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| 1 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 2 | Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers显示文摘 | Chen Wu Yuanyuan Xie Feng Gao Yanan Wang Yawei Guo Huanna Tian Yanshuang Li Wufang Fan | 2013 | Gene2013，，1： | 2 |
| 3 | Advanced Nonflammable Localized High-Concentration Electrolyte For High Energy Density Lithium Battery显示文摘The key to realize long-life high energy density lithium batteries is to exploit functional electrolytes capable of stabilizing both high voltage cathode and lithium anode.The emergence of localized high-concentration electrolytes(LHCEs)shows great promise for ameliorating the above-mentioned interfacial issues.In this work,a lithium difluoro(oxalate)borate(LiDFOB)based nonflammable dual-anion LHCE is designed and prepared.Dissolving in the mixture of trimethyl phosphate(TMP)/1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropylether(D_(2)),the continuously consumption of LiDFOB is suppressed by simply introducing lithium nitrate(LiNO_(3)).Meantime,as most of the TMP molecular are coordinated with Li^(+),the electrolyte does not show incompatibility issue between neither metal lithium nor graphite anode.Therefore,it demonstrates excellent capability in stabilizing the interface of Ni-rich cathode and regulating lithium deposition morphology.The Li||LiNi_(0.87)Co_(0.08)Mn_(0.05)O_(2)(NCM87)batteries exhibit high capacity retention of more than 90%after 200 cycles even under the high cutoff voltage of 4.5 V,1 C rate.This study offers a prospective method to develop safe electrolytes suitable for high voltage applications,thus providing higher energy densities. | Mengmin Jia Chi Zhang Yawei Guo Linshan Peng Xiaoyan Zhang Weiwei Qian Lan Zhang Suojiang Zhang | 2022 | Energy & Environmental Materials2022，5，4： | 2 |
| 4 | The effect of H 2 S concentration on the corrosion behavior of carbon steel at 90°C显示文摘 | Junwen Tang Yawei Shao Jinbiao Guo Tao Zhang Guozhe Meng Fuhui Wang | 2010 | Corrosion Science2010，，6： | 1 |
| 5 | Emerging organic contamination in China显示文摘 | Guibin JIANG Qinghua ZHANG Yawei WANG Hanxia LIU Chunyang LIUO Rui GUO | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
| 6 | The effect of H 2 S concentration on the corrosion behavior of carbon steel at 90<ce:hsp sp='0.25'/>°C显示文摘 | Junwen Tang Yawei Shao Jinbiao Guo Tao Zhang Guozhe Meng Fuhui Wang | 2010 | Corrosion Science2010，，6： | 1 |
| 7 | Sludge re duction potential of the activated sludge process by integrating an oligoehaete reactor显示文摘 | WEI Yuansong WANG Yawei GUO Xuesong | 2009 | Journal of Hazardous Materials2009，163，1： | 1 |
| 8 | YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma显示文摘Background:Y-box binding protein 1(YB1 or YBX1)plays a critical role in tumorigenesis and cancer progression.However,whether YB1 affects malignant transformation by modulating non-codingRNAs remains largely unknown.This study aimed to investigate the relationship between YB1 and microRNAs and reveal the underlying mechanism by which YB1 impacts on tumor malignancy via miRNAs-mediated regulatory network.Methods:The biological functions of YB1 in hepatocellular carcinoma(HCC)cells were investigated by cell proliferation,wound healing,and transwell invasion assays.The miRNAs dysregulated by YB1 were screened by microarray analysis in HCC cell lines.The regulation of YB1 on miR-205 and miR-200b was determined by quantitative real-time PCR,dual-luciferase reporter assay,RNA immunoprecipitation,and pull-down assay.The relationships of YB1,DGCR8,Dicer,TUT4,and TUT1 were identified by pull-down and coimmunoprecipitation experiments.The cellular co-localization of YB1,DGCR8,and Dicer were detected by immunofluorescent staining.The in vivo effect of YB1 on tumor metastasis was determined by injecting MHCC97H cells transduced with YB1 shRNA or shControl via the tail vein in nude BALB/c mice.The expression levels of epithelial tomesenchymal transition markerswere detected by immunoblotting and immunohistochemistry assays.Results:YB1 promoted HCC cell migration and tumor metastasis by regulating miR-205/200b‒ZEB1 axis partially in a Snail-independent manner.YB1 suppressedmiR-205 and miR-200b maturation by interacting with the microprocessors DGCR8 and Dicer as well as TUT4 and TUT1 via the conserved cold shock domain.Subsequently,the downregulation of miR-205 and miR-200b enhanced ZEB1 expression,thus leading to increased cell migration and invasion.Furthermore,statistical analyses on gene expression data from HCC and normal liver tissues showed that YB1 expression was positively associated with ZEB1 expression and remarkably correlated with clinical prognosis.Conclusion:This study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR-205/200b‒ZEB1 axis in HCC cells.Furthermore,these results highlight that YB1 may play biological functions via miRNAs-mediated gene regulation,and it can serve as a potential therapeutic target in human cancers. | Xiumei Liu Di Chen Huan Chen Wen Wang Yu Liu Yawei Wang Chao Duan Zhen Ning Xin Guo Wuxiyar Otkur Jing Liu Huan Qi Xiaolong Liu Aifu Lin Tian Xia Hong-xu Liu Hai-long Piao | 2021 | Cancer Communications2021，41，7： | 1 |
