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| 1 | Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration显示文摘 | Hu Wang Hongna Zuo Jin Liu Fei Wen Yawei Gao Xudong Zhu Bo Liu Feng Xiao Wengong Wang Gang Huang Bin Shen Zhenyu JU | 2018 | Cell Research2018，28，10： | 16 |
| 2 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 3 | Highly reliable relative navigation for multi-UAV formation flight in urban environments显示文摘Formation flight of multiple Unmanned Aerial Vehicles(UAVs)is expected to bring significant benefits to a wide range of applications.Accurate and reliable relative position information is a prerequisite to safely maintain a fairly close distance between UAVs and to achieve inner-system collision avoidance.However,Global Navigation Satellite System(GNSS)measurements are vulnerable to erroneous signals in urban canyons,which could potentially lead to catastrophic consequences.Accordingly,on the basis of performing relative positioning with double differenced pseudoranges,this paper develops an integrity monitoring framework to improve navigation integrity(a measure of reliability)in urban environments.On the one hand,this framework includes a fault detection and exclusion scheme to protect against measurement faults.To accommodate urban scenarios,spatial dependence in the faults are taken into consideration by this scheme.On the other hand,relative protection level is rigorously derived to describe the probabilistic error bound of the navigation output.This indicator can be used to evaluate collision risk and to warn collision danger in real time.The proposed algorithms are validated by both simulations and flight experiments.Simulation results quantitatively reveal the sensitivity of navigation performance to receiver configurations and environmental conditions.And experimental results suggest high efficiency and effectiveness of the new integrity monitoring framework. | Shizhuang WANG Xingqun ZHAN Yawei ZHAI Cheng CHI Jiawen SHEN | 2021 | Chinese Journal of Aeronautics2021，34，7： | 3 |
| 4 | Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration-Resistant Prostate Cancer显示文摘 | Shancheng Ren Yawei Liu Weidong Xu Yi Sun Ji Lu Fubo Wang Min Wei Jian Shen Jianguo Hou Xu Gao Chuanliang Xu Jiaoti Huang Yi Zhao Yinghao Sun | 2013 | The Journal of Urology2013，，： | 2 |
| 5 | Fish red blood cells express immune genes and responses显示文摘The erythrocytes or red blood cells(RBCs)and leucocytes or white blood cells(WBCs)are the most abundant cell types in the circulatory system of vertebrates.The RBCs are responsible for gas exchange while WBCs are solely involved with immunity.In this study,we present evidence that fish RBCs despite their respiratory role they also express immune-related genes and responses in the teleost fish,Nile tilapia(Oreochromis niloticus).Fluorescent staining identified the presence of numerous mitochondria and lysosomes in tilapia RBCs.RNA sequencing of tilapia RBCs and WBCs led to the assembly and annotation of 20.876 transcripts of which 1017 and 3628 transcripts were specific to RBCs and WBCs,respectively.Pairwise sequence comparisons identified 3251 transcripts that were significantly differential expressed of which 707(21.75%)were up-regulated and 2544(78.25%)down-regulated in RBCs when compared to WBCs.809 transcripts were assigned to 16 immune system pathways,21 and 163 transcripts were specifically expressed in tilapia RBCs and WBCs respectively,and 23 and 233 transcripts were highly expressed in RBCs and WBCs respectively.Expression of 7 immune genes(interferon regulatory factors(irf)1e5 and 9 and tlr3)in both WBCs and RBCs was validated by RT-PCR analysis.Quantitative real-time PCR revealed that all genes were up-regulated in poly(I:C)-challenged WBCs and irf(1,3,4,and 9)and tlr3 were also significantly up-regulated in poly(I:C)-challenged RBCs.Therefore,fish RBCs expressed immunity genes and responses and they may play a complementary role in vertebrate immunity. | Yawei Shen Dan Wang Jinliang Zhao Xiaowu Chen | 2018 | Aquaculture and Fisheries2018，3，1： | 2 |
