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| 1 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 2 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 3 | Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor显示文摘CKLF (chemokine-like factor)-like MARVEL (MAL and related proteins for vesicle trafficking and mem-brane link domain) transmembrane domain containing (CMTM) is a novel gene family. One member of this family, CMTM2, also named chemokine-like factor superfamily 2 (CKLFSF2), is expressed highly in the testis and moderately in the prostate, marrow and peripheral blood cells. However, the function of human CMTM2 remains unknown. Here, we found that CMTM2 was upregulated in 5α-dihydrotestos- terone (DHT)-treated LNCaP cells. We investigated the relationship between CMTM2 and the androgen receptor. Our results showed that CMTM2 enhanced DHT-mediated androgen receptor (AR) transacti-vation and the expression of prostate specific antigen (PSA). We also observed that CMTM2 enhanced the AR protein level, which was reversed by silencing endogenous CMTM2 expression, which sug-gested that CMTM2 might play an important role in maintaining the AR protein level. We also found that CMTM2 suppressed Akt activation. A previous study showed that Akt could phosphorylate AR at Ser210 and Ser790 and lead to AR ubiquitylation and degradation as well as suppression of AR activity. Taken together, suppressing Akt activation and increasing the AR protein level might be one of the mechanisms for the CMTM2-mediated enhancement of AR transactivation. | LIU DaZhen YIN CaiHua ZHANG YingMei TIAN LinJie LI Ting LI Dan MA DaLong GUO YingLu WANG Ying | 2009 | Chinese Science Bulletin2009，54，6： | 7 |
| 4 | Center-configuration selection technique for the reconfigurable modular robot显示文摘The reconfigurable modular robot has an enormous amount of configurations to adapt to various environments and tasks. It greatly increases the complexity of configuration research in that the possible configuration number of the recon-figurable modular robot grows exponentially with the increase of module number. Being the initial configuration or the basic configuration of the reconfigurable robot, the center-configuration plays a crucial role in system’s actual applications. In this paper, a novel center-configuration selection technique has been proposed for re-configurable modular robots. Based on the similarities between configurations’ transformation and graph theory, configuration network has been applied in the modeling and analyzing of these configurations. Configuration adjacency matrix, reconfirmation cost matrix, and center-configuration coefficient have been defined for the configuration network correspondingly. Being similar to the center-location problem, the center configuration has been selected according to the largest cen-ter-configuration coefficient. As an example of the reconfigurable robotic system, AMOEBA-I, a three-module reconfigurable robot with nine configurations which was developed in Shenyang Institute of Automation (SIA), Chinese Academy of Sciences (CAS), has been introduced briefly. According to the numerical simulation result, the center-configuration coefficients for these nine configurations have been calculated and compared to validate this technique. Lastly, a center- configu-ration selection example is provided with consideration of the adjacent configura-tions. The center-configuration selection technique proposed in this paper is also available to other reconfigurable modular robots. | LIU JinGuo WANG YueChao LI Bin MA ShuGen TAN DaLong | 2007 | Science in China(Series F)2007，50，5： | 7 |
| 5 | Correlation between magnetic resonance T2 image signal intensity ratio and cell apoptosis in a rabbit spinal cord cervical myelopathy model显示文摘 | Ma Lei Zhang Di Chen Wei Shen Yong Zhang Yingze Ding Wenyuan Zhang Wei Wang Linfeng Yang Dalong | 2014 | Chinese Medical Journal2014，，2： | 6 |
