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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Changes in Extreme Maximum Temperature Events and Population Exposure in China under Global Warming Scenarios of 1.5 and 2.0°C: Analysis Using the Regional Climate Model COSMO-CLM显示文摘We used daily maximum temperature data(1986–2100) from the COSMO-CLM(COnsortium for Small-scale MOdeling in CLimate Mode) regional climate model and the population statistics for China in 2010 to determine the frequency, intensity, coverage, and population exposure of extreme maximum temperature events(EMTEs) with the intensity–area–duration method. Between 1986 and 2005(reference period), the frequency, intensity, and coverage of EMTEs are 1330–1680 times yr^(–1), 31.4–33.3°C, and 1.76–3.88 million km^2, respectively. The center of the most severe EMTEs is located in central China and 179.5–392.8 million people are exposed to EMTEs annually. Relative to 1986–2005, the frequency, intensity, and coverage of EMTEs increase by 1.13–6.84, 0.32–1.50, and15.98%–30.68%, respectively, under 1.5°C warming; under 2.0°C warming, the increases are 1.73–12.48, 0.64–2.76,and 31.96%–50.00%, respectively. It is possible that both the intensity and coverage of future EMTEs could exceed the most severe EMTEs currently observed. Two new centers of EMTEs are projected to develop under 1.5°C warming, one in North China and the other in Southwest China. Under 2.0°C warming, a fourth EMTE center is projected to develop in Northwest China. Under 1.5 and 2.0°C warming, population exposure is projected to increase by23.2%–39.2% and 26.6%–48%, respectively. From a regional perspective, population exposure is expected to increase most rapidly in Southwest China. A greater proportion of the population in North, Northeast, and Northwest China will be exposed to EMTEs under 2.0°C warming. The results show that a warming world will lead to increases in the intensity, frequency, and coverage of EMTEs. Warming of 2.0°C will lead to both more severe EMTEs and the exposure of more people to EMTEs. Given the probability of the increased occurrence of more severe EMTEs than in the past, it is vitally important to China that the global temperature increase is limited within 1.5°C. | Mingjin ZHAN Xiucang LI Hemin SUN Jianqing ZHAI Tong JIANG Yanjun WANG | 2018 | Journal of Meteorological Research2018，32，1： | 11 |
| 3 | Regeneration dynamics of subalpine fir (Abies fargesii) forest across the altitudinal range in the Shennongjia Mountains, central China显示文摘Aims Age structure and regeneration dynamics have been used to infer population response to environmental events and reconstruct forest development history.The aim of this study was to characterize and examine the differences of the age structure and regeneration dynamics of subalpine fir(Abies fargesii)forest across the altitudinal range in the north and south aspects in the Shennongjia Mountains,central China.Methods Ten plots(20×20 m)at each altitudinal zone(i.e.the low elevation,the middle elevation and the high elevation)were established in both the north and south aspects of the Shennongjia Mountains,central China.Dendroecological techniques were applied to obtain information about ages of the trees in the plots.The population age structure was analyzed to investigate the regeneration dynamics across the altitudinal range.Important findings Fir regeneration dynamics and age structure were similar in both aspects,and a unimodal population age structure was found at different altitudinal sites of both aspects,indicating that environmental factors might play an important role in shaping the regeneration dynamics and age structure of A.fargesii across its altitudinal range.There was a sustained recruitment during the 19th century,but the regeneration was rarer in the last century at low and midelevations.A significant greater number of fir seedlings and saplings recruited at high elevations in the last century,and fir tree density at high elevations was significantly higher than that at low elevations.Thus,the fir population at the high elevations showed a significant increase in recruitment and stem density in the last century,and we propose that the gradual infilling of fir seedlings might result in changes in regeneration dynamics and stand structure of the subalpine fir forest at high elevations in the Shennongjia Mountains,central China. | Haishan Dang Kerong Zhang Yanjun Zhang Xunzhang Tong Quanfa Zhang | 2013 | Journal of Plant Ecology2013，6，1： | 6 |
