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| 1 | Temporal variations and source apportionment of volatile organic compounds at an urban site in Shijiazhuang, China显示文摘Shijiazhuang,the city with the worst air quality in China,is suffering from severe ozone pollution in summer.As the key precursors of ozone generation,it is necessary to control the Volatile Organic Compounds(VOCs)pollution.To have a better understanding of the pollution status and source contribution,the concentrations of 117 ambient VOCs were analyzed from April to August 2018 in an urban site in Shijiazhuang.Results showed that the monthly average concentration of total VOCs was 66.27 ppbv,in which,the oxygenated VOCs(37.89%),alkanes(33.89%),and halogenated hydrocarbons(13.31%)were the main composite on.Eight major sources were identified using Positive Matrix Factorization modeling with an accurate VOCs emission inventory as inter-complementary methods revealed that the petrochemical industry(26.24%),other industrial sources(15.19%),and traffic source(12.24%)were the major sources for ambient VOCs in Shijiazhuang.The spatial distributions of major industrial activities emissions were identified by using geographic information statistics system,which illustrated the VOCs was mainly from the north and southeast of Shijiazhuang.The inverse trajectory analysis using Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)and Potential Source Contribution Function(PSCF)clearly demonstrated the features of pollutant transport to Shijiazhuang.These findings can provide references for local governments regarding control strategies to reduce VOCs emissions. | Yanan Guan Lei Wang Shujuan Wang Yihao Zhang Jieying Xiao Xiaoli Wang Erhong Duan Li'an Hou | 2020 | Journal of Environmental Sciences2020，32，11： | 19 |
| 2 | How far is Lignin from being a biomedical material?显示文摘Lignin is a versatile biomass that possesses many different desirable properties such as antioxidant,antibacterial,anti-UV,and good biocompatibility.Natural lignin can be processed through several chemical processes.The processed lignin can be modified into functionalized lignin through chemical modifications to develop and enhance biomaterials.Thus,lignin is one of the prime candidate for various biomaterial applications such as drug and gene delivery,biosensors,bioimaging,3D printing,tissue engineering,and dietary supplement additive.This review presents the potential of developing and utilizing lignin in the outlook of new and sustainable biomaterials.Thereafter,we also discuss on the challenges and outlook of utilizing lignin as a biomaterial. | Sigit Sugiarto Yihao Leow Chong Li Tan Guan Wang Dan Kai | 2022 | Bioactive Materials2022，7，2： | 9 |
| 3 | Angiotensin Ⅱ upregulates fibroblastmyofibroblast transition through Cx43- dependent CaMKⅡ and TGF-β1 signaling in neonatal rat cardiac fibroblasts显示文摘 | Li Cao Yunlin Chen Li Lu Yihao Liu Yaowen Wang Jinqi Fan Yuehui Yin | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 6 |
| 4 | The calcium-dependent protein kinase ZmCDPK7 functions in heat-stress tolerance in maize显示文摘Global warming poses a serious threat to crops.Calcium-dependent protein kinases(CDPKs)/CPKs play vital roles in plant stress responses,but their exact roles in plant thermotolerance remains elusive.Here,we explored the roles of heat-induced ZmCDPK7 in thermotolerance in maize.ZmCDPK7-overexpressing maize plants displayed higher thermotolerance,photosynthetic rates,and antioxidant enzyme activity but lower H2 O2 and malondialdehyde(MDA)contents than wild-type plants under heat stress.ZmCDPK7-knockdown plants displayed the opposite patterns.ZmCDPK7 is attached to the plasma membrane but can translocate to the cytosol under heat stress.ZmCDPK7 interacts with the small heat shock protein sHSP17.4,phosphorylates sHSP17.4 at Ser-44 and the respiratory burst oxidase homolog RBOHB at Ser-99,and up regulates their expression.Site-directed mutagenesis of sHSP17.4 to generate a Ser-44-Ala substitution reduced ZmCDPK7’s enhancement of catalase activity but enhanced ZmCDPK7’s suppression of MDA accumulation in heat-stressed maize protoplasts.sHSP17.4,ZmCDPK7,and RBOHB were less strongly upregulated in response to heat stress in the abscisic acid-deficient mutant vp5 versus the wild type.Pretreatment with an RBOH inhibitor suppressed sHSP17.4 and ZmCDPK7 expression.Therefore,abscisic acid-induced ZmCDPK7 functions both upstream and downstream of RBOH and participates in thermotolerance in maize by mediating the phosphorylation of sHSP17.4,which might be essential for its chaperone function. | Yulong Zhao Hanwei Du Yankai Wang Huali Wang Shaoyu Yang Chaohai Li Ning Chen Hao Yang Yihao Zhang Yulin Zhu Luyao Yang Xiuli Hu | 2021 | Journal of Integrative Plant Biology2021，63，3： | 6 |
