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| 1 | 4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata显示文摘Seven new 4-hydroxybenzyl-substituted amino acid derivatives(1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Gastrodia elata Blume.Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 are pyroglutamate derivatives containing 4-hydroxybenzyl units at the N atom and 4-7 are the first examples of natural products with the 4-hydroxybenzyl unit linked via a thioether bond to 2-hydroxy-3-mercaptopropanoic acid(4-6) and 2-hydroxy-4-mercaptobutanoic acid(7), which would be biogenetically derived from cysteine and homocysteine, respectively. The structures of 1 and 2 were verified by synthesis, while the absolute configurations of 4, 5 and 7 were assigned using Mosher's method based on the MPA determination rule of ΔδRS values. The known compound 4-(hydroxymethyl)-5-nitrobenzene-1,2-diol(8) exhibited activity against Fe^(2+)-cysteine induced rat liver microsomal lipid peroxidation with IC_(50) values of 9.99×10^(-6) mol/L. | Qinglan Guo Yanan Wang Sheng Lin Chenggen Zhu Minghua Chen Zhibo Jiang Chengbo Xu Dan Zhang Huailing Wei Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 18 |
| 2 | Effects of residual organics in municipal wastewater on hydrogenotrophic denitrifying microbial communities显示文摘Hydrogenotrophic denitrification is promising for tertiary nitrogen removal from municipal wastewater. To reveal the influence of residual organics in municipal wastewater on hydrogenotrophic denitrifiers, we adopted high-throughput 16 S r RNA gene amplicon sequencing to examine microbial communities in hydrogenotrophic denitrification enrichments. Using effluent from a municipal wastewater treatment plant as water source, COD,nitrate and p H were controlled the same except for a gradient of biodegradable carbon(i.e., primary effluent(PE), secondary effluent(SE), or combined primary and secondary effluent(CE)). Inorganic synthetic water(IW) was used as a control. Hydrogenophaga, a major facultative autotroph, accounted for 17.1%, 5.3%, 32.7% and 12.9% of the sequences in PE, CE,SE and IW, respectively, implicating that Hydrogenophaga grew well with or without organics.Thauera, which contains likely obligate autotrophic denitrifiers, appeared to be the most dominant genera(23.6%) in IW and accounted for 2.5%, 4.6% and 8.9% in PE, CE and SE,respectively. Thermomonas, which is related to heterotrophic denitrification, accounted for 4.2% and 7.9% in PE and CE fed with a higher content of labile organics, respectively.In contrast, Thermomonas was not detected in IW and accounted for only 0.6% in SE. Our results suggest that Thermomonas are more competitive than Thauera in hydrogenotrophic denitrification with biodegradable organics. Moreover, facultative autotrophic denitrifiers,Hydrogenophaga, are accommodating to residual organic in effluent wastewater, thus we propose that hydrogenotrophic denitrification is amenable for tertiary nitrogen removal. | Wei Xing Jinlong Li Peng Li Chong Wang Yanan Cao Desheng Li Yunfeng Yang Jizhong Zhou Jiane Zuo | 2018 | Journal of Environmental Sciences2018，30，3： | 16 |
| 3 | Energy metabolism disorders and potential therapeutic drugs in heart failure显示文摘Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy supply.This deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of heart.Current HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the disease.Drugs aimed at cardiac energy metabolism have not yet been developed.In this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy metabolism.Finally,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF. | Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 11 |
| 4 | Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities显示文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L. | Yanan Yang Yawen An Wei Wang Ning Du Jinghua Zhang Ziming Feng Jianshuang Jiang Peicheng Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 5 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
