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| 1 | 玉米品质性状的遗传模型分析显示文摘试验采用不完全双列杂交法 ,把 10个自交系配成 2 4个组合 ,对普通玉米的 4个品质性状的遗传模型、基因效应进行了研究。赖氨酸含量的遗传符合加性—显性模型 ,淀粉含量、油分含量、蛋白质含量符合加性—显性—上位性模型 ,4个品质性状的遗传方式均以加性效应为主。 | 祁新 赵颖君 李鹏志 邬信康 QI Xin Zhao Yingjun LI Pengzhi WU Xinkang | 2001 | 吉林农业科学2001，26，3： | 25 |
| 2 | Cardiac autonomic nerve fiber regeneration in chronic heart failure Do Akt gene-transduced mesenchymal stem cells promote repair?显示文摘BACKGROUND: Transplantation of Akt-over-expressing mesenchymal stem cells (Akt-MSCs) has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effects of Akt-MSCs on cardiac autonomic neuropathy in chronic heart failure (CHF). OBJECTIVE: The present study used adriamycin-induced CHF rat models to observe the effect of Akt-MSCs on cardiac autonomic nervous regeneration and the factors mediating this effect. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed at the Central Laboratory of Basic Medical College, China Medical University, between September 2008 and April 2009. MATERIALS: Rabbit anti-choline acetyltransferase (ChAT), growth associated protein-43 (GAP-43), synaptophysin (SYN) polyclonal antibodies and the secondary antibody (goat anti-rabbit IgG) were purchased from Boster, China. Cat-A-Kit assay system was provided by Amersham, USA. METHODS: (1) Adult rat MSCs were isolated and cultured for the preparation of Akt-MSCs. (2) Forty male Wistar rats were intramyocardially administered adriamycin at 2 mg/kg over 3 days for a total of five times and once a week for additional five times thereafter to establish CHF models. At 2 weeks after final adriamycin treatment, 34 successful CHF rat models were randomized to three groups: Akt-MSCs (n = 11), simple MSCs (s-MSCs, n =11), and control (n = 12). Each group was intravenously administered Akt-MSCs (2×106 cells in 100 μL PBS), s-MSCs (2×106 cells in 100 μL PBS) or equal volume of phosphate buffered saline, once a day for a total of three times. MAIN OUTCOME MEASURES: At 4 weeks after final adriamycin treatment, myocardial norepi- nephrine (NE) content was detected using a Cat-A-Kit assay system. Myocardial ChAT, SYN and GAP-43 were performed by immunohistochemistry and Western blot analysis. Prior to, 2 and 4 weeks after adriamycin treatment, echocardiographic examination was performed and left ventricular ejection fraction (LVEF) was determined. RESULTS: Myocardial NE content, as well as SYN-positive and GAP-43-positive nerve fiber density and expression, and LVEF, was the greatest in the Akt-MSCs group, followed by the s-MSCs group, and lastly the control group (P < 0.05 or P < 0.01). ChAT expression was similar between Akt-MSCs and s-MSCs groups, but it was higher compared with the control group (P < 0.05). NE contents were negatively correlated to LVEF (r = -0.64, P = 0.015). CONCLUSION: Transplantation of MSCs, in particular Akt-MSCs, promotes cardiac nervous regeneration in failing heart, which might be mediated by GAP-43. | Hongliang Kong Zhanquan Li Shumei Zhao Li Zhu Yingjun Zhao Weiwei Zhang GuipingXu Wenjun Hao Huijun Li Guoxian Qi | 2010 | Neural Regeneration Research2010，5，1： | 13 |
| 3 | Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/ eIF2a/ATF4/CHOP Signaling Pathway显示文摘Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,but whether it plays a functional role after ischemic stroke and the underlying mechanism remain unclear.In this study,using a mouse model of ischemic stroke via transient middle cerebral artery occlusion(tMCAO),we found that Hes1 was induced following brain injury,and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome,suggesting that Hes1 knockdown exacerbates ischemic stroke.In addition,mechanistically,Hes1 knockdown promoted apoptosis and activated the PERK/eIF2a/ATF4/CHOP signaling pathway