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| 1 | SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion显示文摘Bone marrow mesenchymal stem cells(MSCs)are considered as a promising cell source to treat the acute myocardial infarction.However,over 90%of the stem cells usually die in the first three days of transplantation.Survival potential,migration ability and paracrine capacity have been considered as the most important three factors for cell transplantation in the ischemic cardiac treatment.We hypothesized that stromal-derived factor-1(SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes.In this study,apoptosis was induced by exposure of MSCs to H2O2 for 2 h.After re-oxygenation,the SDF-1 pretreated MSCs demonstrated a significant increase in survival and proliferation.SDF-1 pretreatment also enhanced the migration and increased the secretion of pro-survival and angiogenic cytokines including basic fibroblast growth factor and vascular endothelial growth factor.Western blot and RT-PCR demonstrated that SDF-1 pretreatment significantly activated the pro-survival Akt and Erk signaling pathways and up-regulated Bcl-2/Bax ratio.These protective effects were partially inhibited by AMD3100,an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival,migration and cytokine secretion. | Xiaolei Liu Biyan Duan Zhaokang Cheng Xiaohua Jia Lina Mao Hao Fu Yongzhe Che Lailiang Ou Lin Liu Deling Kong | 2011 | Protein & Cell2011，2，10： | 53 |
| 2 | Efficacy of integrated Traditional Chinese Medicine and anti-retroviral therapy on immunological nonresponse in patients with human immunodeficiency virus/acquired immunodeficiency syndrome: a Meta-analysis of randomized controlled trials显示文摘OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment,on the immunological nonresponse(INR)in people living with human immunodeficiency virus(HIV)(PLWH).METHODS:Relevant literature in databases such as China National Knowledge Infrastructure Database(CNKI),Wanfang Digital Journal,Chinese Medical Journal Database(CMJD),Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane,and Embase was reviewed by two independent investigators.Data were extracted from the studies according to the eligible criteria and analyzed using Review Manager 5.3.RESULTS:Nine randomized controlled trials(RCTs)with 1078 patients were analyzed.Our analyses showed that CD4 T cell counts in the treatment group improved compared with that in the control group[mean difference(MD)=13.51,95%confidence interval(CI):7.42-19.60,P<0.0001].There was no significant difference between the treated and control groups after 3 months(MD=25.31,95%CI:-2.78 to 53.41,P=0.08).However,after 6 and 12 months,the response of the treatment group was superior to the control group(MD=27.45,95%CI:7.09-47.81,P=0.008 and MD=27.34,95%CI:6.31–48.37,P=0.01,respectively).The clinical efficacy of the treatment group was also higher than that of the control group(RR=1.75,95%CI:1.16-2.65,P=0.007).However,CD45 RO and CD45 RA T cell counts did not differ significantly between the two groups(MD=12.37,95%CI:-6.71 to 31.45,P=0.20 and MD=5.67,95%CI:-3.00 to14.35,P=0.20,respectively).CONCLUSION:The combined treatment strategy of integrated TCM and Western Medicine promotes long-term reconstitution of the immune system and thus,is beneficial and has potential use for improving INR in PLWH.However,large-scale RCTs are required to provide evidence for optimal intervention strategies. | TAO Zhuang HUANG Xiaojie LIU Ying WANG Ru DONG Jipeng LIANG Biyan ZOU Wen GAO Guojian WANG Zhuo ZHANG Ke WU Hao ZHANG Tong WANG Jian | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 6 |
| 3 | An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine显示文摘这研究试图由与病毒(HIV )/acquired 免疫不全症候群(爱滋病) 与 TCM 连续地对待 84 个月的人的免疫不全在 110 个盒子的 CD4 T 淋巴细胞房间计数观察变化评估繁体中文药(TCM ) 的治疗学的效果。从从 2004 ~ 2013 与 TCM 对待的 19 个省和城市的 110 个 HIV/AIDS 病人的信息是镇定的。在 CD4 计数的索引的变化( 200 , 201350 , 351500 并且> 500 房间/公里<啜class=“ a-plus-plus ”>在五次的 3 )指( 0 , 12 , 36 , 60 和 84 个月)并且不同治疗[加 antiretroviral 治疗(艺术)的 TCM 和 TCM ]被比较。重复措施测试没显示在组和时间之间的相互作用(P > 0.05 ) 。在四个不同框架增加和二个组的减少的 CD4 计数的学位与基线相比是统计上重要的。在二个组之间的 CD4 计数不是统计上重要的。为 200 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 21 和 28 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 201350 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 6 和 25 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 351500 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 13 和 7 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 CD4 计数 > 500 房间 / 公里 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 34 和 17 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。TCM 的长期的使用能与 HIV/AIDS 在病人维持或变慢,并且可以完成持续有效性衰退 CD4 计数的步。 | Jian Wang Biyan Liang Xiaoping Zhang Liran Xu Xin Deng Xiuhui Li Lu Fang Xinghua Tan Yuxiang Mao Guoliang Zhang Yuguang Wang | 2014 | Frontiers of Medicine2014，8，3： | 5 |
