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| 1 | New method for the preparation of adsorbent with high adsorption capacity显示文摘Polyamidoamine (PAMAM) is a type of macro- molecule having a definite chemical structure and a large number of terminal functional groups. The synthetic ap-proach of the adsorbent with high adsorption capacity in-volved arching of PAMAM onto cellulose beads by reaction with epichlorohydrin. The product thus prepared had a large number of amino groups of 2.94 mmol/g derived from 0.23 mmol/g epoxy groups on cellulose beads. This method pre-sents an effective method for the preparation of high-loading adsorbents. | WANG Yongjian LIU Jianfeng DUO Jia YU Yaoting | 2005 | Chinese Science Bulletin2005，50，21： | 3 |
| 2 | Long intergenic non‐coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder显示文摘 | Yonghua Han Yuchen Liu Yaoting Gui Zhiming Cai | 2012 | J. Surg. Oncol2012，，： | 2 |
| 3 | Non-viral gene carrier mediated short hairpin RNA interference for inhibition of tumor cells growth显示文摘A tumor-targeting gene vector G250mAb-PEI-PEG has been prepared by modification of polyethylenimine (PEI) with polyethyleneglycol (PEG) and G250, a monoclonal antibody against the G250 antigen on tumor cell surface. The transfection efficiency was as high as 70% in G250 positive HeLa cells, whereas the transfection efficiency was relatively low (30%) in normal NIH3T3 cells. A plasmid encoding the short hairpin RNA (shRNA) specific for nucleostemin gene (NS) was efficiently transfected into the HeLa cells with this nonviral gene vector. RNA interference down-regulated the expression of NS gene in HeLa cells, inhibited cells proliferation and induced apoptosis. However, the growth and activity of the NIH3T3 cells were not affected under the same treatment. These results indicate that the reported nonviral gene vector, G250mAb-PEI-PEG, can target and efficiently deliver genes into HeLa cells, and has the potential for the cervical cancer treatment. | DUAN YaJun YANG CuiHong ZHANG ZhenFang LIU JianFeng ZHENG JunNian XU Yong KONG DeLing YU YaoTing | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 4 | Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms显示文摘Early childhood caries(ECC)is a public healthcare concern that greatly reduces the quality of life of young children.As a leading factor of ECC,cariogenic biofilms are composed of acidogenic/aciduric pathogens and extracellular polysaccharides(EPSs),creating an acidic and protected microenvironment.Antimicrobial photodynamic therapy(aPDT)is a noninvasive,painless,and efficient therapeutic approach that is suitable for treating ECC.However,due to the hyperfine structure of cariogenic biofilms,most photosensitizers(PSs)could not access and penetrate deeply in biofilms,which dramatically hamper their efficiency in the clinic.Herein,bioresponsive nanoparticle loaded with chlorin e6(MPP-Ce6)is developed,which largely increases the penetration depth(by over 75%)and retention(by over 100%)of PS in the biofilm compared with free Ce6.Furthermore,MPP-Ce6-mediated aPDT not only kills the bacteria in preformed biofilms but also inhibits multispecies biofilm formation.A rampant caries model is established to mimic ECC in vivo,where the population of cariogenic bacteria is decreased to 10%after MPP-Ce6-mediated aPDT.Importantly,the number and severity of carious lesions are efficiently reduced via Keyes’scoring and micro-CT analysis.This simple but effective strategy can serve as a promising approach for daily oral hygiene in preventing ECC. | Danfeng Liu Xianbin Ma Yaoting Ji Rourong Chen Shuhui Zhou Hantao Yao Zichen Zhang Mengjie Ye Zhigang Xu Minquan Du | 2022 | Bioactive Materials2022，7，8： | 2 |
| 5 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 6 | Freestanding tin disulfide singledayers realizing efficient visible-light water splitting 显示文摘 | Sun Y F Cheng H Gao S Sun Z H Liu Q H Liu Q LeiFC YaoT HeJ F WeiSQ XieY | 2012 | Angewandte Chemie-International Edition2012，51，35： | 1 |
| 7 | Long intergenic non‐coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder显示文摘 | Yonghua Han Yuchen Liu Yaoting Gui Zhiming Cai | 2012 | J Surg Oncol2012，，5： | 1 |
| 8 | Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target显示文摘Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3]. | Yingkuan Shao Kailun Xu Xi Zheng Biting Zhou Xiuli Zhang Lin Wang Yaoting Sun Dan Li Ting Chen Jian Wang Shaojun Yu Lifeng Sun Xiaoming Xu Shaozhi Dai Huanhuan Gao Guan Ruan Wei Liu Xue Cai Tiansheng Zhu Lina Qi Jiani Chen Wangxiong Hu Xingyue Weng Yi Zhu Xueping Xiang Zhiyuan Hu Jinfan Li Lirong Chen Jimin Shao Shu Zheng Tiannan Guo | 2022 | Cancer Communications2022，42，2： | 0 |