after tMCAO.These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis.Furthermore,inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO,implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2a/ATF4/CHOP signaling pathway.Taken together,these results unveil the detrimental role of Hes1 knockdown after ischemic stroke and further relate it to the regulation of ER stress-induced apoptosis,thus highlighting the importance of targeting ER stress in the treatment of ischemic stroke. | Yueyong Li Yingjun Zhang Huangde Fu Huadong Huang Qifeng Lu Houji Qin Yingning Wu Huatuo Huang Guizhen Mao Zhongheng Wei Pinhu Liao | 2020 | Neuroscience Bulletin2020，36，2： | 12 |
| 4 | M1 muscarinic acetylcholine receptor in Alzheimer's disease显示文摘The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease(AD). Muscarinic acetylcholine receptors(mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes(M1–M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment. | Shangtong Jiang Yanfang Li Cuilin Zhang Yingjun Zhao Guojun Bu Huaxi Xu Yun-Wu Zhang | 2014 | Neuroscience Bulletin2014，30，2： | 10 |
| 5 | Tribenuron-Methyl Induces Male Sterility through Anther-Specific Inhibition of Acetolactate Synthase Leading to Autophagic Cell Death显示文摘Tribenuron 甲基(TM ) 是禁止分支链的强大的 sulfonylurea 除草剂由指向 acetolactate synthase (ALS ) 的催化子单元(CSR1 ) 的氨基酸(BCAA ) 生合成。由在低剂量的 TM 的叶的喷洒的男绝育的选择正式就职广泛地在油菜籽(Brassica 马来麝) 为混合种子生产被使用了;然而,内在的机制仍然保持未知。这里,我们 reportgreater TM 累积和在花药的 BCAA 饥饿比在在 TM 申请以后的叶子和茎。csr1-1D (aCSR1 异种) 的组成或花药特定的表示消除了花药选择的 ALS 抑制并且在油菜籽和 Arabidopsis 颠倒了导致 TM 的男无菌的显型。TM 涂抹茎实验的结果,在叶肉或韧皮部由 TM 新陈代谢基因 Bel 的指向的表示在导致 TM 的男绝育的花药和回复与很少 TM 累积的观察结合了,建议叶水花的 TM 通过叶肉和韧皮部主要对花药极运输。显微镜学和 immunoblotting 揭示了那 autophagy,在房间死亡期间导致的一个体积降级过程,在导致 TM 的男无菌的花药并且由被提高花药特定 ALS 击倒。而且,导致 TM 的花粉流产被 autophagy 禁止者 3 麻省显著地禁止。这些数据最终建议 TM 对花药极运输,导致经由花药特定的 ALS 抑制的 BCAA 饥饿并且,,在花药的 autophagic 房间死亡。 | Lun Zhao Xue Jing Li Chen Yingjun Liu Yanan Su Tingting Liu Changbin Gao Bin Yi Jing Wen Chaozhi Ma Jinxing Tu Jitao Zou Tingdong Fu Jinxiong Shen | 2015 | Molecular Plant2015，8，12： | 7 |
| 6 | Response of Pinus taiwanensis growth to climate changes at its southern limit of Daiyun Mountain, China's Mainland Fujian Province显示文摘The Pinus taiwanensis trees of a Chinese endemic species form pure forests at infertile sites in humid subtropical China, which can aid soil reservation and ecological resiliency at such sites. Herein, we used dendrochronological methods to investigate the growth patterns and their relationship with climate by analyzing 158 cores of 79 P. taiwanensis trees at 4 sites in their southernmost distribution in China's Mainland at Daiyun Mountain in Fujian Province. Tree growths at sites with favorable conditions generally showed an age-related growth trend, which decreased from approximately 5 mm to 0.5 mm in about a century. Trees in moderately stressed environments established high growth in their juvenile periods but were highly susceptible to environmental stresses such as a sharp growth decline in the 1990 s. The temperature in February and the moisture in July are the major limiting factors for most of the tree growths, except for a few extremely stressed P. taiwanensis trees. The growth of the dwarf P. taiwanensis trees, with all ring diameters of the first 20 years less than 4 mm, is mainly limited by the dry climate in May. Under the potential future warming trend, drought stress can be particularly threatening to these dwarf P. taiwanensis trees, which are likely to be the germplasm resources for this species in this region. | CHEN Dan FANG KeYan LI YingJun DONG ZhiPeng ZHANG Yu ZHOU FeiFei | 2016 | Science China Earth Sciences2016，59，2： | 6 |
