|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway显示文摘短链的丰满的酸和他们的相应 acyl-CoAs 在新陈代谢的小径的十字路口坐并且在多样的细胞的过程起重要作用。他们也是为蛋白质 translational 以后离氨酸 acylation 修正的先锋。一个引人注目的例子是最新识别的离氨酸 2-hydroxyisobutyrylation (K 从 2-hydroxyisobutyrate 和 2-hydroxyisobutyryl-CoA 被导出的 hib ) 。Histone K hib 被显示了在 spermatogenic 房间与活跃基因表示被联系。然而,调整这条 translational 以后离氨酸 acylation 小径的关键元素仍然保持未知。这妨碍了这修正由施加它的生物功能的机制的描述。这里,我们在开始发育的酵母显示出那 Esa1p,它在人的相当或相同事物 Tip60 能增加 K hib 到在 vitro 并且在 vivo 的底层蛋白质。另外,我们作为主要的酶识别了 HDAC2 和 HDAC3 移开 K hib 。而且,我们报导第一 K 在哺乳动物的房间的 hib proteome,识别 6 548 K 1 725 底层蛋白质上的 hib 地点。我们的学习因此为 histone K hib 标记,和主要 K hib 蛋白质底层。这些结果不仅说明这条新离氨酸 acylation 小径的风景,而且为学习与这条小径联系的细胞的代谢物的多样的功能打开新大街。 | He Huang Zhouqing Luo Shankang Qi Jing Huang Peng Xu Xiuxuan Wang Li Gao Fangyi Li Jian Wang Wenhui Zhao Wei Gu Zhucheng Chen Lunzhi Dai Junbiao Dai Yingming Zhao | 2018 | Cell Research2018，28，1： | 2 |
| 2 | A Feature Optimized Deep Learning Model for Clinical Data Mining显示文摘the Artificial intelligence(AI)has gradually changed from frontier technology to practical application with the continuous progress of deep learning technology in recent years.In this paper,the Random forest(RF)algorithm is adopted to preprocess and optimize the feature subset of ICU data sets.Then these optimized feature subsets are used as input of Long shortterm memory(LSTM)deep learning model,and the early disease prediction of ICU inpatients is carried out by the method of neural network deep learning.Experiments show that this prediction method has higher prediction accuracy compared with other machine learning and deep learning models. | WU Tianshu CHEN Shuyu TIAN Yingming WU Peng | 2020 | Chinese Journal of Electronics2020，29，3： | 1 |
| 3 | Determination of polybrominated diphenyl ethers (PBDEs) in fish samples from rivers and estuaries in Taiwan显示文摘 | PENG Juihwa HUANG Chinwang WENG Yingming YAK H K | 2007 | Chemosphere2007，66，10： | 1 |
| 4 | Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics显示文摘Beyond traditional endothelium-dependent vessel(EDV),vascular mimicry(VM)is another critical tumor angiogenesis that further forms in many malignant metastatic tumors.However,the existing anti-angiogenesis combined chemotherapeutics strategies are only efficient for the treatment of EDV-based subcutaneous tumors,but remain a great challenge for the treatment of in situ malignant metastatic tumor associated with EDV and VM.Here,we demonstrate a self-assembled nanoparticle(VE-DDP-Pro)featuring self-anti-EDV and-VM capacity enables to significantly enhance the treatment efficacy of cisplatin(DDP)against the growth and metastasis of ovarian cancer.The VE-DDP-Pro is constructed by patching DDP loaded cRGD-folate-heparin nanoparticles(VE)onto the surface of protamine(Pro)nanoparticle.We demonstrated the self-anti-angiogenesis capacity of VE-DDP-Pro was attributed to VE,which could significantly inhibit the formation of EDV and VM by regulating signaling pathway of MMP-2/VEGF,AKT/mTOR/MMP-2/Laminin and AKT/mTOR/EMT,facilitating chemotherapeutics to effectively suppress the development and metastasis of ovarian cancer.Thus,combing with the chemotherapeutics effectiveness of DDP,the VE-DDP-Pro can significantly enhance treatment efficacy and prolong median survival of mice with metastatic ovarian cancer.We believe our self-assembled nanoparticles integrating the anti-EDV and anti-VM capacity provide a new preclinical sight to enhance the efficacy of chemotherapeutics for the treatment malignant metastasis tumor. | Jiamao Luo Xinxian Zhong Yingming Peng Chenyuan Hao Xiaomei Liang Yulu Yang Xiubo Shi Xuncai Chen Xiao Yi iaoxuan Li Jianhua Wu Jinheng Li Qian Xiao Chentian Wu b Ruojing Lu b Yao Pan Xuejiao Wang Jun-Bing Fan Yifeng Wang Ying Wang | 2022 | Bioactive Materials2022，7，7： | 1 |
| 5 | SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways显示文摘 | Jeongsoon Park Yue Chen Daniel X. Tishkoff Chao Peng Minjia Tan Lunzhai Dai Zhongyu Xie Yi Zhang Bernadette M.M. Zwaans Mary E. Skinner David B. Lombard Yingming Zhao | 2013 | Molecular Cell2013，，6： | 1 |
