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| 1 | Solar activity effects of the ionosphere: A brief review显示文摘Solar radiation, which varies over multiple temporal scales, modulates remarkably the evolution of the ionosphere. The solar activity dependence of the ionosphere is a key and fundamental issue in ionospheric physics, providing information essential to understanding the variations in the ionosphere and its processes. Selected recent studies on solar activity effects of the ionosphere are briefly reviewed in this report. This report focuses on (1) observations of solar irradiance at X-ray and extreme ultraviolet wavelengths and the outstanding problems of solar proxies, in the view of ionospheric studies, (2) new findings and improved representations of the features of the solar activity dependence of ionospheric key parameters and the corresponding physical processes, (3) possible phenomena in the ionosphere under extremely high and low solar activity conditions that are unique, as indicated by historical solar datasets and the deep solar minimum of solar cycle 23/24, and (4) statistical studies and model simulations of the ionosphere response to solar flares. The above-mentioned studies provide new clues for comprehensively explaining basic processes in the ionosphere and improving the prediction capability of ionospheric models and related applications. | LIU LiBo WAN WeiXing CHEN YiDing LE HuiJun | 2011 | Chinese Science Bulletin2011，56，12： | 45 |
| 2 | Dipeptidyl peptidase Ⅳ(DPP Ⅳ):a novel emerging target for thetreatment of type 2 diabetes显示文摘The enzyme, dipeptidyl peptidase Ⅳ(DPP Ⅳ), is a novel target for the treatment of type 2 diabetes. Dipeptidyl peptidase Ⅳ inhibition improves the impaired insulin secretion and decrease postprandial concentrations of glucagon by enhancing the incretin hormone levels lucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide(GIP). Recently, DPP Ⅳ inhibitors have attracted more and more attention, several of which have entered pre-clinical and clinical trials, and one has received approval for use as an anti-diabetic agent. Among the DPP Ⅳ inhibitors, two leading agents(sitagliptin and vildagliptin) have been shown to be effective in reducing glycosylated hemoglobin(HbA1c) and fasting plasma glucose(FPG) in patients with type 2 diabetes. This review summarizes the evidence supporting DPP IV inhibitors as potential antidiabetic agents. | Jing Wu Yiding Chen Xiaoli Shi Wei Gu | 2009 | Journal of Nanjing Medical University2009，23，4： | 9 |
| 3 | Temperature and substrate availability regulate soil respiration in the tropical mountain rainforests,Hainan Island,China显示文摘Aims Tropical forest plays a key role in global C cycle;however,there are few studies on the C budget in the tropical rainforests in Asia.This study aims to(i)reveal the seasonal patterns of total soil respiration(R_(T)),litter respiration(R_(L))and soil respiration without surface organic litter(R_(NL))in the primary and secondary Asian tropical mountain rainforests and(ii)quantify the effects of soil temperature,soil moisture and substrate availability on soil respiration.Methods The seasonal dynamics of soil CO_(2) efflux was measured by an automatic chamber system(Li-8100),within the primary and secondary tropical mountain rainforests located at the Jianfengling National Reserve in Hainan Island,China.The litter removal treatment was used to assess the contribution of litter to belowground CO_(2) production.Important Findings The annual R_(T) was higher in the primary forest(16.73±0.87 Mg C ha−1)than in the secondary forest(15.10±0.26 Mg C ha−1).The rates of R_(T),R_(NL) and R_(L) were all significantly higher in the hot and wet season(May–October)than those in the cool and dry season(November–April).Soil temperature at 5cm depth could explain 55–61%of the seasonal variation in R_(T),and the temperature sensitivity index(Q_(10))ranked by R_(L)(Q_(10)=3.39)>R_(T)(2.17)>R_(NL)(1.76)in the primary forest and by R_(L)(4.31)>R_(T)(1.86)>R_(NL)(1.58)in the secondary forest.The contribution of R_(L) to R_(T) was 22–23%,while litter input and R_(T) had 1 month time lag.In addition,the seasonal variation of R_(T) was mainly determined by soil temperature and substrate availability.Our findings suggested that global warming and increased substrate availability are likely to cause considerable losses of soil C in the tropical forests. | Zhang Zhou Lai Jiang Enzai Du Huifeng Hu Yide Li Dexiang Chen Jingyun Fang | 2013 | Journal of Plant Ecology2013，6，5： | 8 |
