1997，13，4： | 2 |
| 15 | On-line measurement of the straightness of seamless steel pipe using machine vision technique显示文摘 | lU R S LI Y F YU Q | 2001 | Sensor and Actutors A-Physical2001，94，1： | 2 |
| 16 | Durable Asphalt Pavements Are Self Healing显示文摘The traffic volume and the number of heavy vehicles are growing continuously. Considering the continuous traffic flow and the limited time available for road maintenance,it is very important to design a durable pavement system. Asphalt pavements with a healing capability are believed to be very useful since they can extend the pavement service life thanks to rest periods and hot summers. In order to design durable asphalt pavements,research in understanding and upgrading the self-healing capability of bituminous materials in time is of major importance. The self healing capability of bituminous mastic was evaluated in this research with a direct tension healing test. In the test program,different healing times,crack status and modifications were applied. The results indicate that elastic recovery and flow capacity are important factors for the self healing capability of bituminous materials at different crack phases as simulated with the direct tension test. | QIU J VAN DE VEN M F C WU S P YU J Y MOLENAAR A A A | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 17 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 18 | Improvement of atrial function and atrial reverse remodeling after cardiac resynchronization therapy for heart failure 显示文摘 | Yu CM Fang F Zhang Q | 2007 | J Am Coll Cardiol2007，50，8： | 1 |
| 19 | Effect of iron on the gasification of Victorian brown coal with steam:enhancement of hydrogen production显示文摘 | Yu J Tian F Chow M | 2006 | Fuel2006，85，2： | 1 |
| 20 | Characterization of epitopes for neutralizing monoclonal antibodies to classical swine fever virus E2 and Erns using phage-displayed random peptide library显示文摘 | Zhang F Yu M Weiland E | 2006 | Arch Virol2006，151，1： | 1 |
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