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| 1 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 2 | 3D CFD modeling of acetone hydrogenation in fixed bed reactor with spherical particles显示文摘Acetone hydrogenation in a fixed bed reactor packed with spherical catalyst particles was simulated to study the effects of inlet gas velocity and particle diameter on hydrogenation reaction.Computational results show that the catalyst particles in the reactor are almost isothermal,and the high isopropanol concentration appears at the lee of the particles.With the increase of inlet velocity,the outlet isopropanol mole fraction decreases,and the total pressure drop increases drastically.Small diameter catalyst particles are favorable for acetone hydrogenation,but result in large pressure drop. | Xiaoming Zhou Yanjun Duan Xiulan Huai Xunfeng Li | 2013 | Particuology2013，11，6： | 7 |
| 3 | Synthesis of Mg-Al-carbonate layered double hydroxide by an atom-economic reaction显示文摘A clean method for preparing layered double hydroxides (LDHs) has been developed, featured by using the hydroxides of two different metals as starting materials by atom-economic reactions. The reactions were carried out under hydrothermal conditions in either a high pressure autoclave or a microwave digester. The compositions, structural parameters and thermal behavior of the resulting LDHs are very similar to those of materials produced by using the separate nucleation and aging steps (SNAS) method. The major advantage of the new method is that no by-product is produced, so that filtration and washing processes are unnecessary. The consequent reduction in water consumption is beneficial to the environment. | Xiangyu Xu Dianqing Li Jiaqing Song Yanjun Lin Zhi Lv Min Wei Xue Duan | 2010 | Particuology2010，8，3： | 4 |
| 4 | High Temperature Catalytic Hydrogenation of Acetone over Raney Ni for Chemical Heat Pump显示文摘Exothermic hydrogenation reaction of acetone is an important part of an IAH-CHP, and the performance of IAH-CHP is affected directly by this reaction. This paper studies the influence of space velocity, temperature, hydrogen flow rate and pressure on conversion and selectivity experimentally. The byproducts are analyzed and classified into three types: hydrogenation product, cracking products and condensation products. Both the conversion and selectivity of this reaction have the same trend with the change of space velocity, temperature and hydrogen flow rate, and has the opposite trend with the change of pressure. As the space velocity increases, the conversion curve is a gradual decline parabola but the selectivity curve is close to a straight line. Hydrogen flow rate has a more obvious influence on conversion than temperature, whereas on selectivity the situation is opposite. High pressure increases the conversion of acetone to all products, but the increment of byproducts is more than that of isopropanol, so the selectivity decreases as pressure increases. | DUAN Yanjun XU Min HUAI Xiulan | 2014 | Journal of Thermal Science2014，23，1： | 4 |
| 5 | Smoke suppressant in flame retarded thermoplastic polyurethane composites: Synergistic effect and mechanism study显示文摘Considerable smoke and toxic volatiles generation has compromised the application of thermoplastic polyurethane (TPU) and caused a great threat to human life. Here, nano-MgFe layered double hydroxide (MgFe-LDH) with uniform particle size was synthesized to reduce smoke density and toxic gases of TPU composites using ammonium polyphosphate (APP) as a flame retardant agent. The results show that the combination of 16 wt.% APP and 4 wt.% MgFe-LDH greatly decreased the smoke density (D20min and Ds, max), smoke production rate (SPR) and heat release rate (HRR) of TPU composites. Furthermore, the MgFe-LDH synergist demonstrated high efficiency in decreasing total volatiled products and toxic volatiles evolved, such as the CO, HCN and isocyanates. The reason was mainly attributed to the chemical reaction between MgFe-LDH and APP, which can promote the compactness of char layers with fine microstructure formed in the decomposition process of MgFe-LDH/APP/TPU composites. The protective char layers could act as barriers between combustion zone and matrix to protect the unburned substrate and promote smoke suppression effect. | Hongyuan Ren Kelan Qing Ying Chen Yanjun Lin Xue Duan | 2021 | Nano Research2021，14，11： | 2 |
