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| 1 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 2 | Chinese stalagmite paleoclimate researches: A review and perspective显示文摘Stalagmite is one kind of secondary carbonates formed in limestone caves(speleothem). After cave water droplets containing Ca2+and HCO3 drip onto floor, carbonate in the water might become supersaturated due to CO2 degassing under certain conditions, resulting in the formation of stalagmite in a process year after year. Stalagmite is one of important geological archives for paleoclimate research. The advantages include wide spatial distribution, suitable for U-Th and U-Pb dating, enriched in climate proxies, continuity, long time span, comparability and lower sampling cost etc. These factors have propelled stalagmite paleoclimate research to the forefront of global paleoclimatology with an irreplaceable role. The stalagmite paleoclimate study started in the western countries, mainly in Europe and America in 1960 s–1970 s, while the relevant research in China was progressively developed in the 1980 s–1990 s after the Reform and Opening up. Although there was a huge gap between the overall research level in China and western countries, a solid research foundation, as well as a number of talent teams were established during the period. In the 21 st century, starting from the publication of stalagmite records from Hulu Cave in Nanjing in 2001, the stalagmite paleoclimate research in China has ushered in a flourishing development and a real leap on the basis of international cooperation, resulting in significant international impacts. The landmark achievements, including establishment of the world’s longest(640000 years) East Asian monsoon stalagmite record, as well as the longest Indian monsoon(280000 years),South American monsoon(250000 years), North American westerly climate(330000 years), Central Asian westerly climate(135000 years), and northwestern China westerly climate(500000 years), have laid a milestone in the paleoclimate study in these climate domains. Importantly, these stalagmite records have revealed the relationship of Asian monsoon variations with solar insolation climate change in polar regions, and the South American monsoon changes on orbital-suborbital timescales, which have provided new geological observations for the development of orbital-suborbital climate theory;elaborated coupling and differentiation relationships between the Asian monsoon and the westerly climate;reconstructed the history of Asian monsoon changes in the Holocene in detail, and thus the hydrological and climate variances behind Chinese and Indian civilizationcultural evolutions. Furthermore, a large number of high-resolution stalagmite records over the past 2000 years have been reconstructed, which are important for understanding short-term climate variability and magnitude, events, cycles, and thus the future climate projection. The achievements have also involved the improvements of a number of important techniques, such as U-Th dating method, the establishments of various hydroclimatic proxies, as well as the contributions to the reconstruction of the atmosphere14C variation history over the past ~54000 years. On the perspective of the future, the Chinese stalagmite community should continue to develop key techniques, further clarify the hydroclimatic significance of stalagmite proxies, impel the integration of related disciplines, and concentrate on key scientific issues in global climate change and major social demands. | Hai CHENG Haiwei ZHANG Jingyao ZHAO Hanying LI Youfeng NING Gayatri KATHAYAT | 2019 | Science China Earth Sciences2019，62，10： | 17 |
| 3 | The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer显示文摘Background:As a rate-limiting enzyme of glycolysis,pyruvate kinase muscle isozyme M2(PKM2)participates in tumor metabolism and growth.The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer.The 5-methylcytidine(m5C)modification in PKM2 mRNA might participate in the pathogenesis of bladder cancer and need to be further clarified.This study aimed to investigate the biological function and regulatory mechanism of PKM2 in bladder cancer.Methods:The expression of PKM2 and Aly/REF export factor(ALYREF)was measured by Western blotting,qRT-PCR,and immunohistochemistry.The bioprocesses of bladder cancer cells were demonstrated by a series of experiments in vitro and in vivo.RNA immunoprecipitation,RNA-sequencing,and dualluciferase reporter assays were conducted to explore the potential regulatory mechanisms of PKM2 in bladder cancer.Results:In bladder cancer,we first demonstrated that ALYREF stabilized PKM2 mRNA and bound to its m5C sites in 