| 4 | Nonselective etching of GaN/AlGaN heterostructures by Cl2/Ar/BCl3 inductively coupled plasmas显示文摘A systematic study of the nonselective and smooth etching of GaN/AIGaN het-erostructures was performed using C12/Ar/BCI3 inductively coupled plasmas (ICR).Nonselective etching can be realized by adjusting the BCI3 ratio in the Cl2/Ar/BCI3 mixture (20%—60%), increasing the ICR power and dc bias, and decreasing the chamber pressure. Surface morphology of the etched heterostructures strongly depends on the gas chemistry and the chamber pressure. Specifically, with the addition of 20% BCI3 to Cl2/Ar (4:1) gas mixture, nonselective etching of GaN/Al0.28Ga0.72N heterostructures at high etch rate is maintained and the surface root-mean-square (rms) roughness is reduced from 10.622 to 0.495 nm, which is smoother than the as-grown sample. Auger electron spectroscopy (AES) analysis shows that the effective removal of residual oxygen from the surface of AIGaN during the etching process is crucial to the nonselective and smooth etching of GaN/AIGaN herterostructures at high etch rate. | HAN Yanjun XUE Song WU Tong WU Zhen GUO Wenping LUO Yi HAO Zhibiao SUN Changzheng | 2004 | Science China(Technological Sciences)2004，47，2： | 6 |
| 5 | An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China显示文摘 | Pixi Yan Youshu Zhao Xu Zhang Dawei Xu Xiaoguang Dai Qiaoyang Teng Liping Yan Jiewen Zhou Xiwen Ji Shumei Zhang Guangqing Liu Yanjun Zhou Yoshihiro Kawaoka Guangzhi Tong Zejun Li | 2011 | Virology2011，，1： | 5 |
| 6 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 7 | Simulation and projection of climate change using CMIP6 Muti-models in the Belt and Road Region显示文摘Climate condition over a region is mostly determined by the changes in precipitation,temperature and evaporation as the key climate variables.The countries belong to the Belt and Road region are subjected to face strong changes in future climate.In this paper,we used five global climate models from the latest Sixth Phase of Coupled Model Intercomparison Project(CMIP6)to evaluate future climate changes under seven combined scenarios of the Shared Socioeconomic Pathways and the Representative Concentration Pathways(SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0 and SSP5-8.5)across the Belt and Road region.This study focuses on undertaking a climate change assessment in terms of future changes in precipitation,air temperature and actual evaporation for the three distinct periods as near-term period(2021−2040),mid-term period(2041−2060)and long-term period(2081−2100).To discern spatial structure,Köppen−Geiger Climate Classification method has been used in this study.In relative terms,the results indicate an evidence of increasing tendency in all the studied variables,where significant changes are anticipated mostly in the long-term period.In addition to,though it is projected to increase under all the SSP-RCP scenarios,greater increases will be happened under higher emission scenarios(SSP5-8.5 and SSP3-7.0).For temperature,robust increases in annual mean temperature is found to be 5.2°C under SSP3-7.0,and highest 7.0°C under SSP5-8.5 scenario relative to present day.The northern part especially Cold and Polar region will be even more warmer(+6.1°C)in the long-term(2081−2100)period under SSP5-8.5.Similarly,at the end of the twenty-first century,annual mean precipitation is inclined to increase largely with a rate of 2.1%and 2.8%per decade under SSP3-7.0 and SSP5-8.5 respectively.Spatial distribution demonstrates that the largest precipitation increases are to be pronounced in the Polar and Arid regions.Precipitation is projected to increase with response to increasing warming most of the regions.Finally,the actual evaporation is projected to increase significantly with rate of 20.3%under SSP3-7.0 and greatest 27.0%for SSP5-8.5 by the end of the century.It is important to note that the changes in evaporation respond to global mean temperature rise consistently in terms of similar spatial pattern for all the scenarios where stronger increase found in the Cold and Polar regions.The increase in precipitation is overruled by enhanced evaporation over the region.However,this study reveals that the CMIP6 models can simulate temperature better than precipitation over the Belt and Road region.Findings of this study could be the reliable basis for initiating policies against further climate induced impacts in the regional scale. | YanRan Lü Tong Jiang YanJun Wang BuDa Su JinLong Huang Hui Tao | 2020 | Research in Cold and Arid Regions2020，12，6： | 4 |