| 4 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 5 | Development of a middle and low latitude theoretical ionospheric model and an observation system data assimilation experiment显示文摘On the basis of previous work, we develop a middle and low latitude theoretical ionospheric model in this paper, named Theoretical Ionospheric Model of the Earth in the Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME-IGGCAS). TIME-IGGCAS solves the equations of mass continuity, motion and energy of electron and ions self-consistently and uses an eccentric dipole field approxima-tion to the Earth’s magnetic field. We combine the Eulerian and Lagrangian approaches in the model and take account of the plasma E×B drift velocity. Calculation results reveal that the model is steady and credible and can reproduce most large-scale features of ionosphere. By using TIME-IGGCAS, we carried out an observation system data assimilation experiment. Assimilation results show that the E×B drift velocity can be accurately estimated by ingesting the observed foF2 and hmF2 into the model ap-plying nonlinear least-square fit method. We suggest that this work is of great significance in the de-velopment of ionospheric data assimilation model to give better nowcast and forecast of ionosphere. | YUE XinAn WAN WeiXing LIU LiBo LE HuiJun CHEN YiDing YU Tao | 2008 | Chinese Science Bulletin2008，53，1： | 7 |
| 6 | CO_2选择性氧化甲烷制C_2烃催化剂La_2O_3/ZnO的氧化还原和CO_2吸附性能显示文摘La2O3/ZnO催化剂体系在以二氧化碳作为氧化剂的甲烷氧化偶联反应中具有很高的C2烃选择性和稳定性.采用CO2-TPD-MS和TPR技术考察了La2O3/ZnO对CO2的吸附性质及其氧化还原行为.结果表明:(1)La2O3/ZnO催化剂体系存在着强、弱两种碱中心,其中弱碱中心数量随样品中La2O3含量增加而减少,强碱中心强度随样品中La2O3含量增加而增强.(2)由于组分相互作用,高温下,La2O3/ZnO易产生晶格氧空位,使之对CO2的吸附增强,吸附后的CO2与晶格氧作用形成立方晶型La2O2CO3.(3)La2O3/ZnO表面的La3+和Zn2+可以部分被还原,由于组分间的相互作用,使得二者的还原都较单一组分存在时更难.(4)H2-CO2-H2氧化还原循环实验表明,La2O3/ZnO表面被部分还原后,CO2可以将部分被还原的表面再氧化.在此基础上对La2O3/ZnO催化剂上甲烷与CO2转化为C2烃的机制也进行了讨论. | Chen Changlin, Xu Yide, Cui Wei, Cai Yuran (State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023) | 1998 | 催化学报1998，19，3： | 7 |
| 7 | Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway显示文摘Macrophages and osteoclasts are both derived from monocyte/macrophage lineage,which plays as the osteoclastic part of bone metabolism.Although they are regulated by bone implant surface nanoarchitecture and involved in osseointegration,the beneath mechanism has not been simultaneously analyzed in a given surface model and their communication with osteoblasts is also blurring.Here,the effect of implant surface topography on monocyte/macrophage lineage osteoclastogenesis and the subsequent effect on osteogenesis are systematically investigated.The nanoporous surface is fabricated on titanium implant by etching and anodizing to get the nanotubes structure.The early bone formation around implant is significantly accelerated by the nanoporous surface in vivo.Meanwhile,the macrophage recruitment and osteoclast formation are increased and decreased respectively.Mechanistically,the integrin mediated FAK phosphorylation and its downstream MAPK pathway(p-p38)are significantly downregulated by the nanoporous surface,which account for the inhibition of osteoclastogenesis.In addition,the nanoporous surface can alleviate the inhibition of osteoclasts on osteogenesis by changing the secretion of clastokines,and accelerate bone regeneration by macrophage cytokine profiles.In conclusion,these data indicate that physical topography of implant surface is a critical factor modulating monocyte/macrophage lineage commitment,which provides theoretical guidance and mechanism basis for promoting osseointegration by coupling the osteogenesis and osteoclastogenesis. | Yide He Zhe Li Xin Ding Boya Xu Jinjin Wang Yi Li Fanghao Chen Fanhui Meng Wen Song Yumei Zhang | 2022 | Bioactive Materials2022，7，2： | 4 |
| 8 | Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation,drug delivery and bioactivity显示文摘Mesoporous silica thin film has been widely used in various fields,particularly the medical implant coating for drug delivery.However,some drawbacks remain with the films produced by traditional method(evaporation-induced self-assembly,EISA),such as the poor permeability caused by their horizontal aligned mesochannels.In this study,the vertical aligned mesoporous silica thin film(VMSTF)is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method,resulting in a hierarchical two-layered nanotubular structure.Due to the exposure of opened mesopores,VMSTF exhibits more appealing performances,including rapid degradation,efficient small-molecular drug(dexamethasone)loading and release,enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells.This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances. | Zhe Li Yide He Lasse Hyldgaard Klausen Ning Yan Jing Liu Fanghao Chen Wen Song Mingdong Dong Yumei Zhang | 2021 | Bioactive Materials2021，6，5： | 4 |
