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| 1 | The SLC transporter in nutrient and metabolic sensing, regulation, and drug development显示文摘The prevalence of metabolic diseases is growing worldwide. Accumulating evidence suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic diseases. Consistent with metabolic characteristics, the top five organs in which SLC transporters are highly expressed are the kidney, brain, liver, gut, and heart. We aim to understand the molecular mechanisms of important SLC transporter-mediated physiological processes and their potentials as drug targets. SLC transporters serve as Metabolic gate’ of cells and mediate the transport of a wide range of essential nutrients and metabolites such as glucose, amino acids, vitamins, neurotransmitters, and inorganic/metal ions. Gene-modified animal models have demonstrated that SLC transporters participate in many important physiological functions including nutrient supply, metabolic transformation, energy homeostasis, tissue development, oxidative stress, host defense, and neurological regulation. Furthermore, the human genomic studies have identified that SLC transporters are susceptible or causative genes in various diseases like cancer, metabolic disease, cardiovascular disease, immunological disorders, and neurological dysfunction? Importantly, a number of SLC transporters have been successfully targeted for drug developments。 This review will focus on the current understanding of SLCs in regulating physiology, nutrient sensing and uptake, and risk of diseases. | Yong Zhang Yuping Zhang Kun Sun Ziyi Meng Ligong Chen | 2019 | Journal of Molecular Cell Biology2019，11，1： | 11 |
| 2 | Si/C Composites as Negative Electrode for High Energy Lithium Ion Batteries显示文摘硅很为因为它的高特定的能力,中等潜力,环境友好,和低费用,改进锂离子电池(解放) 的精力密度正在答应否定电极材料。然而, Si 否定电极的体积变化在导致弄成粉,低骑车效率,和永久能力损失的 lithiation/delithiation 过程期间是巨大的。以便克服这个问题,巨大的努力被尝试了。在他们之中,最成功的策略是把另外的部件合并到硅形成合成的,特别碳媒介。在这微型评论,用作解放的否定电极的 Si/C 材料上的最近的进步被总结例如 Si/amorphous 碳合成, Si/graphene composites, Si/carbon nanotubes 或纤维 composites。制造,结构,不同 Si/C composites 的电气化学的表演被讨论。另外,一些未来方向被指出。 | Yi Zhang Yusong Zhu Lijun Fu Jixing Meng Nengfei Yu Jing Wang Yuping Wu | 2017 | Chinese Journal of Chemistry2017，35，1： | 8 |
| 3 | Preparation of an anti-diethylstilbestrol monoclonal antibody and development of an indirect competitive ELISA to detect diethylstilbestrol in biological samples显示文摘Based on the preparation of an anti-diethylstilbestrol(DES) monoclonal antibody,a simple and convenient indirect competitive enzyme-linked immunosorbent assay(ELISA) method for DES detection has been developed.The monoclonal antibody demonstrated high sensitivity to DES with an IC50 value of 275 pg mL-1 and detection limit(LOD) of 90 pg mL-1.The specificity of the assay was studied by measuring cross-reactivity of the antibody with structurally related compounds of ethinyl estradiol(<7%),estrone(<0.1%),estriol(<0.1%),and diethylstilbestrol benzoate(<0.1%).Chicken,fish,shrimp,urine and bile spiked with different concentration of DES were detected by the developed method,and the recovery rates were greater than 79.5%.Intra-and inter-assay variations were about 6%.This method exhibited high stability with a coefficient of variation less than 10% in buffer and in real samples.The LODs in fish/shrimp,liver,feed and urine spiked with DES were 600,600,4800 and 600 pg mL-1,respectively.These results confirmed that the antibody to DES was successfully produced and could be used to establish ELISA methods for DES detection in food producing animals. | LI WeiHua MENG Meng HE FangYang WAN YuPing XUE HuYin LIU Wei YIN WeiWei XU Jing FENG CaiWei WANG ShanLiang LU Xiao LIU JinTing XI RiMo | 2011 | Chinese Science Bulletin2011，56，8： | 4 |
