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| 1 | Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia显示文摘Edaravone 是由禁止 endothelial 损害并且由改善施加 neuroprotective 效果的新奇免费激进的 scavenger 在大脑局部缺血的 neuronal 损坏。最近, edaravone 能减轻病理和 Alzheimers 疾病病人的认知赤字,这被报导。然而,它到脉管的痴呆(VaD ) 的关联不是清楚的。在这研究,我们部分堵塞了老鼠的双边的颈动脉动脉通过手术导致长期的服的 hypoperfusion (CCH ) , VaD 的一个著名老鼠模型。水迷宫和电压降低的禁止的测试被用来评估记忆赤字。superoxide dismutase 的活动 ?( 草皮) 并且喂奶脱氢酶(LDH ) , malondialdehyde 的内容 ?(MDA ) 并且全部的反应的氧种类被测量评估氧化压力水平。西方的污点分析被用来计算 synaptic 蛋白质表达式。有为一个 5 星期的时期的 edaravone 的治疗在有 CCH 的老鼠对空间的颠倒和害怕记忆赤字有能力,这被发现。Edaravone 显著地由增加草皮活动并且减少与 CCH 在老鼠的大脑减少了氧化应力的水平 MDA, LDH,和全部的反应的氧种类的内容。而且, edaravone 处理也与 CCH 在老鼠的海马恢复了多重 synaptic 蛋白质的层次。我们的数据提供在 VaD 支持 edaravone 的 neuroprotective 效果的直接证据。我们建议氧化应力的缓和和 synaptic 蛋白质的恢复在 neuroprotection 起重要作用。 | Xu Li Fen Lu Wei Li Lingzhi Qin Yong Yao Xuerong Ge Qingkai Yu Xinliang Liang Dongmei Zhao Xiaohong Li Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 14 |
| 2 | Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β显示文摘大脑机能障碍,特别认知的缺陷,是在 Alzheimers 疾病(广告) 的主要复杂并发症之一,它威胁世界范围的 4680 万个人的健康。目前,认知机能障碍的致病仅仅部分被理解,并且为在广告的记忆损失的有效治疗留下逃犯。Tetramethylpyrazine (TMP ) 是从 Chuanxiong 净化的主要 bioactive 混合物之一,中国植物为神经与血管、心血管的疾病的处理使用了。TMP 的 neuroprotective 性质在一些 neurodegenerative 疾病是明显的,包括 Parkinsons 疾病。然而, TMP 是否在广告起一个 neuroprotective 作用,仍然是未知的。这里,我们报导有 TMP 的 2 星期的处理救了记忆缺陷在一个著名广告老鼠模型由 streptozotocin 的 intracerebroventricular 注射导致了的短期、长期的害怕。TMP 的管理也恢复了在注射 streptozotocin 的老鼠的空间学习和记忆保留能力。而且, TMP 禁止了 GSK-3 的活动,调停的重要 kinase 在糖尿病 mellitus 的海马趾的 synaptic 和记忆混乱。最后,我们发现 TMP 处理恢复了胆碱能的神经原的功能。我们的数据建议 TMP 的那饮食的举起能在广告对存储器损失提供保护,并且 GSK-3 的抑制可以在这保护的效果起一个重要作用。 | Fen Lu Xu Li Wei Li Ke Wei Yong Yao Qianlin Zhang Xinliang Liang Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 9 |
| 3 | Nonlinear spectral-like schemes for hybrid schemes显示文摘In spectral-like resolution-WENO hybrid schemes,if the switch function takes more grid points as discontinuity points,the WENO scheme is often turned on,and the numerical solutions may be too dissipative.Conversely,if the switch function takes less grid points as discontinuity points,the hybrid schemes usually are found to produce oscillatory solutions or just to be unstable.Even if the switch function takes less grid points as discontinuity points,the final hybrid scheme is inclined to be more stable,provided the spectral-like resolution scheme in the hybrid scheme has moderate shock-capturing capability.Following this idea,we propose nonlinear spectral-like schemes named weighted group velocity control(WGVC)schemes.These schemes show not only high-resolution for short waves but also moderate shock capturing capability.Then a new class of hybrid schemes is designed in which the WGVC scheme is used in smooth regions and the WENO scheme is used to capture discontinuities.These hybrid schemes show good resolution for small-scales structures and fine shock-capturing capabilities while the switch function takes less grid points as discontinuity points.The seven-order WGVC-WENO scheme has also been applied successfully to the direct numerical simulation of oblique shock wave-turbulent boundary layer interaction. | HE ZhiWei LI XinLiang LIANG Xian | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 7 |
