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| 1 | Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway显示文摘Macrophages and osteoclasts are both derived from monocyte/macrophage lineage,which plays as the osteoclastic part of bone metabolism.Although they are regulated by bone implant surface nanoarchitecture and involved in osseointegration,the beneath mechanism has not been simultaneously analyzed in a given surface model and their communication with osteoblasts is also blurring.Here,the effect of implant surface topography on monocyte/macrophage lineage osteoclastogenesis and the subsequent effect on osteogenesis are systematically investigated.The nanoporous surface is fabricated on titanium implant by etching and anodizing to get the nanotubes structure.The early bone formation around implant is significantly accelerated by the nanoporous surface in vivo.Meanwhile,the macrophage recruitment and osteoclast formation are increased and decreased respectively.Mechanistically,the integrin mediated FAK phosphorylation and its downstream MAPK pathway(p-p38)are significantly downregulated by the nanoporous surface,which account for the inhibition of osteoclastogenesis.In addition,the nanoporous surface can alleviate the inhibition of osteoclasts on osteogenesis by changing the secretion of clastokines,and accelerate bone regeneration by macrophage cytokine profiles.In conclusion,these data indicate that physical topography of implant surface is a critical factor modulating monocyte/macrophage lineage commitment,which provides theoretical guidance and mechanism basis for promoting osseointegration by coupling the osteogenesis and osteoclastogenesis. | Yide He Zhe Li Xin Ding Boya Xu Jinjin Wang Yi Li Fanghao Chen Fanhui Meng Wen Song Yumei Zhang | 2022 | Bioactive Materials2022，7，2： | 4 |
| 2 | Growing vertical aligned mesoporous silica thin film on nanoporous substrate for enhanced degradation,drug delivery and bioactivity显示文摘Mesoporous silica thin film has been widely used in various fields,particularly the medical implant coating for drug delivery.However,some drawbacks remain with the films produced by traditional method(evaporation-induced self-assembly,EISA),such as the poor permeability caused by their horizontal aligned mesochannels.In this study,the vertical aligned mesoporous silica thin film(VMSTF)is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method,resulting in a hierarchical two-layered nanotubular structure.Due to the exposure of opened mesopores,VMSTF exhibits more appealing performances,including rapid degradation,efficient small-molecular drug(dexamethasone)loading and release,enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells.This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances. | Zhe Li Yide He Lasse Hyldgaard Klausen Ning Yan Jing Liu Fanghao Chen Wen Song Mingdong Dong Yumei Zhang | 2021 | Bioactive Materials2021，6，5： | 4 |
| 3 | Role of Probucol in Preventing Contrast-Induced Acute Kidney Injury After Coronary Interventional Procedure显示文摘 | Guangping Li Li Yin Tong Liu Xintian Zheng Gang Xu Yanmin Xu Ruyu Yuan Jingjin Che Hongmei Liu Lijuan Zhou Xin Chen Mei He Yiding Li Lei Wu Enzhao Liu | 2009 | The American Journal of Cardiology2009，，4： | 1 |
| 4 | Systematic analysis of distinct flow characteristics and underlying microstructural evolution mechanisms of a novel fine-grained P/M nickel-based superalloy during isothermal compression显示文摘Isothermal forging(IF)is an effective method for forming difficult-to-deform materials like P/M superalloys.Understanding the isothermal compression microstructural evolution mechanism of a novel P/M s-peralloy provides the basis for its optimized IF planning.In this study,the isothermal compression tests of a novel fine-grained P/M nickel-based superalloy were carried out at 1000-1150℃with strain rates of 0.001-0.01 s^(−1).The results indicated that the alloy exhibits three distinct flow characteristics:continuous softening after reaching the peak stress,near-steady superplastic flow,and discontinuous hardening,corresponding to different strain rate sensitivity exponent(m)values.Varied microstructural evolution mechanisms,including grain boundary sliding(GBS),dynamic recrystallization(DRX),and grain growth,are dominated in different m-value domains.Meanwhile,different roles of primaryγ’play in microstruc-tural evolution were clarified.A moderate fraction of primaryγ’with 8.5%-14.2%can well coordinate the GBS and hinder excessive grain growth at a high m value domain(m>0.4).When 0.2 | Hongning Wen Junsong Jin Xuefeng Tang Xinyun Wang Heyang Yang Yiding Zhang Lei Deng Pan Gong Qingsong Wei Yingjie He Jianzheng Guo | 2023 | Journal of Materials Science & Technology2023，，31： | 0 |
| 5 | The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA显示文摘 | Yaqing Zhao Guang ,Zhang Chao He Yide Mei Yunyu Shi Fudong Li | 2018 | Cell Research2018，28，1： | 0 |
| 6 | Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex显示文摘Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex(MEC)carry the vital function of serving as a metric for the surrounding environment.Whether this mechanism processes only spatial information or involves nonspatial information remains elusive.Here,we fabricated an MEC-shaped microelectrode array(MEA)to detect the variation in neural spikes and local field potentials of the MEC when rats forage in a square enclosure with a planar,three-dimensional object and social landmarks in sequence.The results showed that grid cells exhibited rate remapping under social conditions in which spike firing fields closer to the social landmark had a higher firing rate.Furthermore,global remapping showed that hexagonal firing patterns were rotated and scaled when the planar landmark was replaced with object and social landmarks.In addition,when grid cells were activated,the local field potentials were dominated by the theta band(5–8 Hz),and spike phase locking was observed at troughs of theta oscillations.Our results suggest the pattern separation mechanism of grid cells in which the spatial firing structure and firing rate respond to spatial and social information,respectively,which may provide new insights into how the brain creates a cognitive map. | Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan Yiding Wang Botao Lu Jingyu Xie Yuchuan Dai Yilin Song Enhui He Shihong Xu Juntao Liu Mixia Wang Xinxia Cai | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
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