| 6 | Smoking, DNA repair capacity and risk of non - small cell lung cancer 显示文摘 | Shen Hongbing Spitz MR Qiao Yawei | 2003 | Int J Cancer2003，107，1： | 1 |
| 7 | High mass loading Ni_(4)Co_(1)-OH@CuO core-shell nanowire arrays obtained by electrochemical reconstruction for alkaline energy storage显示文摘The design of three-dimensional(30)core-shell hetercistructures is an efficient method to achieve high mass specific capacity of electroactive materials under high mass loading.In this work,porous Ni_(4)Co1-0H nanosheets with a mass loading of 7.7 mg·cm^(-2) are obtained by using Ni_(4)Cor(NO_(3))_(2)(0H)_(4) supported on the CuO nanowires as precursors via an unavoidable electrochemically induced phase reconstruction.During the electrochemical reconstruction process,the N03-anions in Ni_(4)Cor(N0_(3))_(2)(0H)_(4) are easily replaced by OH-anions in the electrolyte.The phase reconstruction is accompanied by the decrease of ionic diffusion.:resistance and the increase of pore volume,and the shift of binding energy.The obtained Ni4Co1-0H nanosheets show a high:mass specific capacity of 363.6 mAh·g^(-1) at 5 mA·cm^(-2).The as-fabricated alkaline hybrid supercapacitor and Ni-Zn battery deliver high energy density of 293.1 and 604.9 Wh·kg^(-1),respectively,indicating.excellent alkaline energy storage performance. | Yawei Yu Xiulan Hu Shuai Wang Handan Qiao Zeyu Liu Kefan Song Xiaodong Shen | 2022 | Nano Research2022，15，1： | 1 |
| 8 | Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment显示文摘Periodontitis is a complex chronic inflammatory disease.The invasion of pathogens induces the inflammatory microenvironment in periodontitis.Cell behavior changes in response to changes in the microenvironment,which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by cells.It has been confirmed that periodontal ligament stem cells(PDLSCs)are vital in the development of periodontal disease.Moreover,PDLSCs are the most effective cell type to be used for periodontium regeneration.This review focuses on changes in PDLSCs,their basic biological behavior,osteogenic differentiation,and drug effects caused by the inflammatory microenvironment,to provide a better understanding of the influence of these factors on periodontal tissue homeostasis.In addition,we discuss the underlying mechanism in detail behind the reciprocal responses of PDLSCs that affect the microenvironment. | Xuetao ZHAO Hongbing LIN Tong DING Yawei WANG Na LIU Yuqin SHEN | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，5： | 1 |
| 9 | Transcriptome analysis of gill from Lateolabrax maculatus and aqp3 gene expression显示文摘The Lateolabrax maculatus is an important marine fish in China that can adapt to a wide range of water salinities.The gill is the main organ involved in fish osmoregulation and in this study,a cDNA library of the L.maculatus gill was constructed to understand gill function in Lateolabrax maculatus and it adaptation to salinity.A total raw data of 5.3G base pairs was obtained,followed removal of low-quality and linker DNA sequences and it yielded a total of 23,038,590 clean reads.After splicing and clustering,31,976 unigenes were obtained.The average transcript length was 1327 bp and N50 was 2057 bp.In comparisons with other tissues analysis of the gill transcriptome revealed a high level of relative expression of apolipoprotein E,CD74,keratin,type I cytoskeleton 13,carbonic anhydrase,betaine-homocysteine S-methyltransferase,and aquaporin 3(AQP3)genes.The L.maculatus aqp3(Lm-aqp3)gene was specific for the gills Lm-aqp3 and this gene has a typical transmembrane structure of six alpha helices and a water channel domain.Phylogenetic analysis indicated that Lm-aqp3 clusters with the homologue genes from Labrus bergylta and Dicentrarchus labrax.Quantitative RT-PCR confirmed that Lm-aqp3 was highly abundant in the gills and low expressed in other tissues(stomach,liver,brain,spleen and testis).Analysis of Lm-aqp3 in freshwater aquaculture fish revealed that gene expression was significantly statistical higher than in seawater(20 ppt)fish,suggesting that Lm-aqp3 may play an important role in water metabolism and osmotic pressure regulation in L.maculatus. | Yawei Shen Yudong He Yanhui Bi Jianpeng Chen Ziwei Zhao Jun Li Xiaowu Chen | 2019 | Aquaculture and Fisheries2019，4，6： | 0 |
