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| 1 | Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients显示文摘 | Naicui Zhai Xiumei Chi Tianyang Li Hongxiao Song Haijun Li Xia Jin Ian Nicholas Crispe Lishan Su Junqi Niu Zhengkun Tu | 2015 | Cellular & Molecular Immunology2015，12，6： | 10 |
| 2 | Presentation of hepatocellular antigens显示文摘肝是抗原特定的 T 房间回答向有免疫力的忍耐在表明偏爱的一个机关。这清楚地在肝移植的 allogeneic 的拒绝被看见,并且多重另外的现象建议这效果是更一般的。这些向经由门静脉,到几个 hepatotropic 病毒的有免疫力的失败,到疟疾寄生虫的自然肝阶段免疫的缺乏,和癌症的经常的转移介绍给肝的抗原包括忍耐。这里,我们考察 T 房间与 hepatocellular 抗原,如此的相遇在发生的上下文,和行动压制完整的 T 房间回答的机制由从事的机制。当许多机制起一个作用时,我们将主张二个重要过程是限制在上干扰素驾驶的否定反馈抑制的 hepatocellular 抗原,和正式就职跨演讲。到从肠的微生物引起的产品的肝的经常的暴露可以驾驶天生的免疫,为通过这机制的特定的 T 房间回答使本地环境变为相反。不过,向 hepatocellular 抗原的忍耐不是整体的并且在特定的情形下面允许有效免疫和 immunopathology。 | Arash Grakoui Ian Nicholas Crispe | 2016 | Cellular & Molecular Immunology2016，13，3： | 5 |
| 3 | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease显示文摘 | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner Ian Nicholas Crispe | 2011 | Gastroenterology Research and Practice2011，，： | 3 |
| 4 | Toll-Like Receptor Signaling and Liver Fibrosis显示文摘 | Tomonori Aoyama Yong-Han Paik Ekihiro Seki Ian Nicholas Crispe | 2010 | Gastroenterology Research and Practice2010，，： | 2 |
| 5 | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease显示文摘 | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner Ian Nicholas Crispe | 2011 | Gastroenterology Research and Practice2011，，： | 1 |
| 6 | HCV immune evasion and regulatory T cell activation: cause or consequence?显示文摘Hepatitis C virus(HCV)infection remains a major public health problem given that an estimated 71 million people are currently infected and 1.75 million are newly infected every year.Up to 85%of HCV infections become persistent and may eventually lead to chronic liver diseases,including cirrhosis and hepatocellular carcinoma.1 Immune responses play a crucial role in virus control and liver injury;however,the underlying mechanism is not completely understood.Patients chronically infected with HCV generally exhibit a weak peripheral blood T cell response against HCV,which could explain viral persistence.As cells that play a key role in dominant immune tolerance,regulatory T(T-reg)cells suppress inflammatory responses and prevent the development of autoimmune diseases. | Haijun Li Tianyang Li Ian Nicholas Crispe Zhengkun Tu | 2018 | Cellular & Molecular Immunology2018，15，5： | 0 |
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