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| 1 | All-in-one cellulose based hybrid tribo/piezoelectric nanogenerator显示文摘Aybrid tribo/piezoelectric nanogenerators (HTPENG) have been proven to be highly efficient and versatile as far as the collection and conversion of ambient energy are concerned, and the introduction of flexible and green materials is a key step for their potential applications. Here, we developed a HTPENG by using nitrocellulose nanofibril paper as the triboelectric layer and BaTiCVMWCNT@ bacterial cellulose paper as the piezoelectric layer. The output of the triboelelctric paper has considerable performance as fluorinated ethylene propylene, and the output of piezoelectric paper is more than ten times higher than the BTO/polydimethylsiloxane structure. The integrated outputs of the sandwich structured HTPENG are 18 V and 1.6 pA·cm^-2, which are capable of lighting up three LED bulbs and charging a 1 pF capacitor to 2.5 V in 80 s. In addition, the voltage signal generated by the HTPENG in contact-separation mode can be used for dynamic pressure detection. The linear range of dynamic pressure is from 0.5 to 3 N·cm^-2 with a high sensitivity of 8.276 V·cm^-2·N^-1 and a detection limit of 0.2 N·cm^-2. This work provides new insights into the design and application of cellulose-based hybrid nanogenerators with high flexibility and simple structure. | Ming Li Yang Jie Li-Hua Shao Yilin Guo Xia Cao Ning Wang Zhong Lin Wang | 2019 | Nano Research2019，12，8： | 9 |
| 2 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 3 | Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients with advanced gastric cancer显示文摘Objective: Previous work indicated that aneuploidy of chromosome 8 in circulating tumor cells(CTCs)correlated with therapeutic efficacy for advanced gastric cancer(AGC) patients. In this follow-up study performed on the same population of AGC patients, we investigated whether and how aneuploidy of chromosome 8 in CTCs correlates with patients' clinical prognosis.Methods: The prospective study was performed on 31 patients with newly diagnosed AGC. Previously established integrated subtraction enrichment(SE) and immunostaining-fluorescence in situ hybridization(i FISH)platform was applied to identify, enumerate and characterize CTCs. Quantification of CTCs and analysis of their aneuploidy of chromosome 8 were performed on patients before and after therapy.Results: CTCs were measured in 93.5% of AGC patients, and two CTC subtypes with diverse threshold values were identified, multiploid CTCs with the threshold of ≥2 per 7.5 m L and multiploid plus triploid CTCs with the threshold of ≥4, which were found to significantly correlate with poor progression-free survival(PFS) and overall survival(OS). In particular, patients with ≥10% increased multiploid CTCs after an initial 6 weeks of therapy had poor PFS and OS, whereas improved PFS and OS were observed on those who had ≥10% decreased multiploid CTCs. After adjusting for clinically significant factors, ≥10% increased post-therapy multiploid CTCs was the only independent predictor of PFS and OS.Conclusions: Aneuploidy of CTCs correlates with prognosis of AGC patients. Quantitative comparison monitoring multiploid CTCs before and after therapy may help predict improved or inferior prognosis and chemoresistance. | Yilin Li Xiaotian Zhang Jifang Gong Qiyue Zhang Jing Gao Yanshuo Cao Daisy Dandan Wang Peter Ping Lin Lin Shen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 7 |
| 4 | Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer:a subpopulation analysis of the JACOB trial显示文摘Background:The JACOB trial(NCT01774786)was a double-blinded,placebo-controlled,randomized,multicenter,international,phase III trial evaluating the efficacy and safety of adding pertuzumab to trastuzumab and chemo-therapy in first-line treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic gastric cancer/gastroesophageal junction cancer(GEJC).The aim of this analysis was to investigate efficacy and safety outcomes in the Chinese subpopulation from the JACOB trial.Methods:This post hoc subpopulation analysis included all patients recruited in China's Mainland(n=163;20.9%)between June 2013 and January 2016.The patients were randomly assigned in a 1:1 ratio to receive pertuzumab plus trastuzumab and chemotherapy(pertuzumab group;n=82)or placebo plus trastuzumab and chemotherapy(con-trol group;n=81).Intravenous pertuzumab(840 mg)and trastuzumab(8 mg/kg loading and 6 mg/kg maintenance doses)were given every 3 weeks until disease progression or unacceptable toxicity.Chemotherapy was given as per standard regimens/doses of capecitabine or 5-fluorouracil plus cisplatin.The primary endpoint was overall survival(OS);secondary efficacy endpoints included progression-free survival(PFS),and overall objective response rate(ORR).Results:The median OS was 18.7 months in the pertuzumab group and 16.1 months in the control group(hazard ratio[HR]0.75;95%confidence