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| 1 | Comparison of pore characteristics in the coal and shale reservoirs of Taiyuan Formation, Qinshui Basin, China显示文摘 | Yu Liu Yanming Zhu | 2016 | International Journal of Coal Science & Technology2016，3，3： | 30 |
| 2 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Illite Crystallinity Mapping of Very Low Grade Metamorphism of Triassic Metapelites in the Zoigê Area,Western China显示文摘X-ray diffraction methods for estimating the metamorphic grade of diagenetic,anchizone and epizone in metapelites are reviewed and applied to samples from a 7000m+ borehole in western China and surface samples from the surrounding Zoigê area.Kübler's illite crystallinity(IC) measurements provide more consistent results than calculated values of percentage of illite in the I/S mixed layers and percentage of I/S mixed layers.Down-borehole IC values display a typical burial metamorphic relationship between stratigraphic level and IC.A method for preparing very low grade metamorphic maps is described,and isograds plotted on a regional geological map at selected values of IC,delineating a high temperature diagenetic zone,an anchizone,and an epizone.The map shows that IC values are controlled by stratigraphic level in the north of the study area(i.e.burial metamorphism),and proximity to an igneous intrusive body in the south(i.e.contact metamorphism). | TANG Yan SANG Longkang YUAN Yanming YU Jishun ZHANG Yunpeng QI Xianmao YANG Yunlong | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 6 |
| 4 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 5 | Comparison of aerosol characteristics during haze periods over two urban agglomerations in China using CALIPSO observations显示文摘 | Qiong Liu Xiaojun Ma Yanrong Yu Yan Qin Yonghang Chen Yanming Kang Hua Zhang Tiantao Cheng Yan Ling Yujie Tang | 2017 | Particuology2017，15，4： | 2 |
| 6 | Interaction between poly(amidoamine) dendrimers and DNA studied by spectroscopic methods显示文摘The interaction between amino-terminated, and ethylenediamine core poly(amidoamine) (PAMAM) den-drimers and herring sperm DNA was investigated by various spectroscopic methods including UV spectroscopy, fluores-cence spectroscopy, microscopic FTIR- and circular dichro-ism (CD-) spectroscopy. Ethidium bromide (EB) is used as a nucleic acid probe for this study. Experimental results show that PAMAM dendrimers can form stable complexes with DNA and the dendrimers bind to DNA sufficiently strong which cannot be displaced by EB, and we also found that the formation of the complexes can cause the conformation change of the DNA secondary structure. According to the Scatchard analysis, the association constant of PAMAM to DNA is calculated to be 2.53 × 104 mol/L?1. | WANG Yanming SONG Yu KONG Deling YU Yaoting | 2005 | Chinese Science Bulletin2005，50，19： | 2 |
| 7 | Progressive silencing of the zinc transporter Zip8 (Sic39a8) in chronic cadmium-exposed lung epithelial cells显示文摘镉(Cd ) ,非本质的金属,暗地里由利用进口小径的必要金属进入房间。锌 transporters Zip8 , Zip14 ,和二价的金属 transporter ( Dmt1 ) 1 现在作为涉及细胞的 Cd 加入的几重要金属 transporters 正在出现,他们的表情被显示了下面调整在几Cd抵抗( Cd R )房间线,然而这些 transporters 的参与在在肺房间的Cd抵抗的发展期间是不清楚的。在这研究,我们因此在我们的以前确定的老鼠肺检查这些金属 transporters 的表示上皮的房间(LEC ) 和 Zip8 的水平是的表演日益增多地 silenced 当 LEC 被使适应增加 CdCl 2 的集中时(从 1 ~ 20 M ) 。细胞的 Cd 内容的随后的测量显示了那 Cd R LEC 展出 Cd 累积的显著减少,可能由于 Zip8 的损失表示。我们调查由 DNA hypermethylation 的 Zip8 基因的 epigenetic silencing 涉及 Zip8 表示的下面规定的可能性。Cd R LEC 比父母房间显示出 DNA methyltransferase 3b (Dnmt3b ) 的更高的 mRNA 水平。Cd 有 5-aza-2-deoxycytidine 的 R LEC, DNA methyltransferases 的一个禁止者,回复到在这些房间的 Cd 的 Zip8 和敏感的表示,为 Cd 进口显示 Zip8 的关键角色。一起拿,我们的结果证明 Zip8 表示的进步 silencing 在肺房间对 Cd 涉及抵抗的获得,代表抵抗导致 Cd 的 cytotoxicity 的适应幸存机制。 | Yangmin Gao Yanming Xu Dandan Wu Feiyuan Yu Lei Yang Yue Yao Zhanling Liang Andy T. Y. Lau | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 2 |
