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| 1 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 2 | Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation:a multicenter study显示文摘The effects of haploidentical rhG-CSF-mobilized blood and marrow transplantation(HBMT) on hematological malignances are well established. Previous prospective single-center studies have demonstrated better survival after HBMT versus haploidentical rhG-CSF-mobilized peripheral blood stem cell transplantation(HPBSCT) for acute leukemia(AL) not in remission(NR) or in more than the second complete remission(>CR2). To test the hypothesis that HBMT is still superior to HPBSCT for patients with AL, multiple myeloma(MM), or non-Hodgkin lymphoma(NHL) in CR1/CR2 and for patients with chronic myeloid leukemia in the first and second chronic phase lacking a matched donor, we designed a propensity score method-based multicenter study.Hematopoietic recovery, acute graft-versus-host disease(aGVHD), and chronic GVHD were comparable between the HBMT group(n=168) and the HPBSCT group(n=42). No significant differences were found in non-relapse mortality rate(20.17%±3.58%and 27.24%±7.16%, P=0.18) or relapse rate(19.96%±3.72% and 28.49%±8.25%, P=0.32) between the HBMT group and the HPBSCT group. HBMT recipients had better overall survival(65.0%±4.2% and 54.2%±8.3%, P=0.037) and disease-free survival(59.9%±4.6% and 44.3%±8.7%, P=0.051). Multivariate analysis showed that HPBSCT was associated with poorer DFS(HR(95%CI), 1.639(0.995–2.699), P=0.052). Our comparisons showed that HBMT was superior to HPBSCT as a post-remission treatment for patients lacking an identical donor. | Xiangyu Zhao Feng Gao Xiaohui Zhang Yu Wang Lanping Xu Kaiyan Liu Xiaosu Zhao Yingjun Chang Han Wei Huan Chen Yuhong Chen Zhengfan Jiang Xiaojun Huang | 2016 | Science China(Life Sciences)2016，59，11： | 7 |
| 3 | Emission of intermediate volatility organic compounds from a ship main engine burning heavy fuel oil显示文摘Intermediate volatility organic compounds(IVOCs)are crucial precursors of secondary organic aerosol(SOA).In this study,gaseous IVOCs emitted from a ship main engine burning heavy fuel oil(HFO)were investigated on a test bench,which could simulate the real-world operations and emissions of ocean-going ships.The chemical compositions,emission factors(EFs)and volatility distributions of IVOC emissions were investigated.The results showed that the main engine burning HFO emitted a large amount of IVOCs,with average IVOC EFs of 20.2-201 mg/kg-fuel.The IVOCs were mainly comprised of unspeciated compounds.The chemical compositions of exhaust IVOCs were different from that of HFO fuel,especially for polycyclic aromatic compounds and alkylcyclohexanes.The volatility distributions of IVOCs were also different between HFO exhausts and HFO fuel.The distinctions in IVOC emission characteristics between HFO exhausts and HFO fuel should be considered when assessing the IVOC emission and related SOA formation potentials from ocean-going ships burning HFO,especially when using fuel-surrogate models. | Haijun Lou Yuejiao Hao Weiwei Zhang Penghao Su Fan Zhang Yingjun Chen Daolun Feng Yifan Li | 2019 | Journal of Environmental Sciences2019，31，10： | 5 |