| 7 | Emission of intermediate volatility organic compounds from a ship main engine burning heavy fuel oil显示文摘Intermediate volatility organic compounds(IVOCs)are crucial precursors of secondary organic aerosol(SOA).In this study,gaseous IVOCs emitted from a ship main engine burning heavy fuel oil(HFO)were investigated on a test bench,which could simulate the real-world operations and emissions of ocean-going ships.The chemical compositions,emission factors(EFs)and volatility distributions of IVOC emissions were investigated.The results showed that the main engine burning HFO emitted a large amount of IVOCs,with average IVOC EFs of 20.2-201 mg/kg-fuel.The IVOCs were mainly comprised of unspeciated compounds.The chemical compositions of exhaust IVOCs were different from that of HFO fuel,especially for polycyclic aromatic compounds and alkylcyclohexanes.The volatility distributions of IVOCs were also different between HFO exhausts and HFO fuel.The distinctions in IVOC emission characteristics between HFO exhausts and HFO fuel should be considered when assessing the IVOC emission and related SOA formation potentials from ocean-going ships burning HFO,especially when using fuel-surrogate models. | Haijun Lou Yuejiao Hao Weiwei Zhang Penghao Su Fan Zhang Yingjun Chen Daolun Feng Yifan Li | 2019 | Journal of Environmental Sciences2019，31，10： | 5 |
| 8 | Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening显示文摘Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical research.Hydroxyapatite(HA),a bioactive ceramic material,has a similar structure and composition to bone mineralization products.In this study,we used HA as a microfluidic chip component to provide a highly bionic bone environment.HA substrates with different microchannel structures were printed by using ceramic stereolithography(SLA)technology,and the minimum trench width was 50μm.The HA substrate with microchannels was sealed by a thin polydimethylsiloxane(PDMS)layer to make a HA-PDMS microfluidic chip.Cell culture experiments demonstrated that compared with PDMS,HA was more conducive to the proliferation and osteogenic differentiation of the human foetal osteoblast cell line(hFOB).In addition,the concentration gradient of the model drug doxorubicin hydrochloride(DOX)was successfully generated on a Christmas tree structure HA-PDMS chip,and the half maximal inhibitory concentration(IC50)of DOX was determined.The findings of this study indicate that the HA-PDMS microfluidic chip has great potential in the field of high-throughput bonerelated drug screening and bone-related research. | Qiangqiang Tang Xiaoyu Li Chen Lai Lei Li Hongkai Wu Yingjun Wang Xuetao Shi | 2021 | Bioactive Materials2021，6，1： | 5 |
| 9 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 10 | Historical trends in the anthropogenic heavy metal levels in the tidal flat sediments of Lianyungang, China显示文摘The sedimentation of metals can preserve the historical record of contaminant input from local and regional sources and provide information on the historical changes in regionalwater and sediment quality. We report the 210Pb activities and the heavy metal (Cd, Cr, Cu, Mn, Pb and Zn)depth profiles from sediment cores retrieved in 2010. The mean sedimentation rates of 0.85-1.5 cm/yr aredetermined by 210 Pbdating. The sediments in the tidal flat have recorded heavy metaldeposition and thus allow the establishment of a connection between the temporal evolution of the heavy metal pollution and the historical changes in the economicdevelopment of Lianyungang. The enrichment factors (EF) are calculated to estimate the level of contamination stored in these sediments. The results show that in the studied sites, Cr and Cudisplay low EF values and are mainly from lithogenic origin. For the other studied trace metals, a great variability in the sedimentary record is observed. Significant anthropogenic enrichment over the last 50 years