| 8 | Conversion of surgically verified unresectable to resectable hepatocellular carcinoma显示文摘 | Zhaoyou Tang Yeqin Yu Zengchen Ma Rong Yang Xinda Zhou Kangda Liu Jizhen Lu Yanming Bao Zhiying Lin Binghui Yang | 1989 | Chinese Journal of Cancer Research1989，，3： | 1 |
| 9 | Variations of monsoonal precipitation over the last 16,000 years in the eastern Nanling Mountains, South China显示文摘 | Wei Zhong Jibin Xue Yanming Zheng Qiaohong Ma Ying Cai Jun Ouyang Liubin Xu Shangzhe Zhou Xuefeng Yu | 2010 | Journal of Paleolimnology2010，，1： | 1 |
| 10 | A free-standing-type design for cathodes of rechargeable Li-O2 batteries显示文摘 | Cui Yanming Wen Zhaoyin Liu Yu | 2011 | Energy & Environmental Science2011，4，11： | 1 |
| 11 | Benthic nutrient fluxes in the intertidal flat within the Changjiang (Yangtze River) Estuary显示文摘In an annual cycle from March 2005 to February 2006, benthic nutrient fluxes were measured monthly in the Dongtan intertidal flat within the Changjiang (Yangtze River) Estuary. Except for NH4+, there always showed high fluxes from overlying water into sediment for other four nutrients. Sediments in the high and middle marshes, covered with halophyte and consisting of macrofauna, demonstrated more capabilities of assimilating nutrients from overlying water than the low marsh. Sampling seasons and nutrient concentrations in the overlying water could both exert significant effects on these fluxes. Additionally, according to the model provided by previous study, denitrifica- tion rates, that utilizing NO3- transported from overlying water (DW) in Dongtan sediments, were estimated to be from -16 to 193 μmol·h-1·m-2 with an average value of 63 μmol·h-1·m-2 (n=18). These estimated values are still un- derestimates of the in-situ rates owing to the lack of consideration of DN, i.e., denitrification supported by the local NO3- production via nitrification. | GAO Lei LI Daoji WANG Yanming YU Lihua KONG Dingjiang LI Mei LI Yun FANG Tao | 2008 | Chinese Journal Of Geochemistry2008，27，1： | 1 |
| 12 | Phase relations of R-T-M temary system, crystal structure and magnetic properties of R(T,M)13 compounds (R = Light rare earth; T = Co, Fe; M = Al, Si) ( Ⅰ ) 显示文摘 | Liang Jingkui Rao Guanghui Tang Weihua Zhao Yanming Guo Yongquan Yan Xiaohua Zhang Yuling Cheng Xiangrong Xie Sishen Yu Yude Tian Jinghua Cheng Xiaolong Liang Jingmei | 1996 | Progress in Natural Science1996，6，6： | 1 |
| 13 | Complication following gastric pull-up reconstruction for advanced hypopharyngeal or cervical esophageal carcinoma: a 20-year review in a Chinese institute显示文摘 | He Shuangba Sun Jingwu Wang Yinfeng Hu Yanming Lv Qiuping Li Xianguang Xu Weiqing Wang Shengjun Yu Zhenkun | 2011 | American Journal of Otolaryngology--Head and Neck Medicine and Surgery2011，，4： | 1 |
| 14 | Fluorescence study on the interactions of PAMAM dendrimers and their derivatives with bovine serum albumin显示文摘The interactions of amino-terminated, and ethylenediamine core poly(amidoamine) (PAMAM) den-drimers and their derivatives with bovine serum albumin (BSA) were investigated by fluorescence spectroscopy. Ex-perimental results showed that the fluorescence intensity of BSA decreased after the addition of different modified den-drimers, and the extent of the fluorescence quenching caused by various modified dendrimers strongly depends upon the different functional groups on their surfaces. We also inves-tigated the influence of pH and ionic strength on the interac-tion between various modified dendrimers and BSA. Circu-lar dichroism (CD) spectroscopic measurements showed that the content of α-helix structure of BSA decreased after the addition of different modified dendrimers, which indicated that dendrimers induced changes in the secondary structure of BSA. | WANG Yanming SONG Yu KONG Deling YU Yaoting | 2005 | Chinese Science Bulletin2005，50，21： | 1 |