| 4 | DNS of a spatially evolving hypersonic turbulent boundary layer at Mach 8显示文摘This paper reports the direct numerical simulation (DNS) for hypersonic turbulent boundary layer over a flat-plate at Ma∞ =8 with the ratio of wall-to-freestream temperature equal to 1.9, which indicates an extremely cold wall condition. It is primarily used to assess the wall temperature effects on the mean velocity profile, Walz equation, turbulent intensity, strong Reynolds analogy (SRA), and compressibility. The present high Mach number with cold wall condition induces strong compressibility effects. As a result, the Morkovin's hypothesis is not fully valid and so the classical SRA is also not fully consistent. However, some modified SRA is still valid at the far-wall region. It is also verified that the semi-local wall coordinate y* is better than conventional y+ in analysis of statistics features in turbulent boundary layer (TBL) in hypersonic flow. | LIANG Xian LI XinLiang | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，7： | 6 |
| 5 | Impacts of Park Landscape Structure on Thermal Environment Using QuickBird and Landsat Images显示文摘Urban parks composed mostly of vegetation and water bodies can effectively mitigate the urban heat island effect. Many studies have investigated the cooling effects of urban parks; however, little attention has been given to park landscape structure. Based on landscape metrics, this study has explored the influences of the park landscape structure on its inner thermal environment, taking heavily urbanized Beijing Municipality in China as the study area. Three indices, including the percentage of landscape(PLAND), landscape shape index(LSI) and aggregation index(AI), were used to measure the composition and configuration characteristics of the landscape components inside the parks. The indices were calculated for five landscape types being interpreted from Quickbird images. Urban thermal conditions were measured using the land surface temperature(LST) derived from Landsat TM images. The results showed that the park LST had a negative relationship with the park size, but no significant relationship was found with park shape. For the park's interior landscape, however, the configuration and composition characteristics of the landscape components inside the park explained 70% of the park LST variance. The area percentage of water bodies and the aggregation index of woodland were identified as the key influencing characteristics. In addition, when the composition and configuration characteristics of the park landscape components were separately considered, the configuration characteristics(LSI and AI) explained approximately 54% of the variance in park LST, which was comparable with that explained by the composition characteristics(PLAND). Thus, this study suggested that an effective and practical way for urban cooling park design is the optimization of spatial configuration of landscape components inside the park. | XU Xinliang CAI Hongyan QIAO Zhi WANG Liang JIN Cui GE Yaning WANG Luyao XU Fengjiao | 2017 | Chinese Geographical Science2017，27，5： | 4 |
| 6 | Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue显示文摘Soft tissue remodeling is a sophisticated process that sequentially provides dynamic biological signals to guide cell behavior.However,capturing these signals within hydrogel and directing over time has still been unrealized owing to the poor comprehension of physiological processes.Here,a bio-mimicking hydrogel is designed via thiol-ene click reaction to capture the early physical signal triggered by inflammation,and the chemical signals provided with chemokine and natural adhesion sites,which guaranteed the precise soft tissue remodeling.This bio-mimicking hydrogel efficiently facilitated cell anchoring,migration,and invasion in the 3D matrix due to the permissive space and the interaction with integrin