| 6 | A structured packed-bed reactor designed for exothermic hydrogenation of acetone显示文摘Fixed-bed reactors randomly packed with catalysts have many disadvantages that may adversely affect the desired chemical reaction.The increasingly used monolithic reactor,in contrast,has many operational advantages;however,for a kinetically-controlled reaction,it does not contain sufficient catalyst to sustain the reaction.To address the problems associated with both randomly packed-bed reactor and the monolithic reactor,a structured packed-bed reactor was proposed and mathematical models were built for randomly packed-bed reactor and structured packed-bed reactor.Their respective performances were compared when applied to the exothermic reaction of the isopropanol-acetone-hydrogen chemical heat pump system.The results showed that the structured packed-bed reactor performed better in terms of pressure drop and heat transfer capacity,and had a lower radial temperature gradient,indicating that this reactor had a higher effective heat conductivity.Isopropanol on the catalyst particle surfaces was more concentrated near the tube wall because a wall effect existed in the boundary layer around the particle-wall contact points. | Yanjun Duan Min Xu Xiaoming Zhou Xiulan Huai | 2014 | Particuology2014，12，6： | 2 |
| 7 | Controllable synthesis of argentum decorated CuO_(x)@CeO_(2) catalyst and its highly efficient performance for soot oxidation显示文摘In this paper,CuO_(x)@Ag/CeO_(2) catalysts were synthesized by simple wet-chemical method and equal volume impregnation method.The obtained catalysts were subjected to soot temperature programmed oxidation(soot-TPO)activity tests and were further characterized by various techniques such as X-ray diffraction(XRD),transmission electron microscopy/high-resolution transmission electron microscopy(TEM/HR-TEM),N_(2) physisorption,X-ray photoelectron spectroscopy(XPS)and H_(2)-temperature programmed reduction(H_(2)-TPR).The results show that CuO_(x)@Ag/CeO_(2) synthesized presents well controlled core-shell structures,with nano-cube like Cu_(2)O as the core and Ag decorated polycrystalline CeO_(2) grafting layers as the shell.Such core-shell structured CuO_(x)@Ag/CeO_(2) can successfully construct a secondary oxygen delivery channel(CuO_(x)→CeO_(2)→Ag)to effectively transfer bulk oxygen of the catalyst to the soot,resulting in its excellent soot oxidation activity compared to CuO_(x)@CeO_(2).The potential benefiting effect by Ag introduction over Cu@Ag/Ce can be concluded as:(ⅰ)pumping lattice oxygen and accelerating gaseous O_(2) dissociation to generate significantly increased active surface oxygen content;(ⅱ)modulating a moderate surface oxygen vacancies concentration to maintain more highly active O_(2) species. | Jie Wan Yanjun Liu Yuanyuan Zhou Han Liu Gongde Wu Jianfei Kan Min Li Duan Weng Xiaodong Wu | 2022 | Journal of Rare Earths2022，40，10： | 1 |
| 8 | Ov-erexpr-ession of Calcineurin in Mouse Causes Sudden Cardiac Death Associated with Decreased Density of K+ Channels显示文摘 | DELI DONG YANJUN DUAN JIQING GUO | 2003 | Cardiovas Res2003，57，： | 1 |
| 9 | Determination of organic acids in red wine and must on only oneRP-LC-column directly after sample dilution and filtration显示文摘 | ZHENG Yanjun DUAN Yuntao ZHANG Yanfang | 2009 | Chromatographia2009，69，11： | 1 |
| 10 | Modulating Effect of Mg-A1-CO3 LDHs on Thermal Stability of PVC Resin显示文摘 | Lin Yanjun Evans G David Duan Xue | | 0，，： | 1 |
| 11 | A review and comparison of surface incident shortwave radiation from multiple data sources: satellite retrievals, reanalysis data and GCM simulations显示文摘Surface incident shortwave radiation(Rs)can promote the circulation of substance and energy,and the accuracy of its estimation is of great significance for climate studies.The Rs can be acquired from satellite retrievals,reanalysis predictions and general circulation model(GCM)simulations.Although Rs estimates have been evaluated and compared in previous studies,most of them focus on evaluating the Rs estimates over specific regions using ground measurements from limited stations.Therefore,it is essential to comprehensively validate Rs estimates from multiple data sources.In this study,ground measurements of 690 stations from BSRN,GEBA,CMA,GC-NET and buoys were employed to validate the Rs estimates from seven representative products(GLASS,GEWEX-SRB,CERES-EBAF,ERA5,MERRA2,CFSR and CMIP6).The validation results indicated that the selected products overestimated Rs globally,with biases ranged from 0.48 to 21.27 W/m^(2).The satellite retrievals showed relatively better accuracy among seven datasets compared to ground measurements at the selected stations.Moreover,the selected seven products were all in poor accuracy at high-latitude regions with RMSEs greater than 50 W/m^(2).The long-term variation trends were also analyzed in this study. | Shuyue Yang Xiaotong Zhang Shikang Guan Wenbo Zhao Yanjun Duan Yunjun Yao Kun Jia Bo Jiang | 2023 | International Journal of Digital Earth2023，16，1： | 1 |