| 15 | Rapid spin-lattice relaxation time mapping incorporating fiip angle calibration in quantitative magnetic resonance imaging显示文摘Driven equilibrium single pulse observation of T1 (DESPOT1) is a rapid spin-lattice relaxation constant (T1) mapping technique in magnetic resonance imaging (MRI).However, DESPOT1 is very sensitive to fiip angle (FA) inhomogeneity, resulting in T1 inaccuracy.Here, a five-point DESPOT1 method is proposed to reduce the sensitivity to FA inhomogeneity through FA measurement and calibra-tion.Phantom and in vivo experiments are performed to validate the technique.As a result, a rapid and accurate T1 mapping is acquired by using the proposed five-point DESPOT1 method. | Zhongliang Zu Qi Liu Yanming Yu Song Gao Shanglian Bao | 2008 | Progress in Natural Science:Materials International2008，18，9： | 1 |
| 16 | Effect of assisted transverse magnetic field on distortion behavior of thin-walled components in WEDM process显示文摘Machining performance of thin-walled components made by aeronautical difficult-toprocess materials is a significant issue in the aviation manufacturing industry.Although wire electric discharge machining-low speed(WEDM-LS)is one of typical non-contact machining processes without macro cutting force,which does well in removing hardness and brittleness materials via pulsed discharge at high temperature,but few researchers have studied the thermal distortion behavior leading to a considerable geometric error in the WEDM-LS of thin-walled components.In this paper,a transverse magnetic field assisted method is applied for affecting the uniformity of discharge point distribution so as to reduce the distortion in WEDM-LS processing thin-wall component.First,the generation mechanism of this new distortion behavior and the impact mechanism of transverse magnetic field(TMF)on distortion are demonstrated by theoretical analysis.In order to further figure out the distortion behavior in the TMF-WEDM process,a new thermophysical model considering the discharge point distribution is established to simulate temperature field,residual stress field and distortion profiles.Then a large number of Taguchi experiments are carried out to investigate the influences of process parameters including pulse discharge energy(pulse on time,pulse off time,and current)and magnetic field strength on distortion in WEDM-LS.To comparatively analyze simulated and experimental results,the accuracy of established thermophysical model is verified within a relative error of 18.38%in distortion.Moreover,it can be revealed that transverse magnetic field contribute to significantly improve the longitudinal distribution uniformity with maximum increase of 12.32%at magnetic field strength:0.15 T,leading to significant reductions of 32.77%in distortion and 22.68%in recast layer.Eventually,we also presented the variation of residual stress and recast layer along thickness direction under different distortion behavior,which are in good agreement with that of distortion behavior. | Yanming ZHANG Guojun ZHANG Zhen ZHANG Yi ZHANG Yu HUANG | 2022 | Chinese Journal of Aeronautics2022，35，2： | 1 |