| 6 | Changes of main secondary metabolites in leaves of Ginkgo biloba in response to ozone fumigation显示文摘To investigate the effect of elevated O3 on the accumulation of main secondary metabolites in leaves of Ginkgo biloba L.,four-year-old trees were exposed in open-top chambers with ambient air and the air with twice ambient O3 concentration in Shenyang in 2006.Elevated O3 increased the concentrations of terpenes,but decreased the concentrations of phenolics in G.biloba leaves.The results showed that secondary compounds from G.biloba leaves responded to the elevated O3 exposure in a different way when compared to previous studies which showed elevated O3 increased the concentrations of phenolics but had no effect on the terpenes in leaves of other deciduous trees.Furthermore,reduced synthesis of phenolics may decrease the resistance of G.biloba to O3 and other environmental factors.On the other hand,the induced synthesis of terpenes may enhance the antioxidant abilities in G.biloba leaves at the end of O3 fumigation. | HE Xingyuan HUANG Wei CHEN Wei DONG Tian LIU Changbing CHEN Zhenju XU Sheng RUAN Yanan | 2009 | Journal of Environmental Sciences2009，21，2： | 8 |
| 7 | Precise measurement technique for the stable acoustic cavitation bubble显示文摘Based on the periodic oscillation of the stable acoustic cavitation bubble, we present a precise measure-ment technique for the bubble evolution. This technique comprises the lighting engineering of pulsing laser beam whose phase can be digitally shifted, and the long distance microphotographics. We used a laser, an acousto-optic modulator, a pulse generator, and a long distance microscope. The evolution of a levitated bubble can be directly shown by a series of bubble’s images at different phases. Numerical simulation in the framework of the Rayleigh-Plesset bubble dynamics well supported the experimental result, and the ambient radius of the bubble, an important parameter re-lated to the mass of the gas inside the bubble, was obtained at the same time. | HUANG Wei CHEN Weizhong LIU Yanan GAO Xianxian JIANG Li'an XU Junfeng ZHU Yifei | 2005 | Chinese Science Bulletin2005，50，21： | 8 |
| 8 | Near-surface Geothermal Gradient Observation and Geothermal Analyses in the Xianshuihe Fault Zone,Eastern Tibetan Plateau显示文摘The Xianshuihe fault(XSHF) zone, characterized by intense tectonic activity, is located at the southwest boundary of the Bayan Har block, where several major earthquakes have occurred, including the 2008 Wenchuan and the 2013 Lushan earthquakes. This study analysed underground temperature sequence data for four years at seven measuring points at different depths(maximum depth: 18.9 m) in the southeastern section of the XSHF zone. High-frequency atmospheric noise was removed from the temperature sequences to obtain relatively stable temperature fields and heat fluxes near the measurement points. Our measurements show that the surrounding bedrock at(the seven stations distributed in the fault zone) had heat flux values range from-41.0 to 206 m W/m^2, with a median value of 54.3 m W/m^2. The results indicate a low heat flux in the northern section of DaofuKangting and a relatively high heat flux in the southern section of Kangting, which is consistent with the temperature distributions of the hot springs near the fault. Furthermore, our results suggest that the heat transfer in this field results primarily from stable underground heat conduction. In addition, the underground hydrothermal activity is also an obvious factor controlling the geothermal gradient. | LIU Qianqian SHI Yanan WEI Dongping HAN Peng CHEN Shunyun LIU Peixun LIU Liqiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 8 |
| 9 | Theoretical insight into the enhanced CH_4 desorption via H_2O adsorption on different rank coal surfaces显示文摘The density functional theory was used to investigate the adsorption of CH_4 and H_2O on different rank coal surfaces.The coal rank is the dominant factor in affecting the adsorption capacity of coal.In order to better understand gas and water interaction with coal of different maturity,we developed fourteen coal models to represent the different rank coal.The interactions of CH_4 and H_2O with coal surfaces were studied and characterized by their adsorption energies,Mulliken charges and electrostatic potential surfaces.The results revealed that the interaction between coal and CH_4 was weak physical adsorption,and that the interaction between coal and H_2 O consisted of physical and chemical adsorption.Adsorption energy of coal–H_2O system was larger than that of coal–CH_4 on all rank coals,suggesting that the adsorption priority in the coal models is H_2 O > CH_4.Consequently,the injection of H_2 O into the different rank coal could effectively enhance the coal bed methane(CBM) recovery. | Yanan Zhou Wenjing Sun Wei Chu Xiaoqiang Liu Fangli Jing Ying Xue | 2016 | Journal of Energy Chemistry2016，25，4： | 8 |