| 4 | Isotopes and Geochronology of the Meixian-type Pb-Zn-(Ag)Deposits,Central Fujian Rift,South China:Implications for Geological Events显示文摘中央福建裂缝是另一新、重要的 volcanogenic 巨大的硫化物 Pb-Zn polymetallic metallogenetic 带。为了发现材料开始和 Meixian 类型 Pb-Zn-Ag 的矿化作用时期,扔,矿石和墙的 S 和 Pb 同位素分析和同位素地球年代学为五主要沉积物摇被讨论。从硫化物矿石的硫同位素的作文在不同存款稍微变化,这被结束,吝啬的价值接近零, 34S 从 ?3.5%到在 +2.0 平均的+5.6%,它显示硫可能从岩浆发源或可能从火山直接爆发或从招待矿石的暴烈的岩石被沥滤。从在大多数存款的矿石的铅显示放射性的开始特性(206Pb/204Pb > 18.140, 207Pb/204Pb > 15.584, 208Pb/204Pb > 38.569 ) 并且矿石的铅同位素值比墙岩石的那些高,它显示铅多半从招待矿石的暴烈的岩石被沥滤。基于同位素数据,二重要 Pb-Zn metallogenesis 中间原生地并且迟了原生地被描出,它是沉积 exhalative metallogenesis (单个锆石 U-Pb ,等时的 Sm-Nd 和标明日期招待矿石的墙岩石的年龄的 Ar-Ar 被计算在 9331788 妈之中)并且 Yanshanian magmatic 热水的附加并且轮流出现的 metallogenesis (恼人的虾锆石 U-Pb 和 Rb-Sr 在 127154 妈之间的等时的年龄)。 | FENG Chengyou ZHANG Dequan LI Daxin SHE Hongquan DONG Yingjun | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 3 |
| 5 | Black-box testing based on colorful taint analysis显示文摘Software vulnerability detection is one of the most important methods for guaranteeing software security.Two main classes of methods can detect vulnerabilities in binary files:white-box testing and black-box testing.The former needs to construct and solve path constraints to detect vulnerabilities.It has two main drawbacks:path exploding and complexity of constraints.The latter often aimlessly exhausts various inputs to test binary files.This paper combines both testing methods to detect vulnerabilities in binary files.By analyzing the input elements that aect check condition corresponding to a certain check point,we can generate one class of inputs that get to the check point to increase fuzzing eciency.By analyzing the relationship between guard conditions and check condition,the redundant check points are removed.Colorful taint analysis method(CTAM)is proposed to compute guard conditions,which is more ecient than traditional taint analysis method(TTAM).We implemented a prototype and made several experiments on it.The results showed that our method could increase the eciency of black-box testing. | CHEN Kai FENG DengGuo SU PuRui ZHANG YingJun | 2012 | Science China(Information Sciences)2012，55，1： | 3 |
| 6 | Mutual Information Based Codebooks Construction for Natural Scene Categorization显示文摘 | XIE Wenjie XU De TANG Yingjun LIU Shuoyan FENG Songhe | 2011 | Chinese Journal of Electronics2011，20，3： | 3 |
| 7 | Progress of Geological Survey Using Airborne Hyperspectral Remote Sensing Data in the Gansu and Qinghai Regions显示文摘Hyperspectral remote sensing is now a frontier of the remote sensing technology.Airborne hyperspectral remote sensing data have hundreds of narrow bands to obtain complete and continuous ground-object spectra.Therefore,they can be effectively used to identify | ZHAO Yingjun QIN Kai SUN Yu LIU Dechang TIAN Feng PEI Chengkai YANG Yanjie YANG Guofang ZHOU Jiajing | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 8 | Whole-exome sequencing reveals twovariants in thegene in two Chinese patients with left ventricular non-compaction cardiomyopathy显示文摘Importance:Pathogenic variants in theRBM20 gene are associated with aggressive dilated cardiomyopathy(DCM).Recently,RBM20 was found to be associated with left ventricular non-compaction cardiomyopathy(LVNC).Thus far,only five families with LVNC have been reported to carry variants inRBM20.It remains unknown whether the variants inRBM20 associated with DCM can also cause LVNC.Objective:To elucidate the causativeRBM20 variant in two unrelated patients with both LVNC and DCM,and to identify the clinical characteristics associated with variants inRBM20.Methods:Trio whole-exome sequencing(WES)was performed.Variants were filtered and classified in accordance with the guidelines of the American College of Medical Genetics and Genomics(ACMG).Results:We identified two distinctde novo variants inRBM20(one per patient)in these two patients with LVNC.Both variants have been reported in patients with DCM,without the LVNC phenotype.Patient 1 was an 11-year-old girl who had DCM,LVNC,and heart failure;the ratio of noncompacted-to-compacted myocardium