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| 1 | Defect-rich MoS2 nanowall catalyst for efficient hydrogen evolution reaction显示文摘为氢进化反应设计有效 electrocatalysts (她的) 由于对干净精力的迫切要求吸引了实质的注意在不久的将来面对精力危机和随后的环境问题。在她的催化剂的大变化之中,铝二硫化物(瞬间 2) 由于它的丰富,低价格,高效率,和明确的催化机制被认为是最著名的催化剂。在这研究,有可控制的厚度的设计缺点的瞬间 2 nanowall (NW ) 催化剂被制作并且展出一显著地提高了她的表演。得益于高度暴露的活跃的边地点和不平的表面由柔韧的 NW 结构伴随了,有优化厚度的充满缺点的瞬间 2 NW 催化剂显示出 85 mV 的 ultralow 发作过电位, 310.6 | Junfeng Xie Haichao Qu Jianping Xin Xinxia Zhang Guanwei Cui Xiaodong Zhang Jian Bao Bo Tang Yi Xie | 2017 | Nano Research2017，10，4： | 8 |
| 2 | Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig显示文摘Background: Betaine affects fat metabolism in animals, but the specific mechanism is still not clear. The purpose of this study was to investigate possible mechanisms of betaine in altering lipid metabolism in muscle tissue in finishing pigs.Methods: A total of 120 crossbred gilts(Landrace × Yorkshire × Duroc) with an average initial body weight of 70.1 kg were randomly allotted to three dietary treatments. The treatments included a corn–soybean meal basal diet supplemented with 0, 1250 or 2500 mg/kg betaine. The feeding experiment lasted 42 d.Results: Betaine addition to the diet significantly increased the concentration of free fatty acids(FFA) in muscle(P < 0.05). Furthermore, the levels of serum cholesterol and high-density lipoprotein cholesterol were decreased(P < 0.05) and total cholesterol content was increased in muscle(P < 0.05) of betaine fed pigs. Experiments on genes involved in fatty acid transport showed that betaine increased expression of lipoprotein lipase(LPL), fatty acid translocase/cluster of differentiation(FAT/CD36), fatty acid binding protein(FABP3) and fatty acid transport protein(FATP1)(P < 0.05). The abundance of fatty acid transport protein and fatty acid binding protein were also increased by betaine(P < 0.05). As for the key factors involved in fatty acid oxidation, although betaine supplementation didn't affect the level of carnitine and malonyl-CoA, betaine increased mR NA and protein abundance of carnitine palmitransferase-1(CPT1)and phosphorylated-AMPK(P < 0.05).Conclusions: The results suggested that betaine may promoted muscle fatty acid uptake via up-regulating the genes related to fatty acid transporter including FAT/CD36, FATP1 and FABP3. On the other hand, betaine activated AMPK and up-regulated genes related to fatty acid oxidation including PPARα and CPT1. The underlying mechanism regulating fatty acid metabolism in pigs supplemented with betaine is associated with the up-regulation of genes involved in fatty acid transport and fatty acid oxidation. | Sisi Li Haichao Wang Xinxia Wang Yizhen Wang Jie Feng | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 8 |
| 3 | Iron polyphthalocyanine sheathed multiwalled carbon nanotubes: A high-performance electrocatalyst for oxygen reduction reaction显示文摘过去的十年为氧减小反应(ORR ) 见证对非宝贵的基于金属的 electrocatalysts 的研究和发展的兴趣的快速的巨浪。直到现在,在酸的电解质的最好的催化剂只是从高温度的热分解的 Fe-N-C-type 材料。尽管有金属的 ORR 活动,酞毒或卟啉 macrocycles 长被知道了,他们的耐久性遗体穷人。在这个工作,我们把这些 macrocycles 用作一个基础开发新奇器官碳的混合材料从在原处用加热方法的低温度的微波的传导性的 multiwalled 碳 nanotube 脚手架上的铁酞毒的聚合。在最佳的 polymerto- 碳比率,混合 electrocatalyst 与潜力(0.80 V ) ,大集体活动(在 0.80 V 的多达 18.0 A/g ) ,和低过氧化物产出的一个积极一半波浪展出优秀 ORR 活动(<3%) 。另外,在聚合物和碳 nanotubes 之间的强壮的电子联合被相信压制 macrocycles 的 demetallization,在酸的显著地改善的骑车的稳定性。我们的学习代表没有高温度的热分解,准备的非宝贵的基于金属的 electrocatalysts 的一个稀罕例子,当为实际应用程序与潜力在酸的媒介举办 ORR 活动时。 | Xinxia wang Bin Wang Jun Zhong Feipeng Zhao Na Han Wenjing Huang Min Zeng Jian Fan Yanguang Li | 2016 | Nano Research2016，9，5： | 7 |