receptors.Besides,the covalently grafted chemokine-like peptide is optimal for colonization and functional differentiation of endothelial cells through a HIF-1αdependent signal pathway.Furthermore,the early polarization of macrophages,collagen deposition and angiogenesis in rat acute wound model,and the increased blood perfusion in mouse skin flap model have confirmed that the bio-mimicking hydrogel realized precise soft tissue remodeling and opens new avenues for the phased repair of different tissues such as nerve,myocardium,and even bone. | Zhengwei Cai Qimanguli Saiding Liang Cheng Liucheng Zhang Zhen Wang Fei Wang Xinliang Chen Gang Chen Lianfu Deng Wenguo Cui | 2021 | Bioactive Materials2021，6，12： | 2 |
| 7 | Building durable aqueous K-ion capacitors based on MXene family显示文摘Obtaining stable aqueous K-ion capacitors is still challenging due to the cathode materials tended to structurally collapse after long-term cycling during large-radius K-ion insertion/extraction.In this work,three different typical MXene electrodes,i.e.,Nb_(2)C,Ti_(2)C,and Ti_(3)C_(2) were individually investigated upon their electrochemical behaviors for potassium-ion(K-ion)storage.All these MXene materials exhibited pseudocapacitive-dominated behaviors,fast kinetics,and durable K-ion storage,delivering superior performance compared with other K-ion host materials.According to the experimental results,it could be ascribed to the intrinsically large interlayer distance for K-ion transport and the superb structural stability of MXene even subjected to long-term potassiation/depotassiation process. | Guojin Liang Xinliang Li Yanbo Wang Shuo Yang Zhaodong Huang Qi Yang Donghong Wang Binbin Dong Minshen Zhu Chunyi Zhi | 2022 | Nano Research Energy2022，1，1： | 2 |
| 8 | Complex Transition of Double-Diffusive Convection in a Rectangular Enclosure with Height-to-Length Ratio Equal to 4: Part I显示文摘This is the first part of direct numerical simulation(DNS)of double-diffusive convection in a slim rectangular enclosure with horizontal temperature and concentration gradients.We consider the case with the thermal Rayleigh number of 105,the Pradtle number of 1,the Lewis number of 2,the buoyancy ratio of composition to temperature being in the range of[0,1],and height-to-width aspect ration of 4.A new 7thorder upwind compact scheme was developed for approximation of convective terms,and a three-stage third-order Runge-Kutta method was employed for time advancement.Our DNS suggests that with the buoyancy ratio increasing form 0 to 1,the flow of transition is a complex series changing from the steady to periodic,chaotic,periodic,quasi-periodic,and finally back to periodic.There are two types of periodic flow,one is simple periodic flow with single fundamental frequency(FF),and another is complex periodic flow with multiple FFs.This process is illustrated by using time-velocity histories,Fourier frequency spectrum analysis and the phase-space trajectories. | Xian Liang Xinliang Li Dexun Fu Yanwen Ma | 2009 | Communications in Computational Physics2009，6，7： | 2 |
| 9 | A simple approach towards one-dimensional mesoporous carbon with superior electrochemical capacitive activity 显示文摘 | LIANG Yanyu FENG Xinliang ZHI Linjie | 2009 | Chem Commun2009，45，7： | 1 |