| 5 | HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-β-induced epithelial-mesenchymal transition显示文摘Smad2 和 Smad3,转变发信号的生长因素(TGF-) 的细胞内部的调停人,直接由激活的类型的 phosphorylated 我从进原子核到的细胞质的受体 kinase,然后梭调整目标基因表示。这里,我们报导 70-kDa 热吃惊蛋白质(HSP70 ) 与 Smad2 和减少 TGF- 信号 transduction 交往。HSP70 的宫外的表示阻止受体依赖者 phosphorylation 和 Smad2 的原子 translocation,并且堵住 TGF -- 在 HaCat 房间的导致的上皮间充质的转变(EMT ) 。我们的调查结果在 TGF 揭示 HSP70 的一个必要角色 -- 由阻碍 Smad2 phosphorylation 的导致的上皮间充质的转变(EMT ) 。 | Yihao Li Xianjiang Kang Qiang Wang | 2011 | Journal of Genetics and Genomics2011，38，3： | 5 |
| 6 | Recent progression and future perspectives in cotton genomic breeding显示文摘Upland cotton is an important global cash crop for its long seed fibers and high edible oil and protein content.Progress in cotton genomics promotes the advancement of cotton genetics,evolutionary studies,functional genetics,and breeding,and has ushered cotton research and breeding into a new era.Here,we summarize high-impact genomics studies for cotton from the last 10 years.The diploid Gossypium arboreum and allotetraploid Gossypium hirsutum are the main focus of most genetic and genomic studies.We next review recent progress in cotton molecular biology and genetics,which builds on cotton genome sequencing efforts,population studies,and functional genomics,to provide insights into the mechanisms shaping abiotic and biotic stress tolerance,plant architecture,seed oil content,and fiber development.We also suggest the application of novel technologies and strategies to facilitate genome-based crop breeding.Explosive growth in the amount of novel genomic data,identified genes,gene modules,and pathways is now enabling researchers to utilize multidisciplinary genomics-enabled breeding strategies to cultivate'super cotton',synergistically improving multiple traits.These strategies must rise to meet urgent demands for a sustainable cotton industry. | Zhaoen Yang Chenxu Gao Yihao Zhang Qingdi Yan Wei Hu Lan Yang Zhi Wang Fuguang Li | 2023 | Journal of Integrative Plant Biology2023，65，2： | 3 |
| 7 | Chronic fatigue syndrome treated by the traditional Chinese proce-dure abdominal tuina:a randomized controlled clinical trial显示文摘OBJECTIVE: To evaluate the effect of the traditional Chinese procedure abdominal Tuina(AT) on chronic fatigue syndrome(CFS).METHODS: This randomized, single assessor-blinded clinical trial was carried out from May 2014 to April 2015. Eighty participants in the trial were divided randomly into two groups: experimental group and control. The experimental group(40 cases) was treated by AT and the control group(40 cases) by acupuncture. Each treatment was conducted once a day, 5 d for one course, at an interval of 2 d between each course. The whole treatment course lasted for 4 weeks. To ascertain the effect of AT and acupuncture, Fatigue Scale-14(FS-14), Self-rating Anxiety Scale(SAS) and Hamilton Rating Scale for Depression(HAMD) scores were used before and after treatment. Patients were followed up for3 months after treatment.RESULTS: After treatment for 4 weeks, 77 patients(39 cases in the experimental group and 38 cases in the control group) completed the trial. The FS-14,SAS and HAMD scores decreased(P < 0.05) significantly compared with those before treatment in both groups. The FS-14 and HAMD(P < 0.05) scores in the experimental group were much lower than those in the control group. The difference in SAS scores between the two groups was not significant.In the final follow-up, CFS in two cases in the experimental group and three in the control group recurred, but the difference was not significant. The scores for the FS-14, SAS and HAMD in the experimental group were superior to those of the control group, and the difference was significant(P < 0.05).No serious adverse events and few adverse events were observed.CONCLUSION: AT elicited a more efficacious effect than acupuncture alone on CFS. | Li Huanan Wang Jingui Zhang Wei Zhao Na Hai Xinhua Sun Shiquan Sun Qing Han Yihao Zhang Runchen Ma Fei | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 8 | BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas显示文摘Objective:BYSL,which encodes the Bystin protein in humans,is upregulated in reactive astrocytes following brain damage and/or inflammation.We aimed to determine the role and mechanism of BYSL in glioma cell growth and survival.Methods:BYSL expression in glioma tissues was measured by quantitative real-time PCR,Western blot,and immunohistochemistry.In vitro assays were performed to assess the role of BYSL in cell proliferation and apoptosis.Protein interactions and co-localization were determined by co-immunoprecipitation and double immunofluorescence.The expression and activity of the AKT/m TOR signaling molecules were determined by Western blot analysis,and the role of BYSL in glioma growth was confirmed in an orthotopic xenograft model.Results:The BYSL m