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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Numericalsimulations of vortex-induced vibration on flexiblecylinders 显示文摘 | Yamamoto C T Meneghini J R Saltara F | 2004 | Journal of Fluids and Structures2004，19，： | 1 |
| 4 | Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo:induction by tumor necrosis factor-a and lipopolysaccharide 显示文摘 | Samad F Yamamoto K Loskutoff D J | 1996 | Clin Invest1996，97，1： | 1 |
| 5 | Reguratory mechanisms for production of IFN and TNF by antitumou T cells or macrogpages in the tumou-bearing state显示文摘 | Yamamoto N Zou J P Li X F | 1995 | J Immunol1995，154，5： | 1 |
| 6 | Modeling crustal deformation and rupture processes related to upwelling of deep CO2-rich fluids during the 1965-1967Matsushiro earthquake swarm in Japan显示文摘 | CAPPA F RUTQVIST J YAMAMOTO K | 2009 | Journal of Geophysical Research Atmospheres2009，114，10： | 1 |
| 7 | Numerical simulation of vortex-induced vibration on flexible cylinders 显示文摘 | Yamamoto C T Meneghini J R Saltara F Fregonesi R A Ferrari J A Jr | 2004 | Journal of Fluids and Structures2004，19，： | 1 |
| 8 | Evidence for elec- tromagnetic granularity in polycrystalline Sm1111 iron pnic- tides with enhanced phase purity显示文摘 | Yamamoto A Jiang J Kametani F | 2011 | Supercond Sci Tech2011，24，04： | 1 |
| 9 | Numerical simulations of vortex-induced vibration on flexible cylinders显示文摘 | Yamamoto C T Meneghini J R Saltrara F | 2004 | Journal of Fluids and Structures2004，19，： | 1 |
| 10 | Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community显示文摘 | SCHNABEL R B LARSON M G YAMAMOTO J F | 2010 | Circulation2010，121，2： | 1 |
| 11 | Cloning and characterization of DNA complementary to human UDP-GalNac:Fuc alpha 1-2Gal alpha 1-3GalNAc transferase(histo-blood group A transferase)mRNA显示文摘 | Yamamoto F Marken J Tsuji T | 1990 | J Biol Chem1990，256，2： | 1 |
| 12 | Cloning and characterization of DNA complementary to human UDP-GalNac:fucal2GalNac transferse mRNA显示文摘 | Yamamoto F Marken J Tsuji T | 1990 | J Bio Chem1990，256，2： | 1 |
| 13 | Cloning and characterization of DNA complementary to human UDP - Gal NAC:Fuc alpha 1 - 2 Gal alpha 1 -3GalNAC transferase (histo- blood A transferase) mRNA 显示文摘 | Yamamoto F Marken J Tsuji T | 1990 | J Biol Chem1990，265，： | 1 |
| 14 | Numerical Simulations of Vortex-Induced Vibration on Flexible Cylinders显示文摘 | Yamamoto C Meneghini J Saltara F Fregonesi R Ferrari J | 2004 | Journal of Fluids and Structures2004，19，4： | 1 |
| 15 | Cloning and characterization of DNA complementary to human UDP-GalNac:fucal2GalNac transferse mRNA显示文摘 | Yamamoto F Marken J Tsuij T et al | 1996 | J Bio Chem1996，42，2： | 1 |
| 16 | Cloning and characterization of DNA comple mentary to human UDP-GalNAc:Fucal2Gal2 Nac transferase(Histo-blood group A transferse)mRNA显示文摘 | Yamamoto F Marken J Tsuji T | 1996 | J Biol Chem1996，42，2： | 1 |
| 17 | Blood velocity profiles in the human renal artery by doppler ultrasound and their relationship to atherosclerosis 显示文摘 | Yamamoto T Ogasawara Y Kimura A Tanaka H Hiramatsu O Tsujioka K Lever M J Par- ker K H Jones C J H Caro C G Kajiya F | 1995 | Arterioscl Throm Vas1995，16，1： | 1 |
| 18 | Cloning and characterization of DNA complementary to human UDP- GalNAc: Fuc alpha 1-2Gal alpha 1-3GalNAc transferase (histo-blood group A transferase) mRNA显示文摘 | Yamamoto F Marken J Tsuji T | 1990 | J Biol Chem1990，265，2： | 1 |
| 19 | Stroke as the first manifestation of calcific aortic stenosis显示文摘 | Oliveira-filho J Massaro AR Yamamoto F | 2000 | Cerebrovasc Dis2000，10，： | 1 |
| 20 | Al binding in the epidermis cell wall inhibits cell elongation of Okra hypocltyl显示文摘 | Ma J F Yamamoto R Nevins D J | 1999 | Plant Cell Physiol1999，40，： | 1 |
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