is revealed at the tidal flat that receives fluvial inputs. Zinc is the elementwith the highest EF values, followed by the order of Pb > Cd > Mn > Cu and Cr. The temporal variations of the heavy metals peakduring the late 1980s to the early2000s and show adecreasing trend afterward. The pollution intensity of the tidal flat isdetermined by using EF and thegeo-accumulation index (Igeo ),which show that, based on the Igeo scale, the tidal flat of Haizhou Bay is unpolluted to moderately polluted. | Rui Zhang Fan Zhang Yingjun Ding Jinrong Gao Jing Chen Li Zhou | 2013 | Journal of Environmental Sciences2013，25，7： | 5 |
| 11 | Insight into vitronectin structural evolution on material surface chemistries: The mediation for cell adhesion显示文摘Biomaterial surface chemistry engenders profound consequences on cell adhesion and the ultimate tissue response by adsorbing proteins from extracellular matrix,where vitronectin(Vn)is involved as one of the crucial mediator proteins.Deciphering the adsorption behaviors of Vn in molecular scale provides a useful account of how to design biomaterial surfaces.But the details of structural dynamics and consequential biological effect remain elusive.Herein,both experimental and computational approaches were applied to delineate the conformational and orientational evolution of Vn during adsorption onto self-assembled monolayers(SAMs)terminating with-COOH,-NH2,-CH3 and-OH.To unravel the interplay between cell binding and the charge and wettability of material surface,somatomedin-B(SMB)domain of Vn holding the RGD cell-binding motif was employed in molecular dynamics(MD)simulations,with orientation initialized by Monte Carlo(MC)method.Experimental evidences including protein adsorption,cell adhesion and integrin gene expressions were thoroughly investigated.The adsorption of Vn on different surface chemistries showed very complex profiles.Cell adhesion was enabled on all Vn-adsorbed surfaces but with distinct mechanisms mostly determined by conformational change induced reorientation.Higher amount of Vn was observed on negatively charged surface(COOH)and hydrophobic surface(CH3).However,advantageous orientations defined by RGD loop conditions were only obtained on the charged surfaces(COOH and NH2).Specifically,COOH surface straightened up the Vn molecules and accumulated them into a higher density,whereas CH3 surface squashed Vn and stacked them into higher density multilayer by tracking adsorption but with the RGD loops restrained.These findings may have a broad implication on the understanding of Vn functionality and would help develop new strategies for designing advanced biomaterials. | Tianjie Li Lijing Hao Jiangyu Li Chang Du Yingjun Wang | 2020 | Bioactive Materials2020，5，4： | 4 |
| 12 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 13 | Effects of yttrium and phosphorus on growth and physiological characteristics of Microcystis aeruginosa显示文摘Yttrium is a main kind of rare earth elements(REEs) with wide applications in modern industry and farming. Phosphorus, an essential element of algae, is used as the nutrients and also one of the main factors of eutrophication. To investigate the effects of yttrium and phosphorus on Microcystis aeruginosa(M. aeruginosa), the growth and physiological changes were studied by lab cultured experiments. In the experiment, exogenous yttrium was tested by a concentration gradient(0.0, 0.1, 0.3, 0.5, 1.0 mg/L),meanwhile, phosphorus was tested by three concentrations(0.0, 0.02, 0.2 mg/L). The results show that the contents of chlorophyll a(chl-a) and soluble protein increase compared with the control and they have certain correlation with algal cells density. The growth status of algae is stimulated by initial yttrium concentration <0.3 and 0.2 mg/L phosphorus, while it is inhabited by 0.5 and 1.0 mg/L yttrium. Besides,the activity of superoxide dismutase(SOD) of algae increases with addition of yttrium dose(0-0.3 mg/L)when phosphorus dose is 0.2 mg/L. Furthermore, when yttrium dose is 0.5 and 1.0 mg/L, the vitality of SOD presents a sharp decline. The malondialdehyde(MDA) contents increase with time and addition of yttrium dose, 0.2 mg/L phosphorus weakens the accumulation of MDA. | Yingjun Wang Yuanwei Li Xiaoyu Luo Yin'an Ren En'guang Gao Haojie Gao | 2018 | Journal of Rare Earths2018，36，7： | 4 |