was 2.7:1.Ade novo heterozygous variant c.1907G>A(p.Arg636His)in exon 9 was identified in this patient.Patient 2 was a 13-year-old boy who had clinical phenotypes identical to those of Patient 1;the ratio of noncompacted-to-compacted myocardium was 3.2:1 in this patient.WES revealed ade novo heterozygous variant c.1909A>G(p.Ser637Gly)in exon 9.Both variants were previously characterized as pathogenic,and our study classified them as pathogenic variants based on the ACMG guidelines.Interpretation:We found that two patients with LVNC had variants inRBM20.Our results extended the clinical spectrum of the twoRBM20 variants and illustrated that the same variant inRBM20 can cause DCM,with or without the LVNC phenotype. | Qiqing Sun Jun Guo Chanjuan Hao Ruolan Guo Xuyun Hu Yuanying Chen Weili Yang Wei Li Yingjun Feng | 2020 | Pediatric Investigation2020，4，1： | 2 |
| 9 | Emissions of intermediate volatility organic compound from waste cooking oil biodiesel and marine gas oil on a ship auxiliary engine显示文摘Ship auxiliary engines contribute large amounts of air pollutants when at berth.Biodiesel,including that from waste cooking oil(WCO),can favor a reduction in the emission of primary pollutant when used with internal combustion engines.This study investigated the emissions of gaseous intermediate-volatile organic compounds(IVOCs)between WCO biodiesel and marine gas oil(MGO)to further understand the differences in secondary organic aerosol(SOA)production of exhausts.Results revealed that WCO exhaust exhibited similar IVOC composition and volatility distribution to MGO exhaust,despite the differences between fuel contents.While WCO biodiesel could reduce IVOC emissions by 50%as compared to MGO,and thus reduced the SOA production from IVOCs.The compositions and volatility distributions of exhaust IVOCs varied to those of their fuels,implying that fuel-component-based SOA predicting model should be used with more cautions when assessing SOA production of WCO and MGO exhausts.WCO biodiesel is a cleaner fuel comparing to conventional MGO on ship auxiliary engines with regard to the reductions in gaseous IVOC emissions and corresponding SOA productions.Although the tests were conducted on test bench,the results could be considered as representative due to the widely applications of the test engine and MGO fuel on real-world ships. | Penghao Su Yuejiao Hao Zhe Qian Weiwei Zhang Jing Chen Fan Zhang Fang Yin Daolun Feng Yingjun Chen Yifan Li | 2020 | Journal of Environmental Sciences2020，32，5： | 2 |
| 10 | Study of hot electrons generated from intense laser-plasma interaction employing Image Plate显示文摘Image Plate (IP) is convenient to be used and very suitable for radiation detection because of its advantages such as wide dynamic range, high detective quantum efficiency, ultrahigh sensitivity and superior linearity. The function mechanism and characteristics of IP are introduced in this paper. IP was employed in the study of hot electrons generated from intense laser-plasma interaction. The angular distri- bution and energy spectrum of hot electrons were measured with IP in the experi- ments. The results demonstrate that IP is an effective radiation detector for the study of laser-plasma interaction. | LIANG WenXi LI YuTong XU MiaoHua YUAN XiaoHui ZHENG ZhiYuan ZHANG Yi LIU Feng WANG ZhaoHua LI HanMing JIN Zhan WEI ZhiYi ZHAO Wei LI YingJun ZHANG Jie | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，10： | 2 |
