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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | DMM:A dynamic memory mapping model for virtual machines显示文摘Memory virtualization is an important part in the design of virtual machine monitors(VMM).In this paper,we proposed dynamic memory mapping(DMM) model,a mechanism that allows the VMM to change the mapping between a virtual machine's physical memory and the underlying hardware resource while the virtual machine is running.By utilizing DMM,the VMM can implement many novel memory management policies,such as Demand Paging,Swapping,Ballooning,Memory Sharing and Copy-On-Write,while preserving compatibility with various architectures.The modular and hierarchical property of the DMM model efficiently incorporates the high-level policies and the low-level implementations,leading to a feature-adjustable VMM design.We presented the principle of the DMM model,and explained the procedures of various memory management policies under this model.Also,we implement the DMM model in KVM,an open source VMM.Our evaluation shows that the DMM model is efficient enough to provide the benefits of dynamic memory resource management with little performance impact. | CHEN HaoGang WANG XiaoLin WANG ZhenLin ZHANG BinBin LUO YingWei LI XiaoMing | 2010 | Science China(Information Sciences)2010，53，6： | 11 |
| 3 | Hemorrhagic Fever with Renal Syndrome — Liaoning Province, China, 1999−2018显示文摘Summary What is already known on this topic?Hemorrhagic fever with renal syndrome(HFRS)is endemic in Liaoning Province.Both Seoul and Hantaan virus are circulating in rodents,and epidemic outbreaks and sporadic cases have been recorded every year since the disease was recognized. | Cui Shang Yingwei Sun Qiangling Yin Xiaoxia Huang Xuesheng Liu Quanfu Zhang Lingling Mao Chuan Li Aqian Li Qin Wang Lina Sun Mifang Liang Shiwen Wang Dexin Li Jiandong Li | 2020 | China CDC weekly2020，2，20： | 6 |
| 4 | Formation of willow leaf-like structures composed of NH2-MIL68(In) on a multifunctional multiwalled carbon nanotube backbone for enhanced photocatalytic reduction of Cr(VI)显示文摘photogenerated 电子 / 洞以及提高的可见轻吸收的有效分离和转移在 photocatalytic 反应起必要作用。支持 Cr (VI ) 的 photocatalytic 减小,一个有毒的重金属离子, multiwalled 碳 nanotube (MWCNT ) 作为一个电子领受人被介绍进 NH 2-MIL-68(In) 。这导致了一棵柳树的生长形成 MWCNT/NH 2-MIL-68(In)(PL-1 ) 的一根 MWCNT 脊梁上的像叶子的金属器官的框架(MOF ) ,它显示出 photogenerated 搬运人的高度有效的转移。而且, MWCNT 加入为 Cr (VI ) 散开介绍了更多的 mesopores 并且没有降低传导乐队位置,提高了可见轻吸附。作为结果, PL-1 的运动常数被发现是几乎三的 photocatalytic 比父母 NH 2-MIL-68(In) 的高预定。因此,在 MWCNT 上种 MOF 由利用太阳能为环境污染的有效补习提供一个灵巧、有希望的答案。这个工作提供为 photocatalytic 反应使用 MWCNT/MOF composites 的第一个例子。 | Yunhong Pi Xiyi Li Qibin Xia Junliang Wu Zhong Li Yingwei Li Jing Xiao | 2017 | Nano Research2017，10，10： | 5 |
| 5 | Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats: a 31p-magnetic resonance spectroscopy study显示文摘 | Sun Yingwei Pan Shinong Chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong | 2014 | Chinese Medical Journal2014，，5： | 5 |
| 6 | Dynamic memory paravirtualization transparent to guest OS显示文摘This paper introduces dynamic paravirtualization, which imitates paravirtualization and aims at reducing VM exits of full virtualization with hardware support. In dynamic paravirtualization, VMM (virtual machine monitor) dynamically monitors and replaces the hot instructions, which cause most VM exits. It is transparent to the guest OS such that the legacy OSes can benefit from this optimization. Our study focuses on reducing the overhead of memory virtualization-dynamic memory paravirtualization (DMP). We implant a new memory management mechanism in VMM such that all user-mode page faults can be handled by the guest OS directly without VM exits. We implement a prototype of dynamic memory paravirtulization based on a version of KVM using Intel VT. Our experimental results show that our technique essentially eliminates the overhead of VM exits caused by page faults. Dynamic memory paravirtualization can achieve the effectiveness of paravirtualization without changing the source code of guest OS. | WANG XiaoLin SUN YiFeng LUO YingWei WANG ZhenLin LI Yu ZHANG BinBin CHEN HaoGang LI XiaoMing | 2010 | Science China(Information Sciences)2010，53，1： | 4 |