| 4 | Musk secretion in muskrats(Ondatra zibethicus L.):association with lipid and cholesterol metabolism-related pathways显示文摘Male muskrats(Ondatra zibethicus L.)secrete musk from their scent glands during musk secretion season.Musk plays an important role as a communication pheromone during the breeding season.In this study,gas chromatography–mass spectrometry(GC–MS)was used to analyze the main components of musk.The GC–MS results after methyl esterification showed that 71.55%of the musk is composed of fatty acids.The other components of muskrat musk include cholesterol(9.31%)and other organics.Transcriptome comparison between musk secretion and non-secretion seasons showed significant changes in the scent glands for 53 genes involved in fatty acid and cholesterol synthesis and metabolism regulatory pathways,which include fatty acid biosynthesis,elongation,and metabolism;steroid biosynthesis;steroid hormone biosynthesis pathways.A reverse transcription–polymerase chain reaction analysis confirmed these detected changes.Overall,our results indicated that lipid synthesis and metabolism play important roles in musk compound synthesis by providing energy for musk production,and the produced musk provides a mechanism for male muskrats to communicate with females during the breeding season. | TIANXIANG ZHANG MEISHAN ZHANG MINGHUI SHI WEIJIANG JIN SHUMIAO ZHANG MENGYUAN FAN YIMENG LI YUPING MENG XUELIN TIAN SHUQIANG LIU DEFU HU | 2021 | BIOCELL2021，45，2： | 2 |
| 5 | Generation of anti-trenbolone monoclonal antibody and establishment of an indirect competitive enzyme-linked immunosorbent assay for detection of trenbolone in animal tissues, feed and urine显示文摘 | Yuanyang Zhang Fangyang He Yuping Wan Meng Meng Jing Xu Jian Yi Yabin Wang Caiwei Feng Shanliang Wang Rimo Xi | 2010 | Talanta2010，，3： | 1 |
| 6 | CO_(2)emission and source partitioning from carbonate and non-carbonate soils during incubation显示文摘The accurate quantification and source partitioning of CO_(2)emitted from carbonate(i.e.,Haplustalf)and non-carbonate(i.e.,Hapludult)soils are critically important for understanding terrestrial carbon(C)cycling.The two main methods to capture CO_(2)released from soils are the alkali trap method and the direct gas sampling method.A 25-d laboratory incubation experiment was conducted to compare the efficacies of these two methods to analyze CO_(2)emissions from the non-carbonate and carbonate-rich soils.An isotopic fraction was introduced into the calculations to determine the impacts on partitioning of the sources of CO_(2)into soil organic carbon(SOC)and soil inorganic carbon(SIC)and into C3 and/or C4 plant-derived SOC.The results indicated that CO_(2)emissions from the non-carbonate soil measured using the alkali trap and gas sampling methods were not significantly different.For the carbonate-rich soil,the CO_(2)emission measured using the alkali trap method was significantly higher than that measured using the gas sampling method from the 14 th day of incubation onwards.Although SOC and SIC each accounted for about 50%of total soil C in the carbonate-rich soil,SOC decomposition contributed 57%–72%of the total CO_(2)emitted.For both non-carbonate and carbonate-rich soils,the SOC derived from C4 plants decomposed faster than that originated from C3 plants.We propose that for carbonate soil,CO_(2)emission may be overestimated using the alkali trap method because of decreasing CO_(2)pressure within the incubation jar,but underestimated using the direct gas sampling method.The gas sampling interval and ambient air may be important sources of error,and steps should be taken to mitigate errors related to these factors in soil incubation and CO_(2)quantification studies. | Yi ZHAO Roland BOL Zhaoan SUN Yuping ZHUGE Xiaoxia SHI Wenliang WU Fanqiao MENG | 2022 | Pedosphere2022，32，3： | 1 |
