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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection显示文摘 | Nezam Afdhal Stefan Zeuzem Paul Kwo Mario Chojkier Norman Gitlin Massimo Puoti Manuel Romero-Gomez Jean-Pierre Zarski Kosh Agarwal Peter Buggisch Graham R. Foster Norbert Br?u Maria Buti Ira M. Jacobson G. Mani Subramanian Xiao Ding Hongmei Mo Jenny C. Ya | 2014 | The New England Journal of Medicine2014，，： | 6 |
| 3 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 4 | Scleral TGF-β1 and Smad3 expression is altered by TCM Bu Jing Yi Shi Tablets in guinea pigs with form-deprivation myopia显示文摘Objective:To explore whether the traditional Chinese medicine(TCM)Bu Jing Yi Shi Tablets alters the expression of scleral TGF-b1 and Smad3 in guinea pigs with formdeprivation myopia(FDM).Methods:Sixty-five guinea pigs were randomly divided into control,model,low-,medium-,and high-dose treatment groups.Except for the control group,FDM was induced by covering the right eye of each animal with opaque latex.The treatment groups were gavaged with different suspension concentrations of Bu Jing Yi Shi Tablets.Refraction and axial length were performed before and after myopia induction.At the end of the experiment,all right eyes were extracted,and scleral sections were prepared for staining and TGF-b1 and Smad3 immunohistochemistry.Scleral thickness and area,the scleral fibroblast quantity,and scleral TGFb1 and Smad3 expressions were measured.Results:The 5 FDM groups had the same initial axial length and diopter,the final diopter and axial length of the model group were significantly increased compared with the control group and treatment groups(P<.01).The axial length of each treatment group decreased as the dose decreased compared with the model group(P<.01);the total scleral area(P<.05 e.01)and the number of scleral fibroblasts(P<.01)in the model group were significantly lower than the treatment groups.Both the TGF-b1 and Smad3 integral optical densities in the model group were significantly lower than the control and medium-and high-dose treatment groups(P<.01).TGF-b1 and Smad3 mRNAs in the model group were decreased compared with the control group,but increased in expression after treatment. | Ya Mo Yi Wang Bin Cao Jiajia Zhang Guoting Ren Ting Yang | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，2： | 3 |
| 5 | Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques显示文摘Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid(PABA)salt of N,N-dimethylamino-2-propanoI(DIP).This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers.The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02-10μg/mL,and the HPLC method for plasma PABA determination had a linear range of 0.05-40μg/mL.Linear pharmacokinetic characteristics were found with single oral doses of 0.5,1.0and 2.0 g.No obvious accumulation effects were observed for DIP and PABA. | Mo Chen Yuan Zhang Xiao-Ting Que Ya Ding Lin Yang Ai-Dong Wen Tai-Jun Hang | 2013 | Journal of Pharmaceutical Analysis2013，3，6： | 2 |
| 6 | Evaluation of Uncertainty in Determination of Reducing Sugar Content in Sugarcane显示文摘[Objective]This study aimed to establish an effective method for evaluating uncertainty in determination of reducing sugar content in sugarcane with Lane-Ernon method.[Method]Based on analysis of the main sources of uncertainty in determination of reducing sugar content in sugarcane and mathematical model construction,combined uncertainty and expanded uncertainty were determined to establish the method for evaluation of uncertainty in determination.[Result]Among uncertainties in determination of reducing sugar content in sugarcane with Lane-Ernon method,the greatest uncertainty was introduced by duplicate determination.According to results of statistical analysis,the expanded uncertainty in determination of reducing sugar content was 0.012%.[Conclusion]This study provided theoretical reference for evaluation of uncertainty in determination of reducing sugar content in sugarcane. | Jie LIAO Feiyan YAN Leixing MO Tianshun WANG Yu YA Yegeng FAN Fang HUANG Bo LIN Li TANG | 2015 | Agricultural Biotechnology2015，4，4： | 2 |
| 7 | Compoutational chemistry: a useful (sometimes mandatory) tool in mass spectrometry studies 显示文摘 | Alcami M Mo O Ya Hez M | 2001 | Mass Spectrom Rev2001，20，4： | 1 |
| 8 | Biochemical and mor- phological changes in dormant (' noneuhurable') Mycobacterium smegmatis cells显示文摘 | Salina EG Zhogina YA Shleeva MO | 2010 | Biochemistry ( Mosc)2010，75，1： | 1 |
| 9 | Compensatory sweating after upper thoracic sympathectomy Prospective study of 123 cases显示文摘 | MO YA J ROMOS R VIVES N | 2004 | Arch Bromconeumol2004，40，8： | 1 |
| 10 | Shock solution for a class of reaction diffusion equations显示文摘 | Chen H J Ya J S Mo J Q | 2013 | Chinese Journal of Engineering Mathematics2013，30，2： | 1 |
| 11 | Preparation of conductive nano silver ink and its application on RFID tags 显示文摘 | Fu Ji Lan Li Ya Ling Mo Li Xin | 2014 | Advanced Ma- terials Research2014，904，： | 1 |
