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| 1 | Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing显示文摘Tracing the emergence of the first hematopoietic stem cells(HSCs)in human embryos,particularly the scarce and transient precursors thereof,is so far challenging,largely due to the technical limitations and the material rarity.Here,using single-cell RNA sequencing,we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis.The transcriptomically defined HSC-primed hemogenic endothelial cells(HECs)were captured at Carnegie stage(CS)12-14 in an unbiased way,showing an unambiguous feature of arterial endothelial cells(ECs)with the up-regulation of RUNX1,MYB and ANGPTL Importantly,subcategorizing CD34+CD45-ECs into a CD44+population strikingly enriched HECs by over 10-fold.We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells,and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs#including EMCN,PROCR and RUNX1T1.We also uncovered another temporally and molecularly distinct intra-embryonic HEC population,which was detected mainly at earlier CS 10 and lacked the arterial feature.Finally,we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSCprimed HECs.The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos,together with the ability to distinguish the HSC-primed HECs from others,will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells. | Yang Zeng Jian He Zhijie Bai Zongcheng Li Yandong Gong Chen Liu Yanli Ni Junjie Du Chunyu Ma Lihong Bian Yu Lan Bing Liu | 2019 | Cell Research2019，29，11： | 14 |
| 2 | Recharge sources and chemical composition types of groundwater and lake in the Badain Jaran Desert, northwestern China显示文摘在 Badain Jaran 沙漠基于湖水和浅地下水的离子化学药品作文的分析,这份报纸在荒芜的区域讨论了离子化学药品作文,湖水的空间变化,和湖水和地下水的可能的供应来源的特征。结果证明 pH,咸度, TDS 和湖水的电的电导率比地下水的那些大。水样品的离子内容被 Na+ 和 Cl 统治。大多数更高的咸度湖是 Na (K)-Cl-(SO4) 类型,并且低咸度湖的一些属于 Na-(Mg )-(Ca)-Cl-(SO4)-(HCO3) 类型。大多数地下水是 Na-(Ca )-(Mg)-Cl-(SO4)-(HCO3) 类型,把湖,和仅仅在场的一些归因于 subsaline Na-Cl-SO4 类型,流动在盐的湖下面。在东南的湖的 pH,咸度, TDS 和电的电导率是相对低的,并且有稍微碱的湖。在北湖的 pH,咸度, TDS 和电的电导率比东南的湖的那些大得多,并且北湖是中等碱、盐的。在 Badain Jaran 沙漠的东南的部分,到北方表演的来自南方的湖水的离子化学药品特征 subsaline salinehypersaline 的一个变化趋势。离子在的化学作文的变化趋势最近 9 年显示大多数离子内容在 Boritaolegai, Badain, Nuoertu 和 Huhejilin 湖有一点儿减小,它清楚地声明新鲜的水供应的数量在 9 年的时期正在增加。湖水的离子化学药品作文表明湖水的流动方向从东南到在 Badain Jaran 沙漠的西北。离子化学药品作文,沙层水水平高度的潮湿内容和湖水和地下水的层次簇分析证明湖水被降水的本地降雨和渗入主要在 Yabulai 山和 Heishantou 山供应,并且从 Qilian 山的供应是几乎不可能的。 | SHAO Tianje ZHAO Jingbo ZHOU Qi DONG Zhibao MA Yandong | 2012 | Journal of Geographical Sciences2012，22，3： | 7 |
| 3 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 4 | Prediction of large-gap quantum spin hall insulator and Rashba-Dresselhaus effect in two-dimensional g-TIA (A = N, P, As, and Sb) monolayer films显示文摘A new family of two-dimensional (2D) topological insulators (TIs) comprising g-TIA (A = N, P, As, and Sb) monolayers constructed by T1 and group-V elements is predicted by first-principles calculations and molecular-dynamics (MD) simulations. The geometric stability, band inversion, nontrivial edge states, and electric polarity are investigated to predict the large-gap quantum spin Hall insulator and Rashba-Dresselhaus effects. The MD results reveal that the g-T1A monolayers remain stable even at room temperature. The g-T1A (A = As, Sb) monolayers become TIs under the influence of strong spin-orbit couplings with large bulk bandgaps of 131 and 268 meV, respectively. A single band inversion is observed in each g-T1A (A = As, Sb) monolayer, indicating a nontrivial topological nature. Furthermore, the topological edge states are described by introducing a sufficiently wide zigzag-nanoribbon. A