RNA and protein levels were elevated in glioma tissues.Silencing BYSL inhibited glioma cell proliferation,impeded cell cycle progression,and induced apoptosis,whereas overexpressing BYSL protein led to the opposite effects.We identified a complex consisting of BYSL,RIOK2,and m TOR,and observed co-localization and positive correlations between BYSL and RIOK2 in glioma cells and tissues.Overexpressing BYSL or RIOK2 increased the expression and activity of AKT/m TOR signaling molecules,whereas downregulation of BYSL or RIOK2 decreased the activity of AKT/m TOR signaling molecules.Silencing BYSL or RIOK2 decreased the growth of the tumors and prolonged the lifespan of the animals in an orthotopic xenograft model.Conclusions:High expression of BYSL in gliomas promoted tumor cell growth and survival both in vitro and in vivo.These effects could be attributed to the association of BYSL with RIOK2 and m TOR,and the subsequent activation of AKT signaling. | Shangfeng Gao Zhuang Sha Junbo Zhou Yihao Wu Yunnong Song Cheng Li Xuejiao Liu Tong Zhang Rutong Yu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 9 | Network Protocol Recognition Based on Convolutional Neural Network显示文摘How to correctly acquire the appropriate features is a primary problem in network protocol recognition field.Aiming to avoid the trouble of artificially extracting features in traditional methods and improve recognition accuracy,a network protocol recognition method based on Convolutional Neural Network(CNN)is proposed.The method utilizes deep learning technique,and it processes network flows automatically.Firstly,normalization is performed on the intercepted network flows and they are mapped into two-dimensional matrix which will be used as the input of CNN.Then,an improved classification model named Ptr CNN is built,which can automatically extract the appropriate features of network protocols.Finally,the classification model is trained to recognize the network protocols.The proposed approach is compared with several machine learning methods.Experimental results show that the tailored CNN can not only improve protocol recognition accuracy but also ensure the fast convergence of classification model and reduce the classification time. | Wenbo Feng Zheng Hong Lifa Wu Menglin Fu Yihao Li Peihong Lin | 2020 | China Communications2020，17，4： | 2 |
| 10 | Exploratory Application of X-ray Photography in the Diagnosis of Poultry Fatty Liver显示文摘[Objectives]This study was conducted to explore the application value of X ray in the diagnosis of poultry fatty liver.[Methods]Serum biochemical tests were performed on laying hens with suspected fatty liver.The X-ray liver images of the left lateral position were observed.And the liver traits were observed by anatomy.[Results]The increase in liver space occupying lesion observed by X-ray photography was consistent with the increase in liver volume observed by anatomy.The biochemical test showed slight liver function abnormalities.[Conclusions]X-ray examination can be used for the auxiliary diagnosis of poultry fatty liver. | Yiqi ZHANG Jiao LI Jintang LUO Dongxu WANG Yuanqing ZHONG Yihao ZHANG Suohua ZHAO | 2019 | Agricultural Biotechnology2019，8，4： | 2 |
| 11 | Protocol Format Extraction Based on an Improved CFSM Algorithm显示文摘As the information technology rapidly develops,many network applications appear and their communication protocols are unknown.Although many protocol keyword recognition based protocol reverse engineering methods have been proposed,most of the keyword recognition algorithms are time consuming.This paper firstly uses the traffic clustering method F-DBSCAN to cluster the unknown protocol traffic.Then an improved CFSM(Closed Frequent Sequence Mining)algorithm is used to mine closed frequent sequences from the messages and identify protocol keywords.Finally,CFGM(Closed Frequent Group Mining)algorithm is proposed to explore the parallel,sequential and hierarchical relations between the protocol keywords and obtain accurate protocol message formats.Experimental results show that the proposed protocol formats extraction method is better than Apriori algorithm and Sequence alignment algorithm in terms of time complexity and it can achieve high keyword recognition accuracy.Additionally,based on the relations between the keywords,the method can obtain accurate protocol formats.Compared with the protocol formats obtained from the existing methods,our protocol format can better grasp the overall structure of target protocols and the results perform better in the application of protocol reverse engineering such as fuzzing test. | Peihong Lin Zheng Hong Lifa Wu Yihao Li Zhenji Zhou | 2020 | China Communications2020，17，11： | 1 |