| 4 | A Fully Homomorphic Encryption Scheme with Better Key Size显示文摘Fully homomorphic encryption is faced with two problems now.One is candidate fully homomorphic encryption schemes are few.Another is that the efficiency of fully homomorphic encryption is a big question.In this paper,we propose a fully homomorphic encryption scheme based on LWE,which has better key size.Our main contributions are:(1) According to the binary-LWE recently,we choose secret key from binary set and modify the basic encryption scheme proposed in Linder and Peikert in 2010.We propose a fully homomorphic encryption scheme based on the new basic encryption scheme.We analyze the correctness and give the proof of the security of our scheme.The public key,evaluation keys and tensored ciphertext have better size in our scheme.(2) Estimating parameters for fully homomorphic encryption scheme is an important work.We estimate the concert parameters for our scheme.We compare these parameters between our scheme and Bra 12 scheme.Our scheme have public key and private key that smaller by a factor of about logq than in Bra12 scheme.Tensored ciphertext in our scheme is smaller by a factor of about log2 q than in Bra 12 scheme.Key switching matrix in our scheme is smaller by a factor of about log3 q than in Bra 12 scheme. | CHEN Zhigang WANG Jian ZHANG ZengNian SONG Xinxia | 2014 | China Communications2014，11，9： | 5 |
| 5 | An implantable microelectrode array for simultaneous L-glutamate and electrophysiological recordings in vivo显示文摘L-glutamate,the most common excitatory neurotransmitter in the mammalian central nervous system(CNS),is associated with a wide range of neurological diseases.Because neurons in CNS communicate with each other both electrically and chemically,dualmode(electric and chemical)analytical techniques with high spatiotemporal resolution are required to better understand glutamate function in vivo.In the present study,a silicon-based implantable microelectrode array(MEA)composed of both platinum electrochemical and electrophysiological microelectrodes was fabricated using micro-electromechanical system.In the MEA probe,the electrophysiological electrodes have a low impedance of 0.018 MΩat 1 kHz,and the electrochemical electrodes show a sensitivity of 56 pAμM^(−1) to glutamate and have a detection limit of 0.5μM.The MEA probe was used to monitor extracellular glutamate levels,spikes and local field potentials(LFPs)in the striatum of anaesthetised rats.To explore the potential of the MEA probe,the rats were administered to KCl via intraperitoneal injection.K+significantly increases extracellular glutamate levels,LFP low-beta range(12–18 Hz)power and spike firing rates with a similar temporal profile,indicating that the MEA probe is capable of detecting dual-mode neuronal signals.It was concluded that the MEA probe can help reveal mechanisms of neural physiology and pathology in vivo. | Wenjing Wei Yilin Song Li Wang Song Zhang Jinping Luo Shengwei Xu Xinxia Cai | 2015 | Microsystems & Nanoengineering2015，1，1： | 4 |
| 6 | Small-volume solution current-time behavior study for application in reverse iontophoresis-based non-invasive blood glucose monitoring显示文摘The reverse iontophoresis-based glucose monitoring circumstance is similar to the small-volume solution in which mass diffusion controls the current response of the electrochemical biosensors.In this study,the law of mass transfer in this type of solution was analyzed and a mathematic model was established to depict the current-time behavior of the fabricated planar electrode used in the non-invasive meter designed by ourselves.A small-volume glucose solution was directly constructed on the electrode to simulate the reverse iontophoresis-based sensing condition.The correctness of the model was demonstrated by chronoamperometry.Animal assay was subsequently carried out to verify the practicality of the model in determination of blood glucose.The results processed by the new method accurately traced the authentic value,confirming the advantage of the new method and the potential in clinical analysis. | CHANG LingQian LIU ChunXiu HE YinZeng XIAO HongHui CAI XinXia | 2011 | Science China Chemistry2011，54，1： | 4 |