| 9 | Empirical modeling of ionospheric F2 layer critical frequency over Wakkanai under geomagnetic quiet and disturbed conditions显示文摘The hourly values of the ionospheric F2 layer critical frequency, foF2, recorded at Wakkanai ionosonde station (45.4°N, 141.7°E) have been collected to construct a middle-latitude single-station model for forecasting foF2 under geomagnetic quiet and disturbed conditions. The module for the geomagnetic quiet conditions incorporates local time, seasonal, and solar variability of climatological foF2 and its upper and lower quartiles. It is the first attempt to predict the upper and lower quartiles of foF2 to account for the notable day-to-day variability in ionospheric foF2. The validation statistically verifies that the model captures the climatological variations of foF2 with higher accuracy than IRI does. The storm-time module is built to capture the geomagnetic storm induced relative deviations of foF2 from the quiet time references. In the geomagnetically disturbed module, the storm-induced deviations are described by diurnal and semidiurnal waves, which are modulated by a modified magnetic activity index, the Kf index, reflecting the delayed responses of foF2 to geomagnetic activity forcing. The coefficients of the model in each month are determined by fitting the model formula to the observation in a least-squares way. We provide two options for the geomagnetic disturbed module, including or not including Kalman filter algorithm. The Kalman filter algorithm is introduced to optimize these coefficients in real time. Our results demonstrate that the introduction of the Kalman filter algorithm in the storm time module is promising for improving the accuracy of predication. In addition, comparisons indicate that the IRI model prediction of the F2 layer can be improved to provide better performances over this region. | LIU Jing LIU LiBo ZHAO BiQiang WAN WeiXing CHEN YiDing | 2012 | Science China(Technological Sciences)2012，55，5： | 4 |
| 10 | Epithelial-mesenchymal transition status of circulating tumor cells in breast cancer and its clinical relevance显示文摘Objective:Circulating tumor cells(CTCs)play a critical role in cancer metastasis,but their prevalence and significance remain unclear.This study attempted to track the epithelial-mesenchymal transition(EMT)status of CTCs in breast cancer patients and investigate their clinical relevance.Methods:In this study,the established negFACS-IF:E/M platform was applied to isolate rare CTCs and characterize their EMT status in breast cancer.A total of 89 breast cancer patients were recruited,including stage 0–III(n=60)and late stage(n=29)cases.Results:Using the negFACS-IF:E/M platform,it was found that in human epidermal growth factor receptor 2(HER2)+patients,mesenchymal CTCs usually exhibited a high percentage of HER2+cells.Stage IV breast cancer patients had considerably more CTCs than stage 0–III patients.Among stage 0–III breast cancers,the HER2 subtype included a significantly higher percentage of mesenchymal and biphenotypic(epithelial and mesenchymal)CTCs than the luminal A or B subtypes.Among stage IV patients,CTCs were predominantly epithelial in cases with local recurrence and were more mesenchymal in cases with distant metastasis.By applying a support vector machine(SVM)algorithm,the EMT status of CTCs could distinguish between breast cancer cases with metastasis/local recurrence and those without recurrence.Conclusions:The negFACS-IF:E/M platform provides a flexible and generally acceptable method for the highly sensitive and specific detection of CTCs and their EMT traits in breast cancer.This study demonstrated that the EMT status of CTCs had high clinical relevance in breast cancer,especially in predicting the distant metastasis or local recurrence of breast cancer. | Jiaojiao Zhou Xuan Zhu Shijie Wu Jingxin Guo Kun Zhang Chunjing Xu Huihui Chen Yuxi Jin Yuting Sun Shu Zheng Yiding Chen | 2020 | Cancer Biology & Medicine2020，17，1： | 3 |
