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| 1 | Syntheses and Fungicidal Activities of Thiazole-5-carboxanilides Bearing Thioether Group显示文摘 | XUE Hansong LIU Aiping LIU Weidong LI Jianming REN Yeguo HUANG Lu HE Lian OU Xiaoming YE Jiao HUANG Mingzhi | 2016 | Chemical Research in Chinese Universities2016，32，5： | 13 |
| 2 | Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors显示文摘Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior lymphodepletion.No dose-limiting toxicity or unexpected adverse events were observed in any of the 15 patients.The best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 month.TCR-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after infusion.We further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal models.Our results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors. | Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，9： | 7 |
| 3 | Effect of Ball Milling on the Defeat of Few-Layer Graphene and Properties of Copper Matrix Composites显示文摘Graphene-reinforced copper composites recently have attracted more attention, since they exhibited excellent mechanical properties and could be used widely in many fields. Few-layer graphene(FLG) and copper powder were mixed by ball milling to produce homogeneous composite powders. Then, FLG-reinforced copper composites(FLG/Cu) were fabricated by spark plasma sintering(SPS) using the composite powders with a FLG volume fraction of 2.4 vol%. The effects of the rotating speed and the time of ball milling were analyzed based on the microstructure evolution and properties of the FLG/Cu composites. Obvious strengthening effect of FLG was found for the composites, and the conductance of the composite reaches 70.4% of IACS. The yield strength of the composite produced by ball milling at a speed of 100 r/min for 4 h is 376 MPa, which is 2.5 times higher than that of copper and higher than that of copper composite enhanced by 5 vol% CNTs(360 MPa). The defects produced in FLG with the increase of rotating speed and time could reduce the mechanical and conductive properties of the composites. | Ye Cui Lidong Wang Bin Li Guojian Cao Weidong Fei | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 6 |
| 4 | Hydrogen production by reforming methane in a corona inducing dielectric barrier discharge and catalyst hybrid reactor显示文摘A novel corona inducing dielectric barrier discharge(CIDBD) and catalyst hybrid reactor was developed for reforming methane. This corona inducing technique allows dielectric barrier discharge(DBD) to occur uniformly in a large gap at relatively low applied voltage.Hydrogen production by reforming methane with steam and air was investigated with the hybrid reactor under atmospheric pressure and temperatures below 600°C.The effects of input power,O2/C molar ratio and preheat temperature on methane conversion and hydrogen selectivity were investigated experimentally.It was found that higher methane conversions were obtained at higher discharge power,and methane conversion increased significantly with input power less than 50 W;the optimized molar ratio of O2/C was 0.6 to obtain the highest hydrogen selectivity(112%);under the synergy of dielectric barrier discharge and catalyst,methane conversion was close to the thermodynamic equilibrium conversion rate. | ZHOU ZhiPeng ZHANG JiMin YE TaoHong ZHAO PingHui XIA WeiDong | 2011 | Chinese Science Bulletin2011，56，20： | 6 |
| 5 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 6 | Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,characterized by highly hypoxic tumor microenvironment.Hypoxia-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,supporting the adaptation of tumor cells to hypoxia.Bruceine D(BD)is an isolated natural quassinoid with multiple anti-cancer effects.Here,we identified BD could significantly inhibit the HIF-1α expression and its subsequently mediated HCC cell metabolism.Using biophysical proteomics approaches,we identified inhibitor of β-catenin and T-cell factor(ICAT)as the functional target of BD.By targeting ICAT,BD disrupted the interaction of bcatenin and ICAT,and promoted β-catenin degradation,which in turn induced the decrease of