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| 1 | Gold nanorods core/AgPt alloy nanodots shell: A novel potent antibacterial nanostructure显示文摘根据银 nanoparticles (Ag NP ) 的当前的问题以抗菌剂性能,我们与取向附生地作为一个潜在的抗菌剂代理人在金 nanorods (Au@PtAg NR ) 上种的 AgPt 合金 nanodots 设计了新奇 trimetallic 核心 / 壳 nanostructure。两 Escherichia coli (E。coli ) 并且葡萄球菌 aureus (S。aureus ) 被学习。抗菌剂活动展出明显的作文依赖。在在合金壳增加 Ag 部分直到 80% 以后,抗菌剂活动逐渐地增加,表明一个灵活方法调节这项活动。在 80% Ag,抗菌剂活动比纯 Ag 壳的好。改进抗菌剂能力主要由于点形态学在壳表面上源于银的高暴露。当为基于 Ag 的 nanomaterials 保留高化学的稳定性时,我们因此证明形成合金是改进抗菌剂活动的一个有效方法。而且,由于悦耳的局部性的表面 plasmonic 反应在在红外线附近(NIR ) 光谱区域,对把 lightsuch 用作杀死的 photothermal 和 phototriggered 银离子 releaseis 的抗菌剂活动的另外的控制期望。作为示范,高度提高了抗菌剂活动被利用 nanostructures 的 NIR photothermal 效果显示出。我们的结果显示如此的定制的 nanostructures 将在对细菌的未来战斗发现一个角色,包括 multidrug 抵抗的增加的严厉的挑战。 | Xiaona Hu Yuyun Zhao Zhijian Hu Aditya Saran Shuai Hou Tao Wen Wenqi Liu Yinglu Ji Xingyu Jiang Xiaochun Wu | 2013 | Nano Research2013，6，11： | 9 |
| 2 | Modified Mechanism of Eutectic silicon in Al_2O_3/Al-Si Alloy显示文摘Al2O3/Al-Si alloy composite was manufactured by squeeze casting. The morphology of the eutectic silicon in the composite was observed by scanning electronic microscope (SEM), and the modified mechanism of eutectic silicon in the composite was approached. The alumina fiber in the composite can trigger twin during the growth of Al-Si eutectic and lead to the modification of eutectic silicon near the fiber. | Zheng Liu, Xiaomei Liu, Yinglu Zhu, Cigao Chen Southern Institute of Metallurgy, Ganzhou 341000, China | 2001 | Rare Metals2001，20，3： | 9 |
| 3 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 4 | Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor显示文摘CKLF (chemokine-like factor)-like MARVEL (MAL and related proteins for vesicle trafficking and mem-brane link domain) transmembrane domain containing (CMTM) is a novel gene family. One member of this family, CMTM2, also named chemokine-like factor superfamily 2 (CKLFSF2), is expressed highly in the testis and moderately in the prostate, marrow and peripheral blood cells. However, the function of human CMTM2 remains unknown. Here, we found that CMTM2 was upregulated in 5α-dihydrotestos- terone (DHT)-treated LNCaP cells. We investigated the relationship between CMTM2 and the androgen receptor. Our results showed that CMTM2 enhanced DHT-mediated androgen receptor (AR) transacti-vation and the expression of prostate specific antigen (PSA). We also observed that CMTM2 enhanced the AR protein level, which was reversed by silencing endogenous CMTM2 expression, which sug-gested that CMTM2 might play an important role in maintaining the AR protein level. We also found that CMTM2 suppressed Akt activation. A previous study showed that Akt could phosphorylate AR at Ser210 and Ser790 and lead to AR ubiquitylation and degradation as well as suppression of AR activity. Taken together, suppressing Akt activation and increasing the AR protein level might be one of the mechanisms for the CMTM2-mediated enhancement of AR transactivation. | LIU DaZhen YIN CaiHua ZHANG YingMei TIAN LinJie LI Ting LI Dan MA DaLong GUO YingLu WANG Ying | 2009 | Chinese Science Bulletin2009，54，6： | 7 |
| 5 | Effect of monovalent anions on cationic Gemini micro-emulsion显示文摘Micro-emulsion usually consists of water, oil, surfactants and co-surfactants, and each component has an effect on the phase behavior and solubilization of the micro-emulsion. When the surfactant in the micro-emulsion system is quaternary ammonium cationic Gemini surfactant, the surfactant mainly combines with the anions in the salt. With the increase of salt concentration, the phase transformation of Winsor I → Winsor III → Winsor II occurred, but the optimum salinity and salt width are different because of the type of salt. The effects of 5 different kinds of monovalent anions, including C_6H_5SO_3^-, I-, Br-, NO_3^- and Cl-, on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are researched by Winsor phase diagram. It is found that the effects of organic anions C_6H_5SO_3-and I-on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are most significant, and the effects of Br-, NO_3^- and Cl-are less significant. Meanwhile, when the optimum solubilization is achieved, the amount of sodium benzoate is the least, indicating that the organic anion has stronger self-organization behavior with quaternary ammonium cationic Gemini surfactants. | Yinglu Gu Shuang Chen Hui'e Liu Yubin Wang Pingping Zhou | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 6 |