| 4 | Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events显示文摘The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants.Ongoing concerns of emergent variants include possible recombinants,as genome recombination is an important evolutionary mechanism for the emergence and re-emergence of human viral pathogens.In this study,we identified diverse recombination events between two Omicron major subvariants(BA.1 and BA.2)and other variants of concern(VOCs)and variants of interest(VOIs),suggesting that co-infection and subsequent genome recombination play important roles in the ongoing evolution of SARS-CoV-2.Through scanning high-quality completed Omicron spike gene sequences. | Junxian Ou Wendong Lan Xiaowei Wu Tie Zhao Biyan Duan Peipei Yang Yi Ren Lulu Quan Wei Zhao Donald Seto James Chodosh Zhen Luo Jianguo Wu Qiwei Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 3 |
| 5 | A scalable bio-inspired polydopamine-Cu ion interfacial layer for high-performance lithium metal anode显示文摘The growth of Li dendrites and the instability of the solid electrolyte in terphase(SEI)layer during plating/stripping has hin dered the practical applicati on of high-energy-density batteries based on a lithium metal anode.Building a stable interfacial layer is effective in preventing lithium corrosiion by the electrolyte and controlling the deposition of lithium metal.Here,we present a robust polydopamine-Cu ion(PDA-Cu^2+)coati ng layer formed by the aggregation of nanoparticles and Cu ions,which can be obtained by a subtle immersion strategy.We demonstrate that the PDA-Cu^2+ protective layer,with a unique structure comprising nanoparticles,can regulate and guide Li metal deposition,and together with Cu ions,forms a lubricating surface to facilitate uniform Li ion diffusion and induce stable SEI layer formation.Li anodes with this PDA-Cu^2+layer modification ultimately achieve higher Coulombic efficiencies,which are consistently stable for over 650 cycles at 0.5 mA·cm^-2 without Li dendrites.The introduced PDA-Cu^2+ coating can adhere to any material of any shape;addition ally,the operation can be realized on a large scale because of its simplicity.These merits provide a promising approach for developing stable and safe lithium metal batteries. | Qianqian Meng Huimin Zhang Yue Liu Shaobo Huang Tianzhu Zhou Xiaofei Yang Biyan Wang Wenfeng Zhang Hai Ming Yu Xiang Meng Li Gaoping Cao Yaqin Huang Li-zhen Fan Hao Zhang Yuepeng Guan | 2019 | Nano Research2019，12，12： | 2 |
| 6 | Reactive oxygen species and nitric oxide induce senescence of rudimentary leaves and the expression profiles of the related genes in Litchi chinensis显示文摘Litchi is one of the most important subtropical evergreen fruit trees in southern Asia.Previous studies indicated that high-temperature conditions encourage growth of rudimentary leaves in panicles and suppress flowering.We have demonstrated that methyl viologen dichloride hydrate(MV)and sodium nitroprusside(SNP)promoted flowering in litchi partially by inhibiting the growth of rudimentary leaves via reactive oxygen species(ROS)and nitric oxide(NO).In the present study,we examined the microstructure and ultrastructure,programmed cell death(PCD)ratio,nuclei morphology of the rudimentary leaves,and the expression of senescence-related genes after the treatment with ROS or NO.The results showed that chromatins of the ROS-or NO-treated cells in the rudimentary leaves were condensed.Fusion of the cytoplasm-digesting vesicles with the vacuole and degradation of cytoplasm forming scattered debris were found in those of the treated cells.Treatment with ROS or NO increased the cell PCD ratio.Morphology of the nuclei stained by propidium iodide(PI)showed that nuclei shape became irregular after the ROS or NO treatment.Further,the expression levels of LcRboh,LcMC-1-like,and LcPirin were higher in the ROS-and NO-treated rudimentary leaves than those in the control ones,suggesting that these genes may be involved in the ROS and NO-induced senescence and abscission of the rudimentary leaves in litchi.Our results suggested that ROS and NO play an important role in inducing the senescence of the rudimentary leaves,and ROS-and NO-induced PCD may be involved in the regulation of the rudimentary leaf growth in litchi. | Haifang Yang Hye-Ji Kim Houbin Chen Yong Lu Xingyu Lu Congcong Wang Biyan Zhou | 2018 | Horticulture Research2018，5，1： | 2 |
