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| 1 | Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/ eIF2a/ATF4/CHOP Signaling Pathway显示文摘Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,but whether it plays a functional role after ischemic stroke and the underlying mechanism remain unclear.In this study,using a mouse model of ischemic stroke via transient middle cerebral artery occlusion(tMCAO),we found that Hes1 was induced following brain injury,and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome,suggesting that Hes1 knockdown exacerbates ischemic stroke.In addition,mechanistically,Hes1 knockdown promoted apoptosis and activated the PERK/eIF2a/ATF4/CHOP signaling pathway after tMCAO.These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis.Furthermore,inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO,implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2a/ATF4/CHOP signaling pathway.Taken together,these results unveil the detrimental role of Hes1 knockdown after ischemic stroke and further relate it to the regulation of ER stress-induced apoptosis,thus highlighting the importance of targeting ER stress in the treatment of ischemic stroke. | Yueyong Li Yingjun Zhang Huangde Fu Huadong Huang Qifeng Lu Houji Qin Yingning Wu Huatuo Huang Guizhen Mao Zhongheng Wei Pinhu Liao | 2020 | Neuroscience Bulletin2020，36，2： | 12 |
| 2 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 3 | Seasonal variations of carboxylic acids and their contributions to the rainwater acidity: A case study of Guiyang and Shangzhong,China显示文摘Low molecule weight carboxylic acids are ubiquitous and important chemical constituents in the troposphere.Seven carboxylic acids in the rainwater of Guiyang and Shangzhong were simultaneously determined by ion chromatography from April 2006 to April 2007.Formic, acetic and oxalic acids were found to be the predominant carboxylic acids.Their volume weighted average concentration (VWA) in the rainwater of Guiyang were 14.24 μmol/L, 9.35 μmol/L and 2.79 μmol/L, respectively;as compared to 4.95 μmol/L, 1.35 μmol/L and 2.31 μmol/L in the rainwater of Shangzhong.In Shangzhong it is witnessed that the concentra-tions of these acids were higher in the summer than in the winter and direct emissions from vegetations or soils may account for the main provenance of the acids.This is, however, not the case in Guiyang, where the concentrations of the carboxylic acids were higher during the non-growing season than during the growing season.The relatively weak scavenging affected by scarce and little rainwater as well as the particles accompanied with the rainfall may have some effect on the carboxylic acids during the wintertime in Guiyang.Carboxylic acids in the rainwater of Guiyang were estimated to account for 18.7% to the free acidity, where formic, acetic and oxalic acids accounted for 7.9%, 4.7%, 6.1%, respectively.In Shangzhong, the 3 primary carboxylic acids represented 58.1% to the free acidity where formic, acetic and oxalic acids represented 25.1%, 7.5%, 25.5%, respectively.Carboxylic anions accounted for 6.6% (1.7%–19.2%) to the total anions in the rainwater of Guiyang.Carboxylic anions repre-sented 13.2% (0.5%–92.2%) to the total anions in the rainwater of Shangzhong.These results indicated that carboxylic acids were the important contributors to the rainwater acidity, especially in remote regions. | XU Gang LEE XinQing LU YingChun CHEN YingJun HUANG DaiKuan | 2010 | Chinese Science Bulletin2010，55，16： | 5 |
| 4 | Genomic variants of genes associated with three horticultural traits in apple revealed by genome re-sequencing显示文摘The apple(Malus×domestica Borkh.)cultivar‘Su Shuai’exhibits greater disease resistance,shorter internodes and lighter fruit flavor compared with its parents‘Golden Delicious’and‘Indo’.To obtain a comprehensive overview of the sequence variation in these three horticultural traits,the genomes of‘Su Shuai’and‘Indo’were resequenced using next-generation sequencing and compared to the genome of‘Golden Delicious’.A wide range of genetic variations were detected,including 2454406 and 18749349 single nucleotide polymorphism(SNP)and 59547 and 50143 structural variants(SVs)in the‘Indo’and‘Su Shuai’genomes,respectively.Among the SVs in‘Su Shuai’,17 genes related to disease resistance,10 genes related to Gibberellin(GA)and 19 genes associated with fruit flavor were identified.The expression patterns of eight of the SV genes were examined using reverse transcription-quantitative polymerase chain reaction(RT-qPCR).The results of this study illustrate the genomic variation in these cultivars and provide evidence for a genetic basis for the horticultural traits of disease resistance,short internodes and lighter flavor exhibited in these cultivars.These results provide a genetic basis for the phenotypic characteristics of‘Su Shuai’and,as such,these SVs could serve as gene-specific molecular markers in maker-assisted breeding of apples. | Shijie Zhang Weiping Chen Lu Xin Zhihong Gao Yingjun Hou Xinyi Yu Zhen Zhang Shenchun Qu | 2014 | Horticulture Research2014，1，1： | 5 |