| 6 | SEQUENCE VARIABILITY OF HUMAN CYTOMEGALOVIRUS UL144 OPEN READING FRAME IN LOW-PASSAGE CLINICAL ISOLATES显示文摘Objective To explore the relationship between human cytomegalovirus (HCMV) UL144 sequence variability and clinical disease. Methods HCMV UL144 open reading frame (ORF) was amplified by PCR assay in 72 lowpassage isolates [65 con-genitally infective children and 7 healthy children who were HCMV-DNA positive by quantitative PCR (qPCR)]. All positive PCR products were analyzed by heteroduplex mobility assay and single-stranded conformation polymorphism (HMA-SSCP) and 32 of them were sequenced. Results Fifty-five patient isolates and five healthy children isolates were HCMV-UL144 positive by PCR. Sequencing and HMA-SSCP analysis showed that significant strain-specific variability was present in the UL144 ORF. Phylogenetic analysis indicated that the nucleotide sequences could be separated into 3 major genotypes. Comparing between UL144 se-quences and the corresponding symptoms showed that genotype 2 did not exist in megacolon isolates. And genotype 1 and 3 were the major types among microcephaly and jaundice isolates respectively. Conclusions HCMV-UL144 existed in most of low passage isolates and sequences were hypervariable. The UL144 ORF and its predicted product with the high level of sequence variability in different kinds of isolates suggest that UL144 ORF might play a role in HCMV infectivity and subsequent diseases. | RongHe QiangRuan ChangXia Lan-qingLiu Sheng-minLǔ YingLu YingQi Yan-pingMa QingLiu Yao-huaJi | 2004 | Chinese Medical Sciences Journal2004，19，4： | 6 |
| 7 | Research progress of nanoparticles as enzyme mimetics显示文摘Natural enzymes as biological catalysts possess remarkable advantages,especially their highly efficient and selective catalysis under mild conditions.However,most natural enzymes are proteins,thus exhibiting an inherent low durability to harsh reaction conditions.Artificial enzyme mimetics have been pursued extensively to avoid this drawback.Quite recently,some inorganic nanoparticles(NPs) have been found to exhibit unique enzyme mimetics.In addition,their much higher stability overcomes the inherent disadvantage of natural enzymes.Furthermore,easy mass-production and low cost endow them more benefits.As a new member of artificial enzyme mimetics,they have received intense attention.In this review article,major progress in this field is summarized and future perspectives are highlighted. | HU XiaoNa LIU JianBo HOU Shuai WEN Tao LIU WenQi ZHANG Ke HE WeiWei JI YingLu REN HongXuan WANG Qi WU XiaoChun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 4 |
| 8 | Icariin on relaxation effect of corpus cavernosum smooth muscle显示文摘NO-cGMP pathway in penile corpus cavernosal smooth muscle plays an important role in penile erection. The level of cGMP is regulated by a balance between the rate of synthesis by guanylate cyclase and the rate of hydrolytic breakdown to guanosine 5’ monophosphate (GMP) by phos-phodiesterase 5(PDE5). Icariin is isolated from natural drug Epimedii herba, it is shown to have the relaxation effect on corpus cavernosal smooth muscle of rabbit (IC50: 4×10-4 mol/L), and the mechanism of the relaxation effect of Icariin on corpus cavernosum believed to have the inhibiting effect on PDE5 and activation of NO-cGMP pathway to enhancing penile erection. | XIN Zhongcheng Kim Euikyung TIAN Zhenji LIN Guiting QUO Yinglu | 2001 | Chinese Science Bulletin2001，46，14： | 4 |