| 7 | Anomalous crystal structure of γ' phase in the Mg-RE-Zn(Ag) series alloys:Causality clarified by ab initio study显示文摘The crystal structure of the single-unit-cell thickness γ ' phase,as a key strengthening phase in Mg-REZn(Ag) series alloys,has been extensively studied,and several structural models have been proposed in the past two decades.However,these reported models,and even the lattice constants at the same proposed structure,are scattered severely,which has led to considerable confusion and not available for further mechanical property simulation and prediction of Mg alloys containing this phase.In this study,by using first-principles calculations,the crystal structure of y' phase is clarified,resolving the discrepancies among different experiments,and its intrinsic mechanical properties have also been studied for the first time.It is verified that the γ ' phase contains quasi-five atomic layers,instead of the previously reported tri-layer,and surprisingly,its crystal structure has many variants,which would change with the alloy composition.Besides,with the help of the simulated selected area electron diffraction(SAED) patterns,it is found that the atoms in the central layer remain partially ordered distribution,and this ordered extent primarily depends on the atomic ratio of RE:Zn(Ag) and the solute content in an alloy.That is,the ordered extent increases with decreasing the atomic ratio of RE:Zn(Ag) and/or increasing solute content of alloy,and vice versa.Ag and Zn dissolved in the γ' phase would produce almost opposed mechanical anisotropy for the γ ' phase under the identical crystal structure,and the addition of Ag shows more efficient on increasing the shear modulus of γ' phase. | Junyuan Bai Xueyong Pang Xiangying Meng Hongbo Xie Hucheng Pan Yuping Ren Min Jiang Gaowu Qin | 2020 | Journal of Materials Science & Technology2020，36，1： | 1 |
| 8 | Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts显示文摘 | Bingrong Dang Yuping Yang Erdong Zhang Wenjian Li Xiangquan Mi Yue Meng Siqi Yan Zhuanzi Wang Wei Wei Chunlin Shao Rui Xing Changjun Lin | 2013 | Life Sciences2013，，： | 1 |
| 9 | Absorption properties of carbonyl-iron/carbon black double-layer microwave absorbers显示文摘 | Wang Meng Duan Yuping Liu Shunhua Li Xiaogang Ji Zhijiang | 2009 | Journal of Magnetism and Magnetic Materials2009，，20： | 1 |
| 10 | 查看详情显示文摘 | WU Yuping ZHOU Zhonghua MENG Yanchao | | 0，，： | 1 |
| 11 | A PRIORI AND A POSTERIORI ERROR ESTIMATES OF A WEAKLY OVER-PENALIZED INTERIOR PENALTY METHOD FOR NON-SELF-ADJOINT AND INDEFINITE PROBLEMS显示文摘在这份报纸,我们为 non-self-adjoint 和不定的问题学习一个弱过去惩罚的内部惩罚方法。一最佳在精力标准的 priori 错误估计被导出。另外,我们介绍一基于剩余一个 posteriori 错误评估者,它被证明在精力标准可靠、有效。一些数字睾丸被介绍验证我们的理论分析。[从作者抽象] | Yuping Zeng Jinru Chen Feng Wang Yanxia Meng | 2014 | Journal of Computational Mathematics2014，32，3： | 1 |
| 12 | Oxygen vacancies effects on phase diagram of epitaxial La1-xSrxMnO3 thin films显示文摘We investigated the effects of oxygen vacancies on the structural,magnetic,and transport properties of La_(1-x)Sr_xMnO_3(x=0.1,0.2,0.33,0.4,and 0.5)grown around a critical point(without/with oxygen vacancies)under low oxygen pressure(10 Pa)and high oxygen pressure(40 Pa).We found that all films exhibit ferromagnetic behavior below the magnetic critical temperature,and that the films grown under low oxygen pressures have degraded magnetic properties with lower Curie temperatures and smaller magnetic moments.These results show that in epitaxial La_(1-x)Sr_xMnO_3 thin films,the magnetic and transport properties are very sensitive to doping concentration and oxygen vacancies.Phase diagrams of the films based on the doping concentration and oxygen vacancies were plotted and discussed. | Qian Wan KuiJuan Jin QingQing Li YaQing Feng Can Wang Chen Ge Meng He HuiBin Lu HaiZhong Guo XiaoLong Li YuPing Yang GuoZhen Yang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 0 |
| 13 | Sparse signal reconstruction via generalized two-stage thresholding显示文摘Dear editor,The sparse representation model has received a great amount of attention in various signal and image processing applications.Compressed sensing(CS)[1]has consistently focused on devising sparse representation methods that seek to efficiently reconstruct a k-sparse(only k nonzero entries,k< | Heping SONG Zehong AI Yuping LAI Hongying MENG Qirong MAO | 2022 | Science China(Information Sciences)2022，65，3： | 0 |
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