| 5 | Neural responses to cartoon facial attractiveness: An eventrelated potential study显示文摘Animation creates a vivid, virtual world and expands the scope of human imagination. In this study, we investigated the time-courses of brain responses related to the evaluation of the attractiveness of cartoon faces using the event-related potential(ERP) technique. The results demonstrated that N170 amplitude was higher for attractive than for unattractive cartoon faces in males, while the opposite was found in females. Facial attractiveness notably modulated the late positive component(LPC), which might reflect the task-related process of aesthetic appraisal of beauty. The mean LPC amplitude in males was significantly higher for attractive cartoon faces than for unattractive faces, while the LPC amplitude in females did not significantly differ between attractive and unattractive cartoon faces. Moreover, the paint mode(computer graphics, gouache, and stick figure) modulated the early encoding of facial structures and the late evaluative process. The early modulation effect by paint mode may be related to the spatial frequency of the pictures. The processing speed and intensity in females were both higher than those in males. In conclusion, our study, for the first time, reported ERP modulation based on the assessment of cartoon facial attractiveness, suggesting the facilitated selection of attractiveness information at the early stage, and that the attentional enhancement of attractive faces at the late stage only exists in males. This suggests that men's brains are hard-wired to be sensitive to facial beauty, even in cartoons. | Yingjun Lu Jingmei Wang Ling Wang Junli Wang Jinliang Qin | 2014 | Neuroscience Bulletin2014，30，3： | 3 |
| 6 | 3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration显示文摘Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone regeneration.However,the mechanism behind scaffold pore morphology-regulated bone regeneration remains unclear,making the structure design of scaffolds for bone repair challenging.To address this issue,we have carefully assessed diverse cell behaviors of bone mesenchymal stem cells(BMSCs)on theβ-tricalcium phosphate(β-TCP)scaffolds with three representative pore morphologies(i.e.,cross column,diamond,and gyroid pore unit,respectively).Among the scaffolds,BMSCs on theβ-TCP scaffold with diamond pore unit(designated as D-scaffold)demonstrated enhanced cytoskeletal forces,elongated nucleus,faster cell mobility,and better osteogenic differentiation potential(for example,the alkaline phosphatase expression level in D-scaffold were 1.5-2 times higher than other groups).RNA-sequencing analysis and signaling pathway intervention revealed that Ras homolog gene family A(RhoA)/Rho-associated kinase-2(ROCK2)has in-depth participated in the pore morphology-mediated BMSCs behaviors,indicating an important role of mechanical signaling transduction in scaffold-cell interactions.Finally,femoral condyle defect repair results showed that D-scaffold could effectively promote endogenous bone regeneration,of which the osteogenesis rate was 1.2-1.8 times higher than the other groups.Overall,this work provides insights into pore morphology-mediated bone regeneration mechanisms for developing novel bioadaptive scaffold designs. | Qiji Lu Jingjing Diao Yingqu Wang Jianlang Feng Fansen Zeng Yan Yang Yudi Kuang Naru Zhao Yingjun Wang | 2023 | Bioactive Materials2023，，8： | 2 |
| 7 | Stakeholders’ power, corporate characteristics, and social and environmental disclosure: evidence from China显示文摘 | Yingjun Lu Indra Abeysekera | 2014 | Journal of Cleaner Production2014，，： | 2 |
| 8 | Achieving high superplasticity of a new Al–Mg–Sc–Zr alloy sheet prepared by a simple thermal–mechanical process显示文摘 | Xiaowu Cao Guofu Xu Yulu Duan Zhimin Yin Liying Lu Yingjun Wang | 2015 | Materials Science & Engineering A2015，，： | 1 |
| 9 | Stress corrosion cracking of a high-strength friction-stir-welded joint of an Al–Zn–Mg–Zr alloy containing 0.25wt.% Sc显示文摘 | Ying Deng Bing Peng Guofu Xu Qinglin Pan Rui Ye Yingjun Wang Liying Lu Zhimin Yin | 2015 | Corrosion Science2015，，： | 1 |
| 10 | Grassland management practices in Chinese steppes impact productivity, diversity and the relationship显示文摘Grasslands are crucial parts of the terrestrial ecosystem, with an extremely high differentiation of productivity and diversity across spatial scales and land use patterns. The practices employed to manage grassland,such as grazing, haymaking, fertilization or reseeding, can improve the grassland condition. This study focuses on the changes in productivity and diversity and the relationship between them as affected by management practices.Productivity and diversity have unequivocally been altered in response to different management practices. When grazing intensity of a typical steppe increased from 1.5 to 9 sheep per hectare, both productivity and diversity declined.Higher grazing