| 12 | On the symplectic superposition method for free vibration of rectangular thin plates with mixed boundary constraints on an edge显示文摘A novel symplectic superposition method has been proposed and developed for plate and shell problems in recent years.The method has yielded many new analytic solutions due to its rigorousness.In this study,the first endeavor is made to further developed the symplectic superposition method for the free vibration of rectangular thin plates with mixed boundary constraints on an edge.The Hamiltonian system-based governing equation is first introduced such that the mathematical techniques in the symplectic space are applied.The solution procedure incorporates separation of variables,symplectic eigen solution and superposition.The analytic solution of an original problem is finally obtained by a set of equations via the equivalence to the superposition of some elaborated subproblems.The natural frequency and mode shape results for representative plates with both clamped and simply supported boundary constraints imposed on the same edge are reported for benchmark use.The present method can be extended to more challenging problems that cannot be solved by conventional analytic methods. | Dian Xu Zhuofan Ni Yihao Li Zhaoyang Hu Yu Tian Bo Wang Rui Li | 2021 | Theoretical & Applied Mechanics Letters2021，11，5： | 1 |
| 13 | 2 μm optical frequency comb generation via optical parametric oscillation from a lithium niobate optical superlattice box resonator显示文摘Optical parametric oscillators(OPOs) can downconvert the pump laser to longer wavelengths with octave separation via χ^((2)), which is widely used for laser wavelength extension including mid-infrared(MIR) generation.Such a process can be integrated in monolithic resonators, being compact and low in threshold. In this work, we show that the monolithic χ^((2))mini-OPO can also be used for optical frequency comb generation around 2096 nm and enters the boundary of MIR range. A new geometry called an optical superlattice box resonator is developed for this realization with near-material-limited quality factor of 4.0 × 10^(7). Only a continuous-wave near-infrared pump laser is required, with OPO threshold of 80 mW and output power up to 340 mW. Revival temporal profiles are measured at a detectable repetition frequency of 1.426 GHz, and narrow beat note linewidth of less than 10 Hz shows high comb coherence. These results are in good agreement with our simulation for a stable comb generation. Such an OPO-based comb source is useful for carbon dioxide sensing or the mine prospect applications and can be generalized to longer MIR wavelengths for general gas spectroscopy. | Xiaohan Wang Kunpeng Jia Mengwen Chen Shanshan Cheng Xin Ni Jian Guo Yihao Li Huaying Liu Liyun Hao Jian Ning Gang Zhao Xinjie Lv Shu-Wei Huang Zhenda Xie Shi-Ning Zhu | 2022 | Photonics Research2022，10，2： | 1 |
| 14 | The effects of Fructus Aurantii extract on the 5-hydroxytryptamine and vasoactive intestinal peptide contents of the rat gastrointestinal tract显示文摘 | Yihao Jiang Xiaowu Bai Xiaoling Zhu Jing Li | 2014 | Pharmaceutical Biology2014，，5： | 1 |
| 15 | Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia显示文摘 | Hong Yu Jiangbo Zhang Rong Fu Hui Liu Huaquan Wang Kai Ding Yihao Wang Lijuan Li Honglei Wang Zonghong Shao Dimitrios P. Bogdanos | 2013 | Clinical and Developmental Immunology2013，，： | 1 |
| 16 | Brassinosteroid and gibberellin coordinate rice seed germination and embryo growth by regulating glutelin mobilization显示文摘Seed germination is the beginning of a new lifecycle,and involves many complex physiological and biochemical reactions including seed reserve mobilization in the endosperm and nutrient transport and reuse in the embryo.Although glutelin is a dominant storage protein in rice,its contribution to seed germination and its regulatory mechanisms are mostly unknown.Gibberellin (GA) and brassinosteroid (BR),two major growth-promoting phytohormones,also play positive roles in controlling seed germination.However,how GA and BR interact and coordinate seed germination and facilitate glutelin mobilization remains unclear.In the present study,biochemical and physiological analyses of seed germination indicated that both GA and BR promote seed germination and post-germination growth.Exogenous application of GA restored germination defects caused by BR deficiency or insensitivity.Proteomic and q RT-PCR results showed that the expression of several glutelin proteins and their encoding genes was induced by BR and GA in the embryo.Expression assays suggested that the increased accumulation of glutelin protein in the embryo was due to the accelerated degradation of glutelin by a cysteine proteinase (REP-1) in the endosperm.The breakdown of glutelin in the endosperm showed a strict positive correspondence with the length of the shoot.The GluA2 mutation led to reduced degradation rate of glutelin and defects in seed germination,and the promotion effect of GA on seed germination was weakened in the glua2mutant.In vitro culture assay of rice embryos showed that glutelin mobilization functioned downstream of the GA and BR pathways to promote shoot elongation.These findings suggest a mechanism that mediates crosstalk between BR and GA in co-regulating rice seed germination and embryo growth. | Min Xiong Lingyi Chu Qianfeng Li Jiawen Yu Yihao Yang Peng Zhou Yong Zhou Changquan Zhang Xiaolei Fan Dongsheng Zhao Changjie Yan Qiaoquan Liu | 2021 | The Crop Journal2021，9，5： | 1 |