HIF-1α expression.Furthermore,BD could inhibit HCC cells proliferation and tumor growth in vivo,and knockdown of ICAT substantially increased resistance to BD treatment in vitro.Our data highlight the potential of BD as a modulator of β-catenin/HIF-1α axis mediated HCC metabolism. | Rui Huang Lijun Zhang Jinmei Jin Yudong Zhou Hongwei Zhang Chao Lv Dong Lu Ye Wu Hong Zhang Sanhong Liu Hongzhuan Chen Xin Luan Weidong Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 7 | Effect of H_2 Reduction Temperature on the Properties of Reduced Graphene Oxide and Copper Matrix Composites显示文摘Reduced graphene oxide(RGO) and copper composites(RGO/Cu) were successfully fabricated based on a molecular-level mixing method(MLM). The composite powders were reduced in H2 at 350, 450, and 550 °C and then consolidated by spark plasma sintering(SPS) in order to evaluate the effect of H2 reduction temperature on the properties of the composites. The results indicate that the strengths of the composite decrease with the increase of H2 reduction temperature, while the electrical conductivity reaches its maximum at 450 °C and minimum at 550 °C. Hot rolling could benefit the electrical conductivity. The yield strength of the RGO/Cu composite reduced to 337 MPa at 350 °C. The electrical conductivity of the RGO/Cu composite reduced at 450 °C after hot rolling reaches 60.26% IACS. The properties of the RGO/Cu composites can be designed by adjusting the reduction degree of RGO and by hot rolling. | Lidong Wang Ye Cui Ruiyu Li Guojian Cao Bin Li Weidong Fei | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 3 |
| 8 | Dynamic Rollover Prediction of Heavy Vehicles Considering Critical Frequency显示文摘Rollover of commercial heavy vehicles can cause enormous economic losses and fatalities.It is easier for such vehicles to rollover if the driver’s steering frequency is close to the critical frequency of the vehicle’s roll motion;however,the critical roll frequency has rarely been investigated.In this study,the second-order transfer function between the steering input and roll angle was developed to calculate the critical frequency of the vehicle’s roll motion.The simulated spectrum and transfer function were then used to dynamically predict the peak lateral load transfer ratio.Laboratory experiments were conducted using a scaled vehicle to verify the critical roll frequency.The results suggest that the peak value of the lateral load transfer ratio during steering can be accurately determined from the driver’s input,and the critical roll frequency has a dominant effect on the dynamic rollover of heavy vehicles. | Zhansheng Ye Weidong Xie Yuming Yin Zhijun Fu | 2020 | Automotive Innovation2020，3，2： | 3 |
| 9 | The velocity structure of the Yinggehai Basin and its hydrocarbon implication显示文摘Two profiles of refraction and wide_angle reflection were completed in the Yinggehai Basin using ocean bottom hydrophones (OBHs) as receiver. These profiles reveal a low velocity layer (LVL) to the west of No. 1 Fault in the basin, with velocity of 3.0-3.5 km/s. Its upper interface lies at 3.5 km below the sea bottom at the NE end of the profiles, and deepens southwestward to 4 6 km near the axis of the basin. It coincides with the top of a gas_bearing, high_pressure layer defined by well logging. This suggests that the LVL is a layer of less_compacted and gas_charged sediments. The lower interface of the LVL is about 9 km in depth. Sediments above the LVL have velocity varying from 2 0 to 4 1 km/s. The acoustic basement is found only east of No. 1 Fault, with velocity of 5 8-6 2 km/s. A NNW_SSE_running OBH seismic profile across the Xisha Trough was completed on the same cruise. Moho and other deep interfaces are clearly visible in the profile. | Kanyuan Xia Di Zhou Daquan Su E. Flueh Sanyu Ye Hanyi He Weidong Chen Yuhong Xie Guixian Wang Saijun Liu et al. | 1998 | Chinese Science Bulletin1998，43，24： | 3 |