intensity(6 to 9 sheep per hectare)accelerated loss of diversity because of lower productivity.Productivity was significantly improved but diversity was lost by fertilizing. N fertilization also reduced the sensitivity of diversity to productivity. A similar response was found in mown grassland with increased productivity and diversity but their relationship was negatively affected.Mowing also slowed down the decline in diversity as productivity increased. Reseeding purple-flowered alfalfa led to an increased diversity, while yellow-flowered alfalfa increased productivity significantly. The negative productivity-diversity relationship was transformed to a positive one by reseeding alfalfa. These results enhance understanding of how productivity, diversity and their relationships change in response to altered grassland management practices, and support an integrated approach for improving both productivity and diversity. | Yingjun ZHANG Wenjie LU Hao ZHANG Jiqiong ZHOU Yue SHEN | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 1 |
| 11 | Discussion a- bout big data mining based on hadoop 显示文摘 | DENG Zhonghua FAN Bing LU Yingjun | 2013 | Applied Mechan- ics and Materials2013，，： | 1 |
| 12 | Natural ingredients from Chinese materia medica for pulmonary hypertension显示文摘Pulmonary hypertension(PH)is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure,which may eventually develop to right heart failure and death.Although newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH,limited types of effective and economical drugs for PH still makes it as a life-threatening disease.Some drugs from Chinese materia medica(CMM)have been traditionally applied in the treatment of lung diseases.Accumulating evidence suggests active pharmaceutical ingredients(APIs)derived from those medicines brings promising future for the prevention and treatment of PH.In this review,we summarized the pharmacological effects of APIs derived from CMM which are potent in treating PH,so as to provide new thoughts for initial drug discovery and identification of potential therapeutic strategies in alternative medicine for PH. | ZHANG Jia-Rui OUYANG Xuan HOU Chi YANG Qi-Feng Wu Yingjun LU Wen-Ju LIU Chun-Li YANG Kai ZHONG Nan-Shan WANG Jian CHEN Yu-Qin | 2021 | Chinese Journal of Natural Medicines2021，19，11： | 1 |
| 13 | Profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria: a retrospective study in China, 2014–2021显示文摘Background: In areas where malaria has been eliminated, delayed care-seeking and diagnosis of imported malaria are constant threats. This study aimed to describe the profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria in China.Methods: This retrospective study assessed surveillance data obtained from 2014 to 2021 in the Chinese provincial-level administrative divisions (PLADs) of Anhui, Henan, Hubei, and Zhejiang, and Guangxi. Epidemiological characteristics were analyzed using descriptive statistics. Furthermore, factors associated with delayed care-seeking and diagnosis among imported malaria cases were identified using multivariate logistic regression.Results: Overall, 11.81% and 30.08% of imported malaria cases had delays in seeking care and diagnosis, respectively. During the study period, there was a decreasing trend in the proportion of imported malaria cases with delayed care-seeking (χ^(2) = 36.099,P < 0.001) and diagnosis (χ^(2) = 11.395,P = 0.001). In multivariate analysis, independent risk factors associated with delayed care-seeking include PLADs (Guangxi as reference), consultations in high-level facilities for the first medical visit, infections with non-Plasmodium falciparum species, and older age. However, PLADs (Guangxi as reference), the purpose of traveling (labour as reference), and infections with non-P. falciparum species increased the risk of delayed diagnosis. Delayed care-seeking (adjusted odds ratio: 1.79,P = 0.001) and diagnosis (adjusted odds ratio: 1.62,P = 0.004) were risk factors for severe disease development.Conclusions: Based on this study’s findings, we strongly advocate for improved access to quality healthcare to reduce the rate of misdiagnosis at the first visit. Infections caused by non-P. falciparum species should be highlighted, and more sensitive and specific point-of-care detection methods for non-P. falciparum species should be developed and implemented. In addition, education programs should be enhanced to reach target populations at risk of malaria infection. All these factors may reduce delayed care-seeking and diagnosis of imported malaria. | Tao Zhang Duoquan Wang Yingjun Qian Wei Ruan Ying Liu Jing Xia Hui Yan Yuan Sui Shenning Lu Xian Xu Jingjing Jiang Xiaofeng Lyu Shuqi Wang Shizhu Li Weidong Li | 2022 | Infectious Diseases of Poverty2022，11，6： | 1 |
| 14 | Synthesis and effect of forming Fe 2 P phase on the physics and electrochemical properties of LiFePO 4 /C materials显示文摘 | Yanbin Xu Yingjun Lu Lan Yan Zhengyin Yang Rudong Yang | 2006 | Journal of Power Sources2006，，1： | 1 |