| 10 | microRNA expression profile of fish erythrocytes显示文摘MicroRNAs(miRNAs)are short noncoding sequences that can regulate the expression of target genes.Erythrocytes,also called red blood cells(RBCs),are the largest proportion of cells in blood.Erythrocytes deliver oxygen in the body of vertebrates and contribute to the body’s immune function.Illumina sequencing technology was used to analyze pooled RNA samples isolated from erythrocytes,in order to characterize their gene expression profile and increase the range of miRNAs identified in Nile tilapia erythrocytes.This study identified conserved(n=309)and novel(n=194)miRNAs.Quantitative reverse-transcription polymerase chain reaction and next-generation sequencing results indicated that miR-451 was the most abundant in RBCs,followed by let-7a-1,miR-2188 and miR-144.Moreover,the tissue expression mode of these highly expressed miRNAs was characterized.Results show that miR-451,miR-2188,and miR-144 were all highly expressed in RBCs but were low abundance in other tissues.miR-1 and miR-10b were also abundantly expressed in muscle,while miR-122 was abundantly expressed in the liver.let-7a-1,miR-10b,and miR-1 were significantly higher in the testis than in the ovary.The tissue distribution of miRNAs implies that these noncoding sequences have a potential role in regulating tissue differentiation or maintaining tissue characteristics.The results of a dual-luciferase reporter assay indicated that miR-144 and miR-10b inhibited the expression of the meningioma expressed antigen 5 gene in vitro.This study contributes to the Nile tilapia miRNA database and reveals the profile of erythrocyte miRNA expression. | Ziwei Zhao Yawei Shen Jinliang Zhao Xiaowu Chen | 2021 | Aquaculture and Fisheries2021，6，6： | 0 |
| 11 | Distribution of Partial Arc Propagation Path on Insulator and Its Discrimination Method显示文摘Pollution flashover is one of themajor insulation accidents that can occur inmodern power systems.If the local arc is not sufficiently elongated by the creepage distance,the flashover performance of the insulator will decrease.The insulator structure and equivalent salt deposition density(ESDD)are the main factors affecting the arc path and length.To investigate the forms of arc paths under different insulator structures and their influence on flashover characteristics,a platformfor recording arc paths is established.This study presents amethod to identify the pattern and distribution of insulator arc paths based on the effect of initial arc on electric field distribution.The results show that there are two main types of local arc paths between umbrellas—the cling-surface arc and the air-jump arc.Moreover,the air-jump arc includes two types—the bridging arc and the gap arc.With the increase in umbrella spacing and ESDD,the probability of arc propagation along the surface increases.The use of the creepage distance can be improved by changing the creepage coefficient to increase the distance between umbrellas.This method has over 90%accuracy.This study is of great significance for improving insulator structure and reducing pollution flashover accidents. | Zhibo Song Hao Yang Wei Shen Yixin Ren Yawei Li Jianlong Ma | 2023 | Energy Engineering2023，120，9： | 0 |