| 9 | International patterns and trends in thyroid cancer incidence, 1973–2002显示文摘 | Briseis A. Kilfoy Tongzhang Zheng Theodore R. Holford Xuesong Han Mary H. Ward Andreas Sjodin Yaqun Zhang Yana Bai Cairong Zhu Grace L. Guo Nathaniel Rothman Yawei Zhang | 2009 | Cancer Causes & Control2009，，5： | 1 |
| 10 | Crossover effects of transition metal ions in high-voltage lithium metal batteries显示文摘Enhancing the cut-off voltage of high-nickel layered oxide cathodes is an efficient way to obtain higher energy density of lithiummetal batteries(LMBs).However,the phase transition of the cathode materials and the uncontrolled decomposition of the electrolytes at high voltage can lead to irreversible dissolution of transition metal ions,which might cause the crossover effects on the lithium metal anodes.Nonetheless,the mechanism and electrolyte dependence of the crossover effects for Li metal anodes are still unclear.Herein,we investigate the crossover effects between LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)and Li-metal anode in two electrolyte systems.For ether-based electrolyte,its poor oxidation stability results in massive dissolution of transition metal ions,leading to dendrite growth on anode and rapid cells failure.Conversely,ester-based electrolyte exhibits good electrochemical performances at 4.5 V with little crossover effect.This study provides an idea for electrolyte systems selection for high-voltage LMBs,and verifies that the crossover effect should not be neglected in LMBs. | Wanxia Li Yulin Jie Yunhua Chen Ming Yang Yawei Chen Xinpeng Li Youzhang Guo Xianhui Meng Ruiguo Cao Shuhong Jiao | 2023 | Nano Research2023，16，6： | 0 |
| 11 | Boosting for Distributed Online Convex Optimization显示文摘Decentralized Online Learning(DOL)extends online learning to the domain of distributed networks.However,limitations of local data in decentralized settings lead to a decrease in the accuracy of decisions or models compared to centralized methods.Considering the increasing requirement to achieve a high-precision model or decision with distributed data resources in a network,applying ensemble methods is attempted to achieve a superior model or decision with only transferring gradients or models.A new boosting method,namely Boosting for Distributed Online Convex Optimization(BD-OCO),is designed to realize the application of boosting in distributed scenarios.BD-OCO achieves the regret upper bound O(M+N/MNT)where M measures the size of the distributed network and N is the number of Weak Learners(WLs)in each node.The core idea of BD-OCO is to apply the local model to train a strong global one.BD-OCO is evaluated on the basis of eight different real-world datasets.Numerical results show that BD-OCO achieves excellent performance in accuracy and convergence,and is robust to the size of the distributed network. | Yuhan Hu Yawei Zhao Lailong Luo Deke Guo | 2023 | Tsinghua Science and Technology2023，28，4： | 0 |
| 12 | AgInS_(2)/ZnS quantum dots for noninvasive cervical cancer screening with intracellular pH sensing using fluorescence lifetime imaging microscopy显示文摘Intracellular pH plays a critical role in biological functions,and abnormal pH values are related to various diseases.Here,we report on an intracellular pH sensor AgInS_(2)(AIS)/ZnS quantum dots(QDs)that show long fluorescence lifetimes of hundreds of nanoseconds and low toxicity.Fluorescence lifetime imaging microscopy(FLIM)combined with AIS/ZnS QDs is used for the imaging of live cells in different pH buffers and different cell lines.The FLIM images of AIS/ZnS QDs in live cells demonstrate different intracellular pH values in different regions,such as in lysosomes or cytoplasm.This method can also distinguish cancer cells from normal cells,and the fluorescence lifetime difference of the AIS/ZnS QDs between the two types of cells is 100±7 ns.Most importantly,the exfoliated cervical cells from 20 patients are investigated using FLIM combined with AIS/ZnS QDs.The lifetime difference value between the normal and cervical cancer(CC)groups is 115±9 ns,and the difference between the normal and the precancerous lesion group is 64±9 ns.For the first time,the noninvasive method has been used for cervical cancer screening,and it has shown great improvement in sensitivity compared with a clinical conventional cytology examination. | Wenhua Su Dan Yang Yulan Wang Yawei Kong Wanlu Zhang Jing Wang Yiyan Fei Ruiqian Guo Jiong Ma Lan Mi | 2022 | Nano Research2022，15，6： | 0 |