| 11 | Therapeutic efficacy of traditional Chinese exercises and massage treatment on lumbar instability:a randomized controlled trial显示文摘OBJECTIVE:To determine the effect of traditional Chinese exercises combined with traditional Chinese massage on lumbar instability.METHODS:Seventy patients with lumbar instability were randomly divided into experimental group and control group.The experimental group was treated with traditional Chinese exercises combined with traditional Chinese massage,while the control group was only treated with traditional Chinese exercises.The Japanese Orthopaedic Association(JOA)scores,Oswestry Disability Index(ODI)and dynamic imaging indexes were used to assess treatment outcomes.RESULTS:After 8 weeks of treatment,the JOA scores of both groups were significantly higher than those before treatment(P<0.05),while ODI was significantly lower(P<0.05).In addition,compared with the control group,the JOA score of the experimental group was significantly increased(P<0.05),and the ODI was significantly decreased(P<0.05).Besides,the dynamic imaging indexes of patients with lumbar instability significantly changed after treatment.The lumbar vertebral laxity was significantly decreased(P<0.05)than those before treatment.CONCLUSION:The traditional Chinese exercises and massage may improve the symptoms of lumbar instability,and traditional Chinese exercises combined with massage treatment may be better than exercises alone. | Chen Wenjin Wang Jianwei Zhou Zhiyi Ren Yide Hua Zhen Yan Zheng Zhang Yafeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 12 | Nighttime electron density enhancements at middle and low latitudes in East Asia显示文摘Nighttime enhancements in ionospheric electron density at mid- and low-latitudes are investigated by using the critical frequency of the F2-layer(fo F2) data measured from ionosonde stations at Okinawa(26.3°N, 127.8°E, Geomagnetic 15.3°N), Yamagawa(31.2°N, 130.6°E, Geomagnetic 20.4°N), Kokubunji(35.7°N, 139.5°E, Geomagnetic 25.5°N), and Wakkanai(45.4°N, 141.7°E, Geomagnetic 35.4°N) in East Asia during several solar cycles. The results show that there are obvious seasonal and solar activity dependencies of the nighttime electron density enhancements. The enhancements are termed pre-midnight enhancement and post-midnight enhancement, according to the local time when the enhancement appeared. The former has a higher occurrence probability in summer months than in winter months. In contrast, the latter has a larger occurrence probability in winter months than in summer months. Moreover, the nighttime enhancements in electron density are more likely to occur at lower solar activity. These seasonal and solar activity variations of the nighttime enhancements in electron density can be explained in terms of the combined effects of downward plasma flux from the plasmasphere and the neutral winds. | ZHANG YanYan LIU LiBo CHEN YiDing LIU Jing YU You LI Ming | 2015 | Science China Earth Sciences2015，58，4： | 2 |
| 13 | China’s ion-adsorption rare earth resources, mining consequences and preservation显示文摘 | X. Jin Yang Aijun Lin Xiao-Liang Li Yiding Wu Wenbin Zhou Zhanheng Chen | 2013 | Environmental Development2013，，： | 2 |
| 14 | Application of voice coil motors in active dynamic vibration absorbers显示文摘 | CHEN Yide FUH Chyunchau TUNG Picheng | 2005 | IEEE Transactions on Magnetics2005，41，3： | 1 |
| 15 | Smart ZnS@C filler for super-anticorrosive self-healing zinc-rich epoxy coating显示文摘The zinc-rich epoxy cathodic protection coating is the most widely used anticorrosion material for marine steel.However,traditional conductive fillers lack the intelligent self-healing effect,which limits the long-term anticorrosion performance.Herein,with uniform carbon-coated ZnS(ZnS@C)nanoballs as the smart active release filler,we propose an anticorrosive and self-healing zinc-rich maleic anhydride epoxy coating.Due to the high pore filling efficiency of the nanoballs,the water vapor transmission rate of the coating with an initial corrosion efficiency of 99.92%and a low-frequency impedance of|Z|f=10mHz=3.88×10^(10) Ω·cm^(2),was reduced by 52%.The carbon-shell of the nanoball increases electron transmission paths in the coating and improves conductivity by nearly two orders of magnitude,which effectively activates more Zn-sites and extends the cathodic protection time.Moreover,once the steel-substrate undergoes regional corrosion,the SO_(4)^(2-)hydrolyzes from the ZnS-core of the nanoball and reacts with iron ions on the corroded area accurately and intelligently to fill the gap and self-heals into a new dense barrier layer(Fe_(2)(SO_(4))_(3),etc.),which significantly improves the shielding protection ability during the long-term usage of the coating.The effective anticorrosion time of the proposed coating could be up to 3,400 h. | Kai Yang Yixue Duan Guicheng Liu Guoyan Ma Hao Fu Xuyong Chen Manxiang Wang Gangqiang Zhu Woochul Yang Yiding Shen | 2022 | Nano Research2022，15，5： | 1 |