| 7 | CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells显示文摘Slug,a member of the Snail family of transcriptional repressors,plays a key role in cancer progression,cellular plasticity,and epithelial to mesenchymal transition(EMT).Slug is a fast-turnover protein and its stability is controlled by post-translational modifications.Here,we identified that Slug is acetylated by acetyltransferase CREB-binding protein(CBP)in breast cancer cells.CBP directly interacts with the C-terminal domain of Slug through its catalytic histone acetyltransferase(HAT)domain,leading to acetylation of Slug at lysines 166 and 211.Analysis with acetylation-specific antibodies revealed that Slug is highly acetylated in metastatic breast cancer cells.Notably,Slug acetylation,mediated by CBP at lysines 166 and 211,doubles its halflife and increases its stability.Further,acetylated Slug downregulates the expression of E-cadherin,the epithelial marker,and upregulates the expression of N-cadherin and vimentin,thereby promoting breast cancer cell migration.In conclusion,the present study demonstrates that CBP-mediated Slug acetylation increases its stability,promoting EMT and migration of breast cancer cells. | Xiaoyan Dai Yanli Xin Weizhi Xu Xinxia Tian Xiaofan Wei Hongquan Zhang | 2021 | Science China(Life Sciences)2021，64，4： | 4 |
| 8 | Selective electrochemical production of hydrogen peroxide at zigzag edges of exfoliated molybdenum telluride nanoflakes显示文摘The two-electron reduction of molecular oxygen represents an effective strategy to enable the green,mild and on-demand synthesis of hydrogen peroxide.Its practical viability,however,hinges on the development of advanced electrocatalysts,preferably composed of non-precious elements,to selectively expedite this reaction,particularly in acidic medium.Our study here introduces 2H-MoTe2 for the first time as the efficient non-precious-metal-based electrocatalyst for the electrochemical production ofhydrogen peroxide in acids.We show that exfoliated 2H-MoTe2 nanoflakes have high activity(onset overpotential〜140 mV and large mass activity of 27 A g^-1 at 0.4 V versus reversible hydrogen electrode),great selectivity(H2O2 percentage up to 93%)and decent stability in 0.5 M H2SO4.Theoretical simulations evidence that the high activity and selectivity of 2H-MoTe2 arise from the proper binding energies of HOO*and O*at its zigzag edges that jointly favor the two-electron reduction instead of the four-electron reduction of molecular oxygen. | Xuan Zhao Yu Wang Yunli Da Xinxia Wang Tingting Wang Mingquan Xu Xiaoyun He Wu Zhou Yafei Li Jonathan NColeman Yanguang Li | 2020 | National Science Review2020，7，8： | 3 |
| 9 | Low sample volume origami-paper-based graphene-modified aptasensors for label-free electrochemical detection of cancer biomarker-EGFR显示文摘In this work,an electrochemical paper-based aptasensor was fabricated for label-free and ultrasensitive detection of epidermal growth factor receptor(EGFR)by employing anti-EGFR aptamers as the bio-recognition element.The device used the concept of paper-folding,or origami,to serve as a valve between sample introduction and detection,so reducing sampling volumes and improving operation convenience.Amino-functionalized graphene(NH 2-GO)/thionine(THI)/gold particle(AuNP)nanocomposites were used to modify the working electrode not only to generate the electrochemical signals,but also to provide an environment conducive to aptamer immobilization.Electrochemical characterization revealed that the formation of an insulating aptamer–antigen immunocomplex would hinder electron transfer from the sample medium to the working electrode,thus resulting in a lower signal.The experimental results showed that the proposed aptasensor exhibited a linear range from 0.05 to 200 ngmL^(−1)(R^(2)=0.989)and a detection limit of 5pgmL^(−1) for EGFR.The analytical reliability of the proposed paper-based aptasensor was further investigated by analyzing serum samples,showing good agreement with the gold-standard enzyme-linked immunosorbent assay. | Yang Wang Shuai Sun Jinping Luo Ying Xiong Tao Ming Juntao Liu Yuanyuan Ma Shi Yan Yue Yang Zhugen Yang Julien Reboud Huabing Yin Jonathan MCooper Xinxia Cai | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 10 | Significantly influenced photocatalytic performance for H_(2)O_(2)generation over ultrathin g-C_(3)N_(4)through regulating the migration orientation of photogenerated charge carriers显示文摘H_(2)O_(2)has been widely applied in the fields of chemical synthesis,medical sterilization,pollutant removal,etc.,due to its strong oxidizing property and the avoidable secondary pollution.Despite of the enhanced performance for H_(2)O_(2)generation over g-C_(3)N_(4)semiconductors through promoting the separation of