| 12 | Determination of organic acids in red wine and must on only one RP-LC-column directly after sample dilution and filtration显示文摘 | ZHENG Yanjun DUAN Yuntao ZHANG Yanfang | 2009 | Chromatographia2009，69，11： | 1 |
| 13 | Acetone hydrogenation in exothermic reactor of an isopropanol–acetone–hydrogen chemical heat pump: effect of intra-particle mass and heat transfer显示文摘Intra-particle mass and heat transfer plays an important role in performance of the exothermic fixed-bed reactor for an isopropanol–acetone–hydrogen chemical heat pump. In this work, an exothermic fixed-bed reactor model, taking into account the actual packing structure, is established in the commercial software Fluent. A 120°segment of a tube with tube-to-particle diameter ratio(n) of4, where realistic particles are packed and set to porous media, is used to simulate the 3D external flow, concentration and temperature fields in the exothermic packed-bed reactor. The influence of catalyst particle diameter(dp) and micropore diameter(d0) on the intra-particle temperature,species distribution, reaction rate and selectivity is discussed. The appropriate dpand d0 are obtained. Simulation results showed that intra-particle temperature gradient is not obvious. Large dpand small d0 lead to remarkable gradient of reaction rate inside the catalyst particle and the decrease in the catalyst efficiency and reduce the acetone conversion and the selectivity in isopropanol. The optimal results reveal that the spherical catalyst with dpof 1 mm and dporeof 10 nm is appropriate for high-temperature acetone hydrogenation. | Yanjun Duan Min Xu Xiulan Huai Xunfeng Li | 2014 | Chinese Science Bulletin2014，59，33： | 0 |
| 14 | Review on recent progress in on-line monitoring technology for atmospheric pollution source emissions in China显示文摘Emissions from mobile sources and stationary sources contribute to atmospheric pollution in China,and its components,which include ultrafine particles(UFPs),volatile organic compounds(VOCs),and other reactive gases,such as NH3and NOx,are the most harmful to human health.China has released various regulations and standards to address pollution from mobile and stationary sources.Thus,it is urgent to develop online monitoring technology for atmospheric pollution source emissions.This study provides an overview of the main progress in mobile and stationary source monitoring technology in China and describes the comprehensive application of some typical instruments in vital areas in recent years.These instruments have been applied to monitor emissions from motor vehicles,ships,airports,the chemical industry,and electric power generation.Not only has the level of atmospheric environment monitoring technology and equipment been improving,but relevant regulations and standards have also been constantly updated.Meanwhile,the developed instruments can provide scientific assistance for the successful implementation of regulations.According to the potential problem areas in atmospheric pollution in China,some research hotspots and future trends of atmospheric online monitoring technology are summarized.Furthermore,more advanced atmospheric online monitoring technology will contribute to a comprehensive understanding of atmospheric pollution and improve environmental monitoring capacity. | Huanqin Wang Jitong Zhou Xue Li Qiang Ling Hongyuan Wei Lei Gao Ying He Ming Zhu Xiao Xiao Youjiang Liu Shan Li Chilai Chen Guotao Duan Zhimin Peng Peili Zhou Yufeng Duan Jianbing Wang Tongzhu Yu Yixin Yang Jiguang Wang Zhen Zhou Huaqiao Gui Yanjun Ding | 2023 | Journal of Environmental Sciences2023，，1： | 0 |
| 15 | An Objective Approach to Generating Multi-Physics Ensemble Precipitation Forecasts Based on the WRF Model显示文摘Selecting proper parameterization scheme combinations for a particular application is of great interest to the Weather Research and Forecasting(WRF)model users.This study aims to develop an objective method for identifying a set of scheme combinations to form a multi-physics ensemble suitable for short-range precipitation forecasting in the Greater Beijing area.The ensemble is created by using statistical techniques and some heuristics.An initial sample of 90 scheme combinations was first generated by using Latin hypercube sampling(LHS).Then,after several rounds of screening,a final ensemble of 40 combinations were chosen.The ensemble forecasts generated for both the training