| 12 | Residue of Organphosphorus Pesticides in Chewing Cane Juices Detected by QuEChERS and GC-NPD Method显示文摘[Objective] The paper was to establish a quick detection method for residue of organphosphorus pesticides in chewing cane juices and provide guarantee for edible safety of chewing juice.[Method] By using QuEChERS and GC-NPD method,a rapid analysis method for residue of six kinds of organphosphorus pesticides( dichlorvos,chlorpyrifos-methyl,malathion,fenthion,chlorpyrifos and triazophos) in sugarcane juices was established.[Result] QuEChERS method was significantly superior to traditional extraction method and could extract six kinds of organphosphorus pesticides from chewing cane juices effectively,which greatly saved organic reagent and time.Good linearity was found in different standard curves;when the concentration of pesticides was from 0.020 to 0.100 mg/L,the recovery rate was from 68.58% to 92.85%,and relative standard deviation( RSD) was ranged from 2.16% to 9.89%.[Conclusion] The sensitivity,accuracy and precision of QuEChERS method were consistent with the technical requirements of pesticide residue determination.It not only could shorten sample processing cycle effectively,but also ensure that no impurity was in the sample peak and the recovery rate was also consistent with the requirements of residual analysis. | Fan Yegeng Liao Jie Liang Jun Mo Leixing Wang Tianshun Ya Yu Liang Qiang Li Song | 2013 | Plant Diseases and Pests2013，4，4： | 1 |
| 13 | Urbanization and Deur- banization in mountain regions of China 显示文摘 | Zhang Baiping Mo Shenguo Tan Ya | 2004 | Mountain Research and Development2004，24，3： | 1 |
| 14 | Anthropometric analysis of the nose in the japanese显示文摘 | Katsuaki MI Yoshihide MO Tomohiro YA | 2002 | Gells Tissues Organs2002，170，： | 1 |
| 15 | Advances in the research of high myopia treatmen显示文摘高度近视是屈光度超过-6.00D的病症,伴有轴向延伸和眼底变化,如颞弧斑块,色素上皮变薄,豹形眼底,紫红斑,视网膜脉络膜萎缩,视力逐渐下降,以及弱视,青光眼,白内障,玻璃体不透明,视网膜脱离等眼科疾病.高度近视是中国失明的常见原因之一.本文将对高度近视的治疗做-综述,以更好地指导临床和提高患者的视力水平. | Ming-Shan Liu Ya Mo | 2017 | TMR Integrative Medicine2017，1，3： | 1 |
| 16 | Stretchable magnesium-air battery based on dual ions conducting hydrogel for intelligent biomedical applications显示文摘Flexible and bio-integrated electronics have attracted great attention due to their enormous contributions to personalized medical devices.Power sources,serving as one of the most important components,have been suffering from many problems,including deficient biocompatibility,poor stretchability,and unstable electrical outputs under deformed conditions,which limits the practical applications in flexible and bio-integrated electronics.Here,we reported a fully stretchable magnesium(Mg)–air battery based on dual-ions-conducting hydrogels(SDICH).The high-performance battery enables long-term operation with lighting 120 lighting emitting diodes(LEDs)for over 5 h.Benefiting from the advanced materials and mechanical designs,the battery exhibits stability electrical outputs under stretching,which allows to operate ordinarily under various mechanical deformations without performance decay.Furthermore,the great biocompatibility of the battery offers great opportunity for biomedical applications,which is demonstrated by a self-adaption wound dressing system.The in vitro and in vivo results prove that the self-adaption wound dressing can effectively prevent wound inflammation and promote wound healing.By exploiting thermal feedback mechanics,the system can adjust antibiotic release rate and dosage spontaneously according to the real-time wound conditions.The proposed fully stretchable Mg-air battery and self-adaption wound dressing display great potential in skin-integrated electronics and personalized medicine. | Xingcan Huang Yiming Liu Wooyoung Park Zhao Zhao Jiyu Li Chee Kent Lim Tsz Hung Wong Chun Ki Yiu Yuyu Gao Jingkun Zhou HuLi Ling Zhao Jian Li Binbin Zhang Ya Huang Rui Shi Dengfeng Li Jiaying Mo Jinpei Wang Chao Zhang Yuhang Li Zuankai Wang Xinge Yu | 2023 | InfoMat2023，5，3： | 0 |
| 17 | Observation of healing between artificial bladder and tissue by scanning electronic microscope显示文摘Object To detect the healing between artificial bladder and tissue. Method:Healing between 4 artificial bladder and surrounding tissue was observed by scanning electronic microscope. Result 4 prosthesis all could heal with tissue,but healing extent was different during different time. Conclusion:This artificial bladder could perform a good connection with tissue and the structure of nylon, surface area of prosthesis, time and infection maybe influenced the healing. | LIU Chun yu 1,WANG Guang you 1,DONG Ya li 2,LI Hong mei 1 MA Teng xiang 1,Lu Zhi qiang 1,Lu Mo zhu 1 ,Gu Han qing 1 1 Tianjin institute of urological surgery 300211 2 Department of electronic microscope, Tianjin medical university | 2002 | Chinese Journal of Biomedical Engineering(English Edition)2002，11，2： | 0 |
| 18 | In Vivo Study of a Natural Whitening Agent显示文摘A natural whitening agent to replace synthetic bioactives was developed.Xin Qi Bai(XQB)was composed of traditional Chinese medicine(TCM)and the whitening efficacy was tested in vivo.Qualified volunteers were selected and used cream with or without XQB for 8 weeks continuously.The individual type angle(ITA°),melanin index(MI)and the stain area(%)were tested after 0,2,4 and 8 weeks.XQB can increase ITA°value,decrease MI value and the stain area of skin.Results showed that XQB has good whitening efficacy in vivo,and is a natural whitening agent. | Li Lingyu Zhu Le Chen Mo Zhao Ya Zhou Ying Yuan Dengfeng Ni Xiangmei Jia Haidong | 2023 | China Detergent & Cosmetics2023，8，4： | 0 |
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