3′-untranslated regions.Overexpression of ALYREF promoted bladder cancer cell proliferation by PKM2-mediated glycolysis.Furthermore,high expression of PKM2 and ALYREF predicted poor survival in bladder cancer patients.Finally,we found that hypoxia-inducible factor-1alpha(HIF-1α)indirectly up-regulated the expression of PKM2 by activating ALYREF in addition to activating its transcription directly.Conclusions:The m5C modification in PKM2 mRNA in the HIF-1α/ALYREF/PKM2 axis may promote the glucose metabolism of bladder cancer,providing a new promising therapeutic target for bladder cancer. | Jing-Zi Wang Wei Zhu Jie Han Xiao Yang Rui Zhou Hong-Cheng Lu Hao Yu Wen-Bo Yuan Peng-Chao Li Jun Tao Qiang Lu Ji-Fu Wei Haiwei Yang | 2021 | Cancer Communications2021，41，7： | 17 |
| 4 | Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice显示文摘 | ChuanYing Fang Hua Zhang Jian Wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang Wang WenSheng Wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo | 2016 | Molecular Plant2016，9，10： | 14 |
| 5 | Structural basis for blocking PD-l-mediated immune suppression by therapeutic antibody pembrolizumab显示文摘 | Zhenkun Na Siok Ping Yeo Sakshibeedu R Bharath Matthew W Bowler Esra Ballkci Cheng-I Wang Haiwei Song | 2017 | Cell Research2017，27，1： | 10 |
| 6 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 7 | Match Point Solution for Robust Flutter Analysis in Constant-Mach Prediction显示文摘This paper presents a method for robust flutter computation which uses flight altitude as the perturbation variable in order to obtain a match point solution. The air density and sound speed of standard atmosphere model are approximated as the polynomial function of altitude, such that the flight altitude becomes the single perturbation variable that describes the aeroelastic system. The uncertainties of generalized stiffness and damping are considered and the uncertain aeroelastic system can be formulated as linear fractional transforma- tion (LFT) representation which is suitable for μ analysis framework. Finally, the match point solutions of robust flutter margins can be computed with structured singular value (SSV) theory. The robust flutter analysis method provided in this paper is suitable for con- stant-Mach flight flutter test and provides valuable reference for flight envelope expansion. | Yun Haiwei Han Jinglong | 2008 | Chinese Journal of Aeronautics2008，21，2： | 9 |
| 8 | Research progress on the correlation between gestational vaginal microecology and vaginal infectious diseases显示文摘The health status of the vaginal microenvironment, a complicated system, is an important indicator of female reproductive health. The vaginal flora is in a state of balance, and the microorganisms coexist and are interdependent to maintain the vaginal micro-ecological balance, which is a kind of dynamic balance influenced by endogenous and exogenous factors. Vaginal infections are traditionally treated by killing microbes in the vagina. Given the extensive study of the internal vaginal environment, people become gradually aware of the significance of maintaining the vaginal micro-ecological balance rather than blindly using antimicrobial agents. The balance in the vaginal internal environment is disrupted during the gestation period as the secretion of progesterone increases. The imbalanced vaginal micro-ecological environment may lead to vaginal infectious diseases. This paper provides a review of the relationship between the vaginal microecology and infectious diseases during gestation period. | Haiwei Dong Xiaohui Yang | 2017 | 国际感染病学(电子版)2017，6，3： | 8 |
| 9 | Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms显示文摘刺激干扰素的基因 56 (ISG56 ) 家庭成员在堵住病毒的复制并且然而,调整细胞的功能起重要作用他们的内在的分子的机制大部分是不清楚的。这里,我们在场 ISG54 的水晶结构,有新奇 RNA 有约束力的结构的 ISG56 家庭蛋白质。结构证明 ISG54 单体有 9 tetratricopeptide 像重复的主题和伙伴到形成交换域的 dimers。C 终端部分合拢进超级螺旋状的结构并且在它的内部表面上有一条广泛地断然控告的核苷酸绑定隧道。EMSA 结果证明 ISG54 明确地绑在一些 RNA,例如 adenylate uridylate (AU ) 富有的 RNA,与或没有 5 ′triphosphorylation。Mutagenesis 和功能的研究证明这个 RNA 有约束力的能力对它的抗病毒的活动重要。我们的结果建议位于这干扰素可诱导的基因的抗病毒的活动下面的新机制 56 家庭成员。 | Zhenlin Yang Huanhuan Liang Qian Zhou Ying Li Haiwei Chen Wen Ye Danying Chen Joy Fleming Hongbing Shu Yingfang Liu | 2012 | Cell Research2012，22，9： | 8 |
