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| 1 | Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells显示文摘人的 pluripotent 干细胞代表功能的胰腺的内分泌的系房间的潜在地无限的来源。这里,我们报导一条高度有效的途径导致人的胚胎的茎(ES ) 细胞和导致的 pluripotent 茎(iPS ) 在一个定义化学药品的文化系统区分进成熟生产胰岛素的细胞的细胞。这条途径获得的区分的人的 ES 房间由流动 cytometry 分析作为 assayed 包括了将近 25% 胰岛素积极的房间,它以比得上成年人的小岛的一种方式响应葡萄糖刺激释放了 insulin/C-peptide。大多数这些生产胰岛素的房间共同表示成熟尾房间特定的标记象 NKX6-1 和 PDX1 那样,在 vivo 显示一个类似的基因表示模式到成年小岛尾房间。在这研究,我们也证明 EGF 便于 PDX1 积极的胰腺的祖先的扩大。而且,我们的协议也成功了高效地导致人的 iPS 房间区分进生产胰岛素的房间。因此,这个工作不仅提供一个新模型在 vitro 学习人的胰腺的专门化和成熟的机制,而且提高为糖尿病的处理利用病人特定的 iPS 房间的可能性。 | Donghui Zhang Wei Jiang Meng Liu Xin Sui Xiaolei Yin Song Chen Yan Shi Hongkui Deng | 2009 | Cell Research2009，19，4： | 90 |
| 2 | Reconstruction of Soil Particle Composition During Freeze-Thaw Cycling: A Review显示文摘在几十年进行的研究证明了结冰融化周期在土壤是精力输入和输出的进程,它帮助驾驶土壤结构的形成,通过由结晶化和由热坡度的水和盐的运动的水扩大。然而,大多数这些研究用俄语或汉语被出版并且对国际研究人员不太可存取。这评论在在土壤结构上结冰并且融化的效果上召集了大量研究。下列调查结果被总结:我) 在结冰融化周期以后的土壤结构更加变化,变化由于粗糙的矿物质粒子和土壤的聚集罚款的土壤的机械破碎粒子;ii ) 土壤的粒子尺寸变得同类,当结冰融化周期的数字增加,在土壤结构的变化变弱;iii ) 在土壤的结冰过程,在土壤粒子结合的变化的一个重要原则表现为:冷凝作用 →
聚集 →
结晶化;iv ) 结冰融化骑车的过程由在土壤以内改变矿物质粒子和结构的 granulometric 作文在土壤结构上有强壮的效果。骑车的过程加强粒子结合的结冰融化,在土壤的总数稳定性引起全面增加,从破坏显示出一个过程到重建。 | ZHANG Ze MA Wei FENG Wenjie XIAO Donghui HOU Xin | 2016 | Pedosphere2016，26，2： | 37 |
| 3 | Glacier changes during the last forty years in the Tarim Interior River basin,northwest China显示文摘By comparing digitized glacier outlines from the Chinese Glacier Inventory (CGI) during the 1960s-1970s and Landsat Enhance Thematic Mapper (ETM+) images from 1999 to 2001, we investigated changes for about 7665 alpine glaciers among 11665 glaciers in seven sub-basins of the Tarim Interior River basin (TIRB). The results showed that the total glacier area was reduced by 3.3% from the 1960s/ 1970s to 1999/2001 and area losses for 1-5 km2 glaciers accounted for 48.3% of the total glacier area loss in the TIRB. However, the glacier area reductions varied from 0.7% to 7.9% among the seven sub-basins of the TIRB during the study period. The glacier area changing with altitude showed that the maximum contribution of area shrinkage occurred at 4900-5400 m. Data from 25 meteorological stations in the TIRB showed increases in both the annual mean air temperature and annual precipitation during 1960-2000. This indicates that the glacier shrinkage in the TIRB over the last 40 years was largely due to regional climate warming that enhanced glacier ablation and overcame the effects of increased precipitation on the glacier mass balance. | Donghui Shangguan Shiyin Liu Yongjian Ding Lianfu Ding Junli Xu Li Jing | 2009 | Progress in Natural Science:Materials International2009，19，6： | 26 |
| 4 | Anti-corrosion performance of waterborne Zn-rich coating with modified silicon-based vehicle and lamellar Zn (Al) pigments | Liuyan Zhang Aibin Ma Jinghua Jiang Dan Song Jianqing Chen Donghui Yang | 2012 | Progress in Natural Science:Materials International2012，22，4： | 26 |
| 5 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 6 | Biomimeitc Design of a Stubble-Cutting Disc Using Finite Element Analysis显示文摘 | Mo Li | 2013 | Journal of Bionic Engineering2013，10，1： | 17 |
| 7 | Thinning and Shrinkage of Laohugou No. 12 Glacier in the Western Qilian Mountains, China, from 1957 to 2007显示文摘Landsat images, real-time kinematic GPS measurements, and topographic maps were used to determine changes in ice elevation, volume, and areal extent of the Laohugou No. 12 glacier (Qilian Mountains, China) between 1957 and 2007. The glacier experienced significant thinning and areal shrinkage in the ablation zone, but slight thickening in part of the accumulation zone. Elevation decreased by 18.6±5.4 m between 1957 and 2007 in the regions covered by the GPS measurements. The total volume loss for the entire glacier was estimated to be 0.218 km3 using a third-order polynomial fit method. The area diminished by 0.28 km2 between 1957 and 1994, 0.26 km2 between 1994 and 2000, and 0.28 km2 between 2000 and 2007, suggesting that the rate of loss in glacial coverage has increased since the mid-1990s. Significant increases in annual mean air temperature may have contributed to shrinkage and thinning of the glacier. | ZHANG Yingsong LIU Shiyin SHANGGUAN Donghui LI Jing ZHAO Jingdong | 2012 | Journal of Mountain Science2012，9，3： | 16 |