| 13 | Effects of degenerative autologous nucleus pulposus on the lumbar sympathetic trunk: Sympathetic inflammation in rats显示文摘Objective: We have reported the presence of discogenic visceral pain secondary to anterior herniation of the lumbar disc. The aim of this study was to observe the inflammatory response of the sympathetic trunk to an autologous degenerative nucleus pulposus(NP) injection under fluoroscopy. Methods: A total of 72 rats were used. In 24 rats,the autologous NP suspension was injected into the right sympathetic trunk. Next,food intake and body weight of each rat were monitored for 14 days. Fourteen days after the injection,the right lumbar sympathetic trunk was harvested for histological assessment,and protein levels of IL-1 β,IL-6,and TNF-α were quantified via ELISA. Results: In the NP-treated group,endoneural hyperemia and intensive infiltration of inflammatory cells could be identified in sections of the sympathetic trunk by the hematoxylin and eosin(H&E) stain. Meanwhile,elevated concentrations of IL-1 β,IL-6,and TNF-α were determined in the sympathetic trunk of the NP group as compared to that of the na?ve and control groups,which indicated the development of an inflammatory response. Furthermore,food intake and body weight of rats in the NP group decreased significantly. Conclusions: The results indicated that an inflammatory response in the sympathetic trunk can be caused by anterior herniation of the lumbar disc,which can generate a sympathetic inflammatory pain response. | Yuanzhang Tang Jingjing Bian Yuna Guo Chenli Sun Yawei Xiuhua Li Jiaxiang Ni | 2017 | Translational Neuroscience and Clinics2017，3，4： | 0 |
| 14 | Mothers’ health-related quality of life: Its relationship with children’s health-related quality of life and behavior in low-income families显示文摘Objective:To examine the association between mothers’health-related quality of life(HRQOL)and their children’s HRQOL and behavior in low-income families.Methods:Mothers of 278 children aged 6-12 years from low-income families were invited to complete the Child Health Questionnaire Parent Form 50(CHQ-PF50)and the Strength and Dif-ficulties Questionnaire(SDQ)for their children as well as the 12-item Short-Form Health Survey version 2(SF-12v2)and the Patient Health Questionnaire-2(PHQ-2).Multiple linear regressions with mother-child pairs as the unit of analysis were performed to examine the associations between maternal and child variables with adjustment of mother-and child-level confounders.Results:Compared with the general population,low-income mothers had a lower mean SF-12v2 mental component summary score and their children also had lower mean CHQ-PF50 physi-cal and psychosocial summary scores and SDQ total difficulties score.Children of mothers with SF-12v2 scores below the population mean of 50 had significantly worse CHQ-PF50 scores and higher SDQ total difficulties scores.The mother’s PHQ-2 depression status had no association with the child’s CHQ-PF50 scores.Conclusion:Our findings suggest that more attention should be paid to reducing the negative impact of health problems on mothers’daily roles in childcare in low-income families. | Rosa Sze Man Wong Vivian Yawei Guo Patrick Ip Carlos King Ho Wong Esther Yee Tak Yu Colman Siu Cheung Fung Cindy Lo Kuen Lam | 2016 | Family Medicine and Community Health2016，4，4： | 0 |
| 15 | 载能离子辐照316L不锈钢的力学性能及微观结构表征显示文摘The 316L type austenitic stainless steel as main structural materials,are widely used for the fission reactors for more than 30 years.Besides,316L steel has been chosen as primary structural material for future advanced nuclear facility,such as fusion reactor and Accelerator Driven Subcritical(ADS)system[1].In this work,one set of the 316L steel specimens were irradiated with H and Heions to the doses of 1.01017 and 1.01018ioncm��2,at room temperature(RT)and 500℃,respectively.Another set of specimens with and without 100 ppm He pre-implantation were irradiated with Feions to the doses of 10,20 and 50 dpa at 450℃and 600℃,respectively. | Shen Tielong Jin Peng Zhu Yabin Cui Minghuan Wei Kongfang Chai Jianlong Guo Yawei Zhang Tongmin Li Jinyu Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 16 | SPS烧结Al_(2)O_(3)-ZrO_(2)-TiC陶瓷微观结构和性能研究显示文摘ZTA-TiC composite,which possesses attractive mechanical properties,good electrical and thermal conductivities,has attracted significant attention because of its potential applications in many aspects,such as bearing components,cutting tool inserts,valve seats,pump components,oxygen sensors,dies and