| 7 | Two-dimensional noble transition-metal dichalcogenides for nanophotonics and optoelectronics:Status and prospects显示文摘An emerging subclass of transition-metal dichalcogenides(TMDs),noble-transition-metal dichalcogenides(NMDs),has led to an increase in nanoscientific research in two-dimensional(2D)materials.NMDs feature a unique structure and several useful properties.2D NMDs are promising candidates for a broad range of applications in areas such as photodetectors,phototransistors,saturable absorbers,and meta optics.In this review,the state of the art of 2D NMDs research,their structures,properties,synthesis,and potential applications are discussed,and a perspective of expected future developments is provided. | Yingwei Wang Li Zhou Mianzeng Zhong Yanping Liu Si Xiao Jun He | 2022 | Nano Research2022，15，4： | 3 |
| 8 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 9 | Contextual and selective attention networks for image captioning显示文摘The steady momentum of innovations has convincingly demonstrated the high capability of attention mechanisms for the sequence to sequence learning.Nevertheless,the computation of attention across a sequence is often independent in either hard or soft mode,thereby resulting in undesired effects such as repeated modeling.In this paper,we introduce a new design to holistically explore the interdependencies between attention histories and locally emphasize the strong focus of each attention on image captioning.Specifically,we present a contextual and selective attention network(namely Co SA-Net)that novelly memorizes contextual attention and brings out the principal components from each attention.Technically,Co SA-Net writes/updates the attended image region features into memory and reads from memory when measuring attention in the next time step to leverage contextual knowledge.Only the regions with the top-k highest attention scores are selected,and each region feature is individually employed to compute an output distribution.The final output is an attention-weighted mixture of all k distributions.In turn,the attention is then upgraded by the posterior distribution conditioned on the output.Our Co SA-Net is appealing given that it is pluggable to the sentence decoder in any neural captioning model.Extensive experiments on the COCO image captioning dataset demonstrate the superiority of Co SA-Net.More remarkably,integrating Co SA-Net to a one-layer long short-term memory(LSTM)decoder increases CIDEr-D performance from 125.2%to 128.5%on the COCO Karpathy test split.When further endowing a two-layer LSTM decoder with Co SA-Net,the CIDEr-D score is boosted to 129.5%. | Jing WANG Yehao LI Yingwei PAN Ting YAO Jinhui TANG Tao MEI | 2022 | Science China(Information Sciences)2022，65，12： | 2 |
| 10 | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy显示文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim | 2022 | Bioactive Materials2022，7，8： | 2 |
| 11 | Ulinastatin improves survival of septic mice by suppressing inflammatory response and lymphocyte apoptosis显示文摘 | Na Huang Fei Wang Yingwei Wang Jiong Hou Jinbao Li Xiaoming Deng | 2013 | Journal of Surgical Research2013，，2： | 2 |
| 12 | TSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis rats显示文摘The proliferation of glomerular mesangial cells (GMC) and secretion of the extracellular matrix (ECM) in rat with Thy-1 nephritis (Thy-1N) resembling human mesangioproliferative glomerulonephritis have been explored for many years; however, the molecular mechanisms of GMC proliferation and ECM production remain unclear. Our previous studies have demonstrated that the thrombospondin-1 (TSP-1) gene was involved in mediating rat GMC proliferation and ECM synthesis induced by sublytic C5b-9 in vitro. In the present study, the roles of the TSP-1 gene in GMC proliferation, ECM production, and urinary protein secretion in Thy-1N rats were determined by using TSP-1 small hairpin RNA, and the results revealed that silencing of the TSP-1 gene in rat renal tissues could diminish GMC proliferation (P < 0.01) and ECM secretion (P < 0.01) as well as urinary protein secretion (P < 0.05) in Thy-1N rats. Together, the current findings suggested that TSP-1 gene expression was required for GMC proliferation and ECM production in Thy-1N rats. | Wen Qiu Yan Li Jianbo Zhou Chenhui Zhao Jing Zhang Kai Shan Dan Zha Yingwei Wang | 2011 | The Journal of Biomedical Research2011，25，6： | 2 |