| 8 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 9 | Identification of Ice Elevation Change of the Shuiguan River No.4 Glacier in the Qilian Mountains,China显示文摘GPS measurement,an effective method for surveying glacier surface topography,has been applied in some glaciers for many years.The Shuiguan River No.4 glacier,a small glacier with its area of 1.84 km2 in 1972,located in the east of the Qilian Mountains,China,was selected to study its ice elevation change using GPS measurement in 2007.This study was conducted on the ablation area with GPS-measured area 0.5 km2.The ice elevation change of the glacier was obtained by comparing the DEM obtained by a 1:50 000 topographic map made in 1972 with the DEM by GPS-measured data acquired in 2007.The differences of the two DEMs showed the thinning condition of the glacier was apparent.The mean thinning was 15±8 m with the mean thinning rate of 0.42±0.22 m a-1 for 1972-2007 in the measurement area,which equaled 0.38±0.20 m yr-1 in water equivalent(w.e.).The prominent thinning occurred on the south part of the glacier,which was the area near the glacier terminus with the maximum thinning of 41±8 m.Assuming the thinning value of 15±8 m for the glacier area below 4640 m a.s.l.,the wasting ice mass was calculated to be 6.4±3.2×10-3 km3 for 1972-2007,corresponding to 5.7±2.8×10-3 km3 w.e.,which meant that the montane runoff released by the glacier was at least 5.7±2.8×106 m3 between 1972-2007. | LI Jing LIU Shiyin SHANGGUAN Donghui ZHANG Yinsong | 2010 | Journal of Mountain Science2010，7，4： | 14 |
| 10 | Occurrence and distribution of antibiotic resistance genes in the sediments of the East China Sea bays显示文摘The coastal area of the East China Sea has experienced rapid urbanization and industrialization in China since 1980 s, resulting in severe pollution of its environments.Antibiotic resistance genes(ARGs) are regarded as a kind of emerging pollutant with potential high risk. The sediment samples were collected from Hangzhou Bay(HB),Xiangshan Bay(XB), and Taizhou Bay(TB) to investigate the spatial occurrence and distribution of 27 ARGs and class I integron–integrase gene(intI1) in the coastal area of the East China Sea. The PCR results showed the frequent presence of 11 ARGs and intI1 in the sediments of the three bays. The qPCR results further showed that sulfonamide resistance was the most prevalent ARG type and antibiotic target replacement and protection were the most important resistance mechanisms in the sediments. Regarding the subtype of ARGs, sulI, tetW, and dfrA13 were the most abundant ARGs, in which sulI was higher in TB(based on both the absolute and relative abundances) and dfrA13 was higher in HB(based on the relative abundances). The network analysis revealed that intI1 had significant correlations with tetC, sulI, sulII, and blaPSE-1. Oil was the key connected factor, which had positive connections with sulI, sulII, and blaPSE-1. In addition, the joint effect of heavy metals and nutrients & organic pollutants might be crucial for the fate of ARGs in the coastal sediments. | Jiayu Chen Zhiguo Su Tianjiao Dai Bei Huang Qinglin Mu Yongming Zhang Donghui Wen | 2019 | Journal of Environmental Sciences2019，31，7： | 13 |
| 11 | Laser performance of the SG-Ⅲ laser facility显示文摘SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Jingqin Su Kuixing Zheng Xiaodong Yuan Hai Zhou Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Xuewei Deng | 2016 | High Power Laser Science and Engineering2016，4，3： | 13 |
| 12 | Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility显示文摘The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Xiaodong Yuan Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Rui Zhang Fang Wang Huaiting Jia Xuewei Deng | 2017 | Matter and Radiation at Extremes2017，2，5： | 13 |
| 13 | Removal of sulfamethazine antibiotics by aerobic sludge and an isolated Achromobacter sp.S-3显示文摘Removal characteristics of sulfamethazine(SMZ) by sludge and a bacterial strain using an aerobic sequence batch reactor(ASBR) were studied.Operating conditions were optimized by varying the reaction time and sludge retention time(SRT).An Achromobacter sp.(S-3) with the ability to remove SMZ was isolated from the ASBR.The effects of different operating parameters(pH and temperature) on the biodegradation of SMZ by S-3 were determined.The results indicate that,between 0.5 and 4 hr,reaction time of the ASBR had a significant effect on the SMZ removal efficiency in the system.The SMZ removal efficiency also increased from 45% to 80% when SRT was prolonged from 5 to 25 days,although longer SRT had no impact on SMZ removal.The SMZ adsorption rate decreased with increasing temperature,which fitted Freundlich isotherm well.The removal of SMZ in the ASBR was due to the combined effects of adsorption and degradation,and degradation played a leading role. | Manhong Huang Shixuan Tian Donghui Chen Wei Zhang Jun Wu Liang Chen | 2012 | Journal of Environmental Sciences2012，24，9： | 12 |