| 17 | Optimization of hot air drying process for tiger nut and analysis of fatty acid composition of tiger nut oil显示文摘Hot air temperature,hot air humidity,and hot wind speed were selected as independent variables of quadratic orthogonal rotation combination test design through single factor test.Drying time,energy consumption,chromatism value,luminosity value,hardness,rehydration ratio,and other indexes of the product were used as the response value of the test.Response surface methodology(RSM)was used to analyze the effects of independent variables on the quality of tiger nut(Cyperus esculentus L.),and the process parameters were combined and optimized.The results show that the suitable technological conditions for hot air drying of tiger nut are as follows:hot air temperature of 63.15°C,hot air humidity of 44.92%,hot air wind speed of 2.48 m/s.Under these conditions,the product has the advantages of the short drying cycle,low energy consumption,good color and luster,low hardness and good rehydration performance.The fatty acid composition and content of tiger nut oil were determined by gas chromatography.The fatty acid composition and content of tiger nut oil were compared with those of soybean oil,olive oil,rapeseed oil and sesame oil,the results show that among the saturated fatty acids in tiger nut oil,palm oil had the highest content of 11.172%,which was between soybean oil and olive oil.The main composition of unsaturated fatty acids in tiger nut oil is oleic acid,with a content of 77.605%,which is 3.6 times higher than that of soybean oil,and even higher than that of olive oil. | He Li Xiaoxiao Niu Jiajun Chai Changle Guo Yihao Sun Jianhua Li Chunying Li | 2021 | International Journal of Agricultural and Biological Engineering2021，14，6： | 1 |
| 18 | VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type Ⅰ receptor degradation显示文摘The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue homeostasis.However,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well understood.Inhibitory(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of Smad7.Mis-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene expression.VprBP was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 poly-ubiquitination.In multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced responses.In the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish embryogenesis.Our findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction. | Yihao Li Chao Cui Feng Xie Szymon Kietbasa Hailiang Mei Maarten van Dinther Hans van Dam Andreas Bauer Long Zhang Peterten Dijke | 2020 | Journal of Molecular Cell Biology2020，12，2： | 1 |
| 19 | Experimental Realization of an Extreme-Parameter Omnidirectional Cloak显示文摘An ideal transformation-based omnidirectional cloak always relies on metamaterials with extreme parameters,which were previously thought to be too difcult to realize.For such a reason,in previous experimental proposals of invisibility cloaks,the extreme parameters requirements are usually abandoned,leading to inherent scattering.Here,we report on the frst experimental demonstration of an omnidirectional cloak that satisfes the extreme parameters requirement,which can hide objects in a homogenous background.Instead of using resonant metamaterials that usually involve unavoidable absorptive loss,the extreme parameters are achieved using a nonresonant metamaterial comprising arrays of subwavelength metallic channels manufactured with 3D metal printing technology.A high level transmission of electromagnetic wave propagating through the present omnidirectional cloak,as well as signifcant reduction of scattering feld,is demonstrated both numerically and experimentally.Our work may also inspire experimental realizations of the other full-parameter omnidirectional optical devices such as concentrator,rotators,and optical illusion apparatuses. | Bin Zheng Yihao Yang Zheping Shao Qinghui Yan Nian-Hai Shen Lian Shen Huaping Wang Erping Li Costas MSoukoulis Hongsheng Chen | 2019 | Research2019，，1： | 1 |
| 20 | Study of orientation and morphology of elliptical particles in drum granulation by dynamic simulation显示文摘 | Qi Lin Lumin Chen Ansheng Feng Yihao Li Xinjie Wang | 2016 | Particuology2016，14，2： | 1 |
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