| 15 | Development and Impacts of the Sierra Leone-China Laboratory for Parasitic Diseases Testing and Surveillance显示文摘BACKGROUND The Republic of Sierra Leone is located on the west coast of Africa,bordering Guinea and Liberia,with a population of 7.8 million in 2019(1).It has a tropical monsoon climate,with high temperatures and plentiful precipitation.As one of the least developed countries in the world(2),Sierra Leone has long struggled with poor health outcomes with a life expectancy at birth of 59 for male and 61 for female,and high maternal and neonatal mortality,threatened by infectious diseases such as malaria,tuberculosis,typhoid fever,cholera,and Lassa fever(3). | Lei Duan Lili Wang Shenning Lu Bei Wang Yanbing Li Qiuli Xu Lulu Huang Wei Ding Yingjun Qian Hongmei Li Xuejiao Ma Duoquan Wang Yayi Guan Xiaochun Wang Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，15： | 1 |
| 16 | The Identification and Geological Significance of Fault Buried in the Gasikule Salt Lake in China based on the Multi-source Remote Sensing Data显示文摘The salinity of the salt lake is an important factor to evaluate whether it contains some mineral resources or not,the fault buried in the salt lake could control the abundance of the salinity.Therefore,it is of great geological importance to identify the fault buried in the salt lake.Taking the Gasikule Salt Lake in China for example,the paper established a new method to identify the fault buried in the salt lake based on the multi-source remote sensing data including Landsat TM,SPOT-5 and ASTER data.It includes the acquisition and selection of the multi-source remote sensing data,data preprocessing,lake waterfront extraction,spectrum extraction of brine with different salinity,salinity index construction,salinity separation,analysis of the abnormal salinity and identification of the fault buried in salt lake,temperature inversion of brine and the fault verification.As a result,the study identified an important fault buried in the east of the Gasikule Salt Lake that controls the highest salinity abnormal.Because the level of the salinity is positively correlated to the mineral abundance,the result provides the important reference to identify the water body rich in mineral resources in the salt lake. | WANG Junhu ZHAO Yingjun WU Ding LU Donghua | 2021 | Acta Geologica Sinica(English Edition)2021，95，3： | 1 |
| 17 | A hierarchical framework for parallel seismic applications 显示文摘 | Lu Jian Li Yingjun Ma Xiaoxing Cai Min Tao Xianping | 2000 | Communications of ACM2000，43，10： | 1 |
| 18 | Sex-specific effects of bisphenol-A on memory and synaptic structural modification in hippocampus of adult mice显示文摘 | Xiaohong Xu Xingyi Liu Qin Zhang Guangxia Zhang Yingjun Lu Qin Ruan Fangni Dong Yanling Yang | 2013 | Hormones and Behavior2013，，5： | 1 |
| 19 | Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014:an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the global pandemic coronavirus disease 2019(COVID-19),has proven itself to be a highly virulent respiratory pathogen with an unpredictable evolutionary capacity,posing a persistent threat to mankind.At the time of this manuscript’s publication. | Qifan Zhou Sidi Yang Liu Cao Yang Yang Tiefeng Xu Qishu Chen Hongzhou Lu Yingjun Li Deyin Guo Xumu Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 20 | Highly Thermally Conductive and Structurally Ultra‑Stable Graphitic Films with Seamless Heterointerfaces for Extreme Thermal Management显示文摘Highly thermally conductive graphitic film(GF)materials have become a competitive solution for the thermal management of high-power electronic devices.However,their catastrophic structural failure under extreme alternating thermal/cold shock poses a significant challenge to reliability and safety.Here,we present the first investigation into the structural failure mechanism of GF during cyclic liquid nitrogen shocks(LNS),which reveals a bubbling process characterized by“permeation-diffusion-deformation”phenomenon.To overcome this long-standing structural weakness,a novel metal-nanoarmor strategy is proposed to construct a Cu-modified graphitic film(GF@Cu)with seamless heterointerface.This well-designed interface ensures superior structural stability for GF@Cu after hundreds of LNS cycles from 77 to 300 K.Moreover,GF@Cu maintains high thermal conductivity up to 1088 W m^(−1)K^(−1)with degradation of less than 5%even after 150 LNS cycles,superior to that of pure GF(50%degradation).Our work not only offers an opportunity to improve the robustness of graphitic films by the rational structural design but also facilitates the applications of thermally conductive carbon-based materials for future extreme thermal management in complex aerospace electronics. | Peijuan Zhang Yuanyuan Hao Hang Shi Jiahao Lu Yingjun Liu Xin Ming Ya Wang Wenzhang Fang Yuxing Xia Yance Chen Peng Li Ziqiu Wang Qingyun Su Weidong Lv Ji Zhou Ying Zhang Haiwen Lai Weiwei Gao Zhen Xu Chao Gao | 2024 | Nano-Micro Letters2024，16，3： | 0 |
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