| 8 | Adaptive neural network tracking design for a class of uncertain nonlinear discrete-time systems with dead-zone显示文摘In this paper,the stability and control issues of a class of uncertain nonlinear discrete-time systems in the strict feedback form are investigated.The dead-zone input in the systems,whose property is non-symmetric and discretized,is investigated.The unknown functions in the systems are approximated by using the radial basis function neural networks(RBFNNs).Backstepping design procedure is employed in the controller and the adaptation laws design.Lyapunov analysis method is utilized to prove the stability of the closed-loop system.A simulation example is given to illustrate the efectiveness of the proposed approach. | LIU YanJun LIU Lei TONG ShaoCheng | 2014 | Science China(Information Sciences)2014，57，3： | 3 |
| 9 | Projection of temperature and precipitation under SSPs-RCPs Scenarios over northwest China显示文摘Climate change significantly affects the environmental and socioeconomic conditions in northwest China.Here we evaluate the ability of five general circulation models(GCMs)from 6th phase of the Coupled Model Inter-comparison Project(CMIP6)to reproduce regional temperature and precipitation over northwest China from 1961 to 2014,and project the future temperature and precipitation during 2021 to 2100 under SSPs-RCPs(SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0 and SSP5-8.5).The results show that the CMIP6 models can simulate temperature better than precipitation.Projections show that the annual mean temperature will further increase under different SSPs-RCPs scenarios in the 21st century.Future climate changes in the near-term(2021-2040),mid-term(2041-2060)and long-term(2081-2100)are analyzed relative to the reference period(1995-2014).In the long term,warming will be significantly higher than the near and mid-terms.In the long term,annual mean temperature will increase by 1.4℃,1.9℃,3.3℃,5.5℃,2.7℃,3.8℃ and 6.0℃ under SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0 and SSP5-8.5,respectively.Spatially,warming in the Junggar Basin will be higher than those in the Tarim Basin.Seasonally,the maximum warming zone will be in the mountainous areas of Tarim Basin during spring and autumn,in the southern basin during winter,and in the east during summer.Precipitation shows an increasing trend under different SSPs-RCPs in the 21st century.In the long term,increase in precipitation will be significantly higher than in the near and mid-terms.Increase in annual precipitation in the long term will be 4.1% under SSP1-1.9,13.9% under SSP1-2.6,28.4% under SSP2-4.5, 35.2% under SSP3-7.0, 6.9% under SSP4-3.4, 8.9% under SSP4-6.0, and 27.3% under SSP5-8.5 relative to the reference period of 1995-2014. Spatially, precipitation increase will be higher in the south than the north, especially higher in mountainous regions than the basin under SSP2-4.5, SSP3-7.0, and SSP5-8.5. Seasonally, highest increase can be expected for winter, followed by spring, with significant increase in mountainous regions of southern Tarim Basin. Summer precipitation will reduce in Tian Shan and basins but will significantly increase in the northern margin of the Kunlun Mountain. | Jiancheng QIN Buda SU Hui TAO Yanjun WANG Jinlong HUANG Tong JIANG | 2021 | Frontiers of Earth Science2021，15，1： | 3 |
