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| 1 | Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease显示文摘 | Elif Sarinay Cenik Ryuya Fukunaga Gang Lu Robert Dutcher Yeming Wang Traci M. Tanaka Hall Phillip D. Zamore | 2011 | Molecular Cell2011，，2： | 1 |
| 2 | Adaptability of four-samples sensory tests and prediction of visual and near-infrared reflectance spectroscopy for Chinese indica rice显示文摘 | Lu Qingyun Chen Yeming Takashi Mikami Motonobu Kawano Li Zaigui | 2006 | Journal of Food Engineering2006，，4： | 1 |
| 3 | Adaptability of Four-samples Sensory Tests and Prediction of Visual and Nearinfrared Reflectance Spectroscopy for Chinese Indica Rice显示文摘 | Lu Qingyun Chen Yeming Takashi Mikami | 2007 | J of Food Engineering2007，79，： | 1 |
| 4 | Adaptability of four-samples sensory tests and prediction of visual and near-infrared reflectance spectroscopy for Chinese indica rice显示文摘 | Lu Qingyun Chen Yeming Takashi Mikami | 2007 | Food Engineering2007，79，4： | 1 |
| 5 | Adaptability of four - samples sensory tests and prediction of visual and near - infrared reflectance spectroscopy for Chinese indica rice 显示文摘 | Lu Qingyuan Chen Yeming Mikami T | 2007 | Journal of Food Engineering2007，79，： | 1 |
| 6 | The m^(6)A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B显示文摘Inherited retinal dystrophies (IRDs) are major causes of visual impairment and irreversible blindness worldwide, while the precise molecular and genetic mechanisms are still elusive. N6-methyladenosine (m^(6)A) modification is the most prevalent internal modification in eukaryotic mRNA. YTH domain containing 2 (YTHDC2), an m^(6)A reader protein, has recently been identified as a key player in germline development and human cancer. However, its contribution to retinal function remains unknown. Here, we explore the role of YTHDC2 in the visual function of retinal rod photoreceptors by generating rod-specific Ythdc2 knockout mice. Results show that Ythdc2 deficiency in rods causes diminished scotopic ERG responses and progressive retinal degeneration. Multi-omics analysis further identifies Ppef2 and Pde6b as the potential targets of YTHDC2 in the retina. Specifically, via its YTH domain, YTHDC2 recognizes and binds m^(6)A-modified Ppef2 mRNA at the coding sequence and Pde6b mRNA at the 5′-UTR, resulting in enhanced translation efficiency without affecting mRNA levels. Compromised translation efficiency of Ppef2 and Pde6b after YTHDC2 depletion ultimately leads to decreased protein levels in the retina, impaired retinal function, and progressive rod death. Collectively, our finding highlights the importance of YTHDC2 in visual function and photoreceptor survival, which provides an unreported elucidation of IRD pathogenesis via epitranscriptomics. | Yeming Yang Xiaoyan Jiang Junyao Chen Lu Liu Guo Liu Kuanxiang Sun Wenjing Liu Xianjun Zhu Qiuyue Guan | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 7 | A Study on the Factors Influencing Learning Burnout Among College Students in an Online Teaching Environment显示文摘With the advancement of economic globalization,mobile networks and media technology are developing rapidly.Media information is manufactured and spread at any time,and people can better understand global information with the help of the media.In the Internet era,college students,overwhelmed by complex information and a lack of information discernment,are susceptible to indulging in the curated online world presented by others.At the same time,negative information such as false,violent,and pornographic also spread rapidly in various media.These phenomena impact students’media literacy and affect their mental health,thereby leading to learning burnout.This study analyzes the current situation of learning burnout among university students,explores the effective path of improving online education of college students,and provides a theoretical basis for reducing the burnout of college students and assisting students in developing a positive mentality. | Yeming Lu Shuai Ma Heung Kou | 2023 | Journal of Contemporary Educational Research2023，7，12： | 0 |
| 8 | The endoplasmic reticulum membrane protein complex subunit Emc6 is essential for rhodopsin localization and photoreceptor cell survival显示文摘The endoplasmic reticulum(ER)membrane protein complex(EMC)is responsible for monitoring the biogenesis and synthetic quality of membrane proteins with tail-anchored or multiple transmembrane domains.The EMC subunit EMC6 is one of the core members of EMC and forms an enclosed hydrophilic vestibule in cooperation with EMC3.Despite studies demonstrating that deletion of EMC3 led to rhodopsin mislocalization in rod photoreceptors of mice,the precise mechanism leading to the failure of rhodopsin trafficking remains unclear.Here,we generated the first rod photoreceptor-specific knockout of Emc6(RKO)and cone photoreceptor-specific knockout of Emc6(CKO)mouse models.Deficiency of Emc6 in rod photoreceptors led to progressive shortening of outer segments(OS),impaired visual function,mislocalization and reduced expression of rhodopsin,and increased gliosis in rod photoreceptors.In addition,CKO mice displayed the progressive death of cone photoreceptors and abnormal localization of cone opsin protein.Subsequently,proteomics analysis of the RKO mouse retina illustrated that several cilium-related proteins,particularly anoctamin-2(ANO2)and transmembrane protein 67(TMEM67),were significantly down-regulated prior to OS degeneration.Detrimental rod photoreceptor cilia and mislocalized membrane disc proteins were evident in RKO mice.Our data revealed that in addition to monitoring the synthesis of rhodopsin-dominated membrane disc proteins,EMC6 also impacted rod photoreceptors'ciliogenesis by regulating the synthesis of membrane proteins associated with cilia,contributing to the mislocalization of membrane disc proteins. | Kuanxiang Sun Lu Liu Xiaoyan Jiang Heting Wang Lin Wang Yeming Yang Wenjing Liu Lin Zhang Xiaohui Zhao Xianjun Zhu | 2024 | Genes & Diseases2024，11，2： | 0 |
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