| 10 | Exosome-mediated metabolic reprogramming:the emerging role in tumor microenvironment remodeling and its influence on cancer progression显示文摘Metabolic reprogramming is reported to be one of the hallmarks of cancer,which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands.Recently,extracellular vesicles(EVs)known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment(TME).Meanwhile,the TME is a highly heterogeneous ecosystem incorporating cancer cells,fibroblasts,adipocytes,endothelial cells,mesenchymal stem cells,and extracellular matrix.Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells,which facilitate cancer progression,angiogenesis,metastasis,drug resistance,and immunosuppression by reprogramming the metabolism of cancer cells and their surrounding stromal cells.In this review,we present the role of exosomes in the TME and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.In addition,we will also discuss the potential role of exosomes targeting metabolic process as biomarkers for tumor diagnosis and prognosis,and exosomes-mediated metabolic reprogramming as potential targets for cancer therapy.Furthermore,a better understanding of the link between exosomes and metabolic reprogramming,and their impact on cancer progression,would provide novel insights for cancer prevention and treatment in the future. | Enli Yang Xuan Wang Zhiyuan Gong Miao Yu Haiwei Wu Dongsheng Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 11 | Adsorption behavior of ammonium by a bioadsorbent-Boston ivy leaf powder显示文摘The adsorption behaviors of ammonium ions from aqueous solution by a novel bioadsorbent,the Boston ivy(Parthenocissus tricuspidata) leaf powder(BPTL) were investigated.The SEM images and FT-IR spectra were used to characterize BPTL.The mathematical models were used to analyze the adsorption kinetics and isotherms.The optimum pH range for ammonium adsorption by BPTL was found to be 5-10.The adsorption reached equilibrium at 14 hr,and the kinetic data were well fitted by the Logistic model.The intraparticle diflusion was the main rate-controlling step of the adsorption process.The high temperature was favorable to the ammonium adsorption by BPTL,indicating that the adsorption was endothermic.The adsorption equilibrium fitted well to both the Langmuir model and Freundlich model,and the maximum monolayer adsorption capacities calculated from Langmuir model were 3.37,5.28 and 6.59 mg N/g at 15,25 and 35°C,respectively,which were comparable to those by reported minerals.Both the separation factor(RL) from the Langmuir model and Freundlich exponent(n) suggested that the ammonium adsorption by BPTL was favorable. Therefore,the Boston ivy leaf powder could be considered a novel bioadsorbent for ammonium removal from aqueous solution. | Haiwei Liu Yuanhua Dong Haiyun Wang Yun Liu | 2010 | Journal of Environmental Sciences2010，22，10： | 7 |
| 12 | Coordination of Urbanization and Water Ecological Environment in Shayinghe River Basin,China显示文摘During the rapid industrialization and urbanization of China,urban agglomeration in river basin areas raises the problems of over-use of water resources and pollution of the water environment.Related research in China has mainly focused on the conflicts among economic growth,urban expansion and water resource shortages within admin-istrative boundaries.However,water environments are much more dependent on their physical boundaries than their administrative boundaries.Consistent with the nature of water environment,this study aims at analyzing coordination relationships between urban development and water environment changes within physical river basin boundaries.We chose the Shayinghe River Basin,China,as our case study area which is facing serious challenges related to water en-vironment protection.Then we classified 35 county-level administrative units into upstream,midstream and down-stream regions based on their physical characteristics;analyzed the coordination degree of urban agglomeration using the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method;and constructed cooperative models using the Linear Programming (LP function) to simulate four scenarios of the coordination relationship be-tween urban population increase and water environment protection based on existing water resources and water pollu-tion data.The results show that the present coordinative situation in Shayinghe River Basin is not sustainable.In gen-eral,more than 50% administrative units are in the bad coordinative situation.In particular,the downstream region is under worse condition than the upstream and midstream regions.Cooperative models in scenario analyses indicate that the population scale set in existing urban master plannings is not coordinated with the water environment protection.To reach the goal of regional sustainable development,the total population needs to be controlled such that it will re-main at 4.5×10 7 or below by 2020 given the capacity of water environment. | ZHANG Xiang HU Hong XU Jiangang YIN Haiwei | 2011 | Chinese Geographical Science2011，21，4： | 7 |