| 6 | Study on the structural changes of bovine serum albumin with effects on polydatin binding by a multitechnique approach显示文摘 | Xialian Peng Di Yao Yingming Pan Qing Yu Shouhai Ni Hedong Bian Fuping Huang Hong Liang | 2011 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2011，，1： | 1 |
| 7 | Effects and mechanisms of H2O2 on production of dicarboxylic acid 显示文摘 | JIAO PENG HUANG YINGMING LI SHULIANG | 2001 | Biotechbology and Bioengeering2001，75，4： | 1 |
| 8 | Synthesis and structural characterization of β-diketiminate-lanthanide amides and their catalytic activity for the polymerization of methyl methacrylate and β-caprolactone显示文摘 | Yao Yingming Zhang Zhenqin Peng Hongmei | 2006 | Inorganic Chemistry2006，45，4： | 1 |
| 9 | Effects of dietary supplementation of Lactobacillus plantarum and Bacillus subtilis on growth performance,survival,immune response,antioxidant capacity and digestive enzyme activity in olive flounder(Paralichthys olivaceus)显示文摘In present study,a 10-month feeding trial was carried out to investigate effects of dietary Lactobacillus plantarum and Bacillus subtilis supplementation singly on growth performance,innate immune response,antioxidant capacity and digestive enzyme activity of olive flounder under a commercial production environment.Two experimental groups fed basal diet with supplementation of L.plantarum(5.0×107 CFU/g diet)and B.subtilis(1.0×108 CFU/g diet)respectively,and control group fed with basal diet without probiotics supplement.At harvest,serum immune parameters,liver antioxidant indices and digestive enzyme activities in liver,stomach and intestines were measured.Fish fed with B.subtilis supplemented diet showed the highest growth rate which was significantly higher than L.plantarum supplemented group(P<0.05)which was also significantly higher than control group(P<0.05).Survival rate were significantly elevated by feeding diet with L.plantarum supplementation(P<0.05),while the improvement was not significant for B.subtilis supplemented diet compared to control group.All the studied immune parameters in serum were substantially enhanced in both experimental groups.Similar results were observed for the antioxidant capacity in liver.Besides,the activities of digestive enzymes increased substantially in both experimental groups compared to control group and the detected improvement in dietary B.subtilis supplemented group were all higher than in L.plantarum supplemented group,though not all the improvements were significant.In summary,the separate supplementation of B.subtilis and L.plantarum in diet is more beneficial for growth performance and healthy status respectively.Hence,in olive flounder aquaculture,favorable effects of compounded supplementation of L.plantarum and B.subtilis are expected. | Yangzhen Li Yingming Yang Limin Song Jialin Wang Yuanri Hu Qian Yang Peng Cheng Jianhai Li | 2021 | Aquaculture and Fisheries2021，6，3： | 1 |
| 10 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 11 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 12 | Synthesis,characterization and photoluminescence of aluminum N-aryloxo functionalized β-ketoiminate complexes显示文摘The synthesis,characterization and luminescent properties of aluminum complexes containing a dianionic N-aryloxo functionalized β-ketoiminate ligand are presented.4-(2-Hydroxy-5-R-phenyl)imino-2-pentanone (R=Me,L 1 H 2;R=tert-butyl,L 2 H 2) ligands reacted with AlEt 3 in tetrahydrofuran to give the aluminum complexes (L 1 AlEt) 2 (1) and (L 2 AlEt) 2 (2) in reasonable isolated yields.X-ray diffraction revealed that complexes 1 and 2 have solvent-free centrosymmetric dimeric structures,and each aluminum center has distorted trigonal bipyramidal geometry.At room temperature,complexes 1 and 2 exhibit blue photoluminescence in acetonitrile with maximum emission wavelengths of 419 and 413 nm,respectively. | FENG Tao PENG HongMei YAO YingMing ZHANG Yong SHEN Qi CHENG YanXiang | 2011 | Chinese Science Bulletin2011，56，14： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员