|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treating inflammatory bowel disease by adsorptive leucocytapheresis:A desire to treat without drugs显示文摘Ulcerative colitis and Crohn’s disease are the major phenotypes of the idiopathic inflammatory bowel disease(IBD),which afflicts millions of individuals throughout the world with debilitating symptoms,impairing function and quality of life.Current medications are aimed at reducing the symptoms or suppressing exacerbations.However,patients require life-long medications,and this can lead to drug dependency,loss of response together with adverse side effects.Indeed,drug side effects become additional morbidity factor in many patients on long-term medications.Nonetheless,the efficacy of anti-tumour necrosis factors(TNF)-αbiologics has validated the role of inflammatory cytokines notably TNF-αin the exacerbation of IBD.However,inflammatory cytokines are released by patients’own cellular elements including myeloid lineage leucocytes,which in patients with IBD are elevated with activation behaviour and prolonged survival.Accordingly,these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis(GMA)with an Adacolumn.Based on this background,recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries.Efficacy rates have been impressive as well as disappointing.In fact the clinical response to GMA seems to define the patients’disease course,response to medications,duration of active disease,and severity at entry.The best responders have been first episode cases(up to 100%)followed by steroid nave and patients with a short duration of active disease prior to GMA.Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA.It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early stage of their IBD.Additionally,GMA is very much favoured by patients for its good safety profile.GMA in 21st century reminds us of phlebotomy as a major medical practice at the time of Hippocrates.However,in patients with IBD,there is a scope for removing from the body the sources of proinflammatory cytokines and achieve disease remission.The bottom line is that by introducing GMA at an early stage following the onset of IBD or before patients develop extensive mucosal damage and become refractory to medications,many patients should respond to GMA and avoid pharmacologics.This should fulfill the desire to treat without drugs. | Abbi R Saniabadi Tomotaka Tanaka Toshihide Ohmori Koji Sawada Takayuki Yamamoto Hiroyuki Hanai | 2014 | World Journal of Gastroenterology2014，20，29： | 11 |
| 2 | Surgical resection of pulmonary metastases from colorectal cancer:four favourable prognostic factors显示文摘 | Koga R Yamamoto J Saiura A | | 0，，： | 2 |
| 3 | Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis显示文摘 | Chang X Yamada R Yamamoto K | | Arthritis Research & Therapy0，，： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress 显示文摘 | Okoshi R Ozaki T Yamamoto H | 2008 | J Biol Chem2008，283，7： | 1 |
| 6 | The use of small titanium screws for orthodontic anchorage显示文摘 | Deguchi D Yamamoto TT Kanomi R | 2003 | Dent Res2003，82，5： | 1 |
| 7 | Effects of the oxide laver formed on TiN coated silicon wafer on the friction and wear characteristics in dry sliding 显示文摘 | Zhou Y M Asaki R Yamamoto K R | 2003 | Surface and Coatings Technology2003，168，1： | 1 |
| 8 | Xanthophyll cycle enzymes are members of the lipocalin family,the first identified from plants显示文摘 | Hieber A D Yamamoto H Y | 1998 | J Biochem1998，273，15： | 1 |
| 9 | Hepatocyte growth factor prevents endothelial cell death through inhibition of bax transloction from cytosol to mitochondrial membrance显示文摘 | Nakagami H Morishita R Yamamoto K | 2002 | Diabetes2002，51，8： | 1 |
| 10 | 3- hydroxy-3-methylglutaryl coenzyme A reduetase inhibitors prevent the development of cardiac hypertrophy and heart failure in rats显示文摘 | HASEGAMA H YAMAMOTO R TAKANO H | 2003 | J Mol Cell Cardiol2003，35，： | 1 |
| 11 | A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice 显示文摘 | Inagi R Yamamoto Y Nangaku M | 2006 | Diabetes2006，55，2： | 1 |
| 12 | Development of wire explosion sprayed coating of cylinder bore 显示文摘 | Yamamoto M Tazaki K Ogawa R | 2000 | Kawasaki Technical Review2000，145，： | 1 |
| 13 | Phosphorylation of p38 mitogen-activated protein kinase downstream of baxcaspase-3 pathway leads to cell death induced by high Dglucose in human endothelial cells显示文摘 | Nakagami H Morishita R Yamamoto K | 2001 | Diabetes2001，50，6： | 1 |
| 14 | 3-hydroxy-3-methy lglutalryl coenzyme A reductase inhibitors prevent the development of cardiac hypertrophy and heart failure in rats显示文摘 | Hasegawa H Yamamoto R Takano H | 2003 | J Mol Cell Cardiol2003，35，8： | 1 |
| 15 | Enzymatic Bleaching of Cotton Fabric with Glucose Oxidase显示文摘 | Buachle-Diller G Yang XD Yamamoto R | 2001 | Textile Research Journal2001，71，5： | 1 |
| 16 | Strong green emission from a-SiAlON activated by divalent ytterbium under blue light irradiation 显示文摘 | Xie R J Hirosaki N Mitomo M Uheda K Suehiro T Xu X Yamamoto Y Sekiguchi T | 2005 | Journal of Physical Chemistry B2005，109，： | 1 |
| 17 | Prevention of lymphocys-tormation following systematic lymphadenectomy 显示文摘 | Yamamoto R Saitoh T Kusaka T etal | 2000 | Jpn J Cli-nOncol2000，30，9： | 1 |
| 18 | Appearance pattern of TDP43 in Japanese frontotemporal lobar degeneration with ubiquitin-posirive inclusions显示文摘 | Higashi S Iseki E Yamamoto R | 2007 | Neurosci Lett2007，419，3： | 1 |
| 19 | Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase activation in human 显示文摘 | Yamamoto M Mohanam S Sawaya R | 1996 | Cancer Res1996，56，2： | 1 |
| 20 | An Bilirubin is an antioxidant of possible physiological importance显示文摘 | STOCHER R YAMAMOTO Y MC Donagh AF | 1987 | Science1987，235，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员