| 10 | Deep ultraviolet light-emitting diodes based on a well-ordered AlGaN nanorod array显示文摘The nanorod structure is an alternative scheme to develop high-efficiency deep ultraviolet light-emitting diodes(DUV LEDs). In this paper, we first report the electrically injected 274-nm AlGaN nanorod array DUV LEDs fabricated by the nanosphere lithography and dry-etching technique. Nanorod DUV LED devices with good electrical properties are successfully realized. Compared to planar DUV LEDs, nanorod DUV LEDs present>2.5 times improvement in light output power and external quantum efficiency. The internal quantum efficiency of nanorod LEDs increases by 1.2 times due to the transformation of carriers from the exciton to the free electron–hole, possibly driven by the interface state effect of the nanorod sidewall surface. In addition, the nanorod array significantly facilitates photons escaping from the interior of LEDs along the vertical direction, contributing to improved light extraction efficiency. A three-dimensional finite-different time-domain simulation is performed to analyze further in detail the TE-and TM-polarized photon extraction mechanisms of the nanostructure. Our results demonstrate the nanorod structure is a good candidate for high-efficiency DUV emitters. | LIANG ZHANG YANAN GUO JIANCHANG YAN QINGQING WU YI LU ZHUOHUI WU WEN GU XUECHENG WEI JUNXI WANG JINMIN LI | 2019 | Photonics Research2019，7，9： | 8 |
| 11 | Heterogeneous lamellar-edged Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray for efficient and stable seawater oxidation显示文摘Development of efficient non-precious catalysts for seawater electrolysis is of great significance but challenging due to the sluggish kinetics of oxygen evolution reaction(OER)and the impairment of chlorine electrochemistry at anode.Herein,we report a heterostructure of Ni_(3)S_(2)nanoarray with secondary Fe-Ni(OH)_(2)lamellar edges that exposes abundant active sites towards seawater oxidation.The resultant Fe-Ni(OH)_(2)/Ni_(3)S_(2)nanoarray works directly as a free-standing anodic electrode in alkaline artificial seawater.It only requires an overpotential of 269 mV to afford a current density of 10 mA·cm^(-2)and the Tafel slope is as low as 46 m V·dec^(-1).The 27-hour chronopotentiometry operated at high current density of 100 mA·cm^(-2)shows negligible deterioration,suggesting good stability of the Fe-Ni(OH)_(2)/Ni_(3)S_(2)@NF electrode.Faraday efficiency for oxygen evolution is up to〜95%,revealing decent selectivity of the catalyst in saline water.Such desirable catalytic performance could be benefitted from the introduction of Fe activator and the heterostructure that offers massive active and selective sites.The density functional theory(DFT)calculations indicate that the OER has lower theoretical overpotential than Cl_(2) evolution reaction in Fe sites,which is contrary to that of Ni sites.The experimental and theoretical study provides a strong support for the rational design of high-performance Fe-based electrodes for industrial seawater electrolysis. | Baihua Cui Zheng Hu Chang Liu Siliang Liu Fangshuai Chen Shi Hu Jinfeng Zhang Wei Zhou Yida Deng Zhenbo Qin Zhong Wu Yanan Chen Lifeng Cui Wenbin Hu | 2021 | Nano Research2021，14，4： | 7 |
| 12 | TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness显示文摘TGF-β-induced factor homeobox 2(TGIF2)is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions.Aberrant expression of TGIF family proteins has been observed in several cancers,including ovarian,esophageal,and colorectal cancers.Here,we report that TGIF2 mediates the EGFR–RAS–ERK signaling pathway to enhance the stemness of lung adenocarcinoma(LUAD)cells and,therefore,promote the progression and metastasis of LUAD.We found that high TGIF2 expression was closely correlated with tumor growth,lymph node metastasis,and survival of patients with LUAD.Mice bearing TGIF2-silenced H1299 xenografts developed smaller tumors and fewer lung metastases.Importantly,silencing TGIF2 decreased the cancer stem cell(CSC)-like properties in A549 and H1299 cells.Furthermore,we identified that TGIF2 binding to the OCT4 promoter promotes its expression.In both LUAD cells and in vivo LUAD mouse models,we revealed that EGFR–RAS–ERK signaling phosphorylated TGIF2 and increased its stability,which was important for TGIF2-promoted LUAD stemness since phosphorylation-deficient TGIF2 mutants lost these functions.Thus,our study revealed that an important factor,TGIF2,bridges EGFR signaling to the CSC characteristics of LUAD cells,which can be utilized as an effective target for LUAD therapy. | Renle Du Wenzhi Shen Yi Liu Wenjuan Gao Wei Zhou Jun Li Shuangtao Zhao Chong Chen Yanan Chen Yanhua Liu Peiqing Sun Rong Xiang Yi Shi Yunping Luo | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 7 |