Dirac point in the middle of the bulk gap connects the valence- and conduction-band edges. The Fermi velocity near the Dirac point with a linear band dispersion is -0.51 × 106 m/s, which is comparable to that of many other 2D nanomaterials. More importantly, owing to the broken inversion symmetry normal to the plane of the g-T1A films, a promising Rashba-Dresselhaus effect with the parameter up to 0.85 eV-A is observed in the g-T1A (A = As, Sb) monolayers. Our findings regarding 2D topological g-T1A monolayers with room-temperature bandgaps, intriguing topological edge states, and a promising Rashba-Dresselhaus effect are of fundamental value and suggest potential applications in nanoelectronic devices. | Xinru Li Ying Dai Yandong Ma Wei Wei Lin Yu Baibiao Huang | 2015 | Nano Research2015，8，9： | 3 |
| 5 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 6 | The discovery of surface runoff in the megadunes of Badain Jaran Desert,China,and its significance显示文摘The Badain Jaran Desert exhibits the greatest difference in altitude of all of the world's deserts.On the slopes of megadunes in the desert,there are physical and chemical deposits produced by surface runoff.In addition,we have observed rarely-seen infiltration-excess surface runoff in the megadune depressions as well as spring streams at the base of megadunes.We used electron microscopy,energy spectrum analysis,infiltration experiments,moisture content determinations and grain-size analysis to study the mineral and chemical composition of the runoff precipitates,and grain-size of the deposits associated with the runoff,together with the hydrological balance in the megadune area,and the atmospheric precipitation mechanism responsible for groundwater recharge and for supplying water to lakes.The observations of shallow runoff and infiltration-excess surface runoff indicate the occurrence of strong and effective precipitation in summer,which would provide an important source for groundwater recharge.Several lines of evidence,such as the physical and chemical deposits resulting from shallow subsurface runoff,spring streams,infiltration-excess runoff,and gravity capillary water with a moisture content of 3-6%,demonstrate that precipitation reaches the base of the megadunes through infiltration and subsequently becomes groundwater.The chemical deposits,such as newly-formed calcite and gypsum,and gray-black physical deposits,as well as different stages in the development of fan-shaped landforms resulting from shallow subsurface runoff,indicate that groundwater recharge in the area is the result of long-term precipitation,rather than intermittent individual major rainfall events.Fine sand layers with a low infiltration capacity lead to subsurface runoff emerging at the ground surface.Five factors play an important role in maintaining a positive water balance and in replenishing groundwater via rainfall:effective rainfall as a water source,the high infiltration capacity of the sands enabling rainfall to rapidly become capillary water in the dunes,low evapotranspiration rates due to the sparse vegetation,the fact that the depth of the sand layer influenced by evaporation is shallow enough to maximize the deep infiltration of rainfall,and rapidly-moving gravity capillary water in the sandy dunes.These five factors together constitute a mechanism for groundwater recharge from rainfall,and explain the origin of the groundwater and lakes in the area.Our findings represent a significant advance in research on the hydrological cycle,including groundwater recharge conditions and recharge mechanisms,in this desert region. | ZHAO JingBo MA YanDong LUO XiaoQing YUE DaPeng SHAO TianJie DONG ZhiBao | 2017 | Science China Earth Sciences2017，60，4： | 3 |