| 9 | Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair显示文摘连接器 histone H1 在 DNA 损坏反应是更高的顺序染色质结构,而是它的参与的一个主人管理者,修理是不清楚的。这里,我们报导连接器 histone H1.2 是混乱毛细管扩张的一个必要管理者变异(ATM ) 激活。我们证明 H1.2 通过和 ATM 热重复领域和 MRE11-RAD50-NBS1 (MRN ) 的抑制的直接相互作用保护染色质免受异常 ATM 激活的伤害复杂依赖者的 ATM 招募。在 DNA 损坏之上, H1.2 通过它的 C 终点和进一步的 proteasomal 降级的 poly-ADP-ribosylation (PARylation ) 经历快速的 PARP1 依赖的染色质分离。由 PARylation 死了的变化妥协 ATM 激活和 DNA 损坏修理的 PARP1 弄空或 H1.2 的 H1.2 排水量的抑制,因此导致损害了房间幸存。一起拿,我们的调查结果建议连接器 histone H1.2 作为一个生理的障碍工作因为指向染色质的 ATM,和调停 PARylation 的活跃 H1.2 周转为柔韧的 ATM 激活和 DNA 损坏修理被要求。 | Zhiming Li Yinglu Li Ming Tang Bin Peng Xiaopeng Lu Qiaoyan Yang Qian Zhu Tianyun Hou Meiting Li Chaohua Liu Lina Wang Xingzhi Xu Ying Zhao Haiying Wang Yang Yang Wei-Guo Zhu | 2018 | Cell Research2018，28，7： | 3 |
| 10 | Athermal 4-channel (de-)multiplexer in silicon nitride fabricated at low temperature显示文摘We have designed and realized an athermal 4-channel wavelength(de-)multiplexer in silicon nitride(Si N).Minimized thermal sensitivity is achieved in a wide wavelength range by using wide and narrow waveguides with low and different thermal-optic coefficients in the two arms of Mach–Zehnder interferometers(MZIs). The Si N core layer and Si O2 cladding layers are deposited by a low-temperature plasma-enhanced chemical vapor deposition process. The fabricated MZI filter exhibits a thermal sensitivity within 2.0 pm∕°C in a wavelength range of 55 nm to near 1300 nm. Then, an athermal(de-)multiplexer based on cascaded MZIs has been demonstrated with a crosstalk ≤-22 d B and a thermal sensitivity <4.8 pm∕°C for all four channels, reduced by 77% compared to a conventional Si N(de-)multiplexer. Owing to the passive operation and compatibility with the CMOS backend process, our devices have potential applications in 3 D integration of photonics and electronics. | SHIQI TAO QINGZHONG HUANG LIANGQIU ZHU JUN LIU YINGLU ZHANG YING HUANG YI WANG JINSONG XIA | 2018 | Photonics Research2018，6，7： | 3 |
| 11 | Anaerobic Induction of Isocitrate Lyase and Malate Synthase in Submerged Rice Seedlings Indicates the Important Metabolic Role of the Glyoxylate Cycle显示文摘The glyoxylate cycle is a modified form of the tricarboxylic acid cycle that converts C2 compounds into C4 dicarboxylic acids at plant developmental stages. By studying submerged rice seedlings,we revealed the activation of the glyoxylate cycle by identifying the increased transcripts of mRNAs of the genes of isocitrate lyase (ICL) and malate synthase (MS), two characteristic enzymes of the glyoxylate cycle. Northern blot analysis showed that ICL and MS were activated in the prolonged anaerobic environment.The activity assay of pyruvate decarboxylase and ICL in the submerged seedlings indicated an 8.8-fold and 3.5-fold increase over that in the unsubmerged seedlings, respectively. The activity assay of acetyl-coenzyme A synthetase in the submerged seedlings indicated a 3-fold increase over that in the unsubmerged seedlings, which is important for initiating acetate metabolism. Consequently, we concluded that the glyoxylate cycle was involved in acetate metabolism under anaerobic conditions. | YingLU Yong-RuiWU BinHAN | 2005 | Acta Biochimica et Biophysica Sinica2005，37，6： | 3 |
| 12 | Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier显示文摘Nowadays,nanoparticles(NPs)are considered to be ideal tools for bioimaging and drug delivery.Although increasing research has focused on NP biodistribution,transportation in the interstitial architecture has been neglected.The entire body is connected by the interstitial architecture,which can provide a long-range and direct pathway for NP biodistribution in a nonvascular system.In this study,we report that 10-nm gold NPs injected directly into the interstitial architecture of the tarsal tunnel of rats(intervaginal space injection(ISI))were delivered to the brain without crossing the blood-brain barrier.Furthermore,NaGdF4 nanoparticles were used to explore the transportation route by magnetic resonance imaging.The results demonstrated that,after ISI,the NaGdF4 nanoparticles were transported through the perivascular interstitial space of the carotid arteries and brain vessels to the brain.This is a special nonvascular transportation route like a stream based on the interstitial architecture that provides an alternative pathway for NP biodistribution. | Nan Hu Xiaoli Shi Qiang Zhang Wentao Liu Yuting Zhu Yuqing Wang Yi Hou Yinglu Ji Yupeng Cao Qian Zeng Zhuo Ao Quanmei Sun Xiaohan Zhou Xiaochun Wu Dong Han | 2019 | Nano Research2019，12，11： | 2 |