photo-generated charge carriers,the effect of migration orientation of charge carriers is still ambiguous.For this emotion,surface modification of g-C_(3)N_(4)was employed to adjust the migration orientation of charge carriers,in order to investigate systematically its effect on the performance of H_(2)O_(2)generation.It was found that ultrathin g-C_(3)N_(4)(UCN)modified by boron nitride(BN),as an effective hole-attract agent,demonstrated a significantly enhanced performance.Particularly,for the optimum UCN/BN-40%catalyst,4.0-fold higher yield of H_(2)O_(2)was obtained in comparison with the pristine UCN.As comparison,UCN modified by carbon dust demonstrated a completely opposite tendency.The remarkably improved performance over UCN/BN was ascribed to the fact that more photo-generated electrons were remained inside of triazine structure of g-C_(3)N_(4),leading to the formation of larger amount of 1,4-endoxide.It is anticipated that our work could provide new insights for the design of photocatalyst with significantly improved performance for H_(2)O_(2)generation. | Xinxia He Hongyan Shang Chuan Wang Le Chen Zehan Gong Jun Wang Shilin Zhao Jun Ma | 2021 | Chinese Chemical Letters2021，32，11： | 2 |
| 11 | Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays显示文摘Parkinson’s disease(PD)is characterized by a progressive degeneration of nigrostriatal dopaminergic neurons.The precise mechanisms are still unknown.Since the neuronal communications are inherently electrical and chemical in nature,dual-mode detection of PD-related neuroelectrical and neurochemical information is essential for PD research.Subthalamic nucleus(STN)highfrequency stimulation(HFS)can improve most symptoms of PD patients and decrease the dosage of antiparkinsonian drugs.The mechanism of STN-HFS for PD still remains elusive.In this study,a silicon-based dual-mode microelectrode array(MEA)probe was designed and fabricated,and systematic dual-mode detection methods were established.The recording sites were modified using Pt nanoparticles and Nafion to improve the signal-to-noise(SNR)ratio.To evaluate its applicability to PD research,in vivo electrophysiological and electrochemical detection was performed in normal and hemiparkinsonian models,respectively.Through comparison of the dual-mode signals,we demonstrated the following in a PD monkey:(1)the maximum dopamine concentration in the striatum decreased by 90%;(2)the spike firing frequency increased significantly,especially in the region of the cortex;(3)the spectrogram analysis showed that much power existed in the 0–10 Hz frequency band;and(4)following repeated subthalamic nucleus high-frequency stimulation trials,the level of DA in the striatum increased by 16.5μM,which led to a better elucidation of the mechanism of HFS.The dual-mode MEA probe was demonstrated to be an effective tool for the study of neurological disorders. | Song Zhang Yilin Song Mixia Wang Guihua Xiao Fei Gao Ziyue Li Guoxian Tao Ping Zhuang Feng Yue Piu Chan Xinxia Cai | 2018 | Microsystems & Nanoengineering2018，4，1： | 2 |
| 12 | Species-specific aminoacylation of Oryza sativa mitochondrial tRNA^(Trp)显示文摘Abstract The details of species- spe- cific aminoacylation in Oryza sativa mitochondrial tRNATrp by bacterial and eukaryotic (cytoplasm) tryptophanyl-tRNA synthetases (TrpRS) were inves- tigated. Seven single or multiple mutations of three bases (G73, U72, A 68) were made in O. sativa mi- tochondrial tRNATrp to the corresponding nucleotides present in human tRNATrp. In vitro transcripts of these mutant genes were tryptophanylated by Bacil- lus subtilis and human tryptophanyl-tRNA syntheta- ses (TrpRS), and the kinetic parameters were deter- mined. The results showed that the aminoacylation of seven mutant transcripts by B. subtilis TrpRS was 53.33%―99.79% less efficient than that by wild-type O. sativa mitochondrial tRNATrp, but was 4―330 times more efficient than that by human TrpRS. The mutant MPH7 (G73, U72 and C68 in O. sativa mito- chondrial tRNA were all replaced by the counterpart residues from human tRNATrp and showed a great change in aminoacylation efficiency. Our results in- dicate that the species-specific identity elements of O. sativa mitochondrial tRNATrp are similar to bacterial and eukaryotic (cytoplasm). They are mainly located at the discriminator base, the first and the fifth pairs of bases, the discriminator base G73, two bases in the acceptor stem G1/U72 and U5/A68. Our results also provide new data in support of the hypothesis that mitochondrial tRNATrp is of eubacterial origin. | JIN Xiaoling TAO Zhijian JIA Jie HE Xinxia JIN Youxin | 2006 | Chinese Science Bulletin2006，51，7： | 2 |