| 10 | 13.4 fs,0.1 Hz OPCPA Front End for the 100 PW-Class Laser Facility显示文摘Here,we report the recent progress on the front end developed for the 100 PW-class laser facility.Using 3 stages of optical parametric chirped-pulse amplification(OPCPA)based on lithium triborate(LBO)crystals,we realized a 5.26 J/0.1 Hz amplified output with a bandwidth over 200 nm near the center wavelength of 925 nm.After the compressor,we obtained a pulse duration of 13.4 fs.As the compression efficiency reached 67%,this OPCPA front end could potentially support a peak power of 263 TW at a repetition rate of 0.1 Hz.To the best of our knowledge,among all the 100 TW-level OPCPA systems,it shows the widest spectral width,the shortest pulse duration,and it is also the first OPCPA system working at a repetition-rate mode. | Xinliang Wang Xingyan Liu Xiaoming Lu Junchi Chen Yingbin Long Wenkai Li Haidong Chen Xun Chen Peile Bai Yanyan Li Yujie Peng Yanqi Liu Fenxiang Wu Cheng Wang Zhaoyang Li Yi Xu Xiaoyan Liang Yuxin Leng Ruxin Li | 2022 | Ultrafast Science2022，，3： | 1 |
| 11 | High‐Performance Electrocatalysts for Oxygen Reduction Derived from Cobalt Porphyrin‐Based Conjugated Mesoporous Polymers显示文摘 | Zhong‐Shuai Wu Long Chen Junzhi Liu Khaled Parvez Haiwei Liang Jie Shu Hermann Sachdev Robert Graf Xinliang Feng Klaus Müllen | 2014 | Adv. Mater2014，，9： | 1 |
| 12 | Dispersion of graphene sheets in organic solvent supported by ionic interactions显示文摘 | Liang Yanyu Wu Dongqing Feng Xinliang | 2009 | Advanced Materials2009，21，17： | 1 |
| 13 | Effects of wall temperature on boundary layer stability over a blunt cone at Mach 7.99显示文摘 | Xian Liang Xinliang Li Dexun Fu Yanwen Ma | 2009 | Computers and Fluids2009，，2： | 1 |
| 14 | Combination of off-line two-dimensional hydropbilic interaction liquid chromatog- raphy for polar fraction and two-dimensional hydrophilic interac- tion liquid chromatography reversed-phase liquid chromatography for medium-polar fraction in a traditional Chinese medicine 显示文摘 | Zheng Liang Kuiyong Li Xinliang Wang | 2012 | J Chromatogr A2012，1224，： | 1 |
| 15 | Dispersion of graphene sheets in or ganic solvent supported by ionic interactions 显示文摘 | Liang Yanyu Wu Dong qing Feng Xinliang | 2009 | Ad- vanced Materials2009，21，17： | 1 |
| 16 | Graphene‐Based Porous Silica Sheets Impregnated with Polyethyleneimine for Superior CO<sub>2</sub> Capture显示文摘 | Shubin Yang Liang Zhan Xiaoyue Xu Yanli Wang Licheng Ling Xinliang Feng | 2013 | Adv Mater2013，，15： | 1 |
| 17 | Competition mechanism of multiple four-wave mixing in highly nonlinear fiber: spatial instability and satellite characteristics显示文摘在多重四波浪的混合的比赛机制(MFWM ) 过程理论上被表明。如果考虑仅仅注入高度非线性的纤维(HNLF ) 的二个波浪,有三个模式,显示全面动态行为,例如固定的点,周期的运动,和混乱运动。特别, MFWM 的模式 C 被分析它的阶段空间轨道表明非线性的波浪波浪相互作用强调。学习证明当阶段空间轨道接近或打通一个僵绳点时,为注射波浪的戏剧的力量弄空能被认识到,与混乱移动的代表性的点,但是当阶段空间轨道在一个中心附近是分布式的时,指,为注射波浪的力量被保留几乎不变,与周期性地移动的代表性的点。最后,在光纤维上的卫星波浪的发展被在幼仔双裂缝实验把它与干扰模式作比较调查。 | Liang ZHAO Junqiang SUN Xinliang ZHANG Cong CHEN | 2012 | Frontiers of Optoelectronics2012，5，4： | 0 |
| 18 | Inducing Fe 3d Electron Delocalization and Spin‑State Transition of FeN_(4) Species Boosts Oxygen Reduction Reaction for Wearable Zinc–Air Battery显示文摘Transition metal-nitrogen-carbon materials(M-N-Cs),particularly Fe-N-Cs,have been found to be electroactive for accelerating oxygen reduction reaction(ORR)kinetics.Although substantial efforts have been devoted to design Fe-N-Cs with increased active species content,surface area,and electronic conductivity,their performance is still far from satisfactory.Hitherto,there is limited research about regulation on the electronic spin states of Fe centers for Fe-N-Cs electrocatalysts to improve their catalytic performance.Here,we introduce Ti_(3)C_(2) MXene with sulfur terminals to regulate the electronic configuration of FeN_(4) species and dramatically enhance catalytic activity toward ORR.The MXene with