| 13 | Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway显示文摘The control of organ size growth is one of the most fundamental aspects of life.In the past two decades,a highly conserved Hippo signaling pathway has been identified as a key molecular mechanism for governing organ size regulation.In the middle of this pathway is a kinase cascade that negatively regulates the downstream component Yes-associated protein(YAP)/transcriptional coactivator with PDZ-binding motif(TAZ)/Yorkie through phosphorylation.Phosphorylation of YAP/TAZ/Yorkie promotes its cytoplasmic localization,leads to cell apoptosis and restricts organ size overgrowth.When the Hippo pathway is inactivated,YAP/TAZ/Yorkie translocates into the nucleus to bind to the transcription enhancer factor(TEAD/TEF)family of transcriptional factors to promote cell growth and proliferation.In this review,we will focus on the structural and functional studies on the downstream transcription factor TEAD and its coactivator YAP. | Liming Chen Portia Gloria Loh Haiwei Song | 2010 | Protein & Cell2010，1，12： | 6 |
| 14 | Orbital-scale Asian summer monsoon variations:Paradox and exploration显示文摘The Asian summer monsoon(ASM) is a vast climate system, whose variability is critical to the livelihoods of billions of people across the Asian continent. During the past half-century, much progress has been made in understanding variations on a wide range of timescales, yet several significant issues remain unresolved. Of note are two long-standing problems concerning orbital-scale variations of the ASM.(1) Chinese loess magnetic susceptibility records show a persistent glacial-interglacial dominated ~100 kyr(thousand years) periodicity, while the cave oxygen-isotope(δ18 O) records reveal periodicity in an almost pure precession band(~20 kyr periodicity)—the 'Chinese 100 kyr problem'.(2) ASM records from the Arabian Sea and other oceans surrounding the Asian continent show a significant lag of 8–10 kyr to Northern Hemisphere summer insolation(NHSI), whereas the Asian cave δ18 O records follow NHSI without a significant lag—a discrepancy termed the 'sea-land precession-phase paradox'. How can we reconcile these differences? Recent and more refined model simulations now provide spatial patterns of rainfall and wind across the precession cycle, revealing distinct regional divergences in the ASM domain, which can well explain a large portion of the disparities between the loess, marine, and cave proxy records. Overall, we also find that the loess, marine, and cave records are indeed complementary rather than incompatible, with each record preferentially describing a certain aspect of ASM dynamics. Our study provides new insight into the understanding of different hydroclimatic proxies and largely reconciles the 'Chinese 100 kyr problem' and 'sea-land precession-phase paradox'. | Hai CHENG Haiwei ZHANG Yanjun CAI Zhengguo SHI Liang YI Chenglong DENG Qingzhen HAO Youbing PENG Ashish SINHA Hanying LI Jingyao ZHAO Ye TIAN Jonathan BAKER Carlos PEREZ-MEJIAS | 2021 | Science China Earth Sciences2021，64，4： | 6 |
| 15 | Genotypic variation in phosphorus acquisition from sparingly soluble P sources is related to root morphology and root exudates in Brassica napus显示文摘Genotypic variations in the adaptive response to low-phosphorus(P) stress and P-uptake efficiency have been widely reported in many crops.We conducted a pot experiment to evaluate the P-acquisition ability of two rapeseed(Brassica napus) genotypes supplied with two sparingly soluble sources of P,Al-P and Fe-P.Then,the root morphology,proton concentrations,and carboxylate content were investigated in a solution experiment to examine the genotypic difference in P-acquisition efficiency.Both genotypes produced greater biomass and accumulated more P when supplied with Al-P than when supplied with Fe-P.The P-efficient genotype 102 showed a significantly greater ability to deplete sparingly soluble P from the rhizosphere soil because of its greater biomass and higher P uptake compared with those of the P-inefficient genotype 105.In the solution experiment,the P-efficient genotype under low-P conditions developed dominant root morphological traits,and it showed more intensive rhizosphere acidification because of greater H+ efflux,higher H+-ATPase activity,and greater exudation of carboxylates than the P-inefficient genotype.Thus,a combination of morphological and physiological mechanisms contributed to the genotypic variation in the utilization of different sparingly soluble P sources in B.napus. | ZHANG HaiWei HUANG Yu YE XiangSheng XU FangSen | 2011 | Science China(Life Sciences)2011，54，12： | 6 |