| 14 | Effects of Rat Cytomegalovirus on the Nervous System of the Early Rat Embryo显示文摘The purpose of the study was to investigate the impact of rat cytomegalovirus(RCMV) infection on the development of the nervous system in rat embryos,and to evaluate the involvement of Wnt signaling pathway key molecules and the downstream gene neurogenin 1(Ngn1) in RCMV infected neural stem cells(NSCs).Infection and control groups were established,each containing 20 pregnant Wistar rats.Rats in the infection group were inoculated with RCMV by intraperitoneal injection on the first day of pregnancy.Rat E20 embryos were taken to evaluate the teratogenic rate.NSCs were isolated from E13 embryos,and maintained in vitro.We found:1) Poor fetal development was found in the infection group with low survival and high malformation rates.2) The proliferation and differentiation of NSCs were affected.In the infection group,NSCs proliferated more slowly and had a lower neurosphere formation rate than the control.The differentiation ratio from NSCs to neurons and glial cells was significantly different from that of the control,showed by immunofluorescence staining.3) Ngn1 mRNA expression and the nuclear β-catenin protein level were significantly lower than the control on day 2 when NSCs differentiated.4) The Morris water maze test was performed on 4-week pups,and the infected rats were found worse in learning and memory ability.In a summary,RCMV infection caused abnormalities in the rat embryonic nervous system,significantly inhibited NSC proliferation and differentiation,and inhibited the expression of key molecules in the Wnt/β-catenin signaling pathway so as to affect NSCs differentiation.This may be an important mechanism by which RCMV causes embryonic nervous system abnormalities. | Xiuning Sun YingJun Guan Fengjie Li Xutong Li Xiaowen Wang Zhiyu Guan Kai Sheng Li Yu Zhijun Liu | 2012 | Virologica Sinica2012，27，4： | 4 |
| 15 | Rh-doped PdAg nanoparticles as efficient methanol tolerance electrocatalytic materials for oxygen reduction显示文摘Direct methanol fuel cells(DMFCs)have received extensive attention on their high efficiency,high reliability,and no carbon emission.Unfortunately,the poor methanol tolerance and sluggish oxygen reduction reaction(ORR)at cathode have seriously hindered their further development.Herein we report the synthesis of a new class of Rh-doped PdAg alloy nanoparticles(NPs)for boosting ORR activity with high methanol tolerance capacity concurrently.The ORR mass activity of typical Rh_4Pd_(40)Ag_(56)NPs is 4.2 times higher than that of commercial Pt catalyst.Moreover,it shows a great methanol tolerance capability by maintaining 92.4%in ORR mass activity in alkaline solution with 0.1 mol L^(à1)methanol,against a big decrease of almost 100%for commercial Pt.Even after 30,000 potential cycles with 1.0 mol L^(à1)methanol,Rh_4Pd_(40)Ag_(56)NPs still retain ORR mass activity of up to 68.3%.DFT calculations reveal that excellent ORR performance with excellent methanol tolerance originates the active d-band-pinning engineering for an efficient site-independent electron-transfer.A generalized d-band mediated fine electron-transfer tuning path has blueprinted for effectively minimizing intrinsic ORR barriers with high current density.The present work highlights the key role of Rh doping in enhancing the ORR activity and methanol tolerance ability of PdAg NPs for future high-performance DMFCs. | Yingjun Sun Bolong Huang Nuoyan Xu Yingjie Li Mingchuan Luo Chunji Li Yingnan Qin Lei Wang Shaojun Guo | 2019 | Science Bulletin2019，64，1： | 4 |
