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| 1 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 2 | Thermal conductivity of diamond/copper composites with a bimodal distribution of diamond particle sizes prepared by pressure infiltration method显示文摘The thermal conductivity of diamond/copper composites with bimodal particle sizes was studied.The composites were prepared through pressure infiltration of liquid copper into diamond preforms with a mixture of 40 and 100 μm-size diamonds.The permeability of the preforms with different coarse-to-fine volume ratios of diamonds was investigated.The thermal conductivity of the diamond/copper composites with bimodal size distribution was compared to the theoretical value derived from an analytical model developed by Chu.It is predicted that the diamond/copper composites could reach a higher thermal conductivity and their surface roughness could be improved by applying bimodal diamond particle sizes. | CHEN Chao GUO Hong CHU Ke YIN Fazhang ZHANG Ximing HAN Yuanyuan FAN Yeming | 2011 | Rare Metals2011，30，4： | 2 |
| 3 | The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis显示文摘The endoplasmic reticulum(ER) membrane protein complex(EMC) regulates the synthesis and quality control of membrane proteins with multiple transmembrane domains. One of the membrane spanning subunits, EMC3, is a core member of the EMC complex that provides essential hydrophilic vestibule for substrate insertion. Here, we show that the EMC subunit Emc3 plays critical roles in the retinal vascular angiogenesis by regulating Norrin/Wnt signaling. Postnatal endothelial cell(EC)-specific deletion of Emc3 led to retarded retinal vascular development with a hyperpruned vascular network, the appearance of bluntended, aneurysm-like tip endothelial cells(ECs) with reduced numbers of filopodia and leakage of erythrocytes at the vascular front. Diminished tube formation and cell proliferation were also observed in EMC3 depleted human retinal endothelial cells(HRECs). We then discovered a critical role for EMC3 in expression of FZD4 receptor of β-catenin signaling using RNA sequencing, real-time quantitative PCR(RT-q PCR) and luciferase reporter assay. Moreover, augmentation of Wnt activity via lithium chloride(Li Cl) treatment remarkably enhanced β-catenin signaling and cell proliferation of HRECs. Additionally, Li Cl partially reversed the angiogenesis defects in Emc3-c KO mice. Our data reveal that Emc3 plays essential roles in angiogenesis through direct control of FZD4 expression and Norrin/β-catenin signaling. | Mu Yang Shujin Li Wenjing Liu† Xiao Li Yunqi He Yeming Yang Kuanxiang Sun Lin Zhang Wanli Tian Lixin Duan Huafu Chen Dezhong Yao Zhenglin Yang Xianjun Zhu | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 4 | Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis显示文摘The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available. | Jiuyang Xu Chaolin Huang Guohui Fan Zhibo Liu Lianhan Shang Fei Zhou Yeming Wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang Lixue Huang Xiaoying Gu Hui Li Yi Zhang Yimin Wang Frederick G.Hayden Peter W.Horby Bin Cao Chen Wang | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 5 | Mechanism of the chemical composition changes of yuba prepared by a laboratory processing method显示文摘 | Yeming Chen Shinsuke Yamaguchi Tomotada Ono | 2009 | J Agric Food Chem2009，57，9： | 1 |
| 6 | Protein particle and soluble protein structure in prepared soymilk显示文摘 | Chen Yeming Tomotada Ono | 2014 | Food Hydrocolloids2014，39，： | 1 |
| 7 | The integral and extrinsic bioactive proteins in the aqueous ex- tracted soybean oil bodies 显示文摘 | ZHAO Luping CHEN Yeming CAO Yanyun | 2013 | J Agric Food Chem2013，61，： | 1 |