interval[CI]0.49 to 1.14).The median PFS was 10.5 and 8.6 months in the pertuzumab and control groups,respectively(HR 0.85;95%CI 0.60 to 1.21),and the median ORRs were 68.9%and 55.7%,respectively.The treatment effect in this Chinese subpopulation showed consistency with that in the global ITT population with numerically lower HR for OS and PFS compared with the control group.The safety profiles of the pertuzumab and control groups in this Chinese subpopulation analysis were generally comparable.The most common grade 3-5adverse events were neutropenia,anemia,and leukopenia.However,due to the nature of being a post hoc subgroup analysis,the results presented here are descriptive only and need to be interpreted with caution.Conclusions:OS and PFS were numerically improved by adding pertuzumab to trastuzumab and chemotherapy as first-line treatment in Chinese HER2-positive gastric cancer/GEJC patients,and this regimen demonstrated an acceptable safety profile. | Tianshu Liu Yanru Qin Jin Li Ruihua Xu Jianming Xu Shujun Yang Shukui Qin Yuxian Bai Changping Wu Yixiang Mao Haiyan Wu Yilin Ge Lin Shen | 2019 | Cancer Communications2019，39，1： | 6 |
| 5 | Impact of EV load uncertainty on optimal planning for electric vehicle charging station显示文摘With the development of electric vehicles(EV), there is a huge demand for electric vehicle charging stations(EVCS). The utilization of renewable energy sources(RES) in EVCS can not only decrease the energy fluctuation by participating in peakload reduction of the grid, but also reduce the pollution to the environment by cutting down the use of fossil fuels. In this paper,the optimal planning for grid-connected EVCS with RES is studied by considering EV load uncertainty. Nine scenarios are set based on a different characteristic of EV load to reveal the impact of EV load on net present cost(NPC) and to express the relationship between the optimal capacity and energy flow. Moreover, since electricity price also plays an important role in EVCS planning, an economic comparison between different cases with different electricity prices for peak-valley-flat period is carried out. The results reveal the economic benefits of applying RES in EVCS, and demonstrate that EV load with different characteristics would influence the capacity of each device(PV, battery, converter) in the EVCS optimal planning. | LONG YiLin LI Yong WANG YaHui CAO YiJia JIANG Lin ZHOU YiCheng DENG YouYue NAKANISHI Yosuke | 2021 | Science China(Technological Sciences)2021，64，11： | 3 |
| 6 | Strategies for improving fertilizer phosphorus use efficiency in Chinese cropping systems显示文摘A four-year project,entitled'The mechanisms of fraction transformation and high use efficiency of P fertilizer in Chinese cropping systems'commenced in 2017.The project was established to answer three key questions and looked at 17 cropping systems on ten soils.First,we asked what are the dynamics of transformation,fixation and mobilization of P fertilizers in soil-cropping systems?Second,what are the mechanisms of soil-cropmicrobe interactions by which P fertilizer can be efficiently used?Third,how to manipulate the processes of P use in cropping systems?The targets of this project are(1)to explore the mechanisms of P fixation,the pathways of loss of P availability and the threshold of migration of fertilizer P in the field;(2)to uncover mechanisms by which soil legacy P is mobilized through root physiological and morphological processes and through arbuscular mycorrhizal fungi and P-solubilizing bacteria in rhizosphere and hyphosphere;(3)to estimate the biological potential of crops for high efficiency P absorption and use;(4)to innovate new approaches for improving the efficiency of P fertilizers.The outcomes will provide theoretical support for setting standards for limitation of P fertilizer application rate in the main cropping zones of China. | Gu FENG Jingping GAI Xionghan FENG Haigang LI Lin ZHANG Keke YI Jialong LV Yiyong ZHU Li TANG Yilin LI | 2019 | Frontiers of Agricultural Science and Engineering2019，6，4： | 2 |
| 7 | HER2 discordance between paired primary gastric cancer and metastasis:a meta-analysis显示文摘Background:A number of stuthes have examined human epidermal growth factor receptor 2(HER2)status in primary gastric cancer(GC) and associated metastasis,some showed their great concordance in HER2 expression,but others demonstrated notable discordance.There is still little consensus on HER2 discordance,therefore,a systematic review and meta-analysis was conducted to assess the status on HER2 discordance between primary GC and its paired metastasis.Methods:PubMed,EMBASE,ASCO and The Cochrane Library were searched for stuthes that explored the concordance between primary tumor and metastasis in patients with GC up to 10 March,2014.Data of discordance of HER2 between primary GC and corresponding metastasis were extracted from the publications and random-effects models were used to estimate pooled discordance