| 16 | A wave of Foxp3^(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance显示文摘Newborn animals require tightly regulated local and systemic immune environments to govern the development and maturation of multiple organs/tissues even though the immune system itself is far from mature during the neonatal period.Regulatory T cells(Tregs)are essential for maintaining immune tolerance/homeostasis and modulating inflammatory responses.The features of Tregs in the neonatal liver under steady-state conditions are not well understood.The present study aimed to investigate the phenotype,functions,and significance of neonatal Tregs in the liver.We found a wave of thymus-derived Treg influx into the liver during 1–2 weeks of age.Depletion of these Tregs between days 7 and 11 after birth rapidly resulted in Th1-type liver inflammation and metabolic disorder.More Tregs in the neonatal liver than in the spleen underwent MHC II-dependent activation and proliferation,and the liver Tregs acquired stronger suppressive functions.The transcriptomic profile of these neonatal liver Tregs showed elevated expression of PPARγand T-bet and features of Tregs that utilize lipid metabolic machinery and are capable of regulating Th1 responses.The accumulation of Tregs with unique features in the neonatal liver is critical to ensure self-tolerance and liver maturation. | Mingyang Li Weijia Zhao Yifan Wang Lixue Jin Gaowen Jin Xiuyuan Sun Wei Wang Ke Wang Xi Xu Jie Hao Rong Jin Wenxian Fu Ying Sun Yingjun Chang Xiaojun Huang Xuyu Zhou Hounan Wu Kunshan Zhang Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 17 | Short-working-distance optical imaging system and method for surface detection of underwater structures显示文摘In the surface imaging of underwater structures, long working distance will reduce image quality due to the turbidity of water. To acquire high definition and large field of view(FOV) images for surface detection, a short-working-distance underwater imaging system is proposed based on camera array. A multi-view calibration and rectification method is developed. A look-up table(LUT) method and a multi-resolution spline(MRS) method are applied to stitch array images real-time and seamlessly.Experiments both in the air and in the water are conducted. Strength and weakness of the LUT and MRS methods are discussed.Based on the results, the effectiveness in surface detection of underwater structures is verified. | LIU Cong WANG ChengFei XU YingJun LI Xu LUO ChunHao DAI MeiLing SHAO XinXing HE XiaoYuan | 2018 | Science China(Technological Sciences)2018，61，5： | 4 |
| 18 | Isotopes and Geochronology of the Meixian-type Pb-Zn-(Ag)Deposits,Central Fujian Rift,South China:Implications for Geological Events显示文摘中央福建裂缝是另一新、重要的 volcanogenic 巨大的硫化物 Pb-Zn polymetallic metallogenetic 带。为了发现材料开始和 Meixian 类型 Pb-Zn-Ag 的矿化作用时期,扔,矿石和墙的 S 和 Pb 同位素分析和同位素地球年代学为五主要沉积物摇被讨论。从硫化物矿石的硫同位素的作文在不同存款稍微变化,这被结束,吝啬的价值接近零, 34S 从 ?3.5%到在 +2.0 平均的+5.6%,它显示硫可能从岩浆发源或可能从火山直接爆发或从招待矿石的暴烈的岩石被沥滤。从在大多数存款的矿石的铅显示放射性的开始特性(206Pb/204Pb > 18.140, 207Pb/204Pb > 15.584, 208Pb/204Pb > 38.569 ) 并且矿石的铅同位素值比墙岩石的那些高,它显示铅多半从招待矿石的暴烈的岩石被沥滤。基于同位素数据,二重要 Pb-Zn metallogenesis 中间原生地并且迟了原生地被描出,它是沉积 exhalative metallogenesis (单个锆石 U-Pb ,等时的 Sm-Nd 和标明日期招待矿石的墙岩石的年龄的 Ar-Ar 被计算在 9331788 妈之中)并且 Yanshanian magmatic 热水的附加并且轮流出现的 metallogenesis (恼人的虾锆石 U-Pb 和 Rb-Sr 在 127154 妈之间的等时的年龄)。 | FENG Chengyou ZHANG Dequan LI Daxin SHE Hongquan DONG Yingjun | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 3 |