| 11 | 3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration显示文摘Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone regeneration.However,the mechanism behind scaffold pore morphology-regulated bone regeneration remains unclear,making the structure design of scaffolds for bone repair challenging.To address this issue,we have carefully assessed diverse cell behaviors of bone mesenchymal stem cells(BMSCs)on theβ-tricalcium phosphate(β-TCP)scaffolds with three representative pore morphologies(i.e.,cross column,diamond,and gyroid pore unit,respectively).Among the scaffolds,BMSCs on theβ-TCP scaffold with diamond pore unit(designated as D-scaffold)demonstrated enhanced cytoskeletal forces,elongated nucleus,faster cell mobility,and better osteogenic differentiation potential(for example,the alkaline phosphatase expression level in D-scaffold were 1.5-2 times higher than other groups).RNA-sequencing analysis and signaling pathway intervention revealed that Ras homolog gene family A(RhoA)/Rho-associated kinase-2(ROCK2)has in-depth participated in the pore morphology-mediated BMSCs behaviors,indicating an important role of mechanical signaling transduction in scaffold-cell interactions.Finally,femoral condyle defect repair results showed that D-scaffold could effectively promote endogenous bone regeneration,of which the osteogenesis rate was 1.2-1.8 times higher than the other groups.Overall,this work provides insights into pore morphology-mediated bone regeneration mechanisms for developing novel bioadaptive scaffold designs. | Qiji Lu Jingjing Diao Yingqu Wang Jianlang Feng Fansen Zeng Yan Yang Yudi Kuang Naru Zhao Yingjun Wang | 2023 | Bioactive Materials2023，，8： | 2 |
| 12 | Artificial heart valves:improved hemocompatibility by titanium oxide coatings prepared by ion beam assisted deposition显示文摘 | Zhang Feng Liu Xianghuai Mao Yingjun | 1998 | Surface and Coatings Technology1998，，： | 1 |
| 13 | Measurements of black and organic carbon emission factors for household coal combustion in China: implication for emission reduction 显示文摘 | CHEN Yingjun ZHI Guorui FENG Yauli | 2009 | Environ Sci Technol2009，43，24： | 1 |
| 14 | A single parameter dynamic searching algorithm for multi-layer neural networks (Part I) 显示文摘 | WANG Xuefeng FENG Yingjun ZHAO Xin | 2008 | International Journal of Innovative Computing Information and Control2008，4，9： | 1 |
| 15 | An E-aluation of Manage- ment Performance about Company Core Competence Based on DEA显示文摘 | Siyong Zhuang Yingjun Feng | 2005 | Journal of Systems Science and In- formation2005，3，2： | 1 |
| 16 | Emission characteristics of carbonaceous particles from various residential coal-stoves in China显示文摘 | ZHI Guorui CHEN Yingjun FENG Yanli | 2008 | Environ Sci Technol2008，42，9： | 1 |
| 17 | A single parameter dynamic searching algorithm for muhi-layer neural networks (Part II) 显示文摘 | WANG Xuefeng ZHAO Xin FENG Yingjun | 2008 | International Journal of Innovative Computing Information and Control2008，4，11： | 1 |
| 18 | Gravity affects the responsiveness of Runx2 to 1, 25-dihydroxyvitamin D3 (VD3)显示文摘 | Feima Guo Zhongquan Dai Feng Wu Zhaoxia Liu Yingjun Tan Yumin Wan Peng Shang Yinghui Li | 2013 | Acta Astronautica2013，，： | 1 |
| 19 | Artificial heart valves:improved hemocompatibility by titanium oxide coatings prepared by ion beam assisted deposition 显示文摘 | Feng Zhang Xianghuai Liu Yingjun | 1998 | Surface and Coatings Technology1998，，： | 1 |
| 20 | Phase II trial of bortezomib plus doxorubicin in hepatocellular carcinoma (E6202): a trial of the Eastern Cooperative Oncology Group显示文摘 | Kristen K. Ciombor Yang Feng Al Bowen Benson Yingjun Su Linda Horton Sarah P. Short John Sae Wook Kauh Charles Staley Mary Mulcahy Mark Powell Katayoun I. Amiri Ann Richmond Jordan Berlin | 2014 | Investigational New Drugs2014，，5： | 1 |
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