| 7 | Quantitative analysis on friction stress of hot-extruded AZ31 magnesium alloy at room temperature显示文摘Mg alloy AZ31 with ~79%(volume fraction of scattering less than 30?) basal-fiber texture through hot extrusion exhibits strong grain-size dependent yield strength. Samples with grain sizes varying from4.5 to 22.3 ηm were obtained by altering annealing time durations. The Hall-Petch relations of tension and compression are σ_(0.2)= 86+200 d^(-1/2) and σ_(0.2)= 17 + 327 d^(-1/2), respectively. Considering the correlation between grain orientation and deformation modes, a novel weighted average method of calculating friction stress 0 was proposed, and results of calculation agreed with the experimental ones, which can reasonably understand the yielding behavior in tension and compression. | Ling Wang Yiquan Zhao Jing Zhang Ru Ma Yandong Liu Yinong Wang Qun Zhang Weigang Li Yuan Zhang | 2018 | Journal of Materials Science & Technology2018，34，10： | 2 |
| 8 | Formation and Movement of Groundwater in the Thick Loess-Palaeosol Sequences of the Chinese Loess Plateau显示文摘Permeability and water-bearing space are important hydrological characteristics of the loess strata. In this study a systematic experiment was conducted to measure the magnetic susceptibility, grain size, porosity, and infiltration rate of the loess and palaeosol layers on a loess tableland of the central Chinese Loess Plateau, in order to investigate the differences in hydrological conditions between the loess and palaeosol layers. The magnetic susceptibility of the loess layer was lower than that of the palaeosol layer, but the average quasi-steady infiltration rate was about 0.31 mm min^(-1) higher, the coarse silt and very fine sand contents were about7.1% greater, and the porosity was about 5.7% higher. These differences were mainly due to pedogenesis, which was affected by the Quaternary climate. The pedogenesis differences between the loess and palaeosol layers resulted in hydrological property differences in terms of permeability and water-bearing space. The loess layer had a higher permeability and more water-bearing space than the palaeosol layer, which meant that the loess layer is more likely to form aquifers and the palaeosol layer is more prone to form aquitards.The groundwater in the loess strata had a multilayered characteristic, which depended on the relative impermeability of palaeosol layer and the alternate deposition of loess-palaeosol layers. The hydrological characteristics of the loess strata demonstrated that the Quaternary climate had an important control function on the formation and movement of groundwater. This knowledge provides a reliable theoretical basis for water resource development and utilization on the Chinese Loess Plateau, and this study extends the application of Quaternary climate change theory to hydrological systems in loess deposits. | MA Yandong ZHAO Jingbo LIU Rui ZHOU Qi YIN Leipeng | 2018 | Pedosphere2018，28，6： | 2 |