| 19 | The in situ observation of modelled sea ice drift characteristics in the Bohai Sea显示文摘Sea ice drift is mainly controlled by ocean currents, local wind, and internal ice stress. Information on sea ice motion, especially in situ synchronous observation of an ice velocity, a current velocity, and a wind speed, is of great significance to identify ice drift characteristics. A sea ice substitute, the so-called 'modelled ice', which is made by polypropylene material with a density similar to Bohai Sea ice, is used to complete a free drift experiment in the open sea. The trajectories of isolated modelled ice, currents and wind in the Bohai Sea during non-frozen and frozen periods are obtained. The results show that the currents play a major role while the wind plays a minor role in the free drift of isolated modelled ice when the wind is mild in the Bohai Sea. The modelled ice drift is significantly affected by the ocean current and wind based on the ice–current–wind relationship established by a multiple linear regression. The modelled ice velocity calculated by the multiple linear regression is close to that of the in situ observation, the magnitude of the error between the calculated and observed ice velocities is less than12.05%, and the velocity direction error is less than 6.21°. Thus, the ice velocity can be estimated based on the observed current velocity and wind speed when the in situ observed ice velocity is missing. And the modelled ice of same thickness with a smaller density is more sensitive to the current velocity and the wind speed changes. In addition, the modelled ice drift characteristics are shown to be close to those of the real sea ice, which indicates that the modelled ice can be used as a good substitute of real ice for in situ observation of the free ice drift in the open sea, which helps solve time availability, safety and logistics problems related to in situ observation on real ice. | Yu Yan Wei Gu Yingjun Xu Qian Li | 2019 | Acta Oceanologica Sinica2019，38，3： | 3 |
| 20 | On the surface roughness characteristics of the land fast sea-ice in the Bohai Sea显示文摘The surface roughness characteristics(e.g., height and slope) of sea ice are critical for determining the parameters of an electromagnetic scattering, a surface emission and a surface drag coefficients. It is also important in identifying various ice types, retrieval ice thickness, surface temperature and drag coefficients from remote sensing data. The point clouds(a set of points which are usually defined by X, Y, and Z coordinates that represents the external surface of an object on earth) of land fast ice in five in situ sites in the eastern coast Bohai Sea were measured using a laser scanner-Trimble GX during 2011–2012 winter season. Two hundred and fifty profiles selected from the point clouds of different samples have been used to calculate the height root mean square, height skewness, height kurtosis, slope root mean square, slope skewness and slope kurtosis of them. The root mean square of the height, the root mean square of the slope and the correlation length are about 0.090, 0.075 and 11.74 m, respectively. The heights of 150 profiles in three sites manifest the Gaussian distribution and the slopes of total 250 profiles distributed exponentially. In addition, the fractal dimension and power spectral density profiles were calculated. The results show that the fractal dimension of land fast ice in the Bohai Sea is about 1.132. The power spectral densities of 250 profiles can be expressed through an exponential autocorrelation function. | LIU Chengyu CHAO Jinlong GU Wei LI Lantao XU Yingjun | 2014 | Acta Oceanologica Sinica2014，33，7： | 3 |
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