| 13 | Rapid detection of Cyfra 21-1 by optical-biosensing based on chemiluminescence immunoassay using bio-functionlized magnetic nanocomposites显示文摘This letter reports a chemiluminescene immunoassay method combined with immunomagnetic separation to rapidly detect Cyfra 21-1, in which bio-functionlized magnetic nanocomposites were used as mobile substrate for capturing and isolating the cyfra 21-1 proteins. After the captured Cyfra 21-1 further reacted with horseradish peroxidase-conjugated anti-Cyfra 21-1 antibody to form a sandwich immunocomplex, the chemiluminescence would be produced as a result of addition of the chemiluminescent substrate. A home-made optical biosensor was designed to detect the chemiluminescence instead of other large instruments. There is a good linear response between the chemiluminescence intensity and the concentration of Cyfra 21-1 in the range from 0.2 to 50 ng/mL. The whole detection process including incubation, washing and detection could be performed within 45 min. The proposed method offers a simple, noninvasive and reliable tool for detecting non-small cell lung cancer and has potential application for clinical testing. | LUO JinPing QU ShuXue LIU JunTao WANG Bin CAI XinXia | 2013 | Chinese Science Bulletin2013，58，21： | 2 |
| 14 | University teaching management reform mindset显示文摘 | Yu Xinxia | 2011 | IEEE2011，，： | 1 |
| 15 | A feasibility study of virtual slides in surgical pathology in China 显示文摘 | Xinxia L Jianying L Haixia X | 2007 | Hu- man Pathology2007，38，12： | 1 |
| 16 | Key technologies of precision demolition blasting of ultra-long urban viaduct in complicated surroundings显示文摘The key technologies of precision blasting were put forward based on the characteristics of urban viaduct blasting demolition in complicated surroundings.Initial bending instability mechanics model of reinforcing steel bar frame of blasting fragmented pier and sequenced collapsed dynamic model were established for quantitative blasting design.Technologies of water pressure blasting were applied in multi-cell box girder fragmentation.The detonating network of non-electric duplication crossover was adopted for the safety and reliability of ultra-long delay.The rationality of blasting scheme and parameters were validated by physical model test.Harmful effects were forecasted and controlled by integrated protective technologies.Specialization,cooperation,precision,execution(SCPE) project management method was put forward for precision management.The key technologies of precision demolition blasting can provide reference for similar projects. | Xie Xianqi Jia Yongsheng Yao Yingkang Sun Jinshan Wu Xinxia Liu Changbang | 2014 | Engineering Sciences2014，12，6： | 1 |
| 17 | Effect of Oxygen and Bacteria on the Property of Polymer Gel显示文摘Cr3+ , Al3+ ,和在厌氧、氧气的环境的复合离子 cross-linked 聚合物胶化答案的粘性性质被调查瞄准遇见油领域的实际需求。在在厌氧、氧气的环境增加 biocide 和冻结以后保留效果的粘性也在论文被学习。结果显示在氧气的环境生产的水引起的 cross-linked 聚合物胶化答案的粘性在厌氧的环境比那高,并且在增加 biocides 以后的 cross-linked 聚合物胶化答案的粘性价值改善了到某程度和聚合物胶化,这在厌氧的环境有胶化 ated 很好。 | Weidong Jiang Xiangguo Lu Xinxia Xu | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 1 |
| 18 | Miniaturized electroanalytical sensor systems in micromachined structures 显示文摘 | Cai Xinxia Andrew G Jonathan M C | 2000 | Electroanalysis2000，12，9： | 1 |
| 19 | Unique signatures of long noncoding RNA expression in response to virus infection and altered in- nate immune signaling显示文摘 | Peng Xinxia Gralinski L Armour C D | 2010 | MBio2010，1，5： | 1 |
| 20 | Minia turized electroa-nalytical sensor systems in mieroma chined structures显示文摘 | Cai Xinxia Andrew G Jonathan M C | 2000 | Electro-analysis2000，12，9： | 1 |
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