sulfur terminals induce the spin-state transition of FeN_(4) species and Fe 3d electron delocalization with d band center upshift,enabling the Fe(II)ions to bind oxygen in the end-on adsorption mode favorable to initiate the reduction of oxygen and boosting oxygen-containing groups adsorption on FeN_(4) species and ORR kinetics.The resulting FeN_(4)-Ti_(3)C_(2)Sx exhibits comparable catalytic performance to those of commercial Pt-C.The developed wearable ZABs using FeN_(4)-Ti_(3)C_(2)Sx also exhibit fast kinetics and excellent stability.This study confirms that regulation of the electronic structure of active species via coupling with their support can be a major contributor to enhance their catalytic activity. | Shengmei Chen Xiongyi Liang Sixia Hu Xinliang Li Guobin Zhang Shuyun Wang Longtao Ma Chi‑Man Lawrence Wu Chunyi Zhi Juan Antonio Zapien | 2023 | Nano-Micro Letters2023，15，4： | 0 |
| 19 | Direct Numerical Simulation on Mach Number and Wall Temperature Effects in the Turbulent Flows of Flat-Plate Boundary Layer显示文摘In this paper,direct numerical simulation(DNS)is presented for spatially evolving turbulent boundary layer over an isothermal flat-plate at Ma∞=2.25,5,6,8.When Ma∞=8,two cases with the ratio of wall-to-reference temperature T_(w)/T_(∞)=1.9 and 10.03 are considered respectively.The wall temperature approaches recovery temperatures for other cases.The characteristics of compressible turbulent boundary layer(CTBL)affected by freestream Mach number and wall temperature are investigated.It focuses on assessing compressibility effects and the validity of Morkovin’s hypothesis through computing and analyzing the mean velocity profile,turbulent intensity,the strong Reynolds analogy(SRA)and possibility density function of dilatation term.The results show that,when the wall temperature approaches recovery temperature,the effects of Mach number on compressibility is insignificant.As a result,the compressibility effect is very weak and the Morkovin’s hypothesis is still valid for Mach number even up to 8.However,when Mach number equal to 8,the wall temperature effect on the compressibility is sensitive.In this case,when T_(w)/T_(∞)=1.9,the Morkovin’s hypothesis is not fully valid.The validity of classical SRA depends on wall temperature directly.A new modified SRA is proposed to eliminate such negative factor in near wall region.Finally the effects of Mach number and wall temperature on streaks are also studied. | Xian Liang Xinliang Li | 2015 | Communications in Computational Physics2015，17，1： | 0 |
| 20 | Mental health, health-related quality of life, and lung function after hospital discharge in healthcare workers with severe COVID-19: a cohort study from China显示文摘Coronavirus disease 2019(COVID-19)is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.It is highly contagious and can cause death in severe cases.As reported by the World Health Organization(WHO),as of 6:36 pm Central European Summer Time(CEST),12 August 2022,there had been 585950285 confirmed cases of COVID-19,including 6425422 deaths(WHO,2022).According to previous studies,healthcare workers(HCWs)have a higher risk of developing COVID-19 compared with the general community,and the severity of COVID-19 is closely related to the health-related effects after discharge(Huang et al.,2021). | Lijuan XIONG Qian LI Xiongjing CAO Huangguo XIONG Daquan MENG Mei ZHOU Yanzhao ZHANG Xinliang HE Yupeng ZHANG Liang TANG Yang JIN Jiahong XIA Yu HU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 0 |
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