| 17 | Halophyte Vegetation Influences Soil Microbial Community of Coastal Salt Marsh显示文摘Coastal wetlands are the most productive ecosystems worldwide and can provide important ecosystem services,yet the characteristics of microbial community within these systems remain poorly understood.Microbial community of salt marsh vegetation and the associated soil physio-chemical properties were investigated in this study.Three typical Suaeda australis,Phragmites australis,Spartina alterniflora wetlands,and non-vegetated bare mudflats in the Zhoushan Islands were studied to advance the understanding of the characteristics of soil bacterial communities in coastal wetlands.Results showed that the bare mudflats exhibited high pH value and soil moisture content compared with the vegetated samples.In different vegetation types,the organic matter content,total nitrogen,and total potassium content decreased in the order:S.alterniflora wetland>P.australis wetland>S.australis wetland,and there was no obvious difference in total phosphorous content.The halophytes could decrease soil salinity compared with bare mudflats.Proteobacteria,Nitrospinae,Bacteroidetes,Acidobacteria,and Nitrospirae were the predominant level across all samples.Functional prediction showed that SPA-covered soil might play vital roles in sulphur cycling,while SUA and PHR covered soils were involved in nitrogen cycling.This study could provide the first insight into the microbial community of this study area and contribute to a better understanding of vegetation microbiota and bioremediation in coastal wetland ecosystem. | GU Chen SHI Jiyan RUI Jianliang YU Yanming HUANG Weibin LU Zhinai CHEN Yao CHEN Xiaojun DONG Shudi HU Zhijun YE Chenghua | 2022 | Journal of Ocean University of China2022，21，6： | 1 |
| 18 | Nonlinear Analysis for the Three-dimensional Temperature fields in Cold Region Tennels显示文摘 | Zhang Xuefu Lai Yanming Yu Wenbing | 2002 | Cold Regions Science and Technology2002，35，1： | 1 |
| 19 | Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment显示文摘Self-assembling carrier-free nanodrugs are attractive agents because they accumulate at tumor by an enhanced permeability and retention(EPR) effect without introduction of inactive substances,and some nanodrugs can alter the immune environment. We synthesized a peptidyl arginine deiminase 4(PAD4) molecular inhibitor, ZD-E-1 M. It could self-assembled into nanodrug ZD-E-1. Using confocal laser scanning microscopy, we observed its cellular colocalization, PAD4 activity and neutrophil extracellular traps(NETs) formation. The populations of immune cells and expression of immune-related proteins were determined by single-cell mass cytometry. ZD-E-1 formed nanoflowers in an acidic environment, whereas it formed nanospheres at pH 7.4. Accumulation of ZD-E-1 at tumor was pHresponsive because of its pH-dependent differences in the size and shape. It could enter the nucleus and bind to PAD4 to prolong the intracellular retention time. In mice, ZD-E-1 inhibited tumor growth and metastasis by inhibiting PAD4 activity and NETs formation. Besides, ZD-E-1 could regulate the ratio of immune cells in LLC tumor-bearing mice. Immunosuppressive proteins like LAG3 were suppressed,while IFN-γ and TNF-a as stimulators of tumor immune response were upregulated. Overall, ZD-E-1 is a self-assembling carrier-free nanodrug that responds to pH, inhibits PAD4 activity, blocks neutrophil extracellular traps formation, and improves the tumor immune microenvironment. | Di Zhu Yu Lu Lin Gui Wenjing Wang Xi Hu Su Chen Yanming Wang Yuji Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 20 | Optimal design of hydraulic manifold blocks based on niching genetic simulated annealing algorithm显示文摘 | 贾春强 Yu Ling Tian Shujun Gao Yanming | 2007 | High Technology Letters2007，13，4： | 1 |
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