| 13 | An A-D-A′-D-A type unfused nonfullerene acceptor for organic solar cells with approaching 14%efficiency显示文摘In recent years,power conversion efficiency(PCE)of organic solar cells(OSCs)has made significant improvement.A large number of studies were reported to achieve high PCEs through exploring new active layer materials,especially the high efficiency fused ring acceptors(FRAs).Compared with FRAs,another type of so-called unfused-ring acceptors(UFAs),possessing some advantages such as simple synthesis and low cost,have attracted a lot of attention.Herein,a new UFA BTzO-4F,incorporating with a benzotriazole moiety and S···O intramolecular noncovalent interactions,has been successfully synthesized.The photovoltaic device based on PBDB-T:BTzO-4F achieved a record PCE of 13.8%for UFAs,which indicates that introducing the benzotriazole moiety is an effective strategy for high quality acceptors.Thus,these findings of this work demonstrate the great potential of UFAs for high performance OSCs. | Xingzheng Liu Yanan Wei Xin Zhang Linqing Qin Zhixiang Wei Hui Huang | 2021 | Science China Chemistry2021，64，2： | 7 |
| 14 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 15 | Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling显示文摘Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury,but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes(CMs) for driving the differentiation of cardiac stem cells(CSCs).Forced hypoxia-inducible factor 1α(HIF-1α) expression and physical hypoxia(5% O_2) treatment could induce Jagged1 expression in neonatal rat CMs. Pharmacological inhibition of HIF-1α by YC-1 attenuated hypoxia-promoted Jagged1 expression in CMs. An ERK inhibitor(PD98059), but not inhibitors of JNK(SP600125), Notch(DAPT), NF-κB(PTDC), JAK(AG490), or STAT3(Stattic) suppressed hypoxiainduced Jagged1 protein expression in CMs. c-Kit^+ CSCs isolated from neonatal rat hearts using a magnetic-activated cell sorting method expressed GATA4, SM22α or vWF, but not Nkx2.5 and cTnI.Moreover, 87.3% of freshly isolated CSCs displayed Notch1 receptor expression. Direct co-culture of CMs with BrdU-labeled CSCs enhanced CSCs differentiation, as evidenced by an increased number of BrdU^+/Nkx2.5^+ cells, while intermittent hypoxia for 21 days promoted co-culture-triggered differentiation of CSCs into CM-like cells. Notably, YC-1 and DAPT attenuated hypoxia-induced differentiation.Our results suggest that hypoxia induces Jagged1 expression in CMs primarily through ERK signaling,and facilitates early cardiac lineage differentiation of CSCs in CM/CSC co-cultures via HIF-1α/Jagged1/Notch signaling. | Keke Wang Ranran Ding Yanping Ha Yanan Jia Xiaomin Liao Sisi Wang Rujia Li Zhihua Shen Hui Xiong Junli Guo Wei Jie | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 7 |
| 16 | Black phosphorus inverter devices enabled by in-situ aluminum surface modification显示文摘Two-dimensional black phosphorus (BP) generally exhibits a hole-dominated transport characteristic when configured as field-effect transistor devices. The effective control of charge carrier type and concentration is very crucial for the application of BP in complementary electronics. Herein, we report a facile and effective electron doping methodology on BP, through in situ surface modification with aluminum (Al). The electron mobility of few-layer BP is found to be largely enhanced to ~ 10.6 cm^2·V^–1·s^–1 by over 6 times after aluminum modification. In situ photoelectron spectroscopy characterization reveals the formation of Al–P covalent bond at the interface, which can also serve as local gate to tune the transport properties in BP layers. Finally, a spatially-controlled aluminum doping technique is employed to establish a p–n homojunction on a single BP flake, and hence to realize the complementary inverter devices, where the highest gain value of ~ 33 is obtained. | Yue Zheng Zehua Hu Cheng Han Rui Guo Du Xiang Bo Lei Yanan Wang Jun He Min Lai Wei Chen | 2019 | Nano Research2019，12，3： | 5 |