| 10 | Experimental study of seepage characteristics of single rock fracture based on stress states and stress history显示文摘Through seepage tests under different loading and unloading confining pressures and different hydraulic gradients,the authors studied the effects of stress states and stress history on fracture permeability evolution for single granite fracture and sandstone fracture. The results show that there exists a linear relationship between the seepage discharge and osmotic pressure in sandstone fissure under each level of confining pressure. With the increasing in the confining pressure,the permeability of the fracture decreases,but the decreasing rate is changeing. During the unloading process,the fracture seepage velocity cannot be fully recovered to the size of the loading process. Therefore,in the unloading process of the confining pressure,the recovery of fracture permeability shows obvious hysteresis effects. The flow rate of the fracture remains unchanged during five cycles of loading and unloading processes of the confining pressure. In each cycle,the evolution character of the flow rate with the confining pressure remains unchanged. These experiments show that the seepage characteristics of sandstone and granite fractures are not the same under the same stress state. | ZHANG Chi ZHANG Yanjun LI Zhengwei ZHANG Tong LIU Tong XIE Yangyang | 2016 | Global Geology2016，19，3： | 2 |
| 11 | ADAM10 overexpression in human non-small cell lung cancer correlateswith cell migration and invasion through the activation of the Notch1 signalingpathway显示文摘 | Jianli Guo Lei He Ping Yuan Peng Wang Yanjun Lu Fangli Tong Yu Wang Yanhua Yin Jun Tian Jun Sun | 2012 | Oncology Reports2012，，： | 1 |
| 12 | Control of the PI3K/Akt pathway by porcine reproductive and respiratory syndrome virus显示文摘 | Liqian Zhu Shen Yang Wu Tong Jianping Zhu Hai Yu Yanjun Zhou Robert B. Morrison Guangzhi Tong | 2013 | Archives of Virology2013，，6： | 1 |
| 13 | Bi-channel near-and far-field optical vortex generator based on a single plasmonic metasurface显示文摘With the recent development of the metasurface,generating an optical vortex in optical far or near fields is realized in various ways.However,to generate vortices in both the near and far fields simultaneously is still a challenge,although it has great potential in the future compact and versatile photonic system.Here,a bi-channel optical vortex generator in both the near and far fields is proposed and demonstrated within a single metasurface,where the surface plasmon vortex and the far-field optical vortex can be simultancously generated under circularly polarized light.The ability of generating vortices with arbitrary topological charges is experimentally demon-strated,which agrces well with simulations.This approach provides great freedom to integrate different vortex generators in a single device and ofers new opprtunities for integrated optical communications,trapping,and other related fields. | QIAO JIANG YANJUN BAO JING LI LIFENG TIAN ToNG CUI LIN SUN BOWEN DU BOWEN LI BENFENG BAI JIA WANG HONGBO SUN Bo SHEN HAN ZHANG FENG LIN XING ZHU ZHEYU FANG | 2020 | Photonics Research2020，8，6： | 1 |
| 14 | Adaptive NN controller design for a class of nonlinearMIMO discrete- time systems显示文摘 | LIU YANJUN TANG LI TONG SHAOCHENG | 2015 | IEEE Transactions onNeural Networks and Learning Systems2015，26，5： | 1 |
| 15 | Projected land use changes in the Qinghai-Tibet Plateau at the carbon peak and carbon neutrality targets显示文摘Based on historical land use for eight periods from 1980 to 2020 and the projected land use under seven Shared Socioeconomic Pathways(SSPs:SSP1-1.9,SSP1-2.6,SSP2-4.5,SSP3-7.0,SSP4-3.4,SSP4-6.0,and SSP5-8.5)from 2021 to 2100,we conducted a study on past and future land use changes in the Qinghai-Tibet Plateau(QTP).This work aims to reveal the land use changes during the carbon peak(2021-2040)and carbon neutrality(2051-2070)periods and at the end of the 21st century(2081-2100).The results show that:(1)in the historical period(1980-2020),the land use types in the QTP were grassland(1475×10^(3)km^(2),58.2%),barren land(685×10^(3)km^(2),27.0%),forest land(243×10^(3)km^(2),9.6%),water(114×10^(3)km^(2),4.5%),cropland(18.6×10^(3)km^(2),0.7%)and urban land(0.3×10^(3)km^(2),0.01%).