and verification cases using these combinations were evaluated based on several verification metrics,including threat score(TS),Brier score(BS),relative operating characteristics(ROC),and ranked probability score(RPS).The results show that TS of the final ensemble improved by 9%-33%over that of the initial ensemble.The reliability was improved for rain≤10 mm day^-1,but decreased slightly for rain>10 mm day^-1 due to insufficient samples.The resolution remained about the same.The final ensemble forecasts were better than that generated from randomly sampled scheme combinations.These results suggest that the proposed approach is an effective way to select a multi-physics ensemble for generating accurate and reliable forecasts. | Chenwei SHEN Qingyun DUAN Wei GONG Yanjun GAN Zhenhua DI Chen WANG Shiguang MIAO | 2020 | Journal of Meteorological Research2020，34，3： | 0 |
| 16 | Evolution of economic linkage network of the cities and counties on the northern slope of the Tianshan Mountains,China显示文摘The exchanges between cities and counties in the northern slope economic belt of Tianshan Mountains(NSEBTM)are increasingly frequent and the economic linkages are increasingly close,but the spatial distribution of economic development and linkages among the cities and counties within NSEBTM is uneven.Therefore,it is of great significance to study the evolution of spatial-temporal pattern of the economic linkage network of cities and counties on NSEBTM to promote the coordinated and integrated development of the regional economy on NSEBTM.In this study,we used the modified gravity model and social network analysis method to analyze the spatio-temporal evolution characteristics of the economic linkage network structure of cities and counties on NSEBTM in 2000,2010,and 2020.The results showed that the comprehensive development quality level of cities and counties on NSEBTM increased from 2000 to 2020,its growth rate also increased,and its gap between cities and counties continued expanding.Both the spatial distribution patterns of the comprehensive development quality level of cities and counties on NSEBTM in 2000 and 2010 were presented as“high in the middle and low at both ends”,while the spatial distribution pattern of 2020 was exhibited as“high value and low value staggered”.The total amount of external economic linkages of cities and counties on NSEBTM showed an obvious upward trend,and its gap between cities and counties continued expanding,presenting a pattern of“a strong middle section and weak ends”.The direction of economic linkages of NSEBTM existed obvious central orientation and geographical proximity.The density of economic linkage network of NSEBTM increased from 2000 to 2020,and the structure of economic linkage network changed from single-core structure centered with Urumqi City to multicore structure centered with Urumqi City,Karamay City,Shihezi City,and Changji City,shifting from unbalanced development to balanced development.In the future,we should accelerate the construction of urban agglomeration on NSEBTM,cultivate a modern Urumqi metropolitan area,improve comprehensive development quality of the cities and counties at the eastern and western ends,strengthen the intensity of economic linkages between cities and counties,optimize the economic linkage network,and promote the coordinated and integrated development of regional economy. | YANG Zeyu ZHANG Shubao LEI Jun ZHANG Xiaolei TONG Yanjun DUAN Zuliang FAN Liqin | 2023 | Regional Sustainability2023，4，2： | 0 |
| 17 | Temporal and spatial responses of ecological resilience to climate change and human activities in the economic belt on the northern slope of the Tianshan Mountains, China显示文摘In the Anthropocene era,human activities have become increasingly complex and diversified.The natural ecosystems need higher ecological resilience to ensure regional sustainable development due to rapid urbanization and industrialization as well as other intensified human activities,especially in arid and semi-arid areas.In the study,we chose the economic belt on the northern slope of the Tianshan Mountains(EBNSTM)in Xinjiang Uygur Autonomous Region of China as a case study.By collecting geographic data and statistical data from 2010 and 2020,we constructed an ecological resilience assessment model based on the ecosystem habitat quality(EHQ),ecosystem landscape stability(ELS),and ecosystem service value(ESV).Further,we analyzed the temporal and spatial variation characteristics of ecological resilience in the EBNSTM from 2010 to 2020 by spatial autocorrelation analysis,and explored its responses to