| 9 | Lipid profiling of mammalian cells with in situ matrix-assisted laser desorption ionization-mass spectrometry显示文摘The analysis of cellular lipids and phospholipids has been of continuously increasing research interest due to the importance of these molecules in psychological process.In this work,a mass spectrometry-based method for direct,in situ analysis of lipids in cells was reported.Mammalian cells were directly cultured on ITO-coated glass and then analyzed by matrix-assisted laser desorption ionization-mass spectrometry(MALDI-MS).The matrix application process was achieved by electrospray coating,which produced a homogenous layer of matrix crystal on the sample.The detection results and reproducibility are satisfactory.With this method,a profile of abundant membrane lipids is generated,which is characteristic of cell type.In conclusion,this in situ MALDI-MS cellular lipid analysis method provides a platform for sensitive and robust molecular profiling of mammalian cells. | ZHANG YanDong LI HaiFang MA Yuan LIN JinMing | 2014 | Science China Chemistry2014，57，3： | 1 |
| 10 | Silver-coated elevated bowtie nanoantenna arrays: Improving the near-field enhancement of gap cavities for highly active surface-enhanced Raman scattering显示文摘改进热点紧张是在散布的提高表面的拉曼(重量的单位) 的一个关键问题。bowtie nanoantenna (BNA ) 是过去常集中光能进 nanoscale 卷并且生产强壮的热点的一台有效设备。Nanosphere 平版印刷术(NSL ) 是一种大区域、便宜的技术生产 BNA 数组;然而,制作 NSL 的 BNA 的 SERS 活动是有限的。在这份报纸,我们在场由修改他们的几何学改进常规制作 NSL 的 BNA 的 SERS 活动的一个简单方法。新配置被称为银涂的提高的 bowtie nanoantenna (SCEBNA ) 。SCEBNA 由于闪电杆效果,联合的回声,和 plasmonic FabryP 的形成的综合贡献在差距洞执行集中的近地的改进 ? 楷桴吗? | Lei Feng Renping Ma Yandong Wang Daren Xu Dongyang Xiao Lingxiao Liu Nan Lu | 2015 | Nano Research2015，8，11： | 1 |
| 11 | Magnetism in non transition metal doped Cd S studied by density functional theory显示文摘 | Ma Yandong Dai Ying Huang Baibiao | 2011 | Computational Materials Science2011，50，5： | 1 |
| 12 | Automatic Removal of the Eye Blink Artifact from EEG Using an ICA-based Template Matching Approach显示文摘 | Li Yandong Ma Zhongwei Lu Wenkai | 2006 | Physiological Measurement2006，27，4： | 1 |
| 13 | Two-dimensional square transition metal dichalcogenides with lateral heterostructures显示文摘 | Qilong Sun Ying Dai Na Yin Lin Yu Yandong Ma Wei Wei Baibiao Huang | 2017 | Nano Research2017，10，11： | 1 |
| 14 | Graphene adhesion on MoS2 monolayer: an ab initio study 显示文摘 | Ma Yandong Dai Ying Guo Meng et ai | 2011 | Nanoscale2011，3，9： | 1 |
| 15 | 3,5,4′-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1α显示文摘 | Lijie Ma Yilin Zhao Beixi Li Qingwei Wang Xueying Liu Xiangjun Chen Yandong Nan Li Liang Ruijing Chang Lifeng Liang Peipei Li Faguang Jin | 2013 | Respiratory Physiology & Neurobiology2013，，3： | 1 |
| 16 | Automatic Removal of the Eye Blink Artifact from EEG Using an ICA-based Template Matching Approach显示文摘 | Li Yandong Ma Zhongwei Lu Wenkai | 2006 | Physiological Measurement2006，27，4： | 1 |
| 17 | Magnetism in non-transition-metal doped CdS studied by density functional theory显示文摘 | Ma Yandong Ying Dai Baibiao Huang | 2010 | Computational Materials Science2010，，： | 1 |
| 18 | Feedfor- ward and feedback optimal control for offshore structures subjected to irregular wave forces显示文摘 | MA Hui TANG Gongyou ZHAO Yandong | 2006 | The Ocean Engi- neering2006，33，89： | 1 |
| 19 | Group 14 element-based non-centrosymmetric quantum spin Hall insulators with large bulk gap显示文摘迄今为止,很多二维(2D ) 拓扑的绝缘体(TI ) 在组 14 元素的蜂房格子被认识到,但是都是 inversionsymmetric。基于第一原则的计算,这里,我们预言 2D 的一个新家庭有可观的体积的倒置不对称的 TI 从 105 兆电子伏豁开到 284 兆电子伏,在 X2GeSn (X = H, F, Cl, Br,我) 单层,为房间温度应用使他们原则上合适。转换乐队订单的重要拓扑的特征与 X = 在太古的 X2GeSn 被识别(F, Cl, Br,我) ,而 H2GeSn 在 8% 格子扩大经历重要乐队倒置。拓扑地保护的边状态与 X = 在 X2GeSn 被识别(F, Cl, Br,我) ,以及在拉紧的 H2GeSn。更重要地,这些系统的边,它展出 single-Dirac-cone 特征完全在他们的体积乐队差距的中间定位了,为无驱散的运输是理想的。因此,组 14 元素的蜂房格子为量状态的操作提供一个迷人的运动场。 | Yandong Ma Liangzhi Kou Aijun Du Thomas Heine | 2015 | Nano Research2015，8，10： | 1 |
| 20 | Hot deformation behavior of spray-deposited Al–Zn–Mg–Cu alloy显示文摘 | Yandong Jia Fuyang Cao Shu Guo Pan Ma Jingshun Liu Jianfei Sun | 2013 | Materials and Design2013，，： | 1 |
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