(2)Relative to the baseline period(1995-2014),the area of grassland is projected to decrease by 0.7%(SSP4-6.0)-5.4%(SSP2-4.5)(0.5-3.9%of the total area of the QTP),2.8%(SSP4-6.0)-12.5%(SSP3-7.0)(2.1-9.4%of the total area of the QTP)and 6.1%(SSP4-6.0)-21.7%(SSP4-3.4)(4.6-16.4%of the total area of the QTP)in the future three periods.In contrast,the forest land area is projected to increase,by approximately 2.5%(SSP4-6.0)to 30.1%(SSP3-7.0)(0.3-4.3%of the total area of the QTP),9.2%(SSP4-6.0)to 56.5%(SSP2-4.5)(1.3-8.0%of the total area of the QTP),and 21.2%(SSP4-6.0)to 72.8%(SSP2-4.5)(3.0-10.2%of the total area of the QTP)in the future three periods,respectively.(3)Approximately 0.4(SSP4-6.0)to 6.9%(SSP5-8.5),0.9(SSP4-6.0)to 2.7%(SSP4-3.4),and 0.04(SSP5-8.5)to 3.5%(SSP1-1.9)of land is expected to convert from grassland to forest land in the future three periods,respectively.The shift from grassland to forest land area is likely to enhance the carbon sink potential of the QTP in the future period. | Runhong XU Peijun SHI Miaoni GAO Yanjun WANG Guojie WANG Buda SU Jinlong HUANG Qigen LIN Tong JIANG | 2023 | Science China Earth Sciences2023，66，6： | 0 |
| 16 | Surface control of layered double hydroxides by in-situ initiating&terminating polymerization显示文摘Appropriate surface modification or functionalization is prerequisite for the application of inorganic nanoparticles.And surface control between organic and inorganic interface plays an important role in constructing organic-inorganic composites.In-situ polymerization has been extensively studied to improve the compatibility and dispersibility of inorganic nanoparticles,but the polymerized nanoparticles tend to concatenate and form large composites,restricting further applications.Herein,uniform and dense polyacrylic acid(PAA)membranes have been grafted on layered double hydroxide(LDH)nanosheets via an in-situ initiating and terminating radical graft polymerization method.With initiating and terminating on the same particle,the size,morphology and density of grafted PAA onto the surface of LDHs can be controlled by adjusting the ratio of initiated sites to terminated sites,the amount of redox initiator or monomer.As a result,with only 17.33%organic grafting ratio,PAA@LDHs with largely improved compatibility can be monodispersed in polyethylene(PE)and polyvinyl chloride(PVC)matrices,which is determined by a fluorescence microscope technique. | Dan Tong Yuquan Zhu Kaitao Li Kuilin Du Wendi Liu Yanjun Lin | 2022 | Nano Research2022，15，2： | 0 |
| 17 | Laboratory and field experiment on measurement of soil thermal conductivity by probe method显示文摘The authors presented a new measuring method of the soil thermal conductivity,the probe method,which is designed and made based on the theory of line heat source. This method is used to measure thermal conductivity of coarse sand,fine sand and silty clay in different water contents. The results that measured by the probe method are well consistent with those of QTM-D_2. The soil thermal conductivity increases in different levels with the increase of the water content. Compared the soil thermal conductivity measured by the probe method in laboratory with in-situ experiment,it shows that the measuring gap gradually increases with the increase of the depth. The reason is that the in-situ measuring thermal conductivity can reflect the actual situation of the soil mass. | ZHANG Tong ZHANG Yanjun LIU Tong XIE Yangyang ZHANG Chi | 2015 | Global Geology2015，18，4： | 0 |
| 18 | Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus显示文摘Dear editor,Swine influenza virus(SIV)is a member of the Orthomyxoviridae family,influenza A virus genus,which can cause the swine influenza—an acute and highly contagious respiratory disease in pigs(Brown,2000;Kothalawala et al.,2006).The SIV was first observed in 1918 in the United States and the progenitor of the SIV was the H1N1 influenza virus which caused the Spanish influenza pandemic of 1918(Shope,1931). | Shuaiyong Wang Manzhu Wang Lingxue Yu Juan Wang Jiecong Yan Xinli Rong Yanjun Zhou Tongling Shan Wu Tong Guoxin Li Hao Zheng Guangzhi Tong Hai Yu | 2022 | Virologica Sinica2022，37，4： | 0 |