| 14 | Thermal decomposition kinetics of titanium hydride and Al alloy melt foaming process显示文摘A temperature programmed decomposition (TPD) apparatus with metal tube struc- ture, in which Ar is used as the carrier gas, is established and the TPD spectrum of titanium hy- dride is acquired. Using consulting table method (CTM), spectrum superposition method (SSM) and differential spectrum technique, TPD spectrum of titanium hydride is separated and a set of thermal decomposition kinetics equations are acquired. According to these equations, the rela- tionship between decomposition quantity and time for titanium hydride at the temperature of 940 K is obtained and the result well coincides with the Al alloy melt foaming process. | YANG Donghui*1, HE Deping*1& YANG Shangrun*2 1. Department of Materials Science and Engineering, Southeast University, Nanjing 210096, China 2. Department of Chemistry, Nanjing University, Nanjing 210093, China | 2004 | Science China Chemistry2004，47，6： | 12 |
| 15 | Review on long-period stacking-ordered structures in Mg-Zn-RE alloys显示文摘The recent development of high-strength magnesium alloys is focused on the role of the strengthening phases with a novel long-period stacking-ordered (LPSO) structure. This review detailed the main factors influencing the formation of LPSO phases, including alloying ele-ments, preparation methods, and heat treatments. Furthermore, process control in structure types, formation and transformation behavior, strengthening and toughening mechanisms of the LPSO phase were discussed. Finally, the current problems and development trends of high-strength Mg-Zn-RE alloys were also put forward. | Lu, Fumin Ma, Aibin Jiang, Jinghua Yang, Donghui Zhou, Qi | 2012 | Rare Metals2012，31，3： | 12 |
| 16 | A survey on Hydroidomedusae from the upwelling region of southern part of the Taiwan Strait of China I. On new species and records of Anthomedusae显示文摘Through the examination of 377 samples of the Anthomedusae,eight new species and one new record are described. | XU Zhenzu HUANG Jiaqi GUO Donghui | 2007 | Acta Oceanologica Sinica2007，26，5： | 11 |
| 17 | Biofunctionalization of metallic implants by calcium phosphate coatings显示文摘Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability.Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions.Calcium phosphates(CaPs)are the major inorganic component of bone tissues,and thus owning inherent biocompatibility and osseointegration properties.As such,they have been widely used in clinical orthopedics and dentistry.The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs.This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances,and then give insight into the representative biofunctions,i.e.osteointegration,corrosion resistance and biodegradation control,and antibacterial property,provided by CaP coatings for metallic implant materials. | Yingchao Su Irsalan Cockerill Yufeng Zheng Liping Tang Yi-Xian Qin Donghui Zhu | 2019 | Bioactive Materials2019，4，1： | 11 |
| 18 | Dynamic contrast-enhanced MRI versus ^(18)F-FDG PET/CT: Which is better in differentiation between malignant and benign solitary pulmonary nodules?显示文摘Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI) with that of ^(18)F-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules(SPNs).Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs. All these patients underwent DCE-MRI and ^(18)F-FDG PET/CT examinations. The quantitative MRI pharmacokinetic parameters, including the trans-endothelial transfer constant(K^(trans)), redistribution rate constant(K_(ep)), and fractional volume(Ve), were calculated using the Extended-Tofts Linear two-compartment model. The ^(18)F-FDG PET/CT parameter, maximum standardized uptake value(SUV_(max)), was also measured. Spearman's correlations were calculated between the MRI pharmacokinetic parameters and the SUV_(max) of each SPN. These parameters were statistically compared between the malignant and benign nodules. Receiver operating characteristic(ROC) analyses were used to compare the