| 8 | Simple extraction method of non - allergenic intact soybean oil bodies that are ther- mally stable in an aqueous medium 显示文摘 | CHEN Yeming TOMOTADA O | 2010 | J Agric Food Chem2010，58，12： | 1 |
| 9 | The properties and the related protein behaviors of oil bodies in soymilk preparation 显示文摘 | CHEN Yeming ZHAO Luping KONG Xiangzhen | 2014 | Eur Food Res Techn- ol2014，239，3： | 1 |
| 10 | Adaptability of four-samples sensory tests and prediction of visual and near-infrared reflectance spectroscopy for Chinese indica rice显示文摘 | Lu Qingyun Chen Yeming Takashi Mikami Motonobu Kawano Li Zaigui | 2006 | Journal of Food Engineering2006，，4： | 1 |
| 11 | Adaptability of Four-samples Sensory Tests and Prediction of Visual and Nearinfrared Reflectance Spectroscopy for Chinese Indica Rice显示文摘 | Lu Qingyun Chen Yeming Takashi Mikami | 2007 | J of Food Engineering2007，79，： | 1 |
| 12 | Adaptability of four-samples sensory tests and prediction of visual and near-infrared reflectance spectroscopy for Chinese indica rice显示文摘 | Lu Qingyun Chen Yeming Takashi Mikami | 2007 | Food Engineering2007，79，4： | 1 |
| 13 | Adaptability of four - samples sensory tests and prediction of visual and near - infrared reflectance spectroscopy for Chinese indica rice 显示文摘 | Lu Qingyuan Chen Yeming Mikami T | 2007 | Journal of Food Engineering2007，79，： | 1 |
| 14 | Macronutrients and micronutrients of soybean oil bodies extracted at different pH显示文摘 | CHEN Yeming CAO Yanyun ZHAO Lupo | 2014 | J Food Sci2014，79，7： | 1 |
| 15 | Effects of rutin incorporation on the physical and oxidative stability of soy protein-stabilized emulsions显示文摘 | Zhumei Cui Xiangzhen Kong Yeming Chen Caimeng Zhang Yufei Hua | 2014 | Food Hydrocolloids2014，，： | 1 |
| 16 | Mechanism of the chemical composition changes of Yuba prepared by a laboratory processing method显示文摘 | CHEN Yeming YAMAGUCHI S ONO T | | 0，，09： | 1 |
| 17 | The mechanisms for Yuba formation and its stable lipid显示文摘 | CHEN Yeming ONOT | | 0，，10： | 1 |
| 18 | Mechanism of the chemical composition changes of yuba prepared by a laboratory processing method显示文摘 | CHEN Yeming YAMAGUCHI S ONO T | 2009 | Journal of Agricultural and Food Chemistry2009，57，9： | 1 |
| 19 | The mechanisms for yuba formation and its stable lipid显示文摘 | CHEN Yeming YAMAGUCHI S | 2010 | Journal of Agricultural and Food Chemistry2010，58，10： | 1 |
| 20 | Cerebral ischemic injury after transcatheter aortic valve replacement in patients with pure aortic regurgitation显示文摘Considering the surgical risk stratification for patients with severe calcific aortic stenosis(AS),transcatheter aortic valve replacement(TAVR)is a reliable alternative to surgical aortic valve replacement(SAVR)(Fan et al.,2020,2021;Lee et al.,2021).Despite the favorable clinical benefits of TAVR,stroke remains a dreaded perioperative complication(Auffret et al.,2016;Kapadia et al.,2016;Kleiman et al.,2016;Huded et al.,2019).Ischemic overt stroke,identified in 1.4%to 4.3%of patients in TAVR clinical practice,has been associated with prolonged disability and increased mortality(Auffret et al.,2016;Kapadia et al.,2016;Levi et al.,2022).The prevalence of hyperintensity cerebral ischemic lesions detected by diffusion-weighted magnetic resonance imaging(DW-MRI)was reported to be about 80%,which is associated with impaired neurocognitive function and vascular dementia(Vermeer et al.,2003;Barber et al.,2008;Kahlert et al.,2010). | Xianbao LIU Hanyi DAI Jiaqi FAN Dao ZHOU Gangjie ZHU Abuduwufuer YIDILISI Jun CHEN Yeming XU Lihan WANG Jian'an WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
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