proportions.Results:Eighteen articles including 1,867 patients were included for the meta-analysis in accordance with the selection criteria.Pooled discordance proportions were 7%[95%confidence interval(CI):5-10%]for HER2 status.Pooled proportions of tumors shifting from positive to negative and from negative to positive were 17%(95%CI:7-29%) and 4%(95%CI:2-6%) respectively.No publication bias was found in the meta-analysis.Conclusions:The discordance of HER2 status is not rare in primary and metastatic GC through our metaanalysis.Prospective stuthes are needed to testify the clinical significance of the discordance of HER2 status. | Zhi Peng Jianling Zou Xiaotian Zhang Yehong Yang Jing Gao Yilin Li Yanyan Li Lin Shen | 2015 | Chinese Journal of Cancer Research2015，27，2： | 2 |
| 8 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 9 | Determination of Arctic melt pond fraction and sea ice roughness from Unmanned Aerial Vehicle (UAV) imagery显示文摘Melt ponds on Arctic sea ice are of great significance in the study of the heat balance in the ocean mixed layer, mass and salt balances of Arctic sea ice, and other aspects of the earth-atmosphere system. During the 7 th Chinese National Arctic Research Expedition, aerial photographs were taken from an Unmanned Aerial Vehicle over an ice floe in the Canada Basin. Using threshold discrimination and three-dimensional modeling, we estimated a melt pond fraction of 1.63% and a regionally averaged surface roughness of 0.12 for the study area. In view of the particularly foggy environment of the Arctic, aerial images were defogged using an improved dark channel prior based image defog algorithm, especially adapted for the special conditions of sea ice images. An aerial photo mosaic was generated, melt ponds were identified from the mosaic image and melt pond fractions were calculated. Three-dimensional modeling techniques were used to generate a digital elevation model allowing relative elevation and roughness of the sea ice surface to be estimated. Analysis of the relationship between the distributions of melt ponds and sea ice surface roughness shows that melt ponds are smaller on sea ice with higher surface roughness, while broader melt ponds usually occur in areas where sea ice surface roughness is lower. | WANG Mingfeng SU Jie LI Tao WANG Xiaoyu JI Qing CAO Yong LIN Long LIU Yilin | 2018 | Advances in Polar Science2018，29，3： | 1 |
| 10 | Heterojunction interface editing in Co/NiCoP nanospheres by oxygen atoms decoration for synergistic accelerating hydrogen and oxygen evolution electrocatalysis显示文摘Controllable designing of well-defined heterojunction nanostructures provides an insightful strategy for accelerating the kinetics of the hydrogen and oxygen evolution reactions(HER/OER),but such task is still challenging.Herein,we proposed a protocol of heterojunction interface editing(HIE)strategy by oxygen atoms decoration for synergistic boosting electrocatalytic HER and OER performances.A novel Co/NiCoP nanospheres(NSs)heterojunction was synthesized by crystal seed template transformation method with Ni_(5)P_(4) microspheres as seeds.The effective oxygen atoms interface editing increased the oxidation state of Co atoms and prolonged the Co-P bond length of Co/NiCoP NSs heterojunction,thus the electron localization on P sites was enhanced,leading to the dramatically elevated HER and OER performances simultaneously.The as-constructed O-Co/NiCoP NSs show excellent electrocatalytic activity with 361 and 430 mV vs.reversible hydrogen electrode(RHE)to arrive high current density of 300 mA·cm^(-2)for HER and OER in 1 M KOH as well as good stability.The proposed HIE concept could provide a new perspective on the catalyst design for energy conversion systems. | Yan Lin Xiaojiao Cui Yilin Zhao Zhicheng Liu Guoxin Zhang Yuan Pan | 2023 | Nano Research2023，16，7： | 1 |
| 11 | Serum levels of TUBB3 correlate with clinical outcome in Chinese patients with advanced gastric cancer receiving first-line paclitaxel plus capecitabine显示文摘 | Jingwei Yu Jing Gao Zhihao Lu Yilin Li Lin Shen | 2012 | Medical Oncology2012，，5： | 1 |
| 12 | MiR-202 inhibits the proliferation and invasion of colorectal cancer by targeting UHRF1显示文摘 | Yilin Lin Zhihua Chen Suyong Lin Yan Zheng Yisu Liu Ji Gao Shaoqin Chen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 1 |
| 13 | An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites显示文摘 | Wentao Shi Chunxiu Liu Yilin Song Nansen Lin Shuai Zhou Xinxia Cai | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 14 | Antioxidant and hypolipidaemic effects of a novel yam-boxthorn noodle in an in vivo murine model显示文摘 | LIN Jinyuan LU Shin LIOU Yilin | 2006 | Food Chemistry2006，94，3： | 1 |