diagnostic capability between the DCE-MRI and ^(18)F-FDG PET/CT indexes.Results: Positive correlations were found between K^(trans) and SUV_(max), and between K_(ep) and SUV_(max)(P<0.05).There were significant differences between the malignant and benign nodules in terms of the K^(trans), K_(ep) and SUV_(max) values(P<0.05). The areas under the ROC curve(AUC) of K^(trans), K_(ep) and SUV_(max) between the malignant and benign nodules were 0.909, 0.838 and 0.759, respectively. The sensitivity and specificity in differentiating malignant from benign SPNs were 90.6% and 82.4% for K^(trans); 87.5% and 76.5% for K_(ep); and 75.0% and 70.6%for SUV_(max), respectively. The sensitivity and specificity of K^(trans) and K_(ep) were higher than those of SUV_(max), but there was no significant difference between them(P>0.05).Conclusions: DCE-MRI can be used to differentiate between benign and malignant SPNs and has the advantage of being radiation free. | Feng Feng Fulin Qiang Aijun Shen Donghui Shi Aiyan Fu Haiming Li Mingzhu Zhang Ganlin Xia Peng Cao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 10 |
| 19 | Carbon dioxide capture using polyethylenimine-loaded mesoporous carbons显示文摘A high efficiency sorbent for CO2 capture was developed by loading polyethylenimine (PEI) on mesoporous carbons which possessed well-developed mesoporous structures and large pore volume. The physicochemical properties of the sorbent were characterized by N2 adsorption/desorption, scanning electron microscopy (SEM), thermal gravimetric analysis (TG) and Fourier transform infrared spectroscopy (FT-IR) techniques followed by testing for CO2 capture. Factors that affected the sorption capacity of the sorbent were studied. The sorbent exhibited extraordinary capture capacity with CO2 concentration ranging from 5% to 80%. The optimal PEI loading was determined to be 65 wt.% with a CO2 sorption capacity of 4.82 mmol-CO2 /g-sorbent in 15% CO2 /N2 at 75°C, owing to low mass-transfer resistance and a high utilization ratio of the amine compound (63%). Moisture had a promoting effect on the sorption separation of CO2 . In addition, the developed sorbent could be regenerated easily at 100°C, and it exhibited excellent regenerability and stability. These results indicate that this PEI-loaded mesoporous carbon sorbent should have a good potential for CO2 capture in the future. | Jitong Wang Huichao Chen Huanhuan Zhou Xiaojun Liu Wenming Qiao Donghui Long Licheng Ling | 2013 | Journal of Environmental Sciences2013，25，1： | 9 |
| 20 | Bioaugmentation with a pyridine-degrading bacterium in a membrane bioreactor treating pharmaceutical wastewater显示文摘The bacterial strain Paracoccus denitrificans W12,which could utilize pyridine as its sole source of carbon and nitrogen,was added into a membrane bioreactor(MBR)to enhance the treatment of a pharmaceutical wastewater.The treatment efciencies investigated showed that the removal of chemical oxygen demand,total nitrogen,and total phosphorus were similar between bioaugmented and non-bioaugmented MBRs,however,significant removal of pyridine was obtained in the bioaugmented reactor.When the hydraulic retention time was 60 hr and the influent concentration of pyridine was 250–500 mg/L,the mean efuent concentration of pyridine without adding W12 was 57.2 mg/L,while the pyridine was degraded to an average of 10.2 mg/L with addition of W12.The bacterial community structure of activated sludge during the bioaugmented treatment was analyzed using polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE).The results showed that the W12 inoculum reversed the decline of microbial community diversity,however,the similarity between bacterial community structure of the original sludge and that of the sludge after bioaugmentation decreased steadily during the wastewater treatment.Sequencing of the DNA recovered from DGGE gel indicated that Flavobacteriaceae sp.,Sphingobium sp.,Comamonas sp.,and Hyphomicrobium sp.were the dominant organisms in time sequence in the bacterial community in the bioaugmented MBR.This implied that the bioaugmentation was afected by the adjustment of whole bacterial community structure in the inhospitable environment,rather than being due solely to the degradation performance of the bacterium added. | Donghui Wen Jing Zhang Ruilin Xiong Rui Liu Lujun Chen | 2013 | Journal of Environmental Sciences2013，25，11： | 9 |
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