| 17 | Graphite dust deposition in the HTR-10 steam generator显示文摘Graphite dust has an important effect on the safe operation of a high-temperature gas-cooled reactor(HTR).The present study analyzes temperature and flow field distributions in the HTR-10 steam generator.The temperature and flow field distributions are then used to study thermophoretic deposition and turbulent deposition.The results show that as the dust diameter increases,the thermophoretic deposition decreases,while the turbulent deposition first decreases and then increases.The thermophoretic deposition is higher at higher reactor powers,with turbulent deposition growing more rapidly at higher reactor power.For small particles,the thermophoretic deposition effect is greater than the turbulent deposition effect,while for large particles,the turbulent deposition effect is dominant. | Wei Peng Yanan Zhen Xiaoyong Yang Suyuan Yu | 2013 | Particuology2013，11，5： | 5 |
| 18 | Intrinsic polarization coupling in 2Dα‐In_(2)Se_(3)toward artificial synapse with multimode operations显示文摘Emulation of advanced synaptic functions of the human brain with electronic devices contributes an important step toward constructing high‐efficiency neuromorphic systems.Ferroelectric materials are promising candidates as synaptic weight elements in neural network hardware due to their controllable polarization states.However,the increased depolarization field at the na-noscale and the complex fabrication process of the traditional ferroelectric materials hamper the development of high‐density,low‐power,and highly sensitive synaptic devices.Here,we report the implementation of two‐dimensional(2D)ferroelectricα‐In_(2)Se_(3)as an active channel material to emulate typical synaptic functions.Theα‐In_(2)Se_(3)‐based synaptic device fea-tures multimode operations,enabled by the coupled ferroelectric polarization under various voltage pulses applied at both drain and gate terminals.Moreover,the energy consumption can be reduced to~1 pJ by using high‐κdielectric(Al2O3).The successful control of ferroelectric polarizations inα‐In_(2)Se_(3)and its application in artificial synapses are expected to inspire the implementation of 2D ferroelectric materials for future neuromorphic systems. | Jing Gao Yue Zheng Wei Yu Yanan Wang Tengyu Jin Xuan Pan Kian Ping Loh Wei Chen | 2021 | SmartMat2021，2，1： | 4 |
| 19 | A novel composite(FMC)to serve as a durable 3D-clam-shaped bifunctional cathode catalyst for both primary and rechargeable zinc-air batteries显示文摘Novel and highly durable air cathode electrocatalyst with three dimensional(3D)-clam-shaped structure,MnO_2nanotubes-supported Fe_2O_3(Fe_2O_3/MnO_2) composited by carbon nanotubes(CNTs)((Fe_2O_3/MnO_2)3/4-(CNTs)_(1/4)) is synthesized using a facile hydrothermal process and a following direct heattreatment in the air. The morphology and composition of this catalyst are analyzed using scanning electronic microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD) and energy dispersive X-ray spectroscopy(EDX). The morphology characteristics reveal that flower-like Fe_2O_3 particles are highly dispersed on both MnO_2 nanotubes and CNT surfaces, coupling all three components firmly. Electrochemical measurements indicate that the synergy of catalyst exhibit superior bifunctional catalytic activity for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER) as well as stability than Pt/C and IrO_2 catalysts. Using these catalysts for air-cathodes, both primary and rechargeable zinc-air batteries(ZABs) are assembled for performance validation. In a primary ZAB,this 3D-clamed catalyst shows a decent open circuit voltage(OCV, $1.48 V) and a high discharge peak power density(349 mW cm^(-2)), corresponding to a coulombic efficiency of 92%. In a rechargeable ZABs with this bifunctional catalyst, high OCV(>1.3 V) and small charge-discharge voltage gap(<1.1 V) are achieved along with high specific capacity(780 mAh g^(-1) at 30 mA cm^(-2)) and robust cycle-life(1,390 cycles at cycle profile of 20 mA/10 min). | Nengneng Xu Xuemei Li Haoran Li Yanan Wei Jinli Qiao | 2017 | Science Bulletin2017，62，17： | 4 |
| 20 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
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