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| 1 | 不同基因型戊型肝炎病毒重组蛋白的抗原性分析显示文摘目的 :探讨不同基因型和亚型戊型肝炎病毒 (HEV)重组蛋白氨基酸序列的变化对HEV抗原性的影响 ,筛选出最佳的HEV抗原用于戊型肝炎的免疫诊断。方法 :用已知序列的HEV基因工程表达蛋白作为包被抗原 ,对已知血清标本进行酶联免疫吸附试验测定。结果 :6种不同抗原对 3 0份正常献血者血清无抗原性 ,对 17份急性戊型肝炎病人血清和 5份实验感染动物血清均呈阳性反应 ,但血清抗体滴度的高低与所用抗原的基因型有关 ,尤其是受到该抗原第 76位氨基酸变化的影响。结论 | 孟继鸿 戴星 窦晓光 YE KHUDYAKOV H A FIELDS | 2002 | 东南大学学报(医学版)2002，21，1： | 30 |
| 2 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 5 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 6 | Pharmacokinetic and toxicity study of intravitreal erythropoietin in rabbits显示文摘瞄准:为潜在的临床的使用学习 intravitreal erythropoietin (EPO ) 的 pharmacokinetics 和毒性。方法:为毒性学习,有 EPO 的 intravitreal 注射(IVit ) 的 4 个组(60 只兔子) 被学习(10U, 100U,或 1 000U ) 每为单个注射的眼睛和为每月的注射的 0.6 U/eye (在兔子的设计治疗学的水平)(6 ×) 。眼睛检查,闪光网膜电图(尔格) ,和荧光黄 angiography (FA ) 在注射前后被执行。兔子在不同间隔为组织学的学习被打死。为 pharmacokinetic 学习,在进左眼睛的 5 U EPO 的 IVit 以后, 44 只兔子在不同间隔,和 EPO 层次被打死在玻璃,水,视网膜和浆液被连接酶的免疫分析吸着剂试金。结果:根本,时间,点检验了,眼睛在正常限制以内。没有重要尔格或 FA 变化被观察。视网膜的组织学仍然保持未改变。在眼睛的分隔空间的 EPO 的 pharmacokinetic 侧面如下被总结。EPO 在的半衰期时间玻璃,水并且浆液分别地是 2.84, 3.24 和 2.12 d;并且 C 最大 分别地是 4615.75, 294.31 和 1.60 U/L。在注射眼睛的视网膜的 EPO 集中在 6 h 追随者注射在 1.36 U/g 蛋白质达到顶点,与观察是 3.42 d 的半衰期。结论:在一个宽范围的 EPO 的 IVit 很好被容忍,为兔子的保险箱看。在直到比治疗学的层次高的 10 褶层的剂量, EPO 与更快的清理有 pharmacokinetic 侧面,它为阵发性的 IVit 是有利的。 | Jing-fa ZHANG Ya-lan WU Jing-ying XU Wen YE Yu ZHANG Huan WENG Wo-dong SHI Guo-xu XU Luo LU Wei DAI Stephen H SINCLAIR Wei-ye LI Guo-tong XU | 2008 | Acta Pharmacologica Sinica2008，29，11： | 4 |
| 7 | Consolidation and dynamics of 3D unsaturated porous seabed under rigid caisson breakwater loaded by hydrostatic pressure and wave显示文摘In this study,based on the dynamic Biot's theory 'u-p' approximation,a 3D finite element method(FEM) numerical soil model is developed,in which the Generalized Newmark-β method is adopted to determine the time integration.The developed 3D FEM soil model is a part of the coupled model PORO-WSSI 3D for 3D wave-seabed-marine structures interaction problem,and is validated by the analytical solution proposed by Wang(2000) for a laterally infinite seabed loaded by a uniform force.By adopting the developed 3D soil model,the consolidation of seabed under a caisson breakwater and hydrostatic pressure is investigated.The numerical results show that the caisson breakwater built on seabed has very significant effect on the stresses/displacements fields in the seabed foundation after the transient deformation and primary consolidation are completed.The parametric study indicates that the Young's modulus E of seabed is the most important parameter to affect the settlement of breakwater,and the displacement fields in seabed foundation.Taking the consolidation status as the initial condition,the interaction between ocean wave,caisson breakwater and seabed foundation is briefly investigated.The 3D ocean wave is determined by solving the Navier-Stokes equations with finite volume method(FVM).The numerical results indicate that there is intensive interaction between | YE JianHong JENG DongSheng CHAN A H C | 2012 | Science China(Technological Sciences)2012，55，8： | 4 |
| 8 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 9 | Competition between radiation damping and transverse relaxation effects on NMR signal intensities 显示文摘 | Mao X A Guo J X Ye C H | 1994 | Chem Phys Lett1994，218，： | 2 |
| 10 | Concentration and chemical composition of PM 2.5 in Shanghai for a 1-year period显示文摘 | Boming Ye Xueli Ji Haizhen Yang Xiaohong Yao Chak K Chan Steven H Cadle Tai Chan Patricia A Mulawa | 2002 | Atmospheric Environment2002，，4： | 2 |
| 11 | In situ visualization study of CO2 gas bubble behavior in DMFC anode flow fields显示文摘 | Yang H Zhao T S Ye Q | 2005 | Journal of Power Sources2005，139，12： | 1 |
| 12 | Effect of Interracial Free Energy on Hydriding Reaction of Mg-Ni Thin Films 显示文摘 | Ouyang L Z Ye SY Dong H W | 2007 | ApplPhysLett2007，90，02： | 1 |
| 13 | Distributions of C-reactive protein and its association with metabolic syndromein middle-aged and older Chinese people显示文摘 | Ye X Yu Z Li H | 2007 | Am Coll Cardiol2007，49，17： | 1 |
| 14 | Therapeutic angiogenesis for pa- tients with limb ischemia by autologous transplantation of bone-marrow cells: a pilot study and a randomized controlled trial 显示文摘 | Tateishi YE Matsubara H Murohara T | 2002 | Lancet2002，360，42： | 1 |
| 15 | 显示文摘 | Jagtoyen M Oksefjell T | 1991 | Mater Sci Forum1991，，： | 1 |
| 16 | Analysis on the weld defects of AZ91D magnesium alloy joints显示文摘 | YE H YAN Z L SHEN B XUE Z F | 2009 | Materials Science Forum2009，610，： | 1 |
| 17 | Effect of introducing Bacillus thuringiensis gene on nitrogen metabolism in cotton显示文摘 | CHEN D H Ye G Y Yang C Q | 2005 | Field Crops Research2005，92，： | 1 |
| 18 | Metal-organic molecular architectures with 2,2′-bipyridyl-like and carboxylate ligands显示文摘 | Ye B H Tong M L Chen X M | 2005 | Coord Chem Rev2005，249，： | 1 |
| 19 | Construction and co-expression of a polycistronic plasmid encoding carbonyl reductase and glucose dehydrogenase for production of ethyl (S)-4-chloro- 3-hydroxybutanoate显示文摘 | Ye Q Cao H Yan M | 2010 | Bioresour Technol2010，101，17： | 1 |
| 20 | Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure-activity relationships 显示文摘 | Ye M Qu G Guo H | 2004 | J Steroid Biochem Mol Biol2004，91，12： | 1 |
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