| 13 | Minimizing the effect of near-distance dielectric sensitivity on retrieving average aspect ratio of gold nanorod by optical extinction spectroscopy:in the case of CTAB adsorption显示文摘The aspect ratio(AR)is one of the most intriguing parameters of gold nanorods(GNRs),which plays an important role in determining localized surface plasmon(LSPR)properties.Instead of conventional imaging techniques,the optical extinction spectroscopy(OES)method has been developed for allowing fast statistically measuring the average AR under static approximation.In this work,combining with the previous achievements in spectroscopic technique,we further analyze the effects of gold dielectric function and near distance dielectric sensitivity.The former may reflect possible dielectric loss of real Au samples from ideal single crystalline.The latter reflects the cetyltrimethylammonium bromide(CTAB)adsorption on the surface of GNR induces different LSPR shifts below and above critical micelle concentration(CMC).However,their effect on the determination of AR has not been evaluated in OES method.The average AR measurements as a function of absorbance of CTAB-GNRs and LSPR maximum below the CMC were studied.Our results indicate that after considering these factors,the mean ARs obtained from spectroscopic techniques are closer to those obtained from imaging techniques. | Zhijian Hu Yinglu Ji Shuai Hou Xiaochun Wu | 2014 | Chinese Science Bulletin2014，59，16： | 2 |
| 14 | Actin-binding Rho activating protein is expressed in the central nervous system of normal adult rats显示文摘Previous studies show that actin-binding Rho activating protein (Abra) is expressed in cardiomyocytes and vascular smooth muscle cells.In this study,we investigated the expression profile of Abra in the central nervous system of normal adult rats by confocal immunofluorescence.Results showed that Abra immunostaining was located in neuronal nuclei,cytoplasm and processes in the central nervous system,with the strongest staining in the nuclei;in the cerebral cortex,Abra positive neuronal bodies and processes were distributed in six cortical layers including molecular layer,external granular layer,external pyramidal layer,internal granular layer,internal pyramidal layer and polymorphic layer;in the hippocampus,the cell bodies of Abra positive neurons were distributed evenly in pyramidal layer and granular layer,with positive processes in molecular layer and orien layer;in the cerebellar cortex,Abra staining showed the positive neuronal cell bodies in Purkinje cell layer and granular layer and positive processes in molecular layer;in the spinal cord,Abra-immunopositive products covered the whole gray matter and white matter;co-localization studies showed that Abra was co-stained with F-actin in neuronal cytoplasm and processes,but weakly in the nuclei.In addition,in the hippocampus,Abra was co-stained with F-actin only in neuronal processes,but not in the cell body.This study for the first time presents a comprehensive overview of Abra expression in the central nervous system,providing insights for further investigating the role of Abra in the mature central nervous system. | Lihua Liu Mingying Luo Baolin Yang Xiaoqiong Wu Wu Zhu Yinglu Guan Weijun Cai Kerstin Troidl Wolfgang Schaper Jutta Schaper | 2012 | Neural Regeneration Research2012，7，13： | 2 |
| 15 | Blind Separation and Equalization Using Fractional Sampling of Digital Communications Signals显示文摘 | ZHANG Yinglu KASSAM S A | 2001 | Signal Proc- essing2001，81，22： | 1 |