| 15 | Supramolecular electrostatic self-assembly of mesoporous thin-walled graphitic carbon nitride microtubes for highly efficient visible-light photocatalytic activities显示文摘For efficient solar energy conversion,the morphology engineering of hollow graphitic carbon nitride(gC3 N4)is one of the promising approachs benefiting from abundant exposed active sites and short photocarrier transport distances,but is difficult to control on account of easy structural collapse.Herein,a facile supramolecular electrostatic self-assembly strategy has been developed for the first time to fabricate mesoporous thin-walled g-C3N4 microtubes(mtw-CNT)with shell thickness of ca.13 nm.The morphological control of g-C3N4 enhances specific surface area by 12 times,induces stronger optical absorption,widens bandgap by 0.18 e V,improves photocurrent density by 2.5 times,and prolongs lifetimes of charge carriers from bulk to surface,compared with those of bulk g-C3N4.As a consequence,the transformed g-C3N4 exhibits the optimum photocatalytic H2-production rate of 3.99 mmol·h^-1·g^-1(λ>420 nm)with remarkable apparent quantum efficiency of 8.7%(λ=420±15 nm)and long-term stability.Moreover,mtw-CNT also achieves high photocatalytic CO2-to-CO selectivity of 96%(λ>420 nm),much better than those on the most previously reported porous g-C3N4 photocatalysts prepared by the conventional hard-templating and soft-templating methods. | Yilin Chen Xingchen He Dongsheng Guo Yanqin Cai Jingling Chen Yun Zheng Bifen Gao Bizhou Lin | 2020 | Journal of Energy Chemistry2020，29，10： | 1 |
| 16 | Competitive adsorption of binary mixture of Leptospirillum ferriphilum and Aeidithiobacillus caldus onto pyrite 显示文摘 | Song Jian Lin Jianqu Ren Yilin eta| | 2010 | Biotech Biopro Eng2010，15，6： | 1 |
| 17 | Formulations of Some Bit Switching Functions in DES显示文摘In the data encryption standard (DES) algorithm, there exist several bit-switching functions, including permutations, expansion, and permuted choices. They are generally presented in the form of matrixes and realized by using table look-up technique in the implementation of the cryptosystem. This paper presents explicit formulas for the initial permutation IP, its inverse IP-1 , the expansion function E, and the permuted choice PC_1. It also gives the program realizations of these functions in C++ applying these formulas. With the advantage of the omission of the storage space for these matrixes and the tedious inputs of tables in the implementations of DES, our experimental results shows that the explicit formulas are useful in some situations, such as wireless sensor networks where the memory capacity is limited, especially when the size of file for encrypting is not too large, preferably smaller than 256KB. | YOU Lin YANG Yilin WEN Wanli | 2013 | Wuhan University Journal of Natural Sciences2013，18，5： | 1 |
| 18 | Fdoped and ZnO- pillared titanates as visible-light-driven photocatalysts 显示文摘 | Zhang Kezhi Lin Bizhou Chen Yilin | 2011 | Journal of Colloid and Interface Science2011，358，2： | 1 |
| 19 | Divisor Class Halving Algorithms for Genus Three Hyperelliptic Curves显示文摘In an(hyper)elliptic curve cryp to sys tem,the most important operation or the most time-consuming operation is the divisor scalar multiplication which consists of a sequence of doubling(of divisor)and addition(of two divisors).Point halving algorithms for elliptic curve cryptosystem and divisor halving algorithms for genus-2 hyperelliptic curve cryptosystem had been successively put forward to take the place of doubling algorithms for speeding up(hyper)elliptic curve cryptosystem.We present an outline for an algorithm for divisor halving on genus-3 hyperelliptic curves over the binary field and give some explicit formulae for a class of genus-3 curves.Our algorithm improves previously known best doubling algorithms in most cases.A halve-and-add binary method for divisor scalar multiplications is presented. | YOU Lin YANG Yilin GAO Shuhong | 2020 | Chinese Journal of Electronics2020，29，1： | 1 |
| 20 | Semi-empirical estimation for enhancing negative thermal expansion in PbTiO_(3)-based perovskites显示文摘Generally,most materials expand when heated and contract when cooled,whereas negative thermal expansion(NTE)materials are very rare.As a typical NTE material,PbTiO_(3) and related compounds have drawn particular interest in recent years.The discovery of an enhanced NTE system in PbTiO_(3) is beneficial to deepen our understanding of its mechanism and regulate its properties.At present,the method of discriminating an enhanced NTE material based on PbTiO_(3) is not universal.Here,we propose a semi-empirical method through evaluating the average lattice distortion in related systems to estimate the relative coefficient of thermal expansion conveniently.The rationality of the method was verified by the analysis of the 0.6PbTiO_(3)-0.4Bi(Ga_(x)Fe_(1-x))O_(3) system.So far,all PbTiO_(3)-based compounds with enhanced NTE conform well to this method.This method provides the possibility to find more enhanced NTE PbTiO_(3)-based materials. | Tao Yang Longlong Fan Yilin Wang Kun Lin Jun Chen Xianran Xing | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，4： | 1 |
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