climate change and human activities using the geographically weighted regression(GWR)model.The results showed that the ecological resilience of the EBNSTM was at a low level and increased from 0.2732 to 0.2773 during 2010–2020.The spatial autocorrelation analysis of ecological resilience exhibited a spatial heterogeneity characteristic of'high in the western region and low in the eastern region',and the spatial clustering trend was enhanced during the study period.Desert,Gobi and rapidly urbanized areas showed low level of ecological resilience,and oasis and mountain areas exhibited high level of ecological resilience.Climate factors had an important impact on ecological resilience.Specifically,average annual temperature and annual precipitation were the key climate factors that improved ecological resilience,while average annual evapotranspiration was the main factor that blocked ecological resilience.Among the human activity factors,the distance from the main road showed a negative correlation with ecological resilience.Both night light index and PM2.5 concentration were negatively correlated with ecological resilience in the areas with better ecological conditions,whereas in the areas with poorer ecological conditions,the correlations were positive.The research findings could provide a scientific reference for protecting the ecological environment and promoting the harmony and stability of the human-land relationship in arid and semi-arid areas. | ZHANG Shubao LEI Jun TONG Yanjun ZHANG Xiaolei LU Danni FAN Liqin DUAN Zuliang | 2023 | Journal of Arid Land2023，15，10： | 0 |
| 18 | 2,3-Seco and 3-nor guaianolides from Achillea alpina with antidiabetic activity显示文摘In this study,we presented the isolation and characterization of eight novel seco-guaianolide sesquiterpenoids(1-8)and two known guaianolide derivatives(9 and 10),from the aerial part of Achillea alpina L..Compounds 1-3 were identified as guaianolides bearing an oxygen insertion at the 2,3 position,while compounds 4-8 belonged to a group of special 3-nor guaianolide sesquiterpenoids.The structural elucidation of 1-8,including their absolute configurations,were accomplished by a combination of spectroscopic data analysis and quantum electronic circular dichroism(ECD)calculations.To evaluate the potential antidiabetic activity of compounds 1-10,we investigated their effects on glucose consumption in palmitic acid(PA)-mediated HepG2-insulin resistance(IR)cells.Among the tested compounds,compound 7 demonstrated the most pronounced ability to reverse IR.Moreover,a mechanistic investigation revealed that compound 7 exerted its antidiabetic effect by reducing the production of the pro-inflammatory cytokine IL-1β,which was achieved through the suppression of the NLRP3 pathway. | XUE Guimin ZHAO Chenguang XUE Jinfeng DUAN Jiangjing PAN Hao ZHAO Xuan YANG Zhikang CHEN Hui SUN Yanjun FENG Weisheng | 2023 | Chinese Journal of Natural Medicines2023，21，8： | 0 |
| 19 | Charge-reversible crosslinked nanoparticle for pro-apoptotic peptide delivery and synergistic photodynamic cancer therapy显示文摘Although anti-cancer nanotherapeutics have made breakthroughs,many remain clinically unsatisfactory due to limited delivery efficiency and complicated biological barriers.Here,we prepared charge-reversible crosslinked nanoparticles(PDC NPs)by supramolecular self-assembly of pro-apoptotic peptides and photosensitizers,followed by crosslinking the self-assemblies with polyethylene glycol to impart tumor microenvironment responsiveness and charge-reversibility.The resultant PDC NPs have a high drug loading of 68.3%,substantially exceeding that of 10%–15%in conventional drug delivery systems.PDC NPs can overcome the delivery hurdles to significantly improve the tumor accumulation and endocytosis of payloads by surface charge reversal and responsive crosslinking strategy.Pro-apoptotic peptides target the mitochondrial membranes and block the respiratory effect to reduce local oxygen consumption,which extensively augments oxygen-dependent photodynamic therapy(PDT).The photosensitizers around mitochondria increased along with the peptides,allowing PDT to work with pro-apoptotic peptides synergistically to induce tumor cell death by mitochondria-dependent apoptotic pathways.Our strategy would provide a valuable reference for improving the delivery efficiency of hydrophilic peptides and developing mitochondrial-targeting cancer therapies. | Haijing Qu Han Chen Wei Cheng Yuqing Pan Zhiran Duan Yanjun Wang Xing-Jie Liang Xiangdong Xue | 2023 | Nano Research2023，16，12： | 0 |
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