| 16 | Rapamycin promotes Schwann cell migration and nerve growth factor secretion显示文摘Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Sc hwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration(1.53 nmol/L) more significantly promoted Schwann cell migration than the highest FK506 concentration(100 μmol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy. | Fang Liu Haiwei Zhang Kaiming Zhang Xinyu Wang Shipu Li Yixia Yin | 2014 | Neural Regeneration Research2014，9，6： | 6 |
| 17 | 基于单摄像机空位检测技术的全天停车需求分析显示文摘为了给交通管理和决策制定提供依据,已有很多针对停车需求的研究,其中对停车场实际数据的统计分析尤为重要.本研究借助单摄像机空位检测系统,获取了位于阿布扎比市区的通用路外停车场全天的停车状况.具体检测方法为,根据停车位的视觉特征并利用图像识别来定义车位的占用或空闲状态.本文的空位检测系统具备两个突出优点:首先,和其他方法相比,它需要的像素点更少,单个摄像机能覆盖超过150个停车位;其次,无论白天还是夜间,系统的工作性能受光照条件的影响很小.实验结果表明,在研究时段内,占用车位的检测精度为99.9%,空闲车位的检测精度为97.9%.此外,当停车场接近饱和时,由于利用率不能包含没有获得停车位的驾驶员的停车需求,本文基于此问题提出了一种更加准确的描述方法. | JERMSURAWONG Jermsak AHSAN Umair HAIDAR Abdulhamid DONG Haiwei MAVRIDIS Nikolaos | 2014 | 交通运输系统工程与信息2014，14，2： | 6 |
| 18 | Catalytic conversion of lignocellulosic biomass into chemicals and fuels显示文摘In the search of alternative resources to make commodity chemicals and transportation fuels for a low carbon future,lignocellulosic biomass with over 180-billion-ton annual production rate has been identified as a promising feedstock.This review focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels.Following a brief introduction on the structure,major resources and pretreatment methods of lignocellulosic biomass,the catalytic conversion of three main components,i.e.,cellulose,hemicellulose and lignin,into various compounds are comprehensively discussed.Either in separate steps or in one-pot,cellulose and hemicellulose are hydrolyzed into sugars and upgraded into oxygen-containing chemicals such as 5-HMF,furfural,polyols,and organic acids,or even nitrogen-containing chemicals such as amino acids.On the other hand,lignin is first depolymerized into phenols,catechols,guaiacols,aldehydes and ketones,and then further transformed into hydrocarbon fuels,bioplastic precursors and bioactive compounds.The review then introduces the transformations of whole biomass via catalytic gasification,catalytic pyrolysis,as well as emerging strategies.Finally,opportunities,challenges and prospective of woody biomass valorization are highlighted. | Weiping Deng Yunchao Feng Jie Fu Haiwei Guo Yong Guo Buxing Han Zhicheng Jiang Lingzhao Kong Changzhi Li Haichao Liu Phuc T.T.Nguyen Puning Ren Feng Wang Shuai Wang Yanqin Wang Ye Wang Sie Shing Wong Kai Yan Ning Yan Xiaofei Yang Yuanbao Zhang Zhanrong Zhang Xianhai Zeng Hui Zhou | 2023 | Green Energy & Environment2023，8，1： | 6 |
| 19 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 20 | Utilizing surfactants to control the sorption,desorption, and biodegradation of phenanthrene in soil-water system显示文摘An integrative technology including the surfactant enhanced sorption and subsequentdesorption and biodegradation of phenanthrene in the soil-water system was introduced and tested. For slightly contaminated agricultural soils, cationic-nonionic mixed surfactant- enhanced sorption of organic contaminants onto soils could reduce their transfer to plants, therefore safe-guarding agricultural production. After planting, residual surfactants combined with added nonionic surfactant could also promote thedesorption and biodegradation of residual phenanthrene, thus providing a cost-effective pollution remediation technology.0ur results showed that the cationic-nonionic mixed surfactantsdodecylpyridinium bromide (DDPB) and Triton X-100 (TX100) significantly enhanced soil retention of phenanthrene. The maximum sorption coefficient Kd* of phenanthrene for contaminated soils treated by mixed surfactants was about24.5 times that of soils without surfactant (Kd ) and higher than the combined effects of DDPB and TX100 individually, which was about 16.7 and 1.5 times Kd , respectively.0n the other hand, TX100 could effectively remove phenanthrene from contaminated soils treated by mixed surfactants, improving the bioavailability of organic pollutants. Thedesorption rates of phenanthrene from these treated soils were greater than 85% with TX100 concentration above2000 mg/L and approached 100% with increasing TX100 concentration. The biodegradation rates of phenanthrene in the presence of surfactants reached over 95% in30days. The mixed surfactants promoted the biodegradation of phenanthrene to some extent in 10-22days, and had no obvious impact on phenanthrene biodegradation at the end of the experiment. Results obtained from this study provide some insight for the production of safe agricultural products and a remediation scheme for soils slightly contaminated with organic pollutants. | Haiwei Jin Wenjun Zhou Lizhong Zhu | 2013 | Journal of Environmental Sciences2013，25，7： | 4 |
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