| 7 | Cucurbit[8]uril-mediated multi-color fluorescence system for time-dependent information encryption显示文摘Programming microscopic assembly mode to control macroscopic property is an attractive research objective.In particular,controlling molecular assembly to control fluorescence is of considerable interest for developing smart fluorescent materials.Herein,a color-tunable supramolecular emissive system was developed based on cucurbit[8]uril mediated host-guest assembly.Chemical designing for the molecular structures with minimized change resulted in different assembly modes and hence generating distinctive fluorescence,including green,yellow and orange with the addition of cucurbit[n]uril.Taking advantage of this feature,the advanced information encryption material(4D code)with multiple encryption levels and time-dependent encryption feature was developed.Such a code was dynamic on time scale,generating a series of 3D codes with time.The encrypted information only can be recognized by integrating time-coursed codes.This work provides a new insight for designing intelligent fluorescent materials for information encryption with high level of security. | Biyan Lin Qian Wang Zhen Qi Hanren Xu Da-Hui Qu | 2023 | Science China Chemistry2023，66，4： | 1 |
| 8 | A simple eolori- metric method for determination of hydrogen peroxide in plant tis- sues显示文摘 | ZHOU Biyan WANG Jihua GUO Zhenfei | 2006 | Plant Growth Regulation2006，49，： | 1 |
| 9 | Effects of graphene oxide on surface energy,mechanical,damping and thermal properties of ethylene-propylene-diene rubber/petroleum resin blends显示文摘 | Cben Biyan Ma Nan Bai Xin | 2012 | RSC Advances2012，2，11： | 1 |
| 10 | A simple colorimetric method for determination of hydrogen peroxide in plant tissues显示文摘 | ZHOU Biyan WANG Jihua GUO Zhenfei | 2006 | Plant Growth Regulation2006，49，： | 1 |
| 11 | A simple colorimetric method for determination of hydrogen peroxide in plant tissues显示文摘 | ZHOU Biyan WANG Jihua GUO Zhenfei | | 0，，： | 1 |
| 12 | A flexible non- amino acid-based formal asymmetric synthesis of naturally occurring (2R, 3S )-2-aminotetradeca-5,7-dien-3-ol: ob- servation of a remarkable protecting group effect 显示文摘 | He Biyan Wu Tianjun Yu Xianyong | 2003 | Tetrahedron : Asymmetry2003，14，14： | 1 |
| 13 | Research papers: nitric oxide is involved in abscisic acidinduced antioxidant activities in Stylosanthes guianensis显示文摘 | Zhou Biyan Guo Zhenfei Xing Jinpeng | 2005 | J Exp Bot2005，56，： | 1 |
| 14 | Drought Stress Induces Flowering and Enhances Carbohydrate Accumulation in Averrhoa Carambola显示文摘Star fruit(Averrhoa carambola)is an important fruit tree in tropical and subtropical Asia.The tree blooms several times and fruits accordingly within one year.Controlling the flowering time and understanding the physiological mechanism of the induction of floral buds in A.carambola are indispensable to the industry.In this study,A.carambola potted trees were subjected to drought stress in a growth chamber.To avoid excessive drought stress and leaf abscission,trees were watered every 7 d and were sprayed with water every 2 d.The flowering rate was recorded,and the carbohydrate contents of the leaves,phloem,and xylem tissues were determined during the treatment and after re-watering.The results showed that drought stress increased the flowering rate in both drooping and water shoots,increased the relative conductivity,decreased the relative water content(RWC)of leaves.The total soluble sugar,sucrose,fructose,and glucose in leaves of the drooping shoots were increased.The starch contents in the xylem of both drooping and water shoots were also increased by the treatment.The results indicated that drought stress enhances carbohydrate accumulation in A.carambola.This study provides a potential way by water control to induce flowering without chemical in A.carambola. | WU Pingping WU Chubin ZHOU Biyan | 2017 | Horticultural Plant Journal2017，3，2： | 1 |
| 15 | Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation related scar tissue显示文摘 | Sairyo K Biyan IA Goe| VK et at | 2007 | Spine2007，32，11： | 1 |
| 16 | Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China显示文摘 | Biyan He Minhan Dai Weidong Zhai Lifang Wang Kejian Wang Junhui Chen Jianrong Lin Aiqin Han Yanping Xu | 2009 | Marine Chemistry2009，，1： | 1 |
| 17 | Studies of BaO-NdzOs- TiO3 thin films by RF sputter and its TMLs显示文摘 | WU Biyan DONG Shurong | 2006 | Spec- troscopy and Material Properties2006，2，6： | 1 |
| 18 | Adsorption of methyl tert -butyl ether (MTBE) from aqueous solution by porous polymeric adsorbents显示文摘 | Biyan Ji Fei Shao Guanjiu Hu Shourong Zheng Qingmei Zhang Zhaoyi Xu | 2008 | Journal of Hazardous Materials2008，，1： | 1 |
| 19 | PCRC evolutionary game method and its application in multi-objective optimization design 显示文摘 | Biyan Li Rui Meng | 2011 | Ad- vanced in Control Engineering and Information Science2011，15，： | 1 |
| 20 | A simple colorimetric method for determination of hydrogen peroxide in plant tissues显示文摘 | Biyan Zhou Jihua Wang Zhenfei Guo Huoquan Tan Xiaochuan Zhu | 2006 | Plant Growth Regulation (-)2006，，2： | 1 |
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