| 9 | Efficacy of TCM Fumigation Using Dampness-and-cold-dispelling Formula Combined with Methotrexate and Leflunomide Treating Rheumatoid Arthritis with Cold-dampness Bi Syndrome显示文摘Background:Rheumatoid arthritis(RA),a chronic autoimmune disease,has a high incidence and disability rate,causing patients significant discomfort.Although several medicines can be effective,they are also associated with significant adverse effects.In contrast,fumigation as one of the most often used traditional Chinese medicine(TCM)external therapy has shown both efficacy and safety with less side effect.In light of this,we comple-ment western medicine treatment with TCM fumigation therapy to improve patients’clinical efficacy,alleviate symptoms,and improve prognosis.Objective:To investigate the therapeutic effect of TCM fumigation and modern medicine combined therapy in treating RA patients with cold-dampness Bi syndrome.Methods:A single-center,randomized,controlled study was designed.From January 2022 to December 2022,a total of 60 RA patients with cold-dampness Bi syndrome were enrolled in the study.The control group(30 cases)received conventional modern medicine treatment with methotrexate for 4 weeks,while the observation group(30 cases)for 4 weeks received a combination of TCM fumigation treatment and conventional modern medicine.The effects of the two groups were comprehensively compared,including the changes in TCM symptom scores and laboratory indicators,as well as the use of visual analogue scale(VAS)and health status rating scale(HAQ)before and after treatment.Results:The total effective rate of the observation group was 93.3%,which was significantly higher than that of the control group,which is 70%(P<0.05).Before treatment,there were no significant differences in joint functional activity,pain visual analogue scale(VAS),health assessment questionnaire(HAQ-DI)and laboratory indexes between the two groups(P>0.05).After treatment,each group compared to their initial condition,respectively,showed major improvement of joint functional activity and significantly decreased VAS,HAQ-DI,and RA-related biomarkers(P<0.05);inter-group comparison of these indicators showed significanty further enhanced effect of TCM fumigation combined therapy on the RA-related biomarkers and joint functional activity of patients(P<0.05),yet the control group receiving only modern medicine showed better results of the VAS and HAQ-DI.Conclusion:The TCM fumigation combined therapy is effective to treat RA patients with cold-dampness Bi syn-drome,and to enhance their life quality,improving the joint function,and reducing inflammation. | Yaoting Du Lin Liu Zhenzhen Niu Xihong Guan Bowen Zeng | 2024 | Clinical Complementary Medicine and Pharmacology2024，4，1： | 0 |
| 10 | 类风湿关节炎与牙周炎的可能关联性:系统评价与Meta分析显示文摘目的:已有研究表明类风湿关节炎(Rheumatoid Arthritis.RA)的患者对牙周炎的易感性更高.但独立研究的结果仍存在争议。本篇Meta分析的目的是综合评价RA和牙周炎的关联性。材料和方法:在PubMed和EMBASE进行系统性文献检索。用标准表格提取数据.并计算每项研究的优势比(OR)和95%可信区间(CI)。采用固定和随机效应模型估计适宜的合并数据。结果:本研究共纳入八项病例一对照研究。各研究纳入范围从104例到151.569例。RA患者的牙周炎患病率为15.5%~100%.而对照组牙周炎患病率为10%~82.1%。在第一组(对照组)和第二组中.异质性分别为38%和11%。采用固定效应模型分析.第一组和第二组的牙周炎总合并ORs估计值分别为4.68(95%CI:3.11—7.05)和1.28(95%CI:1.24-1.33)。结论:本篇Meta分析表明RA和患牙周炎的总体风险增加显著相关。 | Qingqin Tang Haitao Fu Baodong Qin Zhide Hu Yaoting Liu Yan Liang Lin Zhou Zaixing Yang Renqian Zhong 成宵(译) 滕伟(审) | 2018 | 中国口腔医学继续教育杂志2018，21，4： | 0 |
| 11 | Evidence for GAL3ST4 mutation as the potential cause of Dectus excavatum显示文摘 | Song Wu Xiaojuan Sun Weimin Zhu Yi Huang Lisha Mou Mingming Liu Xia Li Feiyang Li Xianxin Li Yong Zhang Zheng Wang Wencui Li Zesong Li Aifa Tang Yaoting Gui Rongfu Wang Weiping Li Zhiming Cai Daping Wang | 2012 | Cell Research2012，22，12： | 0 |
| 12 | Research on Practicability and Feasibility for a New-Type Tuned Mass Damper System-TMD显示文摘Based on the principle of tuned mass damper (TMD). the method of using laminated rubber bearing (LRB) to connect TMD with structure is discussed in this paper. This is a new type of TMD system-suspended structure. To test the function of quake-reduction and the possibility of application, this paper explores the suspended top floor through shaking table test. In the model test, an electro-hydraulic shaking table was used. The main structure model was a four-story steel frame structure. The block to combat the structural quake was a concrete block. LRB was used to connect the block to the main structure. In order to analyze the efficiency of TMD, the fundamental frequencies of the main structure and block of TMD were measured separately first. Then. the frequencies of the main structure with the block and without the block were compared respectively under sine and imitative quake waves. The test shows that this new-typeTMD system is effective in combating the structural quake often reducing the acceleration of the top floor by more than 25 %. Because of the easy availability of the method, it is endowed with practical feasibility. | Zhang Yaoting Lei Ping’an Liu Zaihua Lin Ning Department of Civil Engineering, Huazhong University of Science and Technology , Wuhan 430074 | 2001 | Journal of China University of Geosciences2001，12，4： | 0 |
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