prosthetic components applications.The commercialα-Al_(2)O_(3)(99.99%)with average particle size of 30 nm YSZ(3 mol%Y2O3 stabilized ZrO_(2) 99.99%)and TiC(99%)both with average particle size of 50 nm were used as starting powders.Theα-Al_(2)O_(3),ZrO_(2) and TiC was mixed in different ratios and mechanically milled in a planetary ball mill.Alcohol as the milling media was added into the powder mixture and was wet-mixed by ZrO_(2) grinding ball milling in a zirconia jar for 20 h.After being mixed,dried and sieved,the powders were loaded into the cylinder dies and sintered by the spark plasma sintering(SPS)apparatus in vacuum(<10 Pa)at temperature of 1400℃,with a pressing pressure of 40 MPa.The holding time was 10 min.Before examination,the surfaces of the samples were ground to remove the graphite layer. | Zhu Yabin Liu Chao Tai Pengfei Chai Jianlong Guo Yawei Li Shufen Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 17 | MgAl_(2)O_(4)掺杂对ZTA-MgAl_(2)O_(4)复相陶瓷力学及热学性能影响显示文摘MgAl_(2)O_(4) is a very suitable reinforcing phase owing to the advantageous performance such as high melting point,high strength,high hardness,corrosion resistance and good thermal shock stability.In this paper,the effects of MgAl_(2)O_(4) addition on microstructure and mechanical properties of ZTA-MgAl_(2)O_(4) composite ceramics prepared by Spark Plasma Sintering(SPS)were investigated. | Guo Yawei Chai Jianlong Zhu Yabin Wei Kongfang Li Shufeng Shen Tielong Yao Cunfeng Cui Minghuan Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 18 | SiC含量对ZTA和ATZ复相陶瓷力学及热学性能的影响显示文摘Oxide/carbide composite ceramics were prepared by spark plasma sintering(SPS)usingα-Al2O3,ZrO2andβ-SiC powders as raw materials.The effects of SiC doping on the microstructure,mechanical and thermal properties of zirconia toughened alumina(ZTA)and alumina toughened zirconia(ATZ)based composites were investigated.Fig.1 shows the effect of SiC content on the mechanical properties of the complex phase ceramics.With the increase of SiC content,the bending strength of SiC-ATZ80mol%composite phase ceramics decreased from 992 to 761 MPa.The reason is that the thermal expansion mismatch between the SiC and the substrate induces thermal stress,resulting in the different shrinkage between the substrate and the SiC affecting its strength. | Chai Jianlong Guo Yawei Zhu Yabin Li Shufeng Shen Tielong Yao Cunfeng Cui Minghuan Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 19 | ZrC掺杂对ZTA复相陶瓷微观结构和力学性能的影响显示文摘The effects of ZrC-doping(10v.%,15v.%,20v.%,25v.%)on microstructural and mechanical properties of ZTA20mol%(zirconia-20mol%toughened alumina)ceramic composites were investigated.Samples were prepared by Spark Plasma Sintering(SPS)at 1400℃and 40 MPa for a soaking time of 15 min.The relative density of samples measured by the Archimedes method was to 99.08%.The XRD patterns(Fig.1)show that the phases of the sintered samples are ZrC,α-Al2O3 and ZrO2,which are the same as the raw powders.This gives that no impurity phase was formed after sintering,indicating that the ceramic composites had excellent chemical compatibility during the sintering. | Li Shufen Zhu Yabin Guo Yawei Chai Jianlong Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 20 | Bio-inspired Filter Design Based on Vortex Control Mechanism of Parallel Groove Structure显示文摘Solid–liquid separation is widely used in daily life and practical engineering.Traditional industrial filters are prone to clogging,but this rarely occurs in filter-feeding organisms.Inspired by the filter feeding mechanism of balaenid whales and considering the local grooves in the fringes layer,a new bionic filter is produced by 3D printing technology through the bionic design of the parallel channels inside the mouth of balaenid whales.At the same time,a test platform composed of the bionic filter,peristaltic pump,fluid pulse rectifier and water tank is built to carry out the fluid flow pattern dyeing and particle filtration experiments.It is found that fluid separation occurs near the groove structure and local vortices are generated.The vortex control filtration mechanism makes the particles in the front grooves tend to accumulate on the left side,which has a certain anti-clogging effect.Moreover,the increase of flow velocity leads to the enhancement of vortices,which makes the accumulation effect on the left more obvious.This study initially practices the bionic application from biological model to engineering design,and the vortex control anti-clogging filtration mechanism proposed in the study has a wide range of application prospects and values. | Yawei Zhu Dean Hu Yonggang Guo Hao Ding Gang Yang | 2023 | Journal of Bionic Engineering2023，20，1： | 0 |
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