| 19 | The Novel PRRSV Strain HBap4-2018 with a Unique Recombinant Pattern Is Highly Pathogenic to Piglets显示文摘Currently, various porcine reproductive and respiratory syndrome virus(PRRSV) variants emerged worldwide with different genetic characteristics and pathogenicity, increasing the difficulty of PRRS control. In this study, a PRRSV strain named HBap4-2018 was isolated from swine herds suffering severe respiratory disease with high morbidity in Hebei Province of China in 2018. The genome of HBap4-2018 is 15,003 nucleotides in length, and compared with NADC30-like PRRSV, nsp2 of HBap4-2018 has an additional continuous deletion of five amino acids. Phylogenetic analysis based on complete genome and ORF5 showed that HBap4-2018 belonged to lineage 8 of PRRSV-2, which was characterized by highly variable genome. However, HBap4-2018 was classified into lineage 1 based on phylogenetic analysis of nsp2,sharing higher amino acid homology(85.3%–85.5%) with NADC30-like PRRSV. Further analysis suggested that HBap4-2018 was a novel natural recombinant PRRSV with three recombinant fragments in the genome, of which highly pathogenic PRRSV(HP-PRRSV) served as the major parental strains, while NADC30-like PRRSV served as the minor parental strains. Five recombination break points were identified in nsp2, nsp3, nsp5, nsp9 and ORF6, respectively,presenting a novel recombinant pattern in the genome. Piglets inoculated with HBap4-2018 presented typical clinical signs with a mortality rate of 60%. High levels of viremia and obvious macroscopic and histopathological lesions in the lungs were observed, revealing the high pathogenicity of HBap4-2018 in piglets. | Pengfei Chen Xiangmei Tan Mengqin Lao Xia Wu Xiongwei Zhao Shuting Zhou Jiarong Yu Junrui Zhu Lingxue Yu Wu Tong Fei Gao Hai Yu Changlong Liu Yifeng Jiang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，6： | 0 |
| 20 | Evolution of economic linkage network of the cities and counties on the northern slope of the Tianshan Mountains,China显示文摘The exchanges between cities and counties in the northern slope economic belt of Tianshan Mountains(NSEBTM)are increasingly frequent and the economic linkages are increasingly close,but the spatial distribution of economic development and linkages among the cities and counties within NSEBTM is uneven.Therefore,it is of great significance to study the evolution of spatial-temporal pattern of the economic linkage network of cities and counties on NSEBTM to promote the coordinated and integrated development of the regional economy on NSEBTM.In this study,we used the modified gravity model and social network analysis method to analyze the spatio-temporal evolution characteristics of the economic linkage network structure of cities and counties on NSEBTM in 2000,2010,and 2020.The results showed that the comprehensive development quality level of cities and counties on NSEBTM increased from 2000 to 2020,its growth rate also increased,and its gap between cities and counties continued expanding.Both the spatial distribution patterns of the comprehensive development quality level of cities and counties on NSEBTM in 2000 and 2010 were presented as“high in the middle and low at both ends”,while the spatial distribution pattern of 2020 was exhibited as“high value and low value staggered”.The total amount of external economic linkages of cities and counties on NSEBTM showed an obvious upward trend,and its gap between cities and counties continued expanding,presenting a pattern of“a strong middle section and weak ends”.The direction of economic linkages of NSEBTM existed obvious central orientation and geographical proximity.The density of economic linkage network of NSEBTM increased from 2000 to 2020,and the structure of economic linkage network changed from single-core structure centered with Urumqi City to multicore structure centered with Urumqi City,Karamay City,Shihezi City,and Changji City,shifting from unbalanced development to balanced development.In the future,we should accelerate the construction of urban agglomeration on NSEBTM,cultivate a modern Urumqi metropolitan area,improve comprehensive development quality of the cities and counties at the eastern and western ends,strengthen the intensity of economic linkages between cities and counties,optimize the economic linkage network,and promote the coordinated and integrated development of regional economy. | YANG Zeyu ZHANG Shubao LEI Jun ZHANG Xiaolei TONG Yanjun DUAN Zuliang FAN Liqin | 2023 | Regional Sustainability2023，4，2： | 0 |
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