| 6 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 7 | CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2,and STAT3 pathway in colorectal cancer显示文摘CMTM4(CKLF-like MARVEL transmembrane domain containing 4),a potential tumor suppressor gene,is involved in several types of malignancies.It has been reported to be downregulated and exhibit anti-tumorigenic activities by regulating cell growth and cell cycle in clear cell renal cell carcinoma.It has also been identified as a tumor suppressor in hepatocellular carcinoma(HCC),and its negative expression is a risk factor for poor prognosis of HCC patients.In the present study,an integrated bioinformatics analysis based on The Cancer Genome Atlas(TCGA)database showed that CMTM4 was frequently reduced in colorectal cancer(CRC)and high expression of CMTM4 was associated with increased overall survival rates.Based on these findings,we adopted gain-of-function and lost-of-function strategies using SW480 and HT29 CRC cell lines which have relatively low and high endogenous CMTM4 levels,respectively.We observed impeded cell proliferation and migration upon overexpression of CMTM4 in SW480 cells,and the opposite effects were observed upon knockdown of CMTM4 in HT-29 cells.Cell signaling pathways essential for CRC progression were then examined,and the phosphorylation levels of AKT,ERK1/2,and STAT3 were found to be decreased by CMTM4 overexpression in SW480 cells and elevated by CMTM4 silencing in HT29 cells.Their inhibitors were used to validate that the three signaling pathways contributed to the inhibitory effects of CMTM4 on CRC cells.Taken together,our results suggest that CMTM4 plays a tumor suppressive role in CRC. | Hui Xue Ting Li Pingzhang Wang Xiaoning Mo Hejun Zhang Shigang Ding Dalong Ma Wenping Lv Jing Zhang Wenling Han | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 5 |
| 8 | Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis显示文摘确实有趣的新基因(戒指) 手指蛋白质在人的染色体代表一个大蛋白质家庭,并且在生理的活动和癌症开发玩 crucialroles。一些戒指手指蛋白质的生物功能仍然是 unknown.Here,我们描述了新奇、人的 Golgi 局部性的戒指手指蛋白质的生物活动 121 (RNF121 ) ,是的 functionof,这样远,未知。不同于 endoplasmic 在 Caenorhabditis elegans 的蜂窝胃局部性的 RNF121,人的 RNF121 对 Golgi 仪器主要局部性。RNF121 击倒的禁止的房间生长和导致的 apoptosis,它被 caspase-3 激活和劈开伴随 poly (腺苷 diphosphate 核糖) 聚合酶。Z-VAD-FMK,一个 pan-caspase 禁止者,禁止了 RNF121 击倒导致 apoptosis。野类型的 RNF121 的在表示上,然而并非 RNF121 的 theRING 领域异种,减少的 RNF121 击倒导致 apoptosis,显示戒指领域被要求调整 forRNF121 的 apoptosis。而且, RNF121 击倒的提高的导致 etoposide 的 apoptosis。这是到 demonstratethat RNF121 的第一研究是 apoptosis 的一个新奇管理者并且为癌症提供一个新潜在的目标治疗。 | Yuanbo Zhao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 3 |
| 9 | Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies显示文摘PDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and As2O3 in three hematologic tumor cell lines. In vivo studies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xenograft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemotherapeutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemosensitizer. | WANG YanFang SHI Lin SONG QuanSheng ZHANG YingMei LOU YaXin ZHENG Yi MA DaLong WANG Ying KE XiaoYan | 2009 | Chinese Science Bulletin2009，54，21： | 3 |
| 10 | Dysregulation of HSG triggers vascular proliferative disorders 显示文摘 | Chen KH Guo XM Dalong MA | 2004 | Nature Cell Biol2004，6，9： | 1 |
| 11 | Shorl interfering RNA against the PDCD5 attenuates cell apoptnsis and caspase-3 activity induced by Bax overexpression 显示文摘 | Chen Lina Wang Ying Ma Dalong | 2006 | Apnptosis2006，11，： | 1 |
| 12 | TFAR19, a novel apoptosis related gene cloned from human leukemia cell line TF-1,could,enchance apoptosis of some tumur cells induced by growth factor with drawa显示文摘 | Liu HT Wang YG Ma Dalong | 1999 | BBRC1999，254，： | 1 |
| 13 | Dysregulation of HSG triggers vascular proliferative disorders 显示文摘 | Chen Kuang-Hueih Guo Xiaomei Ma Dalong | 2004 | Nat Cell Biol2004，6，： | 1 |
| 14 | Cloning of a novel human caspase-9 splice variant containing only the CARD domain显示文摘 | Pingzhang Wang Taiping Shi Dalong Ma | 2006 | Life Sciences2006，，10： | 1 |
| 15 | Dysregulation of HSG triggers vascular proliferative disorders显示文摘 | Chen KH Guo XM Dalong MA | 2004 | Nature Cell Biol2004，6，9： | 1 |
| 16 | Dysregulation of HSG triggers vascular proliferative disorders 显示文摘 | Chen Kuanghueih Guo Xiaomei Ma Dalong | 2004 | Nat Cell Biol2004，6，： | 1 |
| 17 | Molecular cloning and characterization of chemokine-like factor 1 ( CKLF1 ), a novel human cytokine with unique structure and potential chemotactic activity显示文摘 | Wenling HAN Yaxin LOU Dalong MA | 2001 | Biochem J2001，357，1： | 1 |
| 18 | Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8显示文摘 | Caining Jin Peiguo Ding Dalong Ma | 2005 | FEBS Lett2005，579，28： | 1 |
| 19 | Dysregulation of HSG triggers vascular proliferative disorders显示文摘 | Chen Kuanghueih Guo Xiaomei Ma Dalong | 2004 | Nat Cell Biol2004，6，： | 1 |
| 20 | Optimal ultrasonic extraction condition and determination of polysaccharides in Tilia amurensis flower显示文摘 | MU Liqiang LIU Liping MA Dalong | 2010 | J Forestry Research2010，21，1： | 1 |
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