| 10 | Inactivation of Staphylococcus aureus and Enterococcus faecalis by a direct-current,cold atmospheric-pressure air plasma microjet显示文摘Objective:A direct-current,cold atmospheric-pressure air plasma microjet(PMJ)was performed to inactivate Staphylococcus aureus(S.aureus)and Enterococcus faecalis(E.faecalis)in air.The process of sterilization and morphology of bacteria was observed.We wish to know the possible inactivation mechanisms of PMJ and explore a potential application in dental and other temperature sensitive treatment.Methods:In this study,we employed a direct current,atmospheric pressure,cold air PMJ to inactivate bacterias.Scanning electron microscopy was employed to evaluate the morphology of S.aureus and showed rupture of cell walls after the plasma treatment and Optical emission spectrum(OES)were used to understand the possible inactivation mechanisms of PMJ.Results:The inactivation rates could reach 100%in 5 min.When the distance between the exit nozzle of the PMJ device and Petri dish was extended from 1 cm to 3 cm,effective inactivation was also observed with a similar inactivation curve.Conclusion:The inactivation of bacteria is attributed to the abundant reactive oxygen and nitrogen species,as well as ultroviolet radiation in the plasma.Different life spans and defensibilities of these killing agents may hold the key to understanding the different inactivation curves at different treatment distances. | Ye Tian Peng Sun Haiyan Wu Na Bai Ruixue Wang Weidong Zhu Jue Lnang Fuxiang Liu | 2010 | The Journal of Biomedical Research2010，24，4： | 2 |
| 11 | Preparation and luminescent properties of (Ca 1- x ,Sr x )S:Eu 2+ red-emitting phosphor for white LED显示文摘 | Yunsheng Hu Weidong Zhuang Hongqi Ye Shusheng Zhang Ying Fang Xiaowei Huang | 2004 | Journal of Luminescence2004，，3： | 2 |
| 12 | Controlling plasmon‐exciton interactions through photothermal reshaping显示文摘We investigated the plasmon-exciton interactions in an individual gold nanorod(GNR)with monolayer MoS2 at room temperature with the single-particle spectroscopy technique.To control the plasmon-exciton interaction,we tuned the local surface plasmon resonance of an individual GNR in-situ by employing the photothermal reshaping effect.The scattering spectra of the GNR-MoS2 hybrids exhibited two dips at the frequencies of the A and B excitons of monolayer MoS2,which were caused by the plasmon-induced resonance energy transfer effect.The resonance energy transfer rate increased when the surface plasmon resonance of the nanorod matched well with the exciton transition energy.Also,we demonstrated that the plasmon-enhanced fluorescence process dominated the photoluminescence of the GNR-MoS2 hybrid.These results provide a flexible way to control the plasmon-exciton interaction in an all-solid-state operating system at room temperature. | Aiqin Hu Shuai Liu Jingyi Zhao Te Wen Weidong Zhang Qihuang Gong Yongqiang Meng Yu Ye Guowei Lu | 2020 | Opto-Electronic Advances2020，3，1： | 2 |
| 13 | Determination of the optical constants of polymer light-emitting diode films from single reflection measurements 显示文摘 | ZHU Dexi SHEN Weidong YE Hui | 2008 | Journal of Physics D: Applied Physics(S0022-3727)2008，41，23： | 1 |
| 14 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 15 | A novel red phosphor for white light emitting diodes显示文摘 | Hu Yunsheng Zhuang Weidong Ye Hongqi | 2005 | Journal of Alloys and Compounds2005，390，12： | 1 |
| 16 | An integral criterion for appraising the overall quality of a computer-based hydro-turbine governing system显示文摘 | Ye Luqing Li Weidong Li Zhaohui | 1995 | IEEE Transactions on Energy Conversion1995，10，2： | 1 |
| 17 | A novel red phosphor for white light emitting diodes显示文摘 | HU Yunsheng ZHUANG Weidong YE Hongqi | 2005 | Alloys and Compounds2005，390，1： | 1 |
| 18 | A novel red phosphor for white light emitting diodes显示文摘 | Yunsheng Hu Weidong Zhuang Hongqi Ye Donghui Wang Shusheng Zhang Xiaowei Huang | 2004 | Journal of Alloys and Compounds2004，，1： | 1 |
| 19 | Thermodynamic Description of $${\hbox{SrO-Al}_{2}\hbox{O}_{3}}$$ System and Comparison with Similar Systems显示文摘 | Xinyu Ye Weidong Zhuang Jingfang Wang Wenxia Yuan Zhiyu Qiao | 2007 | Journal of Phase Equilibria and Diffusion2007，，4： | 1 |
| 20 | A novel red phosphor for white light emitting diodes显示文摘 | Hu Yunsheng Zhuang Weidong Ye Hongqi | 2005 | Journal of Al- loys and Compounds2005，390，： | 1 |
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