| 16 | Interaction of hTCF4 by yeast two-hybrid system显示文摘To investigate the interaction of hTCF4, the yeast two-hybrid system has been used for testing the interaction of mutants of hTCF4 with themselves. Mutants of hTCF4 (hTCF4 Ⅰ ) and hTCF4 Ⅱ) have been obtained by polymerase chain reaction (PCR). Bait (hTCF4 Ⅰ -pDBLeu and hTCF4Ⅱ-pDBLeu) and prey (hTCF4 Ⅰ -pPC86 and hTCF4Ⅱ-pPC86) have been constructed by DNA recombination for yeast two-hybrid. Interaction of hTCF4Ⅱ with itself is found in the reverse yeast two-hybrid system (GIBCOBRL Co.). However, no interactions are found in hTCF4Ⅱ with hTCF4 Ⅰ and in hTCF4 Ⅰ with hTCF4 Ⅰ . These results suggest that hTCF4 could interact with itself to form homodimer or homocopolymer and perform the transcriptional activating function through LZ or HLH motifs in nucleus of renal cell carcinoma. | LIN Guiting ZHANG Zhiwen ZANG long XIN Dianqi CHANG Zhijie GUO Yinglu | 2000 | Chinese Science Bulletin2000，45，21： | 1 |
| 17 | IGFBP‐6 plays a role as an oncosuppressor gene in NPC pathogenesis through regulating EGR‐1 expression显示文摘 | Yuan‐SungKuo Yueh‐BihTang Tung‐YingLu Han‐ChungWu Chin‐TarngLin | 2010 | J Pathol2010，，3： | 1 |
| 18 | Prediction of buried calcite dissolution in the Ordovician carbonate reservoir of the Tahe Oilfield, NW china: Evidence from formation water显示文摘 | Zhuang Ruan Bingsong Yu Lidong Wang Yinglu Pan Guanghui Tan | 2013 | Chemie der Erde - Geochemistry - Interdisciplinary Journal for Chemical Problems of the Geosciences and Geoecology2013，，4： | 1 |
| 19 | Carbonate reservoirs modified by magmatic intrusions in the Bachu area,Tarim Basin,NW China显示文摘Oil and gas exploration in carbonate rocks was extremely successful in recent years in the Ordovician in Tarim Basin.NW China.Here,we investigate the carbonate reservoirs in the Bachu area of the Tarim Basin through petrological and geochemical studies combined with oil and gas exploration data.Geochemical analysis included the major,trace,and rare earth elements;fluid inclusion thermometry;clay mineral characterization;and carbon and oxygen isotopes of the carbonate rocks.Homogenization temperatures of the fluid inclusions of Well He-3 in the Bachu area indicate three groups,60-80 ℃,90-130 ℃,and 140-170 ℃,and suggest that the carbonate rocks experienced modification due to heating events.The porosity in the reservoir is defined by fractures and secondary pores,and there is a notable increase in the porosity of the carbonate reservoirs in proximity to magmatic intrusion,particularly approximately 8-10 m from the intrusive rocks.The development of secondary pores was controlled by lithofacies and corrosion by various fluids.We identify supercritical fluids with high density(138.12-143.97 mg/cm^3) in the Bachu area.The negative correlations of δ^(13)C(-2.76‰ to-0.97‰) and δ^(18)O(-7.91‰ to-5.07‰) suggest that the carbonate rocks in the study area were modified by high-salinity hydrothermal fluid.The formation of clay minerals,such as illite and montmorillonite,caused a decrease in porosity.Our study demonstrates the effect of magmatic intrusions in modifying the reservoir characteristics of carbonate rocks and has important implications for oil and gas exploration. | Kang Xu Bingsong Yu Hanning Gong Zhuang Ruan Yinglu Pan Yan Ren | 2015 | Geoscience Frontiers2015，6，5： | 1 |
| 20 | Aberrant activity of Wnt/Frizzled signaling pathway in renal cancer cell lines显示文摘The expression of Wnt, Wnt receptor-Frizzled, and several other key components in Wnt pathway in renal cancer cell lines was studied. The result of semi-quantitative RT-PCR has shown that the expression level of Wnt5A and hFz5 mRNA were higher in renal cancer cell line (GRC-1) than in normal renal cell line (HK-2). This result has been confirmed by in situ hybridization. The expression of p-catenin protein was obviously higher in GRC-1 than in HK-2 (P<0.01), but there were no different expressions of its mRNA between 3 lines. The reasons of the overexpression of β-catenin has been investigated by means of immunocytochemistry, SSCP and so on, no mutation of β-catenin gene and APC were found. That means that the overexpression of Wnt5A/hFz5 might be the reason of overexpression of β-catenin. It was concluded that the aberrant activity of Wnt pathway might play an important role in renal cell carcinoma. | ZANG Tong ZHUANG Liyan ZHANG Zhiwen XIN Dianqi GUO Yinglu | 2000 | Chinese Science Bulletin2000，45，18： | 1 |
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