| 13 | Dynamic cache partitioning based on hot page migration显示文摘静态的缓存划分能减少内部申请的缓存干扰并且当他们在在一样的多核心处理器分享最后水平缓存的核心上运行时,改进一个弄脏缓存的应用程序和一个缓存敏感的应用程序的合成性能。在一个虚拟化的系统,自从不同应用程序可能在不同时间在不同虚拟机(VM ) 上运行,预先静态地划分缓存是不适用的。这份报纸建议划分使用热页察觉和页移植根据缓存敏感的应用程序的优先的知识动态地改进共同招待的虚拟机的合成表演的计划的动态缓存。,试验性的结果在大多数情况中证明我们的页移植计划的开销是低的,合成性能是在免费作文上的改进。 | Xiaolin WANG Xiang WEN Yechen LI Zhenlin WANG Yingwei LUO Xiaoming LI | 2012 | Frontiers of Computer Science2012，6，4： | 2 |
| 14 | A novel recombinant DNA vaccine encodingMycobacterium tuberculosis ESAT-6 and FL protects againstMycobacterium tuberculosis challenge in mice显示文摘Mycobacterium tuberculosis 6-kDa early secretory antigenic target(ESAT-6)is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis.The fms-like tyrosine kinase 3 ligand(FL)that induces potent immune response has been used as an adjuvant in vaccine development.In this study,a new recombinant plasmid(pIRES-epitope-peptides-FL)encoding three T cell epitopes of ESAT-6 and FL was constructed,and the immunogenicity of the DNA vaccine was assessed in C57BL/6 mice immunized with the plasmid DNA vaccine.Additionally,a strategy of intramuscular injection with the DNA vaccine(prime)and intranasal administration of the epitope peptides(boost)was employed to induce higher immune reaction of the mice.The results showed that mice vaccinated with the recombinant plasmid DNA vaccine and boosted with the peptides not only increased the levels of Th1 cytokines(IFN-γand IL-12),the number of IFN-γ+T cells and activities of cytotoxic T lymphocytes as well as IgG,but also enhanced protection against Mycobacterium tuberculosis challenge.In conclusion,these data indicate that the novel recombinant pIRES-epitope-peptides-FL plasmid is a useful DNA vaccine for preventing Mycobacterium tuberculosis infection. | Qingtao Jiang Jing Zhang Xia Chen Mei Xia Yanlai Lu Wen Qiu Ganzhu Feng Dan Zhao Yan Li Fengxia He Guangyong Peng Yingwei Wang | 2013 | The Journal of Biomedical Research2013，27，5： | 2 |
| 15 | Encapsulation of ultrafine Pd nanoparticles within the shallow layers of UiO-67 for highly efficient hydrogenation reactions显示文摘Metal-organic frameworks(MOFs)have been used to encapsulate active metal nanoparticles(MNPs)to fabricate MNPs@MOFs composites with high catalytic efficiencies.However,the diffusion of reactants and the accessibility of MNPs located in the center of MOFs may be hindered due to the inherent microporous structures of MOFs,which would affect the catalytic activities of MNPs.Herein,we report a solvent assisted ligand exchange-hydrogen reduction(SALE-HR)strategy to selectively encapsulate ultrafine MNPs(Pd or Pt)within the shallow layers of a MOF,i.e.,UiO-67.The particle sizes of the encapsulated MNPs and the thickness of the MNPs-embedded layers can be adjusted easily by controlling the SALE conditions(e.g.time and temperature).Crucially,the LE-Pd@UiO-80-0.5 composite with the thinnest Pd-embedded layers displays remarkable catalytic efficiency with a high turnover frequency(TOF)value of 600 h^-1towards hydrogenation of nitrobenzene under 1 atm H_2at room temperature.The results indicate that the catalytic efficiency and the utilization of MNPs can be enhanced by compactly encapsulating MNPs within the shallow layers of MOFs as close to their outer surfaces as possible,owing to the short masstransfer distance and enhanced accessibility of overall MNPs. | Zhiming Cui Ting Fan Liyu Chen Ruiqi Fang Chuanmao Li Yingwei Li | 2021 | Science China Chemistry2021，64，1： | 1 |
| 16 | Design and testing of a high temperature superconducting pulsed pow- er transformer 显示文摘 | Haitao Li Yu Wang Yingwei Zhu | 2012 | IEEE Transactions on Applied Super- conductivity2012，22，55： | 1 |
| 17 | A novel reputation computation model based on subjective logic for mobile ad hoe networks 显示文摘 | Liu Yining Li Keqiu Jin Yingwei | 2011 | Future Generation Computer Systems2011，27，： | 1 |
| 18 | Endomorphins and morphine limit anoxia–reoxygenation-induced brain mitochondrial dysfunction in the mouse显示文摘 | Yun Feng Yingwei Lu Xin Lin Yanfeng Gao Qianyu Zhao Wei Li Rui Wang | 2008 | Life Sciences2008，，13： | 1 |
| 19 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 20 | Ulinastatin improves survival of septic mice by suppressing inflammatory response and lymphocyte apoptosis显示文摘 | Na Huang Fei Wang Yingwei Wang Jiong Hou Jinbao Li Xiaoming Deng | 2012 | Journal of Surgical Research2012，，： | 1 |
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