| 12 | 载能离子辐照316L不锈钢的力学性能及微观结构表征显示文摘The 316L type austenitic stainless steel as main structural materials,are widely used for the fission reactors for more than 30 years.Besides,316L steel has been chosen as primary structural material for future advanced nuclear facility,such as fusion reactor and Accelerator Driven Subcritical(ADS)system[1].In this work,one set of the 316L steel specimens were irradiated with H and Heions to the doses of 1.01017 and 1.01018ioncm��2,at room temperature(RT)and 500℃,respectively.Another set of specimens with and without 100 ppm He pre-implantation were irradiated with Feions to the doses of 10,20 and 50 dpa at 450℃and 600℃,respectively. | Shen Tielong Jin Peng Zhu Yabin Cui Minghuan Wei Kongfang Chai Jianlong Guo Yawei Zhang Tongmin Li Jinyu Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 13 | MgAl_(2)O_(4)掺杂对ZTA-MgAl_(2)O_(4)复相陶瓷力学及热学性能影响显示文摘MgAl_(2)O_(4) is a very suitable reinforcing phase owing to the advantageous performance such as high melting point,high strength,high hardness,corrosion resistance and good thermal shock stability.In this paper,the effects of MgAl_(2)O_(4) addition on microstructure and mechanical properties of ZTA-MgAl_(2)O_(4) composite ceramics prepared by Spark Plasma Sintering(SPS)were investigated. | Guo Yawei Chai Jianlong Zhu Yabin Wei Kongfang Li Shufeng Shen Tielong Yao Cunfeng Cui Minghuan Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 14 | SiC含量对ZTA和ATZ复相陶瓷力学及热学性能的影响显示文摘Oxide/carbide composite ceramics were prepared by spark plasma sintering(SPS)usingα-Al2O3,ZrO2andβ-SiC powders as raw materials.The effects of SiC doping on the microstructure,mechanical and thermal properties of zirconia toughened alumina(ZTA)and alumina toughened zirconia(ATZ)based composites were investigated.Fig.1 shows the effect of SiC content on the mechanical properties of the complex phase ceramics.With the increase of SiC content,the bending strength of SiC-ATZ80mol%composite phase ceramics decreased from 992 to 761 MPa.The reason is that the thermal expansion mismatch between the SiC and the substrate induces thermal stress,resulting in the different shrinkage between the substrate and the SiC affecting its strength. | Chai Jianlong Guo Yawei Zhu Yabin Li Shufeng Shen Tielong Yao Cunfeng Cui Minghuan Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 15 | METTL14 is a chromatin regulator independent of its RNA N^(6)-methyladenosine methyltransferase activity显示文摘METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m^(6)A methyltransferase complex(MTC)that installs m^(6)A.Surprisingly,depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of mouse embryonic stem cell(mESC).While comparable global hypo-methylation in RNA m^(6)A was observed in Mettl3 or Mettl14 knockout mESCs,respectively.Mettl14 knockout led to a globally decreased nascent RNA synthesis,whereas Mettl3 depletion resulted in transcription upregulation,suggesting that METTL14 might possess an mA-independent role in gene regulation.We found that METTL14 colocalizes with the repressive H3K27me3 modification.Mechanistically,METTL14,but not METTL3,binds H3K27me3 and recruits KDM6B to induce H3K27me3 demethylation independent of METTL3.Depletion of METTL14 thus led to a global increase in H3K27me3 level along with a global gene suppression.The effects of METTL14 on regulation of H3K27me3 is essential for the transition from self-renewal to differentiation of mESCs.This work reveals a regulatory mechanism on heterochromatin by METTL14 in a manner distinct from METTL3 and independently of m^(6)A,and critically impacts transcriptional regulation,stemness maintenance,and differentiation ofmESCs. | Xiaoyang Dou Lulu Huang Yu Xiao Chang Liu Yini Li Xinning Zhang Lishan Yu Ran Zhao Lei Yang Chuan Chen Xianbin Yu Boyang Gao Meijie Qi Yawei Gao Bin Shen Shuying Sun Chuan He Jun Liu | 2023 | Protein & Cell2023，14，9： | 0 |