| 16 | A new automatic parameter setting method of a simplified PCNN for image segmentation显示文摘 | Chen Yuli Park Sung Kee Ma Yide | 2011 | IEEE Transactions on Neural Networks2011，22，6： | 1 |
| 17 | Responses of soil CH_(4) fluxes to nitrogen addition in two tropical montane rainforests in southern China显示文摘Background:Atmospheric nitrogen(N)deposition is projected to increase in the next few decades,which may have a marked impact on soil-atmosphere CH_(4) fluxes.However,the impacts of increased atmospheric N depositions on soil CH_(4) flux in tropical rainforests are still poorly understood.From January 2015 to December 2018,a field experiment was conducted in a primary tropical montane rainforest(PTMR)and a secondary tropical montane rainforest(STMR)in southern China to quantify the impact of N additions at four levels(N0:0 kg N⋅ha^(-1)⋅year^(-1);N25:25 kg N⋅ha^(-1)⋅year^(-1);N50:50 kg N⋅ha^(-1)⋅year^(-1);N100:100 kg N⋅ha^(-1)⋅year^(-1)on soil CH_(4) flux.Results:Four years of measurements showed clear seasonal variations in CH_(4) flux in all treatment plots for both forest types(PTMR and STMR),with lower rates of soil CH_(4) uptake during the wet season and higher rates of soil CH_(4) uptake during the dry season.Soil CH_(4) uptake rates were significantly and negatively correlated with both soil temperature and soil moisture for both forest types.Annual CH_(4) uptake for the N0 plots from the PTMR and STMR soils were2.20 and1.98 kg N⋅ha^(-1)⋅year^(-1),respectively.At the PTMR site,mean CH_(4) uptake compared with the N0 treatment was reduced by 19%,29%,and 36%for the N25,N50,and N100 treatments,respectively.At the STMR site,mean CH_(4) uptake compared with the N0 treatment was reduced by 15%,18%,and 38%for the N25,N50,and N100 treatments,respectively.High level N addition had a stronger inhibitory impact on soil CH_(4) uptake than did the low level N addition.Conclusion:Our data suggest that soil CH_(4) uptake in tropical rainforests is sensitive to N deposition.If atmospheric N deposition continues to increase in the future,the soil CH_(4) sink strength of tropical rainforests may weaken further. | Fangtao Wu Changhui Peng Chuanyao Wang Huai Chen Weiguo Liu Zhihao Liu Hui Wang Hong Li Dexiang Chen Yide Li Shirong Liu | 2022 | Forest Ecosystems2022，9，3： | 1 |
| 18 | The histone methyltransferase SUVR2 promotes DSB repair via chromatin remodeling and liquidliquid phase separation显示文摘Maintaining genomic integrity and stability is particularly important for stem cells,which are at the top of the cell lineage origin.Here,we discovered that the plant-specific histone methyltransferase SUVR2 maintains the genome integrity of the root tip stem cells through chromatin remodeling and liquid-liquid phase separation(LLPS)when facing DNA double-strand breaks(DSBs).The histone methyltransferase SUVR2(MtSUVR2)has histone methyltransferase activity and catalyzes the conversion of histone H3 lysine 9 monomethylation(H3K9me1)to H3K9me2/3 in vitro and in Medicago truncatula.Under DNA damage,the proportion of heterochromatin decreased and the level of DSB damage marker y-H2AX increased in suvr2 mutants,indicating that MtSUVR2 promotes the compaction of the chromatin structure through H3K9 methylation modification to protect DNA from damage.Interestingly,MtSUVR2 was induced by DSBs to phase separate and form droplets to localize at the damage sites,and this was confirmed by immunofluorescence and fluorescence recovery after photobleaching experiments.The IDR1 and lowcomplexity domain regions of MtSUVR2 determined its phase separation in the nucleus,whereas the IDR2 region determined the interaction with the homologous recombinase MtRAD51.Furthermore,we found that MtSUVR2 drove the phase separation of MtRAD51 to form'DNA repair bodies,'which could enhance the stability of MtRAD51 proteins to facilitate error-free homologous recombination repair of stem cells.Taken together,our study reveals that chromatin remodeling-associated proteins participate in DNA repair through LLPS. | Qianwen Liu Peng Liu Tuo Ji Lihua Zheng Chen Shen Shasha Ran Jinling Liu Yafei Zhao Yiding Niu Tao Wang Jiangli Dong | 2022 | Molecular Plant2022，15，7： | 1 |
| 19 | A new automatic parameter setting method of a simplified PCNN for image segmentation 显示文摘 | Chen Yuli Park Sung-Kee Ma Yide | 2011 | IEEE Transactions on Neural Networks2011，22，6： | 1 |
| 20 | A new automatic param- eter setting method of a simplified PCNN for image segmenta- tion显示文摘 | Yuli Chen Sung-Kee Park Yide Ma | 2011 | IEEE Transactions on Neural Networks2011，22，6： | 1 |
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