| 16 | Long noncoding RNA lnc_217 regulates hepatic lipid metabolism by modulating lipogenesis and fatty acid oxidation显示文摘Nonalcoholic fatty liver disease (NAFLD) is considered a major health epidemic with an estimated 32.4% worldwide prevalence. No drugs have yet been approved and therapeutic nodes remain a major unmet need. Long noncoding RNAs are emerging as an important class of novel regulators influencing multiple biological processes and the pathogenesis of NAFLD. Herein, we described a novel long noncoding RNA, lnc_217, which was liver enriched and upregulated in high-fat diet-fed mice, and a genetic animal model of NAFLD. We found that liver specific knockdown of lnc_217 was resistant to high-fat diet-induced hepatic lipid accumulation and decreased serum lipid in mice. Mechanistically, we demonstrated that knockdown of lnc_217 not only decreased de novo lipogenesis by inhibiting sterol regulatory element binding protein-1c cleavage but also increased fatty acid β- oxidation through activation of peroxisome proliferator-activated receptor α and carnitine palmitoyltransferase-1α. Taken together, we conclude that lnc_217 may be a novel regulator of hepatic lipid metabolism and a potential therapeutic target for the treatment of hepatic steatosis and NAFLD-related metabolic disorders. | Xiaoqing Yuan Yawei Liu Xule Yang Yun Huang Xuan Shen Hui Liang Hongwen Zhou Qian Wang Xu Zhang John Zhong Li | 2023 | The Journal of Biomedical Research2023，37，6： | 0 |
| 17 | Correction to:Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘CORRECTION TO:PROTEIN CELL(2021)http://gffzzd3cc09b8251d45dfoc0quk6kc6oqk6kn5.ffgz.tsg.suse.edu.cn/10.1007/S13238-021-00837-8 In the original publication of the article figure 1 is incorrectly published.The correct Figure 1 is provided in this correction.OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The images or other third party material in this article are included in the article's Creative Commons licence,unless indicated otherwise in a credit line to the material.If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this licence,visit http://gffzzeb6f7f563f66445dsc0quk6kc6oqk6kn5.ffgz.tsg.suse.edu.cn/licenses/by/4.0/. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2022 | Protein & Cell2022，13，6： | 0 |
| 18 | Hemocytes transcriptome profile of the Chinese mitten crab(Eriocheir sinensis)显示文摘The Chinese mitten crab(Eriocheir sinensis)possesses an open circulatory system,in which hemolymph moves through interconnected sinuses or spaces surrounding organs called hemocoels.The hemocytes are classified into hyalinocytes,semigranulocytes,and granulocytes;and limited transcriptomics research is available.In this study,the transcriptome of the crab E.sinensis hemocytes was characterized.A total of 14,380,229 clean reads representing a total of 4.31 Gb nucleotides dataset were produced.A total of 67,047 contigs were obtained and 12.49%(8375)and 9.74%(6533)of the contigs were matched to data publicly available from the GenBank nr nucleotide and Uniprot databases,respectively.Among these contigs,4344 contigs belong to three categories of Gene Ontology,126 contigs to 21 subcategories of KEGG,and 4962 contigs to 25 categories of the COG database.A total of 508,379 and 345 transcripts of the E.sinensis showed>40%sequence similarity with transcripts expressed in the vertebrate blood cells from tilapia(Oreochromis niloticus),Chinese softshell turtle(Trionyx sinensis)and chicken(Gallus gallus)respectively.A total of 53,077 single nucleotide polymorphisms were identified and 9912 SSRs for microsatellite mining were found.The most frequent repeat motifs detected were dinucleotide repeats,accounting for 37.52%of the total repeats.Our data provides an important gene resource for the exploitation of molecular marker-assisted breeding,immune mechanisms and conservation of germplasm in the crab E.sinensis. | Xiaowu Chen Yawei Shen Yanwui